Could Viagra help prevent Alzheimer’s disease?
<p>Viagra is used by millions of people each year to treat erectile dysfunction. But new research shows that it might not just be helpful in the bedroom – there’s a suggestion that Viagra may also help to prevent Alzheimer’s disease.</p>
<p>Despite what it’s best known for, sildenafil – marketed as Viagra – isn’t a one-trick pony. It was <a rel="noreferrer noopener" href="https://cosmosmagazine.com/science/biology/how-i-discovered-viagra/" target="_blank">originally developed to treat angina</a> – although it didn’t make it through trials – and there’s some evidence it could <a rel="noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">help </a><a rel="noreferrer noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">t</a><a rel="noopener" href="https://www.pasteur.fr/en/viagra-prevent-transmission-malaria-parasite" target="_blank">reat malaria</a>. Tadalafil, a similar drug to Viagra, <a rel="noreferrer noopener" href="https://cosmosmagazine.com/health/medicine/sex-med-looks-promising-as-heart-failure-drug/" target="_blank">has been proposed</a> as a heart failure treatment.</p>
<p>A <a rel="noreferrer noopener" href="https://doi.org/10.1038/s43587-021-00138-z" target="_blank">paper</a> in <em>Nature Aging </em>has expanded its potential further, using records from insurance claims to examine the link between Viagra and Alzheimer’s disease.</p>
<p>The researchers, who are based in the US, examined the insurance records of 7.23 million people, alongside genetic and other biological data. They looked through the data to pull out indicators of Alzheimer’s disease, and then examined the relationship between these indicators and over 1,600 prescribed medicinal drugs.</p>
<p>Viagra had the highest link to lower chance of Alzheimer’s, with its prescription being associated with a 69% reduced risk of the disease.</p>
<p>The researchers point out that while this link is significant, it doesn’t establish causality: it may be that Viagra prevents Alzheimer’s, or it may be that people who have fewer biological precursors to Alzheimer’s are also more likely to recieve a Viagra prescription.</p>
<p>There could also be other confounding factors at play. Sildenafil, for instance, is more likely to be prescribed to wealthy people, and wealthy people are also less likely to get Alzheimer’s disease. The sample size of Viagra users was also – unsurprisingly – mostly male.</p>
<p>“Taken together, the association between sildenafil usage and decreased incidence of AD [Alzheimer’s disease] does not establish causality or its direction,” write the researchers in their paper.</p>
<p>“Our results therefore warrant rigorous clinical trial testing of the treatment efficacy of sildenafil in patients with AD, inclusive of both sexes and controlled by placebo.”</p>
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<p><em><a rel="noopener" href="https://cosmosmagazine.com/health/medicine/viagra-prevent-alzheimers-disease-study/" target="_blank">This article</a> was originally published on <a rel="noopener" href="https://cosmosmagazine.com" target="_blank">Cosmos Magazine</a> and was written by <a rel="noopener" href="https://cosmosmagazine.com/contributor/ellen-phiddian" target="_blank">Ellen Phiddian</a>. Ellen Phiddian is a science journalist at Cosmos. She has a BSc (Honours) in chemistry and science communication, and an MSc in science communication, both from the Australian National University.</em></p>
<p><em>Image: Getty Images</em></p>
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