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What happens in our body when we encounter and fight off a virus like the flu, SARS-CoV-2 or RSV?

<p><em><a href="https://theconversation.com/profiles/lara-herrero-1166059">Lara Herrero</a>, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a> and <a href="https://theconversation.com/profiles/wesley-freppel-1408971">Wesley Freppel</a>, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a></em></p> <p><a href="https://www.labcorp.com/coronavirus-disease-covid-19/covid-news-education/covid-19-vs-flu-vs-rsv-how-tell-difference">Respiratory viruses</a> like influenza virus (flu), SARS-CoV-2 (which causes COVID) and respiratory syncytial virus (RSV) can make us sick by infecting our respiratory system, including the nose, upper airways and lungs.</p> <p>They spread from person to person through respiratory droplets when someone coughs, sneezes, or talks and can cause death in serious cases.</p> <p>But what happens in our body when we first encounter these viruses? Our immune system uses a number of strategies to fight off viral infections. Let’s look at how it does this.</p> <h2>First line of defence</h2> <p>When we encounter respiratory viruses, the <a href="https://www.sciencedirect.com/science/article/pii/S193131281600038X?via%3Dihub/">first line of defence</a> is the physical and chemical barriers in our nose, upper airways, and lungs. Barriers like the mucus lining and hair-like structures on the surface of cells, work together to trap and remove viruses before they can reach deeper into our respiratory system.</p> <p>Our defence also includes our behaviours such as coughing or sneezing. When we blow our nose, the mucus, viruses, and any other pathogens that are caught within it are expelled.</p> <p>But sometimes, viruses manage to evade these initial barriers and sneak into our respiratory system. This activates the cells of our innate immune system.</p> <h2>Patrolling for potential invaders</h2> <p>While our acquired immune system develops over time, our innate immune system is present at birth. It generates “non-specific” immunity by identifying what’s foreign. The cells of innate immunity act like a patrol system, searching for any invaders. These innate cells patrol almost every part of our body, from our skin to our nose, lungs and even internal organs.</p> <p>Our respiratory system has different type of innate cells such – as macrophages, neutrophils and natural killer cells – which patrol in our body looking for intruders. If they recognise anything foreign, in this case a virus, they will initiate an attack response.</p> <p>Each cell type plays a slightly different role. Macrophages, for example, will not only engulf and digest viruses (phagocytosis) but also release a cocktail of different molecules (cytokines) that will warn and recruit other cells to <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.12580">fight against the danger</a>.</p> <p>In the meantime, natural killer cells, aptly named, attack infected cells, and stop viruses from multiplying and <a href="https://www.nature.com/articles/s41577-021-00558-3">invading our body further</a>.</p> <p>Natural killer cells also promote inflammation, a <a href="https://www.hindawi.com/journals/jir/2018/1467538/">crucial part of the immune response</a>. It helps to recruit more immune cells to the site of infection, enhances blood flow, and increases the permeability of blood vessels, allowing immune cells to reach the infected tissues. At this stage, our immune system is fighting a war against viruses and the result can cause inflammation, fevers, coughs and congestion.</p> <h2>Launching a specific attack</h2> <p>As the innate immune response begins, another branch of the immune system called the adaptive immune system is <a href="https://www.ncbi.nlm.nih.gov/books/NBK21070/">activated</a>.</p> <p>The adaptive immune system is more specific than the innate immune system, and it decides on the correct tools and strategy to fight off the viral invaders. This system plays a vital role in eliminating the virus and providing long-term protection against future infections.</p> <p>Specialised cells called T cells and B cells are key players in acquired immunity.</p> <p>T cells (specifically, helper T cells and cytotoxic T cells) recognise viral proteins on the surface of infected cells:</p> <ul> <li> <p>helper T cells release molecules that <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764486/">further activate immune cells</a></p> </li> <li> <p>cytotoxic T cells directly kill infected cells with a very great precision, <a href="https://www.frontiersin.org/articles/10.3389/fimmu.2018.00678/full">avoiding any healthy cells around</a>.</p> </li> </ul> <p>B cells produce antibodies, which are proteins that can bind to viruses, neutralise them, and mark them for <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247032/">destruction by other immune cells</a>.</p> <p>B cells are a critical part of memory in our immune system. They will remember what happened and won’t forget for years. When the same virus attacks again, B cells will be ready to fight it off and will neutralise it faster and better.</p> <p>Thanks to the adaptive immune system, vaccines for respiratory viruses such as the COVID mRNA vaccine keep us protected from <a href="https://www.health.gov.au/our-work/covid-19-vaccines/our-vaccines/how-they-work">being sick or severely ill</a>. However, if the same virus became mutated, our immune system will act as if it was a new virus and will have to fight in a war again.</p> <h2>Neutralising the threat</h2> <p>As the immune response progresses, the combined efforts of the innate and adaptive immune systems helps control the virus. Infected cells are cleared, and the virus is neutralised and eliminated from the body.</p> <p>As the infection subsides, symptoms gradually improve, and we begin to feel better and to recover.</p> <p>But recovery varies depending on the specific virus and us as individuals. Some respiratory viruses, like rhinoviruses which cause the common cold, may cause relatively mild symptoms and a quick recovery. Others, like the flu, SARS-CoV-2 or severe cases of RSV, may lead to more severe symptoms and a longer recovery time.</p> <p>Some viruses are very strong and too fast sometimes so that our immune system does not have the time to develop a proper immune response to fight them off. <img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/207023/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/lara-herrero-1166059">Lara Herrero</a>, Research Leader in Virology and Infectious Disease, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a> and <a href="https://theconversation.com/profiles/wesley-freppel-1408971">Wesley Freppel</a>, Research Fellow, Institute for Glycomics, <a href="https://theconversation.com/institutions/griffith-university-828">Griffith University</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-happens-in-our-body-when-we-encounter-and-fight-off-a-virus-like-the-flu-sars-cov-2-or-rsv-207023">original article</a>.</em></p>

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Long COVID could be caused by the virus lingering in the body. Here’s what the science says

<p><a href="https://theconversation.com/profiles/stephen-kent-1283387">Stephen Kent</a>, <em><a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a></em> and <a href="https://theconversation.com/profiles/chansavath-phetsouphanh-1436741">Chansavath Phetsouphanh</a>, <em><a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a></em></p> <p>While most people survive and recover from COVID, for some people symptoms can <a href="https://www.nature.com/articles/s41586-021-03553-9">persist for months</a> or years. When symptoms last longer than 12 weeks, the condition is known as <a href="https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html">long COVID</a>.</p> <p>Long COVID encompasses up to <a href="https://www.nature.com/articles/s41579-022-00846-2?utm_source=substack&amp;utm_medium=email">200 different symptoms</a>. To determine evidence-based treatments for these symptoms, we need to understand the causes. One factor that may be associated with long COVID is that the virus hasn’t fully cleared from the body after the initial infection.</p> <p>We know from other viruses that viral fragments can remain in different tissues for months or even years. This could be the case with SARS-CoV-2, the virus that causes COVID. Here’s what the science says so far.</p> <h2>Other viruses lurk in the body</h2> <p>Herpesviruses (such as Epstein-Barr virus, the cause of glandular fever), as well as HIV (human immunodeficiency virus) can exist in a “latency state” for life. This means the virus conceals itself within cells and remains dormant.</p> <p>HIV, in particular, can remain dormant in infected cells throughout the body. Even though it’s inactive, it can still promote immune activation and inflammation.</p> <p>Other viruses such as <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728251/">Zika</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492426/">measles</a> and <a href="https://bmjopen.bmj.com/content/6/1/e008859">Ebola</a> have been found in tissues of infected people months or years after initial infection. This viral persistence can <a href="https://www.ahajournals.org/doi/10.1161/circulationaha.105.548156">cause chronic illness</a>.</p> <p>Several studies have shown COVID can also reactivate the Epstein-Barr virus, which has remained in the body in a latent state. Research shows this has been <a href="https://www.jci.org/articles/view/163669">linked to</a> fatigue and problems with thinking and reasoning in <a href="https://www.mdpi.com/2076-0817/10/6/763">people with long COVID</a>.</p> <figure class="align-center "><img src="https://images.theconversation.com/files/530287/original/file-20230606-15-u0ykc8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530287/original/file-20230606-15-u0ykc8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/530287/original/file-20230606-15-u0ykc8.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/530287/original/file-20230606-15-u0ykc8.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/530287/original/file-20230606-15-u0ykc8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/530287/original/file-20230606-15-u0ykc8.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/530287/original/file-20230606-15-u0ykc8.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=3 2262w" alt="Man looks at laptop, confused" /><figcaption><span class="caption">Latent viruses can cause fatigue and problems with thinking and reasoning.</span> <span class="attribution"><a class="source" href="https://unsplash.com/photos/4-EeTnaC1S4">Wes Hicks/Unsplash</a></span></figcaption></figure> <h2>How do we know COVID stays in the body?</h2> <p>Several studies have identified the genetic sequences of SARS-CoV-2 (RNA) as well as SARS-CoV-2 proteins in tissues and stool (poo) samples months following infection.</p> <p>These studies include multiple autopsy reports that <a href="https://www.nature.com/articles/s41586-022-05542-y">found viral RNA and protein in a variety of tissues</a> from people who died up to seven months after infection. SARS-CoV-2 RNA was detected in at least half the samples of heart, lymph glands, eye, nerve, brain and lung tissue tested.</p> <p>In people who survived, <a href="https://www.nature.com/articles/s41586-021-03207-w">viral RNA was found</a> four months after infection within intestinal tissues obtained through colonoscopy, when a thin tube is used to take tissue from the large intestine. These patients had asymptomatic COVID and were PCR-negative from swabs of the nose and throat at four months.</p> <p>A 2022 study found SARS-CoV-2 in the stool of about half of the participants in the first week after infection. At four months, there was no virus present in the respiratory tract but <a href="https://doi.org/10.1016/j.medj.2022.04.001">12.7% of stool samples were RNA positive</a>. A further 3.8% of faecal samples remained positive for RNA at seven months.</p> <p><a href="https://doi.org/10.1016/S2213-2600(21)00240-X">Initial studies</a> did not always suggest a strong relationship between the long-term detection of SARS-CoV-2 and long COVID symptoms.</p> <p>But more recently, the presence of SARS-CoV-2 RNA (or protein translated from RNA) in the <a href="https://academic.oup.com/cid/article/76/3/e487/6686531">blood</a> and gut tissue was found to <a href="https://doi.org/10.1053/j.gastro.2022.04.037">increase the likelihood</a> of developing long COVID symptoms.</p> <figure class="align-center "><img src="https://images.theconversation.com/files/530289/original/file-20230606-27-p7vgd8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530289/original/file-20230606-27-p7vgd8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=335&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/530289/original/file-20230606-27-p7vgd8.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=335&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/530289/original/file-20230606-27-p7vgd8.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=335&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/530289/original/file-20230606-27-p7vgd8.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=421&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/530289/original/file-20230606-27-p7vgd8.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=421&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/530289/original/file-20230606-27-p7vgd8.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=421&amp;fit=crop&amp;dpr=3 2262w" alt="Person gets a blood test" /><figcaption><span class="caption">The presence of SARS-CoV-2 in the blood increases the likelihood of developing long COVID symptoms.</span> <span class="attribution"><a class="source" href="https://unsplash.com/photos/ufwC2cmbaaI">Nguyễn Hiệp/Unsplash</a></span></figcaption></figure> <h2>How might the delay in clearing the virus impact people with long COVID?</h2> <p>Delayed clearance of SARS-CoV-2 particles in different parts of the body could drive illness through several potential processes:</p> <p><strong>1) Inflammation</strong>. The continued immune stimulation by viral proteins causes inflammation, makes our immune system tired, and alters how our immune cells work as time goes on.</p> <p><a href="https://www.nature.com/articles/s41590-021-01113-x">We have previously shown</a> immune dysfunction and inflammation persist up to eight months in people with long COVID that initially had mild to moderate disease.</p> <p><strong>2) Activation of other dormant viruses</strong>. The continued immune response to persistent SARS-CoV-2 can cause reactivation of latent viruses.</p> <p>Antibodies reactive to Epstein-Barr virus are elevated in people with long COVID suggesting Epstein-Barr virus <a href="https://doi.org/10.1101/2022.08.09.22278592">reactivation</a>, likely through activating the immune system.</p> <p>Other latent viruses, such as human endogenous retroviruses (HERVs; ancient viruses that have become a part of our DNA, like a genetic fossil) have recently been shown to become reactivated after infection. HERV proteins <a href="https://www.sciencedirect.com/science/article/pii/S2589004223006818">were detected</a> in blood cells and tissues of COVID patients.</p> <p>These proteins could potentially drive inflammatory processes in long COVID.</p> <figure class="align-center "><img src="https://images.theconversation.com/files/530290/original/file-20230606-27-6s4g00.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530290/original/file-20230606-27-6s4g00.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/530290/original/file-20230606-27-6s4g00.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/530290/original/file-20230606-27-6s4g00.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=400&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/530290/original/file-20230606-27-6s4g00.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/530290/original/file-20230606-27-6s4g00.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/530290/original/file-20230606-27-6s4g00.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=503&amp;fit=crop&amp;dpr=3 2262w" alt="3D illustration of the Epstein-Barr virus in green and red" /><figcaption><span class="caption">Reactivation of the Epstein-Barr virus could drive inflammation in long COVID.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-illustration/epsteinbarr-virus-ebv-herpes-which-causes-556379407">Shutterstock</a></span></figcaption></figure> <p><strong>3) Antibodies made by combating SARS-CoV-2 could become “self” reactive.</strong> These autoantibodies (antibodies produced by our immune system that mistakenly target and attack our own body’s tissues or organs) might cross-react with host receptors or proteins and <a href="https://www.nature.com/articles/s41577-020-00458-y">drive autoimmune</a> disease.</p> <p>Importantly, recent studies have shown new onset of autoimmune diseases (such as type 1 diabetes, inflammatory bowel disease and psoriasis) are significantly associated with SARS-CoV-2 infection and <a href="https://www.nature.com/articles/s41584-023-00964-y">a link between autoimmunity and long COVID</a> is plausible.</p> <p>This suggests COVID not only has immediate health impacts but could also potentially trigger long-term changes in the immune system.</p> <p>While the studies mentioned above provide initial evidence of persistence of SARS-CoV-2 long after initial infection, more studies are needed to show a convincing link between lingering virus and long COVID. This should include examination of viral RNA and protein in both blood and tissues in people with long COVID independent of disease severity. And it must involve well-developed cohort studies that track large groups of people internationally.</p> <p><a href="https://clinicaltrials.gov/ct2/show/NCT05668091">Several</a> <a href="https://clinicaltrials.gov/ct2/show/NCT05576662">trials are underway</a> to assess whether treating long COVID with antivirals such as Paxlovid may reduce viral antigens and improve symptoms, although this remains experimental.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/205025/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/stephen-kent-1283387">Stephen Kent</a>, Professor and Laboratory Head, <em><a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a></em> and <a href="https://theconversation.com/profiles/chansavath-phetsouphanh-1436741">Chansavath Phetsouphanh</a>, Senior Research Associate, Kirby Institute, <em><a href="https://theconversation.com/institutions/unsw-sydney-1414">UNSW Sydney</a></em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/long-covid-could-be-caused-by-the-virus-lingering-in-the-body-heres-what-the-science-says-205025">original article</a>.</em></p> <p><em>Images: Getty</em></p>

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COVID nasal sprays may one day prevent and treat infection

<p>We have vaccines to boost our immune response to SARS-CoV-2, the virus that causes COVID. We have medicines you can take at home (and in hospital) to treat COVID. Now researchers are trialling something new.</p> <p>They want to develop drugs that stop the virus getting into the body in the first place. That includes nasal sprays that stop the virus attaching to cells in the nose.</p> <p>Other researchers are looking at the potential for nasal sprays to stop the virus replicating in the nose, or to make the nose a hostile place to enter the body.</p> <p>Here’s where the science is up to and what we can expect next.</p> <h2>How could we block the virus?</h2> <p>“Viral blockade”, as the name suggests, is a simple premise based on blocking SARS-CoV-2. In other words, if something gets in its way, the virus cannot attach to a cell and it can’t infect you.</p> <p>As SARS-CoV-2 is a respiratory virus, it makes sense to deliver this type of medicine where the virus mainly enters the body – via the nose, in a nasal spray.</p> <p>There are various groups around the world working on this concept. Some research is still being conducted in the lab. Some agents have progressed to preliminary human trials. None are yet available for widespread use.</p> <p><strong>Heparin</strong></p> <p>Heparin is a common medicine that’s been used for decades to thin the blood. Studies in mice show that when heparin is delivered via the nose, <a href="https://link.springer.com/article/10.1007/s11095-022-03191-4" target="_blank" rel="noopener">it’s safe</a> and <a href="https://journals.asm.org/doi/10.1128/JVI.01987-20" target="_blank" rel="noopener">effective</a> in preventing the virus binding to nose cells. Researchers believe heparin binds to the virus itself and stops the virus attaching to the cells it’s trying to infect.</p> <p>A <a href="https://clinicaltrials.gov/ct2/show/NCT05204550" target="_blank" rel="noopener">clinical trial</a> is being <a href="https://www.premier.vic.gov.au/covid-nasal-spray-treatment-clinical-trials-begin" target="_blank" rel="noopener">conducted in Victoria</a> in collaboration between multiple Melbourne-based research centres and the University of Oxford.</p> <p><strong>Covixyl-V</strong></p> <p>Covixyl-V (ethyl lauroyl arginine hydrochloride) is another nasal spray <a href="https://assets.researchsquare.com/files/rs-911449/v1/0577f1f1-56f8-476f-97f6-d27d332ea9ca.pdf?c=1643375660" target="_blank" rel="noopener">under development</a>. It aims to prevent COVID by blocking or modifying the cell surface to prevent the virus from infecting.</p> <p>This compound has been explored for use in various viral infections, and <a href="https://assets.researchsquare.com/files/rs-911449/v1/0577f1f1-56f8-476f-97f6-d27d332ea9ca.pdf?c=1643375660" target="_blank" rel="noopener">early studies</a> in cells and small animals has shown it can prevent attachment of SARS-CoV-2 and reduce the overall viral load.</p> <p><strong>Iota-carrageenan</strong></p> <p>This molecule, which is extracted from seaweed, acts by blocking virus entry into <a href="https://www.frontiersin.org/articles/10.3389/fviro.2021.746824/full" target="_blank" rel="noopener">airway cells</a>.</p> <p>One study of about 400 health-care workers suggests a nasal spray may reduce the incidence of COVID <a href="https://www.dovepress.com/efficacy-of-a-nasal-spray-containing-iota-carrageenan-in-the-postexpos-peer-reviewed-fulltext-article-IJGM" target="_blank" rel="noopener">by up to 80%</a>.</p> <p><strong>IGM-6268</strong></p> <p>This is <a href="https://www.nature.com/articles/s41586-021-03673-2" target="_blank" rel="noopener">an engineered antibody</a> that binds to SARS-CoV-2, <a href="https://www.sciencedaily.com/releases/2021/06/210603171306.htm" target="_blank" rel="noopener">blocking</a> the virus from attaching to cells in the nose.</p> <p>A nasal and oral (mouth) spray are in a clinical trial <a href="https://clinicaltrials.gov/ct2/show/NCT05184218?term=IGM-6268&amp;draw=2&amp;rank=2" target="_blank" rel="noopener">to assess safety</a>.</p> <p><strong>Cold atmospheric plasma</strong></p> <p>This is a gas that contains charged particles. At cold temperatures, it can <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165322" target="_blank" rel="noopener">alter the surface</a> of a cell.</p> <p>A <a href="https://www.thno.org/v12p2811.htm" target="_blank" rel="noopener">lab-based study</a> shows the gas changes expression of receptors on the skin that would normally allow the virus to attach. This results in less SARS-CoV-2 attachment and infection.</p> <p>Scientists now think this technology could be adapted to a nasal spray to prevent SARS-CoV-2 infection.</p> <h2>How could we stop the virus replicating?</h2> <p>Another tactic is to develop nasal sprays that stop the virus replicating in the nose.</p> <p>Researchers are designing genetic fragments that bind to the viral RNA. These fragments – known as “<a href="https://www.nature.com/articles/s41467-022-32216-0" target="_blank" rel="noopener">locked nucleic acid antisense oligonucleotides</a>” (or LNA ASOs for short) – put a proverbial spanner in the works and stop the virus from replicating.</p> <p>A spray of these genetic fragments delivered into the nose <a href="https://www.nature.com/articles/s41467-022-32216-0" target="_blank" rel="noopener">reduced virus replication in the nose</a> and prevented disease in small animals.</p> <h2>How could we change the nose?</h2> <p>A third strategy is to change the nose environment to make it less hospitable for the virus.</p> <p>That could be by using a nasal spray to change moisture levels (with saline), alter the pH (making the nose more acidic or alkaline), or adding a virus-killing agent (iodine).</p> <p>Saline can reduce the amount of <a href="https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2768627" target="_blank" rel="noopener">SARS-CoV-2 in the nose</a> by simply washing away the virus. One study has even found that saline nasal irrigation <a href="https://journals.sagepub.com/doi/10.1177/01455613221123737" target="_blank" rel="noopener">can lessen COVID disease</a> severity. But we would need further research into saline sprays.</p> <p>An Australian-led study has found that an iodine-based nasal spray <a href="https://www.theajo.com/article/view/4466/html" target="_blank" rel="noopener">reduced the viral load</a> in the nose. Further <a href="https://www.uwa.edu.au/news/Article/2022/February/Study-finds-nasal-spray-could-aid-battle-against-COVID" target="_blank" rel="noopener">clinical trials</a> are planned.</p> <p><a href="https://www.sciencedirect.com/science/article/pii/S1386653222001809#!" target="_blank" rel="noopener">One study</a> used a test spray – containing ingredients including eucalyptus and clove oils, potassium chloride and glycerol. The aim was to kill the virus and change the acidity of the nose to prevent the virus attaching.</p> <p>This novel formulation has been tested in the lab and in a <a href="https://www.sciencedirect.com/science/article/pii/S1386653222001809#!" target="_blank" rel="noopener">clinical trial</a> showing it to be safe and to reduce infection rate from about 34% to 13% when compared to placebo controls.</p> <h2>Barriers ahead</h2> <p>Despite promising data so far on nasal sprays for COVID, one of the <a href="https://www.nature.com/articles/d41586-022-03341-z" target="_blank" rel="noopener">major barriers</a> is keeping the sprays in the nose.</p> <p>To overcome this, most sprays need multiple applications a day, sometimes every few hours.</p> <p>So based on what we know so far, nasal sprays will not singlehandedly beat COVID. But if they are shown to be safe and effective in clinical trials, and receive regulatory approval, they might be another tool to help prevent it.</p> <p><strong>This article originally appeared on <a href="https://theconversation.com/covid-nasal-sprays-may-one-day-prevent-and-treat-infection-heres-where-the-science-is-up-to-193840" target="_blank" rel="noopener">The Conversation</a>.</strong></p> <p><em>Image: Shutterstock</em></p>

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Why has my cold dragged on so long, and how do I know when it’s morphed into something more serious?

<p>Common colds are caused by viruses. There are no effective cures, and antibiotics do not work on viruses, so treatment is targeted at managing the symptoms until your immune system has cleared the cold.</p> <p>So why might someone go to a doctor at all for a cold?</p> <p>Well, occasionally a cold might turn into something more serious requiring assessment and specific treatment, and a GP visit could be warranted. Or you may just want reassurance and advice.</p> <h2>Don’t rush to the GP for something totally normal</h2> <p>Problems arise when there too many unwarranted visits to GPs for cold symptoms.</p> <p>Studies have shown <a href="https://www.annfammed.org/content/11/1/5" target="_blank" rel="noopener">antibiotics</a> are <a href="https://onlinelibrary.wiley.com/doi/abs/10.5694/mja16.01042" target="_blank" rel="noopener">still prescribed widely</a> for viral colds, even though they don’t help, and this contributes to antibiotic resistance. It hastens the arrival of an era when many antibiotics simply don’t work at all.</p> <p>On average, children have <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152362/" target="_blank" rel="noopener">four to six colds</a> per year, while in adults the average is <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152362/" target="_blank" rel="noopener">two to three</a>.</p> <p>Some people are more <a href="https://www.sciencedirect.com/science/article/abs/pii/S1530156705601189?via%3Dihub" target="_blank" rel="noopener">prone</a> to colds, but we don’t know exactly why.</p> <p>The usual cold persists about one week, although 25% last two weeks. In one <a href="https://journals.asm.org/doi/10.1128/jcm.35.11.2864-2868.1997" target="_blank" rel="noopener">study</a> with 346 adults, the infection lasted 9.5 to 11 days.</p> <p>Cold symptoms may last longer in younger children. One <a href="https://publications.aap.org/pediatrics/article-abstract/87/2/129/56810/Upper-Respiratory-Tract-Infections-in-Young?redirectedFrom=fulltext" target="_blank" rel="noopener">study</a> showed an average duration of colds ranged from 6.6 to 9 days. But symptoms lasted more than 15 days in 6.5% of 1-3 year old children in home care, and 13.1% of 2-3 year old children in day care.</p> <p>A cough tends to last longer than other symptoms, and often beyond the actual viral infection. The average <a href="https://www.annfammed.org/content/11/1/5" target="_blank" rel="noopener">duration</a> of a cough is about 17.8 days.</p> <h2>Discoloured sputum, cough or snot</h2> <p>Discoloured mucus in snot or cough is a common trigger for requesting antibiotics from a GP. But as we know, antibiotics are useless against a virus. They only work against bacterial infection.</p> <p>In fact, thick or coloured nasal mucus secretion is common following colds. Only a tiny proportion <a href="https://europepmc.org/article/pmc/pmc7151789" target="_blank" rel="noopener">involve</a> bacterial infection.</p> <p>When it happens, this is termed <a href="https://www.nps.org.au/australian-prescriber/articles/treating-acute-sinusitis-3" target="_blank" rel="noopener">acute rhinosinusitis</a>. But antibiotics are not recommended unless it lasts more than ten to 14 days and there are <a href="https://europepmc.org/article/pmc/pmc7151789" target="_blank" rel="noopener">signs</a> of bacterial sinusitis infection, such as:</p> <ul> <li>symptoms worsening after improvement in the original cold</li> <li>return of fever and</li> <li>strong facial pain.</li> </ul> <p>A prolonged cough after colds is usually caused by an irritated throat or the clearing of sticky mucus coming down from the nose. The cough may sound moist (so wrongly called “chesty”) due to the phlegm, but only small amounts of phlegm are coughed up.</p> <p>Yellow or green coloured mucus is often interpreted as a <a href="http://theconversation.com/health-check-what-you-need-to-know-about-mucus-and-phlegm-33192" target="_blank" rel="noopener">sign</a> of bacterial infection.</p> <p>But yellow or green sputum alone <a href="https://www.tandfonline.com/doi/full/10.1080/02813430902759663" target="_blank" rel="noopener">does not</a> mean you have a serious bacterial infection. One study found being prescribed antibiotics under these circumstances <a href="https://erj.ersjournals.com/content/38/1/119" target="_blank" rel="noopener">failed</a> to shorten recovery time.</p> <p>Nasal saline sprays and washes can be used to rinse out the nose and sinuses and possibly <a href="https://dtb.bmj.com/content/57/4/56" target="_blank" rel="noopener">shorten</a> rhinosinusitis and cough after colds.</p> <h2>Could it just be hayfever, or another underlying issue?</h2> <p>Hayfever or allergic rhinitis is a common cause for prolonged symptoms after a cold, especially cough and nasal congestion and maybe also sneezing.</p> <p>The damage in the upper airways following a viral infection may allow airborne allergens to trigger hayfever. Self-medicating with antihistamines, nasal saline spray or intranasal steroids is worthwhile if <a href="https://theconversation.com/health-check-why-do-i-have-a-cough-and-what-can-i-do-about-it-119172" target="_blank" rel="noopener">allergic rhinitis</a> is suspected.</p> <p>There may be other reasons for persistence of cough, such as exacerbation of underlying asthma or chronic lung disease. If so, this may require a visit to your GP.</p> <h2>What about bronchitis or pneumonia?</h2> <p>Many people worry about developing a chest infection after a cold.</p> <p>Acute bronchitis is a self-limiting infectious disease characterised by acute cough with or without sputum but without <a href="https://www.nhs.uk/conditions/pneumonia/" target="_blank" rel="noopener">signs of pneumonia</a> (such as high temperatures and feeling breathless). Most acute bronchitis cases are caused by viruses. Antibiotics are often prescribed, but produce <a href="https://www.tandfonline.com/doi/full/10.1080/14787210.2016.1193435" target="_blank" rel="noopener">no significant clinical improvement</a> compared with placebo, so are not recommended.</p> <p>Pneumonia is a potentially serious secondary disease that <a href="https://pubmed.ncbi.nlm.nih.gov/28159155/" target="_blank" rel="noopener">may follow</a> an episode of flu in a small number of cases, but is <a href="https://www.ncbi.nlm.nih.gov/books/NBK532961/" target="_blank" rel="noopener">relatively rare</a> following a cold. Symptoms and signs of pneumonia feature heavily in the list of warning signs that signal the need for a medical assessment.</p> <h2>When should I seek medical help for a cough or a cold?</h2> <p>Contact a GP if you experience:</p> <ul> <li>shortness of breath or trouble breathing</li> <li>feeling faint or dizzy</li> <li>chest pain</li> <li>dehydration</li> <li>fever or cough symptoms that improve but then return or worsen</li> <li>worsening of chronic medical conditions such as asthma.</li> </ul> <p>This is not a complete list, but may guide you on what to expect and what to watch out for.</p> <p>You might also contact your GP (perhaps for a telehealth consult) if you are finding your symptoms very unpleasant, or are concerned your condition is more serious or prolonged than expected. You might just need reassurance and education about self care options.</p> <p><strong>This article originally appeared on <a href="https://theconversation.com/why-has-my-cold-dragged-on-so-long-and-how-do-i-know-when-its-morphed-into-something-more-serious-190429" target="_blank" rel="noopener">The Conversation</a>.</strong></p> <p><em>Image: Shutterstock</em></p>

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COVID-19 virus-detecting mask can alert of exposure via your smartphone

<p>Move over <a href="https://cosmosmagazine.com/health/covid/rise-of-rapid-antigen-testing/" target="_blank" rel="noreferrer noopener">inaccurate RATs</a>. Get out of my nose and throat PCR swab tests. There’s a new method of COVID-19 detection and it’s wearable.</p> <p>A research team from Tongji University in China, has created a face mask that can detect COVID-19 (as well as other common respiratory viruses such as colds and influenza) and send an alert to your smartphone.</p> <p>The mask is highly sensitive, with the inbuilt sensor able to detect the virus <a href="https://cosmosmagazine.com/health/lets-clear-the-air-on-ventilation-cosmos-weekly-taster/" target="_blank" rel="noreferrer noopener">in the air</a> after only ten minute’s exposure at extremely low concentrations – far less than produced by sneezing, coughing or talking.</p> <p>“Previous research has shown face mask wearing can reduce the risk of spreading and contracting the disease. So, we wanted to create a mask that can detect the presence of virus in the air and alert the wearer,” says Yin Fang, an author of the study and a material scientist at Shanghai Tongji University.</p> <div class="newsletter-box"> <div id="wpcf7-f6-p214217-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div> </div> <p>The sensor on the mask has tiny synthetic molecules – called ‘aptamers’ – which are able to be tweaked to detect proteins unique to specific pathogens, such as SARS-Cov-2, H5N1 (colloquially known as ‘bird flu’) and H1N1 (‘swine flu’). Once the aptamer detects the virus, the sensor amplifies the signal via a specialised component known as an <a href="https://www.researchgate.net/publication/344400852_Ion-Gated_Transistor_An_Enabler_for_Sensing_and_Computing_Integration" target="_blank" rel="noreferrer noopener">ion-gate transistor</a> (which is highly sensitive and able to detect very low voltage signals) and sends an alert to the user’s phone.</p> <p>“Our mask would work really well in spaces with poor ventilation, such as elevators or enclosed rooms, where the <a href="https://cosmosmagazine.com/health/covid-ventilation-standards/" target="_blank" rel="noreferrer noopener">risk of getting infected is high</a>,” Fang says. The device is also highly customisable and can be swiftly modified to detect new and emerging threats.</p> <p>This is not the first time <a href="https://cosmosmagazine.com/health/smart-masks-to-detect-covid-19/" target="_blank" rel="noreferrer noopener">‘smart masks’ have been created</a> to detect COVID-19, but what sets these devices apart is their sensitivity and ‘tunability’ to different viruses.</p> <p>The team is working on reducing the detection time and increasing the sensitivity of their devices. In the future, they hope the technology could be expanded to further applications and wearables for other conditions such as cancers and heart diseases.</p> <p>“Currently, doctors have been relying heavily on their experiences in diagnosing and treating diseases. But with richer data collected by wearable devices, disease diagnosis and treatment can become more precise,” Fang says.</p> <p><img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=214217&amp;title=COVID-19+virus-detecting+mask+can+alert+of+exposure+via+your+smartphone" width="1" height="1" /></p> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/science/covid-19-detecting-mask-smartphone/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/clare-kenyon" target="_blank" rel="noopener">Clare Kenyon</a>. Clare Kenyon is a science journalist for Cosmos. An ex-high school teacher, she is currently wrangling the death throes of her PhD in astrophysics, has a Masters in astronomy and another in education. Clare also has diplomas in music and criminology and a graduate certificate of leadership and learning.</em></p> <p><em>Image: Getty Images</em></p> </div>

Technology

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Why it's important to install updates on your device

<p>Ever wondered if installing updates is worth the bother? Here's what you need to know.</p> <p>Whether you use an iPad, tablet, laptop or desktop computer, you have probably been prompted at one point to update your device. While these pop-up boxes may look like the spam you see on websites, they’re far from it.</p> <p>The device you use will have an operating system built into it, so iPads or Mac laptops will operate on Apple’s iOS system while tablets and laptops not made by Apple will run on Windows. Whichever system your device uses, it will eventually need an update. While it can be easy to dismiss the update notifications when they pop up on your screen, here’s why you shouldn’t.</p> <p><strong>What’s the point?</strong> <br />When a software program is developed, it is put through tests and quality checks and only once that has been satisfied is it released to the general public. However, once the software is out there in the world, and being used in real-life environments, it can come across little issues which get reported back to the developer. These companies then fix the issues and release the solutions as software updates.</p> <p>For electronic devices, especially laptops and desktop computers, security issues can be a big problem. Software updates include security solutions to malware or hackers, as well as fixes to bugs and any other issues that have occurred since the software was released.</p> <p><strong>Is it different to an upgrade?</strong><br />While they may sound similar, a software update and an upgrade provide two different functions. An update will install a current version of your software to your device, so basically updating your existing version of iOS or Windows. On the other side of the coin is an upgrade, which allows you to upgrade a program to its next major version. Generally, there will be a cost for a software upgrade.</p> <p><strong>How do I get updates?</strong><br />If your device is connected to the internet and it detects an update is available, it will prompt you with a notification message. This will alert you to the fact that an update is available and advise you of the next steps to step, such as clicking on a button on the notification message which will start the process for you.</p> <p>In System Settings on Apple devices and Control Panel for Windows devices, there’s an option where you can turn on automatic updating. This can provide significant benefits, such as improved security and reliability.</p> <p>Ultimately, software updates exist for a reason. While they may take a little while to download and install on your device, they are worth it. So, the next time that grey box pops up on your screen saying there’s an update available, click on it. It’ll keep your tablet or laptop secure and up-to-date with your software’s latest features.</p> <p><em>Image credits: Getty Images </em></p>

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First local monkeypox case recorded in NSW

<p dir="ltr">The first case of locally-acquired monkeypox has been recorded in New South Wales, with authorities confirming that 42 people have been infected with the virus to date.</p> <p dir="ltr">Although most contracted monkeypox overseas, two people were infected in other parts of Australia.</p> <p dir="ltr">The announcement, made by NSW Health on Sunday, comes as a first for NSW a week after the JYNNEOS vaccination program was launched for those most at risk from the virus.</p> <p dir="ltr">“NSW Health is urging the community, particularly gay, bisexual and other men who have sex with men (GBMSM), to continue to be vigilant for the symptoms of monkeypox following local transmission of the virus in NSW,” NSW Health said.</p> <p dir="ltr">Symptoms - which include a rash or lesions around the genital area, headache, body aches and fever - commonly appear between seven to 14 days after prolonged skin-to-skin contact with an infected person.</p> <p dir="ltr">Illness generally lasts for two to four weeks, with most experiencing mild symptoms that can be lessened with regular over-the-counter pain medicines and oral fluids and monitored by their GP, according to <a href="https://www.health.nsw.gov.au/Infectious/factsheets/Pages/monkeypox.aspx" target="_blank" rel="noopener">NSW Health</a>. For those with severe illness, antiviral medications are also available.</p> <p dir="ltr">“It is important that people with these symptoms avoid close contact with others, including sexual activity, as condoms are not effective at preventing the transmission of monkeypox,” NSW Health Executive Director of Health Protection Richard Broome said in a <a href="https://www.health.nsw.gov.au/news/Pages/20220821_00.aspx" target="_blank" rel="noopener">statement</a>.</p> <p dir="ltr">NSW Health also warns that monkeypox can also be transmitted by respiratory droplets during the initial infectious period and from contact with contaminated clothing, linen and other items.</p> <p dir="ltr">The news comes after Victorian authorities reported monkeypox was spreading in Melbourne last week, which was the first widespread example of local transmission in Australia since the global outbreak began.</p> <p dir="ltr">Prior to the 2022 outbreak, cases of monkeypox have mostly been reported in Central and Western African countries, with the <a href="https://doi.org/10.1136/bmjgh-2022-009838" target="_blank" rel="noopener">first human case reported</a> in the Democratic Republic of Congo in 1970.</p> <p><span id="docs-internal-guid-15cbbb5d-7fff-9dfb-3b85-b2a7d35bfde2">According to the <a href="https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html" target="_blank" rel="noopener">CDC</a>, 41,358 confirmed cases of monkeypox have been recorded as of publication, with 40,971 reported in locations without any historical cases of the virus, with a total of 89 in Australia and four in New Zealand.</span></p> <p><em>Image: Getty Images</em></p>

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Poxy McPoxface, TRUMP-22, Mpox: Public called on to rename monkeypox virus

<p>The World Health Organisation has called on the expertise of the public to help them rename the monkeypox virus after claiming the name is "misleading".</p> <p>Names for viruses are usually chosen by a committee behind closed doors, but the WHO has decided to open up the process to allow submissions from all over the world. </p> <p>Names such as Poxy McPoxface, TRUMP-22 or Mpox have been put forward so far, prompting the WHO to say they will choosing a serious name. </p> <p>WHO spokesperson Fadela Chaib said, "I am sure we will not come up with a ridiculous name."</p> <p>Dozens of submissions have now been made from a range of contributors including academics, doctors, and a gay community activist.</p> <p>One more technical submission came from Harvard Medical School emergency physician Jeremy Faust, who said the virus should simply be called OPOXID-22.</p> <p>Another proposal, TRUMP-22, appeared to be refer to former US President Donald Trump who used the controversial term "Chinese virus" for the new coronavirus, although its author said it stood for "Toxic Rash of Unrecognized Mysterious Provenance of 2022".</p> <p>Pressure is growing for a new name for the disease, largely because critics say it is misleading, since the virus did not originate in monkeys. </p> <p>A group of leading scientists wrote a position paper in June calling for a name that was "neutral, non-discriminatory and non-stigmatizing" amid fears the name can be used in a racist way.</p> <p>"It's very important we find a new name for monkeypox because this is best practice not to create any offence to an ethical group, a region, a country, an animal etc," Miss Chaib said.</p> <p>"The WHO is very concerned by this issue and we want to find a name that is not stigmatising," she added without giving a timeline of when the new name may be decided. </p> <p>Monkeypox was first discovered in 1958 and named after the first animal to show symptoms.</p> <p>The WHO declared the current outbreak a public health emergency in July having reported more than 32,000 cases from over 80 countries.</p> <p><em>Image credits: Getty Images</em></p>

Caring

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Can your mobile phone get a virus?

<p>With nearly <a href="https://www.bankmycell.com/blog/how-many-phones-are-in-the-world" target="_blank" rel="noopener">84%</a> of the world’s population now owning a smartphone, and our dependence on them growing all the time, these devices have become an attractive avenue for scammers.</p> <p>Last year, cyber security company Kaspersky detected nearly <a href="https://securelist.com/mobile-malware-evolution-2021/105876/" target="_blank" rel="noopener">3.5 million</a> malicious attacks on mobile phone users. The spam messages we get on our phones via text message or email will often contain links to viruses, which are a type of malicious software (malware).</p> <p>There’s a decent chance that at some point you’ve installed <a href="https://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=6138859" target="_blank" rel="noopener">malware</a> that infected your phone and worked (without you noticing) in the background. According to a global report commissioned by private company Zimperium, more than <a href="https://www.zimperium.com/global-mobile-threat-report/" target="_blank" rel="noopener">one-fifth</a> of mobile devices have encountered malware. And four in ten mobiles worldwide are <a href="https://blog.checkpoint.com/2020/08/06/achilles-small-chip-big-peril/" target="_blank" rel="noopener">vulnerable</a> to cyber attacks.</p> <p>But how do you know if your phone has been targeted? And what can you do?</p> <p><strong>How does a phone get infected?</strong></p> <p>Like personal computers, phones can be compromised by malware.</p> <p>For example, the Hummingbad virus infected <a href="https://www.wired.co.uk/article/hummingbad-malware-10-million-android-devices" target="_blank" rel="noopener">ten million</a> Android devices within a few months of its creation in 2016, and put as many as <a href="https://www.theguardian.com/technology/2016/jul/06/what-is-hummingbad-malware-android-devices-checkpoint" target="_blank" rel="noopener">85 million</a> devices at risk.</p> <p>Typically, a phone virus works the same way as a computer virus: a malicious code infects your device, replicates itself and spreads to other devices by auto-messaging others in your contact list or auto-forwarding itself as an email.</p> <p>A virus can limit your phone’s functionality, send your personal information to hackers, send your contacts spam messages linking to malware, and even allow the virus’s operator to “spy” on you by capturing your screen and keyboard inputs, and tracking your geographical location.</p> <p>In Australia, Scamwatch received <a href="https://www.scamwatch.gov.au/news-alerts/missed-delivery-call-or-voicemail-flubot-scams" target="_blank" rel="noopener">16,000 reports</a> of the Flubot virus over just eight weeks in 2021. This <a href="https://suretyit.com.au/blog/what-is-the-flubot-virus/" target="_blank" rel="noopener">virus</a> sends text messages to Android and iPhone users with links to malware. Clicking on the links can lead to a malicious app being downloaded on your phone, giving scammers access to your personal information.</p> <p>Flubot scammers regularly change their <a href="https://www.bitdefender.com/blog/labs/new-flubot-and-teabot-global-malware-campaigns-discovered" target="_blank" rel="noopener">target countries</a>. According to cyber security firm Bitdefender, FluBot operators targeted Australia, Germany, Poland, Spain, Austria and other European countries between December 1 2021 and January 2 of this year.</p> <p><strong>Is either Apple or Android more secure?</strong></p> <p>While Apple devices are generally considered more secure than Android, and <a href="https://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=6637558" target="_blank" rel="noopener">less prone</a> to virus attacks, iPhone users who “jailbreak” or modify their phone open themselves up to security vulnerabilities.</p> <p>Similarly, Android users who install apps from outside the Google Play store increase their risk of installing malware. It’s recommended all phone users stay on guard, as both Apple and Android are <a href="https://www.forbes.com/sites/zakdoffman/2021/03/16/iphone-12-pro-max-and-iphone-13-not-more-secure-than-google-and-samsung-android-warns-cyber-billionaire/?sh=596442d623f8" target="_blank" rel="noopener">vulnerable</a> to security risks.</p> <p>That said, phones are generally better protected against viruses than personal computers. This is because software is usually installed through authorised app stores that vet each app (although some malicious apps can occasionally slip through <a href="https://blog.pradeo.com/spyware-facestealer-google-play" target="_blank" rel="noopener">the cracks</a>).</p> <p>Also, in comparison to computers, phones are more secure as the apps are usually “<a href="https://source.android.com/security/app-sandbox" target="_blank" rel="noopener">sandboxed</a>” in their own isolated environment – unable to access or interfere with other apps. This reduces the risk of infection or cross contamination from malware. However, no device is entirely immune.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/459712/original/file-20220426-12-4550kz.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/459712/original/file-20220426-12-4550kz.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/459712/original/file-20220426-12-4550kz.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=338&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/459712/original/file-20220426-12-4550kz.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=338&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/459712/original/file-20220426-12-4550kz.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=338&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/459712/original/file-20220426-12-4550kz.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=424&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/459712/original/file-20220426-12-4550kz.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=424&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/459712/original/file-20220426-12-4550kz.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=424&amp;fit=crop&amp;dpr=3 2262w" alt="A smartphone with a virus alert warning is held up by a hand in front of a dark background." /></a><figcaption><em><span class="caption">Apple devices are generally considered more secure against malware than Android devices, but they’re still at risk.</span> <span class="attribution"><span class="source">Pixabay/Pexels.com (edited)</span>, <a class="license" href="http://creativecommons.org/licenses/by/4.0/" target="_blank" rel="noopener">CC BY</a></span></em></figcaption></figure> <p><strong>Watch out for the signs</strong></p> <p>While it’s not always easy to tell whether your phone is infected, it will exhibit some abnormal behaviours if it is. Some signs to watch out for include:</p> <ul> <li> <p>poor performance, such as apps taking longer than usual to open, or crashing randomly</p> </li> <li> <p>excessive battery drain (due to the malware constantly working in the background)</p> </li> <li> <p>increased mobile data consumption</p> </li> <li> <p>unexplained billing charges (which may include increased data usage charges as a result of the malware chewing up your data)</p> </li> <li> <p>unusual pop-ups, and</p> </li> <li> <p>the device overheating unexpectedly.</p> </li> </ul> <p>If you do suspect a virus has infected your device, there are some steps you can take. First, to prevent further damage you’ll need to remove the malware. Here are some simple troubleshooting steps:</p> <ol> <li> <p>Use a reliable antivirus app to scan your phone for infections. Some reputable vendors offering paid and free protection services include <a href="https://apps.apple.com/us/app/avast-security-privacy/id1276551855" target="_blank" rel="noopener">Avast</a>, <a href="https://www.avg.com/en-au/antivirus-for-android#pc" target="_blank" rel="noopener">AVG</a>, <a href="https://www.bitdefender.com/solutions/mobile-security-android.html" target="_blank" rel="noopener">Bitdefender</a>, <a href="https://www.mcafee.com/en-us/antivirus/mobile.html" target="_blank" rel="noopener">McAfee</a> or <a href="https://us.norton.com/products/mobile-security-for-android" target="_blank" rel="noopener">Norton</a>.</p> </li> <li> <p>Clear your phone’s storage and cache (in Android devices), or browsing history and website data (in Apple devices).</p> </li> <li> <p>Restart your iPhone, or restart your Android phone to <a href="https://www.digitaltrends.com/mobile/how-to-turn-safe-mode-on-and-off-in-android/" target="_blank" rel="noopener">go into safe mode</a> – which is a feature on Android that prevents third-party apps from operating for as long as it’s enabled.</p> </li> <li> <p>Delete any suspicious or unfamiliar apps from your downloaded apps list and, if you’re an Android user, turn safe mode off once the apps are deleted.</p> </li> </ol> <p>As a last resort, you can back up all your data and perform a factory reset on your phone. Resetting a phone to its original settings will eliminate any malware.</p> <p><strong>Protecting your phone from infection</strong></p> <p>Now you’ve fixed your phone, it’s important to safeguard it against future viruses and other security risks. The mobile security apps mentioned above will help with this. But you can also:</p> <ul> <li> <p>avoid clicking unusual pop-ups, or links in unusual text messages, social media posts or emails</p> </li> <li> <p>only install apps from authorised app stores, such as Google Play or Apple’s App Store</p> </li> <li> <p>avoid jailbreaking or modifying your phone</p> </li> <li> <p>check app permissions before installing, so you’re aware of what the app will access (rather than blindly trusting it)</p> </li> <li> <p>back up your data regularly, and</p> </li> <li> <p>keep your phone software updated to the latest version (which will have the latest security patches).</p> </li> </ul> <p>Continually monitor your phone for suspicious activity and trust your gut instincts. If something sounds too good to be true, it probably is.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/181720/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <figure><iframe src="https://www.youtube.com/embed/nvIXGeB1WgE?wmode=transparent&amp;start=38" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe><figcaption><em><span class="caption">Google’s tips on how to spot malware.</span></em></figcaption></figure> <p><em><a href="https://theconversation.com/profiles/ritesh-chugh-162770" target="_blank" rel="noopener">Ritesh Chugh</a>, Associate Professor - Information and Communications Technology, <a href="https://theconversation.com/institutions/cquniversity-australia-2140" target="_blank" rel="noopener">CQUniversity Australia</a></em></p> <p><em>This article is republished from <a href="https://theconversation.com" target="_blank" rel="noopener">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/can-your-mobile-phone-get-a-virus-yes-and-youll-have-to-look-carefully-to-see-the-signs-181720" target="_blank" rel="noopener">original article</a>.</em></p> <p><em>Image: Getty Images</em></p>

Technology

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New vaccine trial targets 2000-year-old virus

<p><span style="font-weight: 400;">The researchers behind the AstraZeneca COVID-19 vaccine have started a new trial to treat a much older disease: the plague.</span></p> <p><span style="font-weight: 400;">In the phase-one trial, scientists at the University of Oxford will be testing a new vaccine for the ancient virus on at least 40 healthy volunteers aged between 18 and 55.</span></p> <p><span style="font-weight: 400;">The new vaccine, which uses the same technology as the AstraZeneca jab, is being trialled to check how well the body recognises and learns how to fight the plague after vaccination.</span></p> <p><span style="font-weight: 400;">Though the virus hasn’t been seen in most of the world since the Black Death swept through Europe in the 14th century, there are still cases in some rural areas of Africa, Asia and America.</span></p> <p><span style="font-weight: 400;">Between 2010 and 2015, 3,248 cases of the plague were reported globally, including 584 deaths.</span></p> <blockquote style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" class="instagram-media" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CSJQK9CLXF5/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="13"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"></div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"></div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"></div> </div> </div> <div style="padding: 19% 0;"></div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"></div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" rel="noopener" href="https://www.instagram.com/p/CSJQK9CLXF5/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank">A post shared by Oxford Vaccine Group (@oxford_vaccinegroup)</a></p> </div> </blockquote> <p><span style="font-weight: 400;">Just two years later, </span><a rel="noopener" href="https://www.ox.ac.uk/news/2021-07-26-phase-i-trial-begins-new-vaccine-against-plague" target="_blank"><span style="font-weight: 400;">an epidemic</span></a><span style="font-weight: 400;"> in Madagascar saw 2,119 suspected cases and 171 deaths over several months.</span></p> <p><span style="font-weight: 400;">With many of the regions at risk of outbreaks being in remote locations, a vaccine could be a new way to protect these communities.</span></p> <p><span style="font-weight: 400;">Larissa, 26, studies genetics at the University of Oxford and is one of the participants who hopes she can help save lives by getting the jab.</span></p> <p><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7843432/_119964702_capture.png" alt="" data-udi="umb://media/faa0b5599bbf49738fdbc2a4e0278892" /></p> <p><em><span style="font-weight: 400;">Image: Oxford University</span></em></p> <p><span style="font-weight: 400;">“I’m lucky enough to live in a time where vaccines are being developed,” Larissa said.</span></p> <p><span style="font-weight: 400;">“And so, when I saw that there was a study aiming at developing a vaccine against a disease that’s been around for 2000 years and has killed millions and millions of people, I didn’t hesitate, I just wanted to do my bit.”</span></p> <p><span style="font-weight: 400;">When asked if she was worried about side effects, Larissa said she wasn’t “too concerned”.</span></p> <p><span style="font-weight: 400;">“The vaccine that’s being assessed today is using the same platform as the Covid vaccine, which has literally been administered to millions of people around the world.”</span></p> <p><span style="font-weight: 400;">Like the Oxford-AstraZeneca Covid vaccine, the plague vaccine uses a weakened version of adenovirus - a common-cold virus from chimpanzees - that has been genetically altered so people do not get infected.</span></p> <p><span style="font-weight: 400;">The vaccine does not contain plague bacterium, meaning recipients of the jab cannot contract the plague.</span></p> <p><span style="font-weight: 400;">Instead, the adenovirus has additional genes that make proteins from </span><span style="font-weight: 400;">Yersinia pestis</span><span style="font-weight: 400;">, the plague bacterium.</span></p> <p><span style="font-weight: 400;">With these added genes, the vaccine should be able to teach the immune systems of recipients how to fend off a real infection of the plague if it needs to.</span></p> <p><span style="font-weight: 400;">This technique could also be used against other diseases, according to the researchers.</span></p> <p><span style="font-weight: 400;">“We’ve already done clinical trials using similar technology against a bacterium, meningitis B, and a virus, Zika,” Dr Maheshi Ramasamy, the senior clinical researcher of the Oxford Vaccine Group, said.</span></p> <p><span style="font-weight: 400;">“But we’re also looking to develop vaccines against new and emerging diseases such as Lassa fever or the Marburg virus.”</span></p> <p><span style="font-weight: 400;">The plague vaccine trial is expected to run for at least a year.</span></p>

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More unforeseen long-term effects of COVID-19 revealed

<p>Almost a year into the global pandemic, doctors and scientists are still coming to terms with a concerning phenomenon.</p> <p>It's not a mutant strain or a side effect of the vaccine, but the aftermath of the disease that is crippling those diagnosed.</p> <p>Weeks after they were expected to recover from the virus, many are suffering from complications caused by COVID-19, which is affecting their entire body, from severe fatigue to memory lapses to digestive problems, erratic heart rates, fluctuating blood pressure and hair loss.</p> <p>Many of those who are suffering from the after-effects had minimal symptoms when originally diagnosed and doctors assumed recovery would take about two weeks.</p> <p>And then there are the “long haulers”, suffering a condition experts have deemed “post-acute COVID” or “chronic COVID”.</p> <p>“Usually, the patients with bad disease are most likely to have persistent symptoms, but COVID doesn’t work like that,” Oxford University professor of primary care, Trisha Greenhalgh, told<span> </span><a rel="noopener" href="https://www.wsj.com/articles/doctors-begin-to-crack-covids-mysterious-long-term-effects-11604252961" target="_blank"><em>The Wall Street Journal</em></a>.</p> <p>The lead author of an August BMJ study, Professor Greenhalgh was one of the first to define chronic COVID-19 patients as those whose symptoms span multiple organ systems and last over 12 weeks.</p> <p>“The disease itself is not that bad” for them, she explained, yet cognitive issues and heart problems sometimes persist for months.</p> <p>While other outbreaks such as the Spanish flu and ebola have had long-term symptoms, what makes COVID-19 different is that it doesn't just impact the lungs, but the heart, kidneys, nervous and digestive systems.</p> <p>“I haven’t really seen any other illness that affects so many different organ systems in as many different ways as COVID does,” medical director for Mount Sinai Health System’s Centre for Post-COVID Care in New York, Zijian Chen, told the<span> </span><em>WSJ</em>.</p> <p>“We thought it was a virus that, once it does what it does, you recover and you go back to normal.”</p> <p>Turns out, that isn't the case, he added it "is really scary".</p> <p>One explanation for what’s causing the virus’ second act is that inflammation continues to affect organs or the nervous system even after it’s gone, researchers said.</p> <p>“Even those who had no symptoms and were young and fit … even in those patients we saw abnormalities,” director of the University Hospital Frankfurt’s Institute for Experimental and Translational Cardiovascular Imaging, Eike Nagel, said.</p> <p>“You don’t realise how lucky you are with your health until you don’t have it,” 43-year-old lawyer, Elizabeth Moore, told the publication. Since contracting COVID-19 last March, she has struggled with memory problems and gastrointestinal issues, losing almost 14kg.</p> <p>At the end of April, “I thought I beat this thing. I was ecstatic,” she said. But after testing positive for coronavirus antibodies in May, Ms Moore said her health took a sharp turn for the worse, leading to tachycardia (racing heartbeat) and fluctuations in her blood pressure.</p> <p>While those symptoms have improved, the mother-of-three is still dealing with the gastrointestinal problems and a recent test found her stomach lining is inflamed.</p> <p>“I feel like there has to be some sort of next step,” she told the<span> </span><em>WSJ</em>. “Because I’m not ready to accept this as my new reality.”</p>

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"'The virus is afraid of Betty!"

<div class="post_body_wrapper"> <div class="post_body"> <div class="body_text "> <p>Fans around the world have rejoiced with the news that Golden Girl legend Betty White is safe and well amid the coronavirus pandemic.</p> <p>White, 98, is self-isolating in her home in California, with visits from animal friends, including ducks.</p> <p>"No one permitted in except those who must. Has helpers who are great with her," White's rep said in an email to<span> </span><a rel="noopener" href="https://www.today.com/popculture/betty-white-doing-very-well-despite-coronavirus-pandemic-t182392" target="_blank">Today</a>.</p> <p>"The animal community is watching over her," White's publicist said, adding, "The virus is afraid of Betty!"</p> <p><span>Her friend Tom Sullivan confirmed to </span><a rel="noopener" href="https://www.closerweekly.com/posts/betty-white-gushes-shes-blessed-with-incredibly-good-health/" target="_blank">Closer</a><span> that she is also keeping her mind active during the lockdown.</span></p> <p>“She reads the L.A. Times cover to cover,” he said.</p> <p>“She owns literally thousands of crossword puzzle books and is constantly doing them to keep her mind jumping. This is really serious with her.”</p> <p>As well as keeping her mind active, White has been relaxing with a cocktail or two.</p> <blockquote style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" class="instagram-media" data-instgrm-permalink="https://www.instagram.com/p/BHvKyGOgpwy/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="12"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"></div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"></div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"></div> </div> </div> <div style="padding: 19% 0;"></div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"></div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" rel="noopener" href="https://www.instagram.com/p/BHvKyGOgpwy/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank">A post shared by Betty White (@bettymwhite)</a> on Jul 11, 2016 at 2:54pm PDT</p> </div> </blockquote> <p>“Betty loves to joke that vodka keeps her young,” her friend says with a laugh.</p> <p>“She loves the image of her sitting at home in a rocking chair, drinking a martini and watching game shows, but she’s not really a big drinker. That’s not her. She’ll only take a few sips of a cocktail if the occasion calls for it.”</p> <p>White also has a message to the world.</p> <p>“Betty’s message to the world is to slow down and enjoy what you have: family, friends, your pets,” says the friend.</p> <p>“She says that the pandemic is serious, but we have come through worse. It’s Mother Nature’s way of telling us all to slow down.”</p> <p>White has spent 80 years working in television and has the longest career in the history of television.</p> </div> </div> </div>

TV

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“We’ll hold those responsible accountable”: US claims virus came from Wuhan lab

<p>The US Secretary of State Mike Pompeo has claimed there was “enormous evidence” the new coronavirus originated in a Chinese laboratory, but did not provide any of the alleged evidence.</p> <p>Pompeo, a former director of the Central Intelligence Agency, said on Sunday there was “enormous” and “significant” evidence that the coronavirus outbreak began in a laboratory in Wuhan, China.</p> <p>“I think the whole world can see now, remember, China has a history of infecting the world and running substandard laboratories,” Pompeo told ABC’s <em>This Week</em>.</p> <p>“President Trump is very clear: we’ll hold those responsible accountable.”</p> <p>At first, Pompeo said he believed “the best experts so far seem to think it was man-made”.</p> <p>But he later said he agreed with the “wide scientific consensus” from the US intelligence community that “the COVID-19 virus was not man-made or genetically modified”.</p> <p>Pompeo’s statement indicated an escalation in rhetoric amid the country’s tensions with China.</p> <p>US President Donald Trump made a similar unsupported claim on Thursday, saying that <a href="https://www.theguardian.com/us-news/2020/apr/30/donald-trump-coronavirus-chinese-lab-claim">he had proof the pandemic started in a Chinese laboratory</a>.</p> <p>On the same day, Pompeo said in an interview: “We don’t know if it came from the Wuhan Institute of Virology. We don’t know if it emanated from the wet market or yet some other place. We don’t know those answers.”</p> <p>Most epidemiologists believe the virus was likely introduced from bats to humans through an intermediary animal.</p> <p>The US had confirmed more than 1.15 million coronavirus cases and 67,000 deaths as of Monday, according to Johns Hopkins Coronavirus Resource Centre.</p> <p>Trump has faced widespread criticism for having overseen a “<a href="https://www.nytimes.com/2020/04/14/us/politics/coronavirus-trump-who-funding.html">slow and ineffective</a>“ response to the pandemic as states and cities continue to appeal for more federal help in <a href="https://www.vox.com/policy-and-politics/2020/5/3/21245815/larry-kudlow-cnn-jake-tapper-state-of-the-union-coronavirus-stimulus">increasing testing capacity and propping up the economy</a>.</p>

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New virus symptoms to watch out for

<div class="post_body_wrapper"> <div class="post_body"> <div class="body_text "> <div class="post_body_wrapper"> <div class="post_body"> <div class="body_text "> <p>Sudden loss of sense of smell or taste has been identified as a possible new coronavirus symptom by specialists in the UK.</p> <p>Patients experiencing the loss of smell or taste were discovered “in the absence of other symptoms”, said the British Association of Otorhinolarygology (ENT UK).</p> <p>The finding was based on strong evidence from coronavirus patients in China, Italy and South Korea who had the condition, known as anosmia, according to <a rel="noopener" href="https://www.9news.com.au/national/coronavirus-new-symptoms-of-loss-of-taste-smell/52838e66-e11a-4252-9b39-b01fb35d8cea" target="_blank"><em>9News</em></a>.</p> <p>"Evidence from other countries that the entry point for the coronavirus is often in the eyes, nose and throat areas,” ENT UK and the British Rhinological Society said in a joint statement.</p> <p>"We have also identified a new symptom (loss of sense of smell and taste) that may mean that people without other symptoms but with just the loss of this sense may have to self-isolate - again to reduce the spread of the virus."</p> <p>The statement also added that these patients may be the “hidden carriers” of the virus and do not meet current guidelines for testing or self isolation.</p> <p>Currently, the Australian Department of Health guidelines say that fever, cough, sore throat and shortness of breath should trigger self isolation.</p> </div> </div> </div> </div> </div> </div>

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“Wholly untrue”: UNICEF slams weird and dangerous coronavirus advice

<p>As coronavirus panic levels continue to heighten, fake tips on how to avoid catching the disease are circulating wildly on social media.</p> <p>Social media platforms are full of advice on how to avoid catching coronavirus, but many of them are untrue.</p> <p>Humanitarian organisation UNICEF was forced to issue a statement after the organisation was linked to advice urging people to stop eating ice cream.</p> <p>“A recent erroneous online message circulating in several languages around the world and purporting to be a UNICEF communication appears to indicate, among other things, that avoiding ice cream and other cold foods can help prevent the onset of the disease. This is, of course, wholly untrue,” the organisation slammed in a<span> </span><a rel="noopener noreferrer" href="https://www.unicef.org/press-releases/statement-charlotte-petri-gornitzka-unicef-deputy-executive-director-partnerships" target="_blank">statement</a>.</p> <p>“To the creators of such falsehoods, we offer a simple message: STOP. Sharing inaccurate information and attempting to imbue it with authority by misappropriating the names of those in a position of trust is dangerous and wrong.</p> <p>“To members of the public, we ask that you seek accurate information about how to keep yourself and your family safe from verified sources, such as UNICEF or WHO, government health officials and trusted healthcare professionals; and that you refrain from sharing information from untrustworthy or unverified sources.”</p> <p>The organisation also urged people to avoid sharing information from untrustworthy sources.</p> <p>“It can be difficult in today’s information-rich society to know exactly where to go for knowledge about how to keep yourself and your loved ones safe,” UNICEF partnerships deputy executive director Charlotte Petri Gornitzka said.</p> <p>“But it is critical that we remain as diligent about the accuracy of the information we share as we are about every other precaution we take to keep ourselves and our loved ones safe.”</p> <p>Other odd tips that have gone viral include advising people to keep their mouth and throat moist so that “even if the virus gets into your mouth, drinking water and other liquids will wash them down your oesophagus and into the stomach” as well as keeping your indoor temperature above 20c so that coronavirus doesn’t spread any further.</p>

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How the Queen is protecting herself in style from coronavirus

<p>The Queen is taking stylish measures to protect herself from coronavirus after she was seen wearing white gloves during an investiture ceremony for the first time in decades.</p> <p>The appearance of the gloves was just hours after UK Prime Minister Boris Johnson set out the country’s new action plan to fend off the outbreak of the virus.</p> <p>While the Queen usually wears gloves while out on public engagements, her decision to break the habit of greeting guests and collecting honours is a stylish choice to protect herself from germs.</p> <p><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7834948/queen-body.jpg" alt="" data-udi="umb://media/8622fd5f1fe843cc987451e39e619c02" /></p> <p>The Queen can be seen presenting Harry Billinge with an MBE as the D-Day veteran raised <span>£1 for every British soldier who died at Normandy to help fund a memorial.</span></p> <p>She hasn’t been seen wearing gloves during an investiture ceremony for years, as the last time she was seen wearing white gloves was back in 1954 at a ceremony in Yemen.</p> <p>When asked earlier whether Buckingham Palace is doing anything to protect members of the Royal Family from coronavirus, a spokeswoman told<span> </span><em><a rel="noopener noreferrer" href="https://www.express.co.uk/news/royal/1250296/queen-health-latest-queen-coronavirus-uk-outbreak-royal-family-latest-royal-investitures" target="_blank">Express.co.uk</a></em>:<span> </span>"We are following the Government's advice."</p> <p>As many as 51 people have tested positive for coronavirus in the past few weeks in Britain, but health officials have warned it can be expected that the number of cases will grow in the next few weeks.</p> <p>Boris Johnson spoke about the plan of action for the UK from Downing Street.</p> <p>“The plan does not set out what the government will do; it sets out the things we could do at the right time and on the basis of scientific advice.</p> <p>“I do think this is a national challenge. The potential is there for this to be something that our country has to get through but I’ve got absolutely no doubt we’ve got the resources, health service, we’ve got the expertise to do it.</p> <p>“I’m very confident the British public understands and the British public can see exactly what the balance of risk is.</p> <p>"They are getting very clear advice, a very clear picture of how we all need to behave.”</p>

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The coronavirus will hit the tourism and travel sector hard

<p>The spread of infectious diseases is invariably linked to travel. Today, tourism is a huge global business that accounts for <a style="font-size: 14px;" href="https://www.wttc.org/-/media/files/reports/economic-impact-research/regions-2019/world2019.pdf">10.4 per cent of global Gross Domestic Product (GDP) and 10 per cent of global employment.</a></p> <p>Nothing seems to slow its growth as year-over-year <a href="https://unwto.org/world-tourism-barometer-n18-january-2020">increases outpace the economy</a>. The United Nations World Tourism Organization is predicting further <a href="https://unwto.org/world-tourism-barometer-n18-january-2020">growth of three per cent to four per cent in international tourist arrivals for 2020</a>, with <a href="https://unwto.org/world-tourism-barometer-n18-january-2020">international departures worldwide particularly strong</a> in the first quarter of this year.</p> <p>But that was before a new coronavirus (formally known as 2019-nCoV) hit China and then very rapidly started spreading to the rest of the world with <a href="https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6">20 countries and counting</a> isolating cases.</p> <p>Officials in China and those in the rest of world have been much quicker to take more drastic action after learning bitter lessons from the SARS outbreak in 2003, which also started in China.</p> <p>The impact on travel to and from China of this new coronavirus, however, has been devastating. Airlines, including <a href="https://www.cbc.ca/news/business/coronavirus-air-travel-1.5444326">Air Canada</a>, <a href="https://www.cnn.com/2020/01/29/business/british-airways-coronavirus/index.html">have cancelled all flights</a> or <a href="https://www.cnn.com/2020/01/29/business/american-airlines-suspends-china-flights-coronavirus/index.html">significantly reduced the number of flights</a> in and out of China. <a href="https://www.bloomberg.com/news/articles/2020-01-30/russia-closing-border-with-china-to-affect-people-not-goods">Russia closed its land border to passenger travel</a> with China and <a href="https://www.vice.com/en_ca/article/n7jebz/hong-kong-is-closing-its-borders-to-keep-coronavirus-out">Hong Kong shut down its borders, cross-border ferries and railways</a>.</p> <p>How does the impact of 2019-nCoV differ from that of SARS, which also affected tourism dramatically?</p> <p><strong>SARS has higher death toll so far</strong></p> <p>The <a href="https://www.who.int/csr/sars/country/en/">World Health Organization</a> confirmed 8,096 cases and 774 deaths in 26 countries as a result of the SARS coronavirus. First detected in late February 2003, it had run its course five months later.</p> <p>The coronavirus first appeared in December 2019 but has already <a href="http://doi.org/10.1056/NEJMoa2001316">surpassed the total number of SARS cases in just two months</a>, albeit with a much lower death rate. Infectious disease experts expect it <a href="https://www.straitstimes.com/asia/east-asia/wuhan-virus-experts-say-outbreak-will-last-months-at-least">to last for several months</a> yet with tens of thousands afflicted before it runs its course.</p> <p>SARS accounted for a <a href="https://data.worldbank.org/indicator/ST.INT.ARVL">drop in international tourist arrivals of almost 9.4 million</a> and a loss of between US$30 billion and $50 billion. But in 2002, China’s role as both a travel destination and a source country was relatively minor, receiving fewer than 38 million tourists and sending about 17 million tourists abroad.</p> <p>Compare that to 2019 when it is estimated China received <a href="https://www.china-mike.com/china-travel-tips/china-tourism-statistics/">142 million inbound tourists and the Chinese made 134 million trips abroad and 5.5 billion trips domestically</a>.</p> <p>The severe travel restrictions imposed by the Chinese government on its citizens and the stern warnings from Foreign Affairs offices, <a href="https://travel.gc.ca/destinations/china">including Canada’s</a>, to avoid all non-essential travel to China and all travel to Hubei province (Wuhan is its capital and largest city) means that the economic impact of this coronvirus will be felt in every corner of the world and almost every sector of the economy.</p> <p>The market response has been swift, with <a href="https://www.cbc.ca/news/business/coronavirus-economic-impact-1.5437393">share prices of major airlines, cruise lines and tourism companies dropping several percentage points</a>.</p> <p>With the World Health Organization declaring the coronavirus <a href="https://www.who.int/">a public health emergency of global concern</a>, Gloria Guevara, president and CEO of the World Travel and Tourism Council (<a href="https://www.wttc.org/search-results/?query=coronavirus">WTTC</a>) fears that this escalation could have a damaging and lasting economic impact on the sector. She’s <a href="http://www.travelweekly.co.uk/articles/356089/wttc-issues-coronavirus-economic-impact-warning">expressed serious concerns</a> that airport closures, flight cancellations and shuttered borders often have a greater economic impact than the outbreak itself.</p> <p><strong>Hundreds of thousands die from seasonal flus</strong></p> <p>These concerns are well justified when one considers that <a href="https://www.cdc.gov/media/releases/2017/p1213-flu-death-estimate.html">between 291,000 and 646,000 people worldwide die from seasonal influenza-related respiratory illnesses each year</a>, which does not lead to any of these warnings or drastic measures.</p> <p>Canada saw <a href="https://www.who.int/csr/sars/country/en/">251 SARS cases and 43 deaths</a>, but it cost the Canadian economy an estimated <a href="https://www.cbc.ca/news/business/coronavirus-economic-impact-1.5437393">$5.25 billion and 28,000 jobs</a>. At the time, China was a Canadian tourism market of less than <a href="https://www150.statcan.gc.ca/t1/tbl1/en/tv.action?pid=2410000301">100,000 visitors annually; that dropped by 25 per cent due to SARS</a>.</p> <p>Today, China is Canada’s second-largest overseas market, accounting for close to <a href="https://www150.statcan.gc.ca/t1/tbl1/en/tv.action?pid=2410000301">800,000 arrivals</a>, and its highest spending market with more than<a href="https://www.destinationcanada.com/sites/default/files/archive/869-Market%20Highlights%20-%20China%20-%202019/MarketHighlights-CN_EN%5B1%5D.pdf">$2,800 per trip</a>.</p> <p>Depending on how long the restrictions and warnings are in place, losses could easily double of those in 2003. The pain will be felt in every industry as tourism’s supply chain involves everything from agriculture and fishing to banking and insurance. The hardest hit will be its core industries of accommodation, food and beverage services, recreation and entertainment, transportation and travel services.</p> <p>While Air Canada will <a href="https://www.aircanada.com/ca/en/aco/home/book/travel-news-and-updates/2020/china-travel.html">refund fares for cancelled flights</a> to and from China, other airlines may only <a href="https://www.cnn.com/2020/01/28/business/delta-american-united-coronavirus-wuhan-china/index.html">extend change fee waivers</a> or provide credit towards future flights.</p> <p>But this may not be the case for connecting flights from Beijing or Shanghai, the cities most commonly served by North American airlines.</p> <p>A growing number of hotels are also waiving changes and cancellation fees for bookings in China scheduled for the next few weeks. But many travellers to or passing through China may not be able to recover all their money, even if they bought insurance. That’s because most basic travel insurance plans do not cover <a href="https://www.aarp.org/travel/travel-tips/safety/info-2020/insurance-coronavirus-coverage.html">epidemics as a reason for cancellation</a>.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/130872/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: http://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/marion-joppe-952990">Marion Joppe</a>, Professor, Law and Economics of Tourism, <a href="https://theconversation.com/institutions/university-of-guelph-1071">University of Guelph</a></em></p> <p><em>This article is republished from <a href="http://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/the-coronavirus-will-hit-the-tourism-and-travel-sector-hard-130872">original article</a>.</em></p>

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