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Princess of Wales and King Charles: one in two people develop cancer during their lives – the diseases and treatments explained

<p><em><a href="https://theconversation.com/profiles/gavin-metcalf-1340598">Gavin Metcalf</a>, <a href="https://theconversation.com/institutions/anglia-ruskin-university-1887">Anglia Ruskin University</a></em></p> <p>The Princess of Wales released a <a href="https://x.com/KensingtonRoyal/status/1771235267837321694?s=20">moving video message</a> on March 22 to address speculation about her health. In it, the future queen disclosed that she’d been <a href="https://www.bbc.co.uk/news/health-68641710">diagnosed with cancer</a> following tests conducted after she underwent major abdominal surgery at a clinic in London in January.</p> <p>Catherine explained that she was undergoing “preventative chemotherapy” – but emphasised that her surgery had been successful, and that she was “well” and “getting stronger every day”.</p> <p>The message was the <a href="https://www.theguardian.com/uk-news/2024/mar/22/princess-kate-cancer-royal-family-health-annus-horribilis">second announcement</a> of a royal family cancer diagnosis in recent weeks. On February 5, Buckingham Palace <a href="https://www.royal.uk/a-statement-from-buckingham-palace-5Feb24">published a statement</a> that King Charles III had been diagnosed with an undisclosed form of <a href="https://www.bbc.co.uk/news/uk-68208157">cancer, unrelated</a> to the treatment he had been receiving for an enlarged prostate.</p> <figure><iframe src="https://www.youtube.com/embed/3xzKooCaRXU?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>The statement said that he had begun “regular treatments”. The king postponed all public-facing duties during his treatment, but <a href="https://www.bbc.co.uk/news/uk-68213383">reportedly continued</a> with his “constitutional role as head of state, including completing paperwork and holding private meetings”.</p> <p>Cancer is the <a href="https://www.who.int/news-room/fact-sheets/detail/cancer">leading cause of death</a> worldwide. <a href="https://www.nhs.uk/conditions/cancer/#:%7E:text=The%20cancerous%20cells%20can%20invade,of%20cancer%20during%20their%20lifetime.">One in two</a> people will develop some form of cancer in their lifetime – so the condition will affect almost every family. However, many cancers can be cured if, as appears to be the case with the king, the condition is <a href="https://www.bbc.co.uk/news/uk-68213383">detected early</a> and treated effectively.</p> <h2>What is cancer?</h2> <p>Our bodies are made up of more than 100 billion cells, and cancer typically starts with changes in a small group of cells – or even a single one.</p> <p>We have different cell types depending upon where in the body they are and the function that the cell has. The size, amount and function of each of these cells is normally tightly regulated by genes – groups of codes held within our DNA – that instruct cells how to grow and divide.</p> <p>However, changes (mutations) to DNA can alter the way cells grow and multiply – often forming a lump, or solid tumour. Cancers can also develop in blood cells, such as white blood cell cancer which is known as leukaemia. This type of cancer does not form solid tumours; instead, the cancer builds up in the blood or sometimes the marrow in the core of bones, where blood cells are produced.</p> <p>In all, there are <a href="https://www.cancerresearchuk.org/about-cancer/what-is-cancer/how-cancer-starts/types-of-cancer#:%7E:text=For%20example%2C%20nerves%20and%20muscles,of%20cell%20they%20start%20in.">more than 200</a> types of cancer, but all start with mutations in the DNA contained within each and every cell.</p> <h2>What exactly are mutations?</h2> <p>Think of your DNA as a big recipe book, and your genes as individual recipes for making different dishes. Mutations are smudges or missing words from this recipe that can result in key ingredients not being added into the mix.</p> <figure><iframe src="https://www.youtube.com/embed/8BJ8_5Gyhg8?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>Regardless of the type of cancer or the cells from which it develops, mutations in our genes can result in a cell no longer understanding its instructions.</p> <p>These mutations can happen by chance when dividing, but can also be the result of lifestyle choices such as <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141049/">smoking</a>, <a href="https://www.ndph.ox.ac.uk/news/new-genetic-study-confirms-that-alcohol-is-a-direct-cause-of-cancer#:%7E:text=These%20mutations%20both%20disrupt%20the,aldehyde%20dehydrogenase%202%20(ALDH2).">drinking</a>, and <a href="https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/physical-activity-fact-sheet">inactivity</a>.</p> <p>Research has found that in order for a normal cell to turn into a cancerous cell, anywhere from <a href="https://www.sanger.ac.uk/news_item/1-10-mutations-are-needed-drive-cancer-scientists-find/">one to ten different mutations</a> are normally required.</p> <h2>How is cancer treated?</h2> <p>Treatment options for cancer depend on a variety of factors, including where your cancer is, how large it is, and whether it has spread to other parts of the body. The main treatments for cancer include surgery, chemotherapy, and radiotherapy.</p> <p>Chemotherapy uses drugs to target and kill cells that are rapidly dividing in our bodies. This approach is effective at targeting fast-growing cells in various cancers – but also has negative side effects. It also targets healthy cells that rapidly divide, such as hair and the cells lining our digestive system. This can lead to commonly reported <a href="https://www.nhs.uk/conditions/chemotherapy/side-effects/">side-effects</a> such as hair loss, nausea and diarrhoea.</p> <p><a href="https://www.cancerresearchuk.org/about-cancer/treatment/chemotherapy?gad_source=1&amp;gclid=Cj0KCQjw-_mvBhDwARIsAA-Q0Q6tyQxTuBzU7vVD7SHjQ5dF-fRdqnL7S74-k5LXyTqODydsrPfJVsoaAkgyEALw_wcB&amp;gclsrc=aw.ds">Chemotherapy</a> can be used both preventatively – as in the case of the princess – and therapeutically.</p> <figure><iframe src="https://www.youtube.com/embed/FkZn5u3MIiY?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>Preventative chemotherapy, also known as <a href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/adjuvant-therapy">adjuvant chemotherapy</a>, is given after surgery or other primary treatments to eliminate any remaining cancer cells in the body. It aims to reduce the risk of the cancer returning (known as recurrence).</p> <p>Therapeutic chemotherapy is used as a treatment option for cancer that has spread or is well established, such as advanced-stage cancers.</p> <p><a href="https://www.cancerresearchuk.org/about-cancer/treatment/surgery/about">Surgery</a> involves the physical removal of cancerous tissues as well as nearby lymph nodes – small glands which act as filters in your body that cancers can spread through – to eliminate the tumour. Surgery is often used to remove localised cancers that haven’t spread throughout the body.</p> <p><a href="https://www.cancerresearchuk.org/about-cancer/treatment/radiotherapy">Radiotherapy</a> uses high-energy radiation beams that are able to target specific areas where tumour cells are located to destroy or shrink the tumour. Radiotherapy can be applied externally or internally.</p> <p>Chemotherapy, surgery, and radiotherapy are often combined in cancer treatment to improve outcomes for patients.</p> <p>Thanks to developments in cancer research over the last 50 years, survival rates have improved greatly – although the rate of improvement has <a href="https://news.cancerresearchuk.org/2024/02/02/world-cancer-day-2024/#:%7E:text=Improvements%20in%20cancer%20survival%20have%20slowed%20in%20recent%20years&amp;text=Survival%20increased%20three%20to%20five,consistently%20lags%20behind%20comparable%20countries.">slowed recently</a>. Cancer survival depends on various factors such as age – people under 40 have a <a href="https://www.cancer.gov/about-cancer/causes-prevention/risk/age">greater chance</a> of survival – overall health and fitness, as well as family history.</p> <h2>What you should do</h2> <p>Particular changes in your body or warning symptoms could indicate the presence of cancer. These include, but are not limited to:</p> <ul> <li>Unexplained weight loss;</li> <li>Fatigue that doesn’t improve with rest;</li> <li>Changes in bowel or bladder habits;</li> <li>Persistent cough or coughing up blood;</li> <li>Difficulty swallowing;</li> <li>Persistent pain;</li> <li>Noticing lumps, such as in a breast or testicle.</li> </ul> <p>The symptoms may not necessarily be the result of cancer. But it is important to get checked by a doctor if you notice anything out of the ordinary or have had persistent symptoms that don’t ease. Early detection and treatment can <a href="https://www.science.org/doi/full/10.1126/science.aay9040">significantly improve</a> outcomes for many types of cancer.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/226456/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/gavin-metcalf-1340598">Gavin Metcalf</a>, Cancer Biologist and Lecturer in Biomedical Science, <a href="https://theconversation.com/institutions/anglia-ruskin-university-1887">Anglia Ruskin University</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/princess-of-wales-and-king-charles-one-in-two-people-develop-cancer-during-their-lives-the-diseases-and-treatments-explained-226456">original article</a>.</em></p>

Caring

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Major development in Madeleine McCann case

<p>In the ongoing investigation into the disappearance of Madeleine McCann, German police have descended upon a property in Braunschweig, Germany, in search of a key associate of Christian Brueckner, the prime suspect in the case.</p> <p>The urgency of the search stems from the belief that this individual may possess crucial information regarding the fate of the missing girl.</p> <p>The focus of this operation was a residence linked to a 56-year-old man identified only as Ralph H. According to reports from <a href="https://www.thesun.co.uk/news/26665050/hunt-madeleine-mccann-christian-b-pal/" target="_blank" rel="noopener"><em>The Sun</em></a>, Ralph H. is a long-time friend of Brueckner, suspected of being involved in criminal activities alongside him, including home robberies.</p> <p>The property, located just outside Braunschweig, was surrounded by armed officers – however, the operation hit a roadblock as police were unable to enter the premises due to the absence of a search warrant. </p> <p>The urgency surrounding Ralph H. is palpable, with authorities stressing the need to speak with him promptly. “We must find him to ask him about missing Madeleine McCann,” said a<span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;"> detective from Germany’s federal investigative agency, the Bundeskriminalamt (BKA). </span>“He’s not at home, he doesn’t answer the phone, he’s apparently disappeared.”</p> <p>Neighbours of Ralph H. corroborated reports of his absence: “They surrounded his home and shouted out his name but with no luck,” one said. “The officers later asked me if I had any idea where Ralph could be. It was about midday and I thought he was out working. But it turns out he hasn’t been seen for nearly a week now.” </p> <p>Meanwhile, Christian Brueckner, the main suspect in Madeleine McCann's disappearance, is embroiled in a separate legal battle. Currently facing trial for unrelated sexual offences, Brueckner's defence has maintained his silence, refusing to respond to the charges against him. Despite his denial of involvement in Madeleine's case, suspicions loom large, given his proximity to the scene of her disappearance and his criminal history.</p> <p>As the investigation unfolds, the spotlight remains on individuals like Ralph H. and Brueckner, whose connections and actions may hold the key to unraveling the mystery that has gripped the world for nearly two decades.</p> <p><em>Images: Getty</em></p>

Legal

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Five tips for developing and managing your budget – even in tough economic times

<p><em><a href="https://theconversation.com/profiles/oluwabunmi-adejumo-1370664">Oluwabunmi Adejumo</a>, <a href="https://theconversation.com/institutions/obafemi-awolowo-university-2843">Obafemi Awolowo University</a></em></p> <p>There’s nothing quite like a new year to prompt us to take stock of our lives, our health, our goals – and our finances. Many people will start a new year by contemplating how best to budget, plan and save. This is always a good set of aims, but it’s especially important in the inflation-prone and unpredictable economies we’re seeing <a href="https://www.statista.com/statistics/268225/countries-with-the-highest-inflation-rate/">all over Africa and the world</a>.</p> <p>Budgeting is especially key. It is the most effective method to <a href="https://www.thebalancemoney.com/how-to-make-a-budget-1289587">monitor income and expenditure</a>. <a href="https://www.uslendingcompany.com/blog/key-differences-in-writing-a-household-budget-vs-a-personal-budget/">Personal budgets</a> can help you to monitor your resources in pursuit of larger financial goals. Budgeting also offers <a href="https://www.acrwebsite.org/volumes/v46/acr_vol46_2411998.pdf">more opportunities</a> to save money, reduce your debts and live a comfortable life. It can even <a href="https://prucomm.ac.uk/assets/uploads/blog/2013/04/Personal-Budgets-review-of-evidence_FINAL-REPORT.pdf">improve your mental health</a>.</p> <p>But where should you start? What questions do you need to answer in creating a budget? Here are some tips that I’ve learned – not just as an economist, but as a research cost analyst and someone who keeps a budget too.</p> <h2>1. Understand the broader economic conditions</h2> <p>It is imperative that individuals keep themselves aware and up-to-date on the realities of their country’s economic landscape. You don’t have to be a professional economist, but keep an eye on new developments like free business registration, small business development funds and printing of new money notes. What is the current exchange rate? What’s the political landscape and what international factors, like the price of crude oil, are at play? You should also watch the inflation rate and have a sense of unemployment trends.</p> <p>This economic awareness will prepare you to draft your own budget and you’ll have a sense of when external factors mean it’s time to revisit your plans.</p> <h2>2. Review your income sources</h2> <p>The ability to earn income is critical to sustaining livelihoods. Having a definite source of income is the bedrock of budgeting.</p> <p>Some important questions you should ask about your income – and how you might budget with it – include:</p> <ul> <li>What is my current income?</li> <li>What do I use my income for?</li> <li>Am I able to save, given my current income?</li> <li>What proportion of my income do I save and what proportion do I spend?</li> <li>Do I have the capacity to earn more than this?</li> <li>How can I improve my income?</li> </ul> <p>Your answers can help you to identify gaps or untapped potential. Those with irregular or unpredictable income should factor in the element of time-gap in their income, for effective budgeting. Time gap is when they are not earning income. And everyone should make allowance in their budgets for uncertainties like health issues, social engagements, inflation, unemployment, recession and price shocks.</p> <h2>3. Appraise your expenses</h2> <p>Expenses can be broadly categorised into “variable” and “fixed”.</p> <p>Fixed expenses recur within a short period: housing, food, transport, medical costs, electricity, utilities, toiletries and clothing. Variable expenses are more long-term and irregular, such as investment in property or interest-yielding assets, and the purchase of machinery.</p> <p>The main essence of revising our expenses is to analyse and possibly improve our spending habits. In reviewing our expenses, we can consider issues such as:</p> <ul> <li>What is the proportion of consumption-savings ratio from my income? This is how much do I spend compared to how much I save.</li> <li>What are my regular expenses?</li> <li>What are my fixed, capital or investment expenses?</li> <li>What are my extraordinary expenses that need modification?</li> <li>Have there been emergency or extraordinary expenses?</li> </ul> <p>A careful response to the issues raised above offers an occasion to re-evaluate the pattern and direction of our expenses. For instance, overspending, unplanned or extraordinary expenses can be identified. This can lead to an optimal, efficient reallocation of available resources.</p> <h2>4. Stabilise your finances through savings</h2> <p>Savings have been <a href="https://klinglercpa.com/bedrock-principles-for-saving-money/">described</a> as a financial stabiliser, given their potential to cater for urgent needs and create opportunities for investments.</p> <p>Of course, savings have more value when they grow faster than the rate of inflation. Inflation erodes the value of savings. For instance, an amount of 300,000 naira (US$676) saved to purchase an autorickshaw today may be impossible in two months’ time with an inflation rate of 10% when the tricycle price rises to 330,000 naira (US$744). The reverse is the case when there is deflation.</p> <p>Therefore, it is advisable to improve the value of savings through investments in interest-yielding assets such as stocks, shares, bonds, microfinance and production.</p> <p>That’s not to say it’s always easy to save. Many income earners spend as they go, not seeing savings as part of their budgets. Harsh economic realities can also make it difficult – sometimes seemingly impossible – to save. But it’s not impossible: savings can be made in small amounts, through a daily, weekly or monthly contribution to collections, cooperative schemes or microfinance affiliations. For instance, a point of sale business in Nigeria can permit a daily contribution of 500 naira (US$1.13) over 25 work days, giving an average saving of 12,500 naira (US$28.18) per month.</p> <p>The Point-of-Sale business started in Nigeria in 2013 when the Central Bank of Nigeria introduced the agent banking system. A POS agent operates and processes transactions through a POS service provider. Providers of such services include banks, microfinance banks and fintech companies.</p> <h2>5. Run a flexible budget</h2> <p>Once your budget is created, remember that it’s not set in stone. It should be flexible if anything changes in your life. For instance, an amount saved to buy a car can be invested in a promising venture buying shares through public offerings or private placements in multinational organisations like Nestle or Unilever.</p> <p>Also, health emergencies or career advancement programmes can require taking some money out of our savings.</p> <p>In all, budgeting should be flexible enough to incorporate exigencies, especially when catering for the current situation will culminate into a greater good.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/195590/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/oluwabunmi-adejumo-1370664">Oluwabunmi Adejumo</a>, Lecturer/Researcher, <a href="https://theconversation.com/institutions/obafemi-awolowo-university-2843">Obafemi Awolowo University</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/five-tips-for-developing-and-managing-your-budget-even-in-tough-economic-times-195590">original article</a>.</em></p>

Money & Banking

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6 step guide to travelling in developing countries

<p>Developing countries are endlessly fascinating and a travel experience not be missed, though you will need to be prepared.</p> <p><strong>1. Do your research</strong></p> <p>In developing countries, it’s rare that you can just buy a plane ticket, arrive and wing it. You’ll need to research destinations, accommodation, transport options and safety in much more depth than you would for your typical holiday spot. This research should continue right up until you depart. The situations in these countries can change overnight, so you want to be up to date with any dangerous incidents or government warnings.</p> <p><strong>2. Learn the local customs</strong></p> <p>A little consideration goes a long way. You don’t want to be the obnoxious tourist who is offending locals without even realising it. As part of your research, look into things like appropriate dress code, cultural conventions around touching or the correct type of language to use. You’ll also need to make some observations during your first few days in a country and ensure you’re behaving in an appropriate way. Remember that you are a guest in their community and should be respectful of their beliefs and customs.</p> <p><strong>3. Be prepared for limited facilities</strong></p> <p>Be prepared for a different level of comfort than you would expect at home or in a first world country. You’ll mostly need to avoid drinking the tap water and the toilets may leave something to be desired. Toiletries can also be hard to come by, so come with your own supply of wet wipes, hand sanitisers or any personal items you need.</p> <p><strong>4. Choose wisely</strong></p> <p>This applies to everything from your choice of hotel to buying a snack on the street. Even if you’ve booked a hotel online, make sure that you check the security features and quality of the room before you commit to spending the night. Do your own research or ask a travel agent about the safest transport options. Many developing countries don’t have the same standards for their airlines or trains as we do. And when you’re choosing a restaurant, find somewhere that looks clean, busy and is well patronised by locals (not just tourists) – they are the best judges of where to eat.</p> <p><strong>5. Beware of begging</strong></p> <p>Poverty can be a big problem in many developing countries, so it’s common to see people begging on the street. It’s tempting to give people money, especially when it’s children. While it might seem that you are helping them, handouts from travellers can create an ongoing culture of begging. Instead, look for a local charitable organisation to donate to or approach a local school or church and see if there are any supplies you can purchase for them.</p> <p><strong>6. Understand bartering and bribery</strong></p> <p>Bartering is a part of life in many developing countries and is expected everywhere from the local market to taxi drivers. Vendors often like to get tourists to play the game and will encourage you to bargain with them, even if you are happy to pay the original price. You don’t want to be ripped off but also remember that while saving a dollar or so means little to you, it can be a big difference to them. You also need to be aware that many of these countries operate on an unofficial system of bribery, so you might be expected to pay a small fee to make a transaction go smoothly. If the amount is small enough, just pay it and move on.</p> <p><strong>7. Register your travel</strong></p> <p>New Zealand government organisation SafeTravel encourages all travellers to register with them, but this is most important if you’re visiting developing countries. In the event of a disaster, communication can become impossible so it is a good idea if the local embassy knows you are in the country. They may be able to provide assistance or just let your family back home know that you are safe. It’s free and only takes a couple of minutes.</p> <p><em>Image credits: Getty Images</em></p>

Travel Tips

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“We can let you rest now”: Devastating development in missing Nicola Bulley case

<p>Police in the United Kingdom have confirmed that a body found in a cluster of weeds by the River Wyre has been identified as missing mother-of-two Nicola Bulley. </p> <p>Nicola was last seen in St Michael’s on Wyre, Lancashire, just after 9am on January 27. Her body was discovered just over a kilometre from where she disappeared. </p> <p>Nicola was walking her dog along the river after dropping her children off at school when she failed to return. Her mobile phone was found on a bench, still connected to a conference call for work, and her dog - a springer spaniel named Willow - was nearby. </p> <p>“We were called today at 11.36am to reports of a body in the River Wyre, close to Rawcliffe Road," local police reported. "An underwater search team and specialist officers have subsequently attended the scene, entered the water and have sadly recovered a body."</p> <p>Formal identification was required before it could be confirmed that it was Nicola's body, with police announcing the process was complete and the confirmation made at a press conference on Monday. </p> <p>“Sadly, we are now able to confirm that yesterday we recovered Nicola Bulley from the River Wyre,” Lancashire Police's Assistant Chief Constable Peter Lawson said. </p> <p>"Nicola’s family have been informed and are, of course, devastated. Our thoughts are with them at this time, as well as with all her loved ones and the wider community.</p> <p>"We recognise the huge impact that Nicola’s disappearance has had on her family and friends, but also on the people of St Michael’s.</p> <p>"We would like to thank all of those who have helped during what has been a hugely complex and highly emotional investigation.</p> <p>"Today’s development is not the outcome any of us would have wanted, but we hope that it can at least start to provide some answers for Nicola’s loved ones, who remain foremost in our thoughts.”</p> <p>Assistant Chief Constable Lawson added that the case was now being handled by HM Coroner, and that the cause of her death is being treated as unexplained. </p> <p>In the wake of the tragic news breaking, Nicola’s family also issued a statement and emotional tribute for their late loved one. </p> <p>“Finally, Nikki, you are no longer a missing person, you have been found. We can let you rest now,” they said. </p> <p>“We will never be able to comprehend what Nikki had gone through in her last moments and that will never leave us.</p> <p>“We will never forget Nikki - how could we? - she was the centre of our world, she was the one who made our lives so special and nothing will cast a shadow over that.</p> <p>“Our girls will get the support they need from the people who love them the most.”</p> <p><em>Images: Getty </em></p>

Caring

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Chris Hemsworth’s Alzheimer’s gene doesn’t guarantee he’ll develop dementia

<p>Chris Hemsworth, famous for his role as the god Thor in Marvel Cinematic Universe movies, has announced he will be <a href="https://www.theguardian.com/film/2022/nov/21/chris-hemsworth-to-take-time-off-from-acting-after-discovering-alzheimers-risk" target="_blank" rel="noopener">taking a break</a> from acting after being told he has two copies of the <a href="https://www.nia.nih.gov/news/study-reveals-how-apoe4-gene-may-increase-risk-dementia" target="_blank" rel="noopener">APOE4 gene</a>, increasing his risk of Alzheimer’s.</p> <p>Having one copy of the <a href="https://www.science.org/doi/abs/10.1126/science.8346443" target="_blank" rel="noopener">APOE4 gene</a> increases your risk for Alzheimer’s 2-3 times. Two copies increases your risk 10-15 times.</p> <p>But the key here is “risk”. Having one or more copies of the gene doesn’t guarantee Chris or anyone else in a similar situation will go on to develop Alzheimer’s, the most common form of dementia.</p> <p><strong>Sharing the news</strong></p> <p>Hemsworth’s willingness to share his concerns about developing Alzheimer’s with millions should be applauded. It’s a reminder to all of us to keep an eye on our health and reduce our risk of future illness.</p> <p>Alzheimer’s, and dementia more broadly, is <a href="https://www.dementiastatistics.org/statistics/global-prevalence/" target="_blank" rel="noopener">set to challenge</a> health-care systems worldwide.</p> <p>In Australia alone there are <a href="https://www.dementia.org.au/statistics" target="_blank" rel="noopener">up to</a> 500,000 people with dementia, supported by almost 1.6 million carers. By 2036, about <a href="https://www.dementia.org.au/sites/default/files/NATIONAL/documents/The-economic-cost-of-dementia-in-Australia-2016-to-2056.pdf" target="_blank" rel="noopener">450 people</a> are predicted to be diagnosed daily. So understanding how APOE4 alters the risk for the major cause of dementia may be pivotal in preventing cases.</p> <p>But not all people with the APOE4 gene go on to develop Alzheimer’s. This means that there may be a combination of environmental factors interplaying with the gene that lead some people to develop Alzheimer’s, while others do not.</p> <p><strong>What’s APOE4 got to do with Alzheimer’s?</strong></p> <p>Most Australians have APOE3 or APOE2 genes. In Caucasians it’s only <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531868/" target="_blank" rel="noopener">about 15%</a>, like Hemsworth, who have inherited an APOE4 gene.</p> <p>The APOE gene types are best known for their role in modulating the metabolism of lipids (fats), such as cholesterol and triglycerides.</p> <p>They code for synthesis of different versions of the protein APOE, with subtle differences in structure. The APOE proteins become an integral part of lipoproteins in the blood. These are the fat-carrying particles your GP measures to consider your risk of heart disease.</p> <p>APOE proteins have a similar function in the brain, to modulate lipid levels. But in the context of Alzheimer’s, researchers study it for its effect on the integrity of brain cells.</p> <p>Accumulating evidence <a href="https://www.sciencedirect.com/science/article/pii/S0197458022000550" target="_blank" rel="noopener">suggests</a> APOE4, is associated with brain inflammation and cellular damage.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">APOE4 is the strongest genetic risk factor for Alzheimer’s disease. A study in <a href="https://twitter.com/Nature?ref_src=twsrc%5Etfw">@Nature</a> establishes a functional link between APOE4, cholesterol, myelination and memory, offering therapeutic opportunities for Alzheimer’s disease. <a href="https://t.co/bNsmDVPfFW">https://t.co/bNsmDVPfFW</a> <a href="https://t.co/58odE1JASl">pic.twitter.com/58odE1JASl</a></p> <p>— Nature Portfolio (@NaturePortfolio) <a href="https://twitter.com/NaturePortfolio/status/1594762841487249410?ref_src=twsrc%5Etfw">November 21, 2022</a></p></blockquote> <p><strong>Can we prevent Alzheimer’s?</strong></p> <p><strong>1. Look after your capillaries</strong></p> <p>Damaged and leaky blood vessels (capillaries) in the brain lead to inflammation, the death of brain cells and cognitive impairment. In fact, in Alzheimer’s, damaged capillaries are the earliest sign of the type of brain damage that causes disease.</p> <p>The protein encoded by the APOE4 gene may be less able to support healthy capillaries in the brain. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0163782709000563" target="_blank" rel="noopener">We suggested</a> APOE4 increases the abundance of specific complexes of lipoproteins and proteins in blood that silently damage brain capillaries, causing them to leak.</p> <p>We also see more brain capillary leakage in mice fed Western-style diets richer in saturated fats.</p> <p>The relationship between how the APOE proteins mediate lipid metabolism and capillary health in humans is poorly understood.</p> <p>But we have 60 years of research knowledge to say with confidence that eating foods good for the heart should also be good for the brain. This is particularly relevant for people with the APOE4 gene.</p> <p>So if you have the APOE4 gene and want to minimise your risk of Alzheimer’s, a healthy diet is a good place to start.</p> <figure class="align-center zoomable"><em><a href="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=3 2262w" alt="Capillaries" /></a></em><figcaption><em><span class="caption">Looking after your capillaries with a healthy diet is a good place to start.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-illustration/system-many-small-capillaries-branch-out-1745173364" target="_blank" rel="noopener">Shutterstock</a></span></em></figcaption></figure> <p><strong>2. Give your brain a break</strong></p> <p>Reducing unnecessary stimuli to “give your brain a rest” may have big impact over decades of your life. The latter may be a more important consideration if you have the APOE4 gene.</p> <p>That’s because the APOE gene is also linked to how the brain uses energy, which may lead to more <a href="https://www.frontiersin.org/articles/10.3389/fnmol.2018.00216/full" target="_blank" rel="noopener">oxidative stress and damage</a>.</p> <p>While we’ve yet to collect robust data in humans, take a digital detox now and again, plan some down time, and avoid unnecessary stress if you can.</p> <p><strong>Should we test for the APOE4 gene?</strong></p> <p>Some people might be tempted to get tested for the APOE4 gene, especially if there’s a family history of Alzheimer’s.</p> <p>But unless genetic testing is going to change your treatment (for instance, by taking certain medications to slow progression of brain damage), or your behaviour to minimise your risk Alzheimer’s, then testing is not justified.</p> <p>We can’t change the genes our parents gifted us, but we can change our environment.</p> <p>Poor diet, every drop of alcohol you drink, obesity and diabetes, high blood pressure and sedentary behaviour <a href="https://www.dementia.org.au/risk-reduction" target="_blank" rel="noopener">all contribute, over time</a>, to poorer vascular health and increase your risk of dementia.</p> <p>We’re still learning about how these risk factors for Alzheimer’s interact with the APOE4 gene. But there is no reason we shouldn’t all take greater responsibility for minimising our risk of dementia now, whether we have the APOE4 gene or not.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/195094/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em>Writen by John Mamo. Republished with permission from <a href="https://theconversation.com/chris-hemsworths-alzheimers-gene-doesnt-guarantee-hell-develop-dementia-heres-what-we-can-all-do-to-reduce-our-risk-195094" target="_blank" rel="noopener">The Conversation</a>.</em></p> <p><em>Image: Instagram</em></p>

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If you want your child to be more resilient, get them to join a choir, orchestra or band

<p>One of the most important qualities for a young person to develop is resilience. This involves their ability to overcome adversity. </p> <p>Resilience is perhaps more important now than ever. Today’s young people have been <a href="https://www.aihw.gov.au/reports/children-youth/australias-youth-in-brief/contents/summary">facing adversity on a mass-scale</a>, thanks to COVID and all the disruptions to their education and social, home and working lives. </p> <p>The good news is, resilience is not just something you are born with. It <a href="https://www.oecd-ilibrary.org/sites/ca34a20a-en/index.html?itemId=/content/component/ca34a20a-en#chapter-d1e10348">can be learned</a> from our experiences and interactions with others. </p> <p>Parents may not be aware that one way to develop resilience is through group music making, such as in a school or community choir, orchestra or band.</p> <h2>Our research</h2> <p>We wanted to investigate how group music making can develop skills beyond just learning to play an instrument or sing. </p> <p>Our <a href="https://www.utas.edu.au/research/projects/music-resilience-project">study</a> is based on the Tasmanian Youth Orchestras, which include accomplished musicians aged from 14 to 25. This includes the state youth orchestra as well as two other orchestras, specialist ensembles and two choirs.</p> <p>For our project, we collected comments from players, managers and conductors/teachers on a closed Facebook site and then did eight follow-up interviews. </p> <p>Our findings show how qualities like teamwork, empathy and grit – all components of resilience – can be developed through group music making.</p> <h2>Teamwork</h2> <p>In order for a group of players to make a piece of music work, they have to work together. </p> <p>People have to listen to each other, understand what is happening around them, and be prepared to change how they play something (slow or fast, loud or soft) depending on how the group is performing. You need to be able to value the contributions of other people, not just your own. </p> <p>So, <a href="https://www.utas.edu.au/research/projects/music-resilience-project/teamwork">we found</a> if you are playing in a band, you are learning team work skills. As David*, a conductor told us: "After a while, players realised that they were ultimately responsible to the other players not to the conductor."</p> <h2>Empathy</h2> <p>Players also need to be able to understand others in a group and share their feelings. </p> <p>In a choir or orchestra, the music making is a shared creative experience – that involves the whole body. And this is where <a href="https://www.utas.edu.au/research/projects/music-resilience-project/empathy">empathy</a> comes in. </p> <p>Empathy, like teamwork, can be cumulative, growing over time through rehearsals and performances, as players and teachers support one another. As brass player Tom said, "I have to understand that I am not always going to be the main focus of a piece."</p> <p>Another player, Simon, told us about his realisation that other people were also having to work hard (and it wasn’t just about him). </p> <p>"You certainly aren’t the only person having to practise your doubles [playing two notes at once] for that piece."</p> <h2>Grit</h2> <p>It is important for young people to develop a “<a href="https://www.mindsetworks.com/science/">growth mindset</a>”, where they understand effort makes them stronger and learning is a long-term commitment.</p> <p>This is where <a href="https://www.utas.edu.au/research/projects/music-resilience-project/grit">grit</a> also comes in: pursing a goal and sticking with it even if it takes a lot of work or gets difficult.</p> <p>It can take many months to learn a piece of music up to performance standard. And learning an instrument requires practice every day. So commitment is a key part of learning music. </p> <p>Lawrence, a player, told us about participating in his school musical, "There were many points throughout the year which I felt like giving up […] but it was something I had committed to […]. I kept working on playing the music to the best of my ability, even if it felt like I couldn’t do it."</p> <p>Tory, a choir conductor, described performance as both “safe and unsafe”. Young people in a choir learn to deal with the unexpected as part of performance. And this takes a kind a bravery. </p> <p>"You’ve got safety in numbers, to some extent, but you are still stepping into the unknown every time you walk on stage to do a thing. You can rely on each other, because you’ve rehearsed, but stuff does go pear shaped. Stuff happens […] It’s an incredibly useful life skill to be able to go, ‘well, that sucked’ […] and go, all right ‘let’s [go again]’."</p> <h2>Why music?</h2> <p>But what is so special about music in fostering resilience? Young people also work in sporting teams or academic assignments. They can also work together while playing games. </p> <p>Playing music provokes activity in many different parts of the brain at the same time. Listening to music that we like triggers the pleasure/reward centre of the brain. Dopamine and serotonin are released, resulting in that “feel good” sensation, and <a href="https://www.booktopia.com.au/this-is-your-brain-on-music-daniel-levitin/book/9780241987353.html?source=pla&amp;gclid=Cj0KCQjw48OaBhDWARIsAMd966B_bnNSq0206FOdSKqjfAEbrRWPkyKsh1tlY4v7eD1JGqZMB5qYGmoaAgmKEALw_wcB">providing an incentive</a> to keep engaging with music.</p> <p>Learning a musical instrument also <a href="https://www.jneurosci.org/content/early/2021/01/14/JNEUROSCI.1985-20.2020/tab-article-info?versioned=true">strengthens connections</a> in the brain, linking the auditory cortex to parts of the brain involved in the processing of complex information. This link has <a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2015.02023/full">been shown</a> to improve memory, motor functions and learning in other subject areas. </p> <p>Making music with others also <a href="https://www.sciencedirect.com/science/article/pii/S1364661313000491">affects levels</a> of the bonding hormone oxytocin, supporting a sense of togetherness, while reducing levels of the stress hormone cortisol, and boosting immune function.</p> <p>For young people, music can provide valuable respite from study and daily life, and <a href="https://journals.sagepub.com/doi/10.1177/1049732320944142">help</a> manage and express their emotions. </p> <p>So, if you want your child to be a team player who is empathetic and shows grit, our research suggests that joining a music group could be the answer.</p> <p><em>*names have been changed</em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/if-you-want-your-child-to-be-more-resilient-get-them-to-join-a-choir-orchestra-or-band-190657" target="_blank" rel="noopener">The Conversation</a>.</em></p>

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Major development in Madeleine McCann case

<p dir="ltr">Long-time suspect Christian Brueckner has been declared a formal suspect over the disappearance of Madeleine McCann by Portuguese authorities.</p> <p dir="ltr">German newspaper Bild reported that Brueckner has been named as an “arguido” or “official suspect” by prosecutors, two years after he was first identified as a prime suspect by German authorities.</p> <p dir="ltr">The 44-year-old is currently serving a seven-year prison sentence in Germany for the 2005 rape of 72-year-old woman at the same Praia da Luz resort Madeleine disappeared from in 2007.</p> <p dir="ltr">Madeleine disappeared from the apartment her family was staying in on May 3, 2007, a few days before her fourth birthday.</p> <p dir="ltr">In a statement issued by the Faro Department of Criminal Investigation and Prosecution (DIAP), prosecutors confirmed Brueckner’s status as an official suspect on Wednesday, April 20.</p> <p dir="ltr">“As part of the investigation into the circumstances surrounding the disappearance of Madeleine McCann in 2007, a person was made an arguido on Wednesday,” the Portiamo section of the DIAP said.</p> <p dir="ltr">It is understood the push to declare Brueckner as a suspect after it emerged he could potentially escape charges due to Portugal’s 15-year statute of limitations for serious crimes, per <em><a href="https://www.news.com.au/lifestyle/real-life/news-life/christian-brueckner-named-official-suspect-over-madeleine-mccann-disappearance/news-story/ec54721b7de9059c54a1fa54659f6eec" target="_blank" rel="noopener">news.com.au</a></em> and the <em><a href="https://www.dailymail.co.uk/news/article-10740813/Convicted-rapist-Christian-Brueckner-44-official-suspect-Madeleine-McCann-case.html" target="_blank" rel="noopener">Daily Mail</a></em>.</p> <p dir="ltr">“The legal grounds for making Brueckner an arguido include the fact that he allegedly confessed to a friend he had snatched Madeleine and mobile phone records placed him in Praia da Luz the night she vanished,” a “well-placed source” reportedly told the Daily Mail.</p> <p dir="ltr">“But it is obviously linked to the fact that the Portuguese authorities want to keep their options open with the 15-year deadline looming.”</p> <p dir="ltr">Brueckner’s lawyers told the publication he hadn’t been charged over Madeleine’s disappearance.</p> <p dir="ltr">The news comes several months after Brueckner claimed it would have been “absurd” for him to have abducted Madeleine via a string of letters broadcast on German TV.</p> <p dir="ltr">He wrote that he survived working as a drug dealer by following “a few key principles”, including “not abducting anyone”.</p> <p dir="ltr">“Where possible, only driving during the day so that my battered ‘hippy bus’ didn’t attract attention, only driving on the roads I needed to and, most importantly, never provoking police,” he wrote.</p> <p dir="ltr">“So that means not committing any crimes, certainly not abducting anyone.</p> <p dir="ltr">“Having said that, this was just as absurd to me at the time as starting a nuclear war or slaughtering a chicken.”</p> <p><span id="docs-internal-guid-71b067d2-7fff-66aa-62f4-1cba4010a4dd"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

News

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Some Covid patients develop resistance to Sotrovimab treatment

<p dir="ltr">As treatments continue to be developed for patients with COVID-19, some scientists have found that one in particular may cause the virus to mutate so that it becomes harder to treat.</p> <p dir="ltr">A team of Australian researchers analysed samples from the first 100 people to be treated with Sotrovimab - an increasingly popular treatment that targets the Omicron variant and prevents severe COVID-19 symptoms - only to make some interesting findings.</p> <p dir="ltr">They took samples from the patients before and after they were treated with Sotrovimab and sequenced the genome of the virus in each sample.</p> <p dir="ltr">In four of the patients, the team found that the virus had mutated in ways that made it more resistant to treatment within 13 days of treatment.</p> <p dir="ltr">“We discovered that the virus that causes COVID-19 can develop mutations within the patient several days after Sotrovimab treatment, which reduces the effectiveness of this treatment by greater than 100-fold,” Dr Rebecca Rockett, a Sydney researcher in infectious disease and co-author of the study, <a href="https://www.scimex.org/newsfeed/covid-19-patients-can-develop-resistance-to-treatment-with-sotrovimab" target="_blank" rel="noopener">said</a>.</p> <p dir="ltr">This research, published in the <em><a href="https://www.nejm.org/doi/10.1056/NEJMc2120219" target="_blank" rel="noopener">New England Journal of Medicine</a></em>, is the first to show the mutations in clinical models, with previous research finding the mutations developed in animal models and when growing the virus in a lab setting.</p> <p dir="ltr">With this finding, the researchers are calling for the use of Sotrovimab to be monitored to prevent treatment-resistant versions of the virus from spreading in the community.</p> <p dir="ltr">“Resistant virus samples could be readily grown in the laboratory, a marker that individuals who develop resistance may transmit the resistance virus to others,” said Professor Vitali Sintchenko, the study’s senior author and a fellow researcher in infectious disease.</p> <p dir="ltr">“(Sotrovimab) is the only one (treatment) we have evidence against so far, but we need to be more on the front foot in terms of efficacy,” Dr Rockett told <em><a href="https://7news.com.au/news/coronavirus/australian-covid-19-patients-developed-resistance-to-antiviral-drug-as-virus-mutates-within-days-of-first-treatment-study-finds--c-6001171" target="_blank" rel="noopener">7News</a></em>.</p> <p dir="ltr">“I don’t think the infrastructure is in place to capture the resistance. We need better surveillance.”</p> <p dir="ltr">Since the research was published, GSK, the manufacturer of Sotrovimab, has confirmed that the study’s findings were consistent with the company’s large clinical studies.</p> <p dir="ltr">“Resistance is also seen in studies for other COVID-19 monoclonal antibodies and oral treatments, and relates to how the immune system interacts with the virus,” a spokesperson said, per <em>7News.com.au</em>.</p> <p dir="ltr">“This report does not change the positive benefit-risk of sotrovimab for use in the treatment of mild to moderate COVID-19 in patients at high risk of progression.”</p> <p><span id="docs-internal-guid-7f583be8-7fff-e05d-5e6b-eef460dbcdaf"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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Big development in missing Theo Hayez case

<p dir="ltr">A $500,000 ($NZD 536,000) reward for information regarding missing backpacker Theo Hayez has been <a href="https://7news.com.au/sunrise/on-the-show/nsw-government-announce-500000-reward-for-information-about-theo-hayez-disappearance-c-5802924" target="_blank" rel="noopener">announced</a> by the NSW Government, as his family urges anyone who could help to come forward.</p> <p dir="ltr">The 18-year-old was last seen on May 31, 2019, after he was ejected from the Cheeky Monkey’s bar in Byron Bay at 11pm.</p> <p dir="ltr">Police were alerted to the Belgian’s disappearance a week later after he didn’t return to his hostel and couldn’t be contacted.</p> <p dir="ltr">Despite police conducting an extensive air, sea and land search with the help of local volunteers, Theo is still missing three years later.</p> <p dir="ltr">NSW Deputy Premier and Minister for Police Paul Toole said he hoped the significant reward would encourage anyone who knew what happened to Theo to contact authorities.</p> <p dir="ltr">“Theo was a young man who had his entire life ahead of him and his family cannot rest until they know what happened to him,” Mr Toole said on Wednesday.</p> <p dir="ltr">“The pain of losing a loved one is bad enough, but the mystery surrounding this case only adds to that pain.</p> <p dir="ltr">Mr Toole urged anyone who knows or thinks of anything relevant to finding Theo to phone Crime Stoppers, “no matter how small” their tip might be.</p> <p><span id="docs-internal-guid-f94c8536-7fff-c52d-6b33-f1468321d3a7"></span></p> <p dir="ltr">“Police investigating this case need our help to provide that crucial piece of the puzzle that can bring some comfort to the family and friends of Theo,” he said.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">NSW Government announces $500,000 reward into the disappearance of Theo Hayez: <a href="https://t.co/DdxI8HuLRM">https://t.co/DdxI8HuLRM</a> <a href="https://t.co/YohCfhEPaq">pic.twitter.com/YohCfhEPaq</a></p> <p>— NSW Police Force (@nswpolice) <a href="https://twitter.com/nswpolice/status/1496239841516068864?ref_src=twsrc%5Etfw">February 22, 2022</a></p></blockquote> <p dir="ltr">Theo’s family also released a statement saying they hoped the reward would “motivate” people to speak out.</p> <p dir="ltr">“We are very grateful to the NSW Police and NSW Government for their approval of this reward for information that can help understand what happened to Theo on the night of May 31, 2019, in Byron Bay,’ they said.</p> <p dir="ltr">“Our hope with the reward is to reach out to more people as well as motivate people to talk to authorities and overcome any barriers they might have doing so.</p> <p dir="ltr">“$500,000 can change someone’s life. Please, if you have any information that can help us, come forward now. Don’t wait any longer.”</p> <p dir="ltr">Theo was last seen on CCTV from the bar, with Google data showing he then looked up the route back to his hostel but walked in the opposite direction instead.</p> <p dir="ltr">Police have a working theory that the backpacker attempted to climb cliffs at Cosy Corner beach, but fell and was swept out to sea.</p> <p dir="ltr">A hat he was wearing has since been found on the route he walked.</p> <p dir="ltr">However, his family believe that behaviour is uncharacteristic of Theo and think that someone else may be involved.</p> <p dir="ltr">“A key question we are seeking to address is whether he was with someone on the night of May 31, 2019, which we strongly believe to be the case,” Theo’s father, Laurent Hayez, <a href="https://www.abc.net.au/news/2022-02-23/police-offer-reward-for-information-on-theo-hayez/100851652" target="_blank" rel="noopener">said</a>.</p> <p dir="ltr">The matter was referred to the NSW Coroner, and an inquest is currently underway in the Coroner’s Court.</p> <p dir="ltr"><span id="docs-internal-guid-ae71fc09-7fff-de8c-59f4-e83258b0bdd6"></span></p> <p dir="ltr"><em>Image: Laurent Hayez (Facebook)</em></p>

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Life’s stages are changing – we need new terms and new ideas to describe how adults develop and grow

<p>What image comes to mind when you think of a person in their 20s?</p> <p>Do you imagine an adult stressed out by the weight of many new responsibilities in family and work roles?</p> <p>Or do you envision someone who is bursting with hope and undeveloped potential, still more of a kid than an adult, struggling to define a life and making little or no money but managing to find occasional joy nevertheless? Perhaps your soundtrack here is <a href="https://youtu.be/AgFeZr5ptV8">Taylor Swift’s radiant “22”</a>: “We’re happy, free, confused and lonely at the same time. It’s miserable and magical.”</p> <p>How about when you think of someone in their 60s?</p> <p>Do you envision someone – or maybe a happy couple – enjoying life, living well, still vigorous but now freer than before from daily work and family duties?</p> <p>Or do you see someone who is stooped over from a lifetime of carrying burdens, their health diminished, now shuffling toward no particular destination? Here the soundtrack might be the doleful Beatles song “<a href="https://youtu.be/ckV2ogbt8W4">When I’m 64</a>”: “Will you still need me? Will you still feed me? When I’m 64?”</p> <p>The whole arc of adult development has changed over the past several decades, in ways that our psychological theories are still catching up with. In the 21st century, does it still make sense to refer to “young adulthood,” “midlife” and “late adulthood,” as psychologists have been doing for so long? If not, what are more accurate concepts?</p> <p>Most of my career <a href="https://scholar.google.com/citations?user=8bvGDaYAAAAJ&amp;hl=en&amp;oi=sra">as a developmental psychologist</a> has been devoted to answering these questions. My theory of <a href="https://pubmed.ncbi.nlm.nih.gov/10842426/">emerging adulthood</a> recognizes that the lives of younger adults have changed vastly since the 1960s. As the father of 22-year-old twins, I’m keenly aware of their journey through the new life stage I have been researching and writing about for so long. As a 64-year-old, I’m also turning my attention to how the 60s have changed from what they used to be.</p> <h2>A longer-than-ever journey to adulthood</h2> <p>In my research over the past two decades, I’ve found that people ages 19 to 29 are neither fully adult nor in an “extended adolescence” – as this time of life was viewed over the course of the 20th century. In the early 21st century, these years had become a time of gradually and often erratically making one’s way toward <a href="https://www.amazon.com/Emerging-Adulthood-Winding-Through-Twenties/dp/0199929386/ref=sr_1_2?crid=KJSM1BSQUMBJ&amp;keywords=jeffrey+jensen+arnett&amp;qid=1637252495&amp;s=books&amp;sprefix=Jeffrey+Jensen%2Caps%2C175&amp;sr=1-2">a more established adulthood</a>.</p> <p>I invited scholars from all over the world to contribute to a special issue of American Psychologist, one of the top journals in psychology, on the theme of <a href="https://doi.apa.org/fulltext/2020-29966-001.html">“Rethinking Adult Development: New Ideas for New Times.”</a> The recently published results are a wonderfully diverse set of papers that go a long way toward reconceptualizing what adult development looks like now and where it might be going.</p> <p>Most of the authors were developmental psychologists. About half were Americans and half were Europeans, although <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474435/">Shinobu Kitayama and his colleagues</a> offered a refreshingly different Asian cultural perspective.</p> <p>Here are some of the highlights:</p> <p>– Ages 30 to 45 are now “the rush hour of life.” Today people around the world wait later than ever to marry and have kids, and most have only one or two. But then couples typically have the dual challenge of trying to move ahead in their careers while also handling the intense responsibilities of caring for young children. Women have vastly greater opportunities in education and work than they did in 1960, which is welcome but also presents new challenges and stresses.</p> <p>In <a href="https://doi.org/10.1037/amp0000600">their contribution</a> to the special issue, <a href="https://psycnet.apa.org/doiLanding?doi=10.1037%2Famp0000600">Clare Mehta and her colleagues</a> propose the term “established adulthood” to distinguish these years as the most intense and demanding years of adult life, characterized by the “career-and-care-crunch,” when obligations are high in both work and family roles.</p> <p>– In midlife – ages 45-60 – the crunch years of caring for young children abate. Adults reach their peak career earnings and status in their late 40s and 50s. But life can become complicated, as new responsibilities may arise with grandchildren and with aging parents who need more assistance.</p> <p>Overall, as <a href="https://doi.org/10.1037/amp0000591">Frank Infurna and colleagues detail</a> in their contribution, mental health declines in midlife. Reports of depression and anxiety increase. Seeking professional help for mental health issues reaches a lifetime peak.</p> <p>Furthermore, midlife well-being, health and life expectancy have declined notably in the U.S. since 2000, especially among working-class adults who have been left behind by the information-and-technology economy. This has led to an epidemic of <a href="https://press.princeton.edu/books/hardcover/9780691190785/deaths-of-despair-and-the-future-of-capitalism">“deaths of despair”</a> from suicide, opioid overdoses or alchoholism.</p> <p>– Adults in later life, ages 60-75, are thriving like never before. Although life after age 60 is traditionally regarded as a time of inevitable decline, the reality of it has become sharply different –and better – in recent decades.</p> <p>Life expectancy at birth is higher now than it has ever been, worldwide, and adults are smarter and healthier for longer than ever. <a href="https://doi.org/10.1037/amp0000596">Denis Gerstorf and his colleagues</a> show how these positive trends have taken place across many countries over the past century because of improvements in education, nutrition and health care.</p> <p>[<em>Like what you’ve read? Want more?</em> <a href="https://memberservices.theconversation.com/newsletters/?source=inline-likethis">Sign up for The Conversation’s daily newsletter</a>.]</p> <p>Physical health issues do arise with age for most people, but more people than ever before stay healthy through their 60s and early 70s by maintaining healthy diet and physical exercise practices. One of the exciting recent findings highlighted <a href="https://doi.org/10.1037/amp0000612">in Ursula Staudinger’s article</a> is that regular exercise promotes mental health as well as physical well-being, helping to maintain mental sharpness and prevent Alzheimer’s disease.</p> <p>Life satisfaction also seems to rise in later life, as we gain a new freedom to choose the kind of work we do – or stop working altogether and spend more time with the people we care about most. <a href="https://doi.org/10.1037/amp0000615">According to Phillip Ackerman and Ruth Kanfer</a>, more people are working into their late 60s and early 70s than ever before, but they have more freedom to choose how they do it, whether it’s working part time, starting a small business or trying something they have always wanted to do.</p> <h2>Adulthood’s new arc requires new concepts and ideas</h2> <p>Over my decades of writing about emerging adulthood, I’ve learned that it matters how people think about the stages of human development. Thinking shapes expectations and how experiences are interpreted. Lots of compelling and exciting new findings about adult development point to the importance of rethinking previous theories, assumptions and stereotypes about the course of adult life.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/171478/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><span><a href="https://theconversation.com/profiles/jeffrey-arnett-1160487">Jeffrey Arnett</a>, Senior Research Scholar, Department of Psychology, <em><a href="https://theconversation.com/institutions/clark-university-2129">Clark University</a></em></span></p> <p>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/lifes-stages-are-changing-we-need-new-terms-and-new-ideas-to-describe-how-adults-develop-and-grow-171478">original article</a>.</p> <p><em>Image: Hinterhaus Productions/DigitalVision via Getty Images</em></p>

Retirement Life

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Woman develops new accent overnight

<p><span style="font-weight: 400;">Though Angie Yen has never been to Ireland or any immediate family from there, the Brisbane dentist claims to have woken up one day with an Irish accent.</span></p> <p><span style="font-weight: 400;">The 27-year-old believes she has foreign accent syndrome, a isolating and uncommon speech disorder.</span></p> <p><strong>What is foreign accent syndrome?</strong></p> <p><span style="font-weight: 400;">The condition, typically triggered by a head injury, stroke, or brain damage, impairs a person’s ability to control the muscles used to produce speech.</span></p> <p><span style="font-weight: 400;">The result of this is that people can appear to develop what sounds like a foreign accent overnight - despite never speaking with that accent before, nor mixing with people who do or spending time abroad.</span></p> <p><span style="font-weight: 400;">But, Angie hasn’t suffered a stroke, head injury, or brain damage, so experts say her case isn’t so simple.</span></p> <p><span style="font-weight: 400;">Instead, the accent change came about following tonsil surgery.</span></p> <p><span style="font-weight: 400;">“I didn’t have any issues with talking or eating or anything like that, if anything the throat was ust very, very sore,” she told 7NEWS.com.au.</span></p> <p><span style="font-weight: 400;">“Everything was normal, I was just on painkillers, so I was living life normally. There was nothing out of the ordinary.”</span></p> <p><span style="font-weight: 400;">Ten days after the surgery, while singing in the shower hours before a job interview, she noticed something strange.</span></p> <p><span style="font-weight: 400;">“I was singing notes that I didn’t think I could hit before, even though my throat was quite sore. I knew something wasn’t right.”</span></p> <p><span style="font-weight: 400;">When she spoke, her voice didn’t sound like hers either.</span></p> <p><span style="font-weight: 400;">“I was very shocked … I called up one of my friends who had travelled all over the world and asked where my accent is from. He said - you sound like you’re Irish,” she said.</span></p> <p><span style="font-weight: 400;">While she hasn’t been formally diagnosed with the condition, her primary doctor says her symptoms sound like they match.</span></p> <p><span style="font-weight: 400;">“He referred me to get some scans for an MRI and also some blood tests to rule out anything underlying that could be going on,” Angie said.</span></p> <p><span style="font-weight: 400;">The thing that has Angie, her doctors, and experts baffled is that the change didn’t occur until 10 days after surgery.</span></p> <p><strong>Spreading awareness</strong></p> <p><span style="font-weight: 400;">Though Angie has led a very private life, she has decided to document her journey spreading awareness about the condition on TikTok.</span></p> <p><span style="font-weight: 400;">“I felt that somewhere in the world someone might wake up with this one day and just feel as lost, alone, and isolated as I am,” she said. </span></p> <p><span style="font-weight: 400;">“I hope by spreading awareness and letting people know that this is a serious health issue, that eventually we can encourage people to get the help they need and take it seriously.”</span></p> <p><strong>Mixed accents</strong></p> <p><span style="font-weight: 400;">While most commenters said Angie sounds Irish, there has been a mixed response.</span></p> <p><span style="font-weight: 400;">“I’ve also gotten Canadian, American, Jamaican, British, New Zealand - all over the world,” she said.</span></p> <p><span style="font-weight: 400;">“And most countries I’ve never been to. It’s very, very bizarre.”</span></p> <p><span style="font-weight: 400;">That’s not too uncommon for those with foreign accent syndrome, according to Lyndsey Nickels, a Professor of Cognitive Science at Macquarie University.</span></p> <p><span style="font-weight: 400;">“People with foreign accent syndrome don’t speak with all the features of a foreign accent, but there are enough things about the way they speak to make it seem as though they have a different accent,” Nickels told 7NEWS.com.au.</span></p> <p><span style="font-weight: 400;">“Different listeners may have different opinions about what the accent is because the features usually don’t clearly match a single accent.”</span></p> <p><span style="font-weight: 400;">Nickels confirmed the disorder is thought to be caused by brain damage which can make “moving or coordinating the muscles that we use to produce speech” more difficult.</span></p> <p><span style="font-weight: 400;">“This causes inaccuracies in the speech, sounds with vowels being particularly vulnerable,” she said.</span></p> <p><span style="font-weight: 400;">Since the condition is so rare, many people - including some doctors - accuse sufferers of faking it.</span></p> <p><span style="font-weight: 400;">Speech pathologists can help those with the condition to improve speech muscle movement and coordination to regain accuracy in their speech.</span></p> <p><strong>Image credit: 7NEWS</strong></p>

Mind

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Hotel where Michael Hutchence died sells for 300 percent profit

<p><span style="font-weight: 400;">The Intercontinental Hotel Double Bay, the spot where Princess Diana stayed in 1996 and INXS frontman Michael Hutchence was found deceased in 1997 has been sold for $180m to an apartment developer.</span></p> <p><span style="font-weight: 400;">Sources told the </span><span style="font-weight: 400;">Wentworth Courier</span><span style="font-weight: 400;"> the deal was brokered by the Agency’s Steven Chen.</span></p> <p><span style="font-weight: 400;">The buyer, Melbourne apartment developer Fridcorp, later released a statement confirming the purchase of the refurbished 140-room hotel, refurbished by Bates Smart, and land in a joint venture with Piety Group from vendor Shanghai Group, who had paid $140m four years ago.</span></p> <p><span style="font-weight: 400;">The 3670-square-metre luxury hotel originally opened as a Ritz Carlton Hotel in 1991 and was the hotel of choice in the 90s for famous guests, including Princess Diana, Madonna, Bill Clinton, and Elton John.</span></p> <p><span style="font-weight: 400;">The circa $180m price tag is triple the $60m that the site sold for only eight years ago.</span></p> <p><span style="font-weight: 400;">It is understood the deal was done on Friday, May 7.</span></p> <blockquote style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" class="instagram-media" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/B3PG1gNlTij/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="13"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"></div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"></div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"></div> </div> </div> <div style="padding: 19% 0;"></div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"></div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" rel="noopener" href="https://www.instagram.com/p/B3PG1gNlTij/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank">A post shared by InterContinental Double Bay (@intercontinentaldoublebay)</a></p> </div> </blockquote> <p><span style="font-weight: 400;">Several other prominent Sydney-based apartment developers are known to have been interested in the hotel and given its record price, sources say it “Absolutely must be a development site”.</span></p> <p><span style="font-weight: 400;">In a statement sent to </span><span style="font-weight: 400;">The Courier</span><span style="font-weight: 400;">, Fridcorp confirmed the sale and noted that in 2011, Woollahra Council granted a permit to demolish the existing hotel and take advantage of the gorgeous harbour views by adding an eight-storey residential building and retail offering. </span></p> <p><span style="font-weight: 400;">Prior to this, the hotel was rebranded as the Sir Stamford Double Bay in 2001 and operated until 2009, then underwent a complete facelift and became the Intercontinental Sydney Double Bay in 2014.</span></p>

Real Estate

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Woman develops incurable skin condition after New Year's Eve kiss

<p>When Aimee Godden kissed someone on New Year’s Eve, it triggered an incurable skin condition that ended up changing her life.</p> <p>Godden was diagnosed with a mild case of psoriasis when she was 14, an autoimmune condition that causes the skin to go red and inflamed.</p> <p>But as a teenager, the condition wasn’t too noticeable, and she was able to cover the inflammation with clothes or a small amount of makeup.</p> <p>But fast forward to 2018, Godden made the mistake of kissing someone who, unknown to her, had tonsillitis.</p> <p>That was when she started developing large patches of dry skin on her forehead, cheeks and chest.</p> <p>“A doctor diagnosed me with guttate psoriasis and said tonsillitis had triggered it,” she explained.</p> <p>“I was devastated to be told there was no cure and terrified I would look like this forever.</p> <p>“My face was completely different to the one I’d known my whole life.”</p> <p>It took such a huge toll on her life, that she moved back home and refused to leave or even look at herself in the mirror.</p> <p>But in the age of social media, Godden decided to speak up about her condition on Instagram, and that was when things took a dramatic turn.</p> <p>After she posted a photo of her condition, it didn’t take long for it to gain traction with the response she received being overwhelmingly positive.</p> <p>“In public, people have pointed at my face and said ‘urgh’, but online I’ve had such a positive response,” she said.</p> <p>“You expect acceptance and support from friends and family. And when it comes from strangers, it feels so genuine.”</p> <p>Now, she has learnt to accept her skin condition, even though there are times where she feels discomfort and pain.</p> <p>Psoriasis can be itchy and may give off a burning sensation.</p> <p>She manages the condition by living healthily and undergoing light therapy treatment.</p> <p>The first night she went out after developing the condition, she says she felt very self conscious - until a man walked over and asked if he could buy her a drink.</p> <p>They are now expecting their first child in October.</p> <p>“I’d worried psoriasis would stop me finding love,” she said.</p> <p>“But I feel so much love in my life right now.”</p> <p>Godden is now a passionate advocate of loving the skin you’re in.</p> <p>“Whether it’s a scar, spots, pigmentation, a birthmark, hair loss, or skin condition ... We are often told that we need filters, makeup, good lighting and a perfect complexion to look ‘good’,” she wrote in an Instagram post in May, announcing a “Face Equality” selfie challenge.</p> <p>“We are all constantly exposed to the idea that our perceived value is dictated by our appearance.</p> <p>“This week we come together to challenge stigma, to refuse to be othered, and to campaign for a world that no longer reduces our value to our appearance.”</p>

Beauty & Style

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Behind Prince Charles and Prince William’s developing bond

<p>Prince Charles and Prince William’s relationship has not always been smooth sailing, but Prince Harry’s absence seems to have brought the two closer together.</p> <p>Royal observers noted that in their rare joint tour of the Defence Medical Rehabilitation Centre in Nottinghamshire last month, the Duke of Cambridge and his father <a href="https://www.bbc.com/news/uk-england-leicestershire-51459687">appeared relaxed around each other</a>, with “very visible bond”.</p> <p>The Prince of Wales helped his son try out wheelchair basketball at the centre, pushing his wheelchair closer to the ring and rubbing his shoulders.</p> <p>“One sensed a spontaneous warmth between them,” Prince Charles’ biographer Sally Bedell Smith told <em><a href="https://www.vanityfair.com/style/2020/02/prince-william-prince-charles-joint-engagements">Vanity Fair</a></em>.</p> <p>“Apart from the very visible bond, there’s plenty of evidence indicating a closer alignment between Charles and William. During the crisis over Prince Andrew’s scandals last year, both the Queen and Prince Charles ensured that Prince William played an active role in the decision-making.</p> <p>“That cooperation was also apparent in hammering out an agreement with Harry and Meghan to leave their official duties with the royal family.”</p> <p>Royal commentator Katie Nicholl said the closeness was likely due to the father-and-son’s similar roles in the royal family rather than the departure of the Duke of Sussex.</p> <p>“I think there is an understanding between Charles and William that they are both heirs, that they have a sense of duty and responsibility and for many years that William resented that sense of duty, he saw it as a burden,” Nicholl told <em><a href="https://honey.nine.com.au/royals/prince-charles-william-harry-relationship-katie-nicholl/c4439537-4ee2-4b0f-a3d5-a6c62823ba16">9Honey</a></em>.</p> <p>“Since getting married, since becoming a father himself, since having that stability in his life, it’s something that he’s embraced. And I think that connected him with his father. Given the drama, the changes in recent months, I think it probably has brought William and Charles together, they have to stick together.”</p> <p>Social media expert Meg Coffey said the two royals’ display of unity reflect their increasingly active role as future monarchs.</p> <p>“The Royal Family need to be conscious of public scrutiny and override the negative reporting with positive reporting, so definitely from Prince Charles and Prince William’s camps we are seeing a united front, with both being openly vocal in their support of each other and the monarchy,” Coffey told <em>Over60</em>.</p> <p>“To ensure the future of the monarchy Charles and Will know they need to put on a united front amid anything that could be perceived as potentially damaging the future of the crown.</p> <p>“We can assume that they will continue to be united in that goal as they both continue to take on more and more of an active role as they both get ever nearer to taking on the role of King themselves.”</p>

Relationships

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New Madeleine McCann development: Convicted child murderer emerges as "main suspect"

<p>A convicted serial killer has emerged as a key suspect in the search of missing Madeleine McCann, according to reports.</p> <p>48-year-old Martin Ney, who was sentenced to life imprisonment in 2012 for multiple child murders and abuses in Germany, is reportedly being investigated by officers from Portugal’s Policia Judiciaria as a “figure of interest”, <a rel="noopener" href="https://7news.com.au/news/crime/madeleine-mccann-case-paedophile-and-child-killer-martin-ney-a-figure-of-interest-c-95611" target="_blank">AAP</a> reported.</p> <p>“Detectives are preparing the end of the investigation, with a German paedophile who is in prison right now,” said former Portuguese police chief Goncalo Amaral, who first led the search for the young girl.</p> <p>Ney is believed to have been in Portugal when McCann vanished in 2007. It is claimed that he was working for an evangelical church on a project to help the homeless then.</p> <p>Police believe that Ney resembles a photofit of a man who was seen acting suspiciously in Praia da Luz before the then three-year-old McCann disappeared from her family’s holiday apartment in May 2007.</p> <p>Ney has previously been interviewed by detectives investigating McCann’s disappearance but has denied any involvement.</p> <p>Last Friday, May 2 marked the 12th anniversary of McCann’s disappearance. McCann’s parents, Kate and Gerry McCann, said in a statement released on the day: “Thank you to everyone who continues to support us and for your ongoing hope and belief.</p> <p>“The months and years roll by too quickly, Madeleine will be 16 this month. It’s impossible to put into words just how that makes us feel. There is comfort and reassurance though in knowing that the investigation continues, and many people around the world remain vigilant.”</p>

Legal

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Man develops deadly brain infection after cleaning ear with cotton buds

<p>It’s hard to resist the temptation to clean the insides of our ears with cotton buds, despite warnings on the label and health experts telling us otherwise. However, this near-fatal case may change your mind.</p> <p>An English man has sworn off cleaning his ears with cotton swabs after developing an infection that spread from his hearing to the lining of his brain.</p> <p>The 31-year-old man began developing the infection after the tip of a cotton bud he used got stuck in his ear canal, according to a case published in <a rel="noopener" href="https://casereports.bmj.com/content/12/3/e227971" target="_blank">BMJ Case Reports</a> earlier this month.</p> <p>He was experiencing seizures, headaches, ear pain and discharge before being rushed to hospital, <a rel="noopener" href="https://www.livescience.com/64958-cotton-swab-ear-infection.html" target="_blank"><em>Live Science</em></a> reported.</p> <p>The small amount of cotton left turned out to trap debris and induce a severe bacterial infection that progressed to the base of his skull and moved into the lining of his brain, said lead author Dr. Alexander Charlton, a member of the team of ear, nose and throat specialists involved in the man's treatment at University Hospital Coventry in England.</p> <p>Fortunately, Charlton and other doctors were able to remove the debris through a minor surgery. The patient was found to have necrotizing otitis externa, an infection in the soft tissue of the area from the outside of the ear to the eardrum. After almost a week in hospital, the man is expected to be free from long-term hearing issues.</p> <p>However, he was ordered by Charlton not to use cotton buds in his ears anymore, as the doctor said they have been linked to infections and punctured ear drums. "They can only cause problems," Charlton said.</p> <p>Health practitioners acknowledge that cotton buds are a popular ear-cleaning tool among the laymen. "I think that most people will have used them at some stage," Dr Joe Kosterich told <a rel="noopener" href="https://www.myvmc.com/videos/ear-health/" target="_blank">Virtual Medical Centre</a>.</p> <p>"In fact, they are something that shouldn’t be used. We think of them as being soft, but when you press on a cotton wool bud, they’re not actually all that soft. It is possible to perforate the eardrum with them."</p> <p>Ana Kim, MD, the director of Otologic Research at Columbia University Medical Centre also said removing ear wax might make ears more prone to infection. "It keeps the outer ear canal skin moist, allowing for the skin cells to be healthy and enabling the cells to continue shedding skin debris," she told <em><a rel="noopener" href="https://www.businessinsider.sg/seizure-brain-infection-after-using-a-cotton-swab-2019-3/" target="_blank">INSIDER</a>.</em></p> <p>Do you use cotton buds regularly? Let us know in the comments below.</p>

Body

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Why you're tripling the risk of developing a deadly disease if you take these heartburn tablets

<p>A new study has found that popular heartburn pills can triple the risk of potentially deadly infections.</p> <p>The research found that patients on proton pump inhibitors (PPIs) were more likely to fall ill with deadly bugs, including E. coli.</p> <p>Researchers believe the drugs could be allowing harmful organisms to spread by reducing levels of the stomach acid that normally kills them.</p> <p>The drugs, including brands like Zanprol, Prevacid and Prilosec, are prescribed to an estimated 55 million patients in England alone.</p> <p style="text-align: center;"><img style="width: 500px; height: 305.993690851735px;" src="https://oversixtydev.blob.core.windows.net/media/7821146/1.jpg" alt="" data-udi="umb://media/11eb887af851492099913bbf604cd8e1" /></p> <p style="text-align: left;">The tablets work by reducing the production of acid by blocking the enzyme in the wall of the stomach that produces acid.</p> <p>Microbiologists at Plymouth Hospitals NHS Trust studied 126 hospital patients sick with drug resistant bugs called ESBL-enterobacteriae.</p> <p>These bugs, such as E.coli, occur naturally in the bowel where they do no harm. However, if they escape to other parts of the body they can become life-threatening.</p> <p>The reports of ESBL-bugs are increasing and don’t respond to commonly-used antibiotics like penicillin.</p> <p>Patients in the study were asked if they had taken heartburn medicines in the past six months.</p> <p>The study, published in the Journal of Hospital Infection, found infected patients were three times more like to have taken PPIs than a group of healthy volunteers.</p> <p>In a report the scientists explained: “PPIs are widely overprescribed and heavily promoted by the pharmaceutical industry.”</p> <p>“This is the first time this risk factor has been identified in a UK hospital population, and the magnitude is greater than in previous community-based studies.</p> <p>“Reducing inappropriate use of PPIs may reduce transmission.”</p> <p>Several studies in recent years have linked over-use of PPIs with stomach cancer, stroke and even reduced sperm count in men.</p> <p>Despite PPIs only being prescribed for normally four weeks, it’s feared that millions stay on the tablets for years.</p> <p>Research shows 25 per cent of patients are still on them after a year and four per cent continue on the pills after five years.</p> <p>Less than half of those who remain on the tablets long-term are advised by doctors to try to come off them.</p> <p>Do you take heartburn tablets on a regular basis? Tell us in the comments below. </p> <p> </p>

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