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Princess Diana's brother shares "immensely sad" personal news

<p>Princess Diana's younger brother Charles Spencer has shared that he and his wife are divorcing after 13 years of marriage. </p> <p>The Earl's relationship with his wife, Karen Gordon, reportedly broke down while Spencer was writing his harrowing memoir which detailed the physical and sexual abuse he suffered at boarding school. </p> <p>Revealing the split to the <em><a href="https://www.dailymail.co.uk/news/article-13509355/charles-spencer-sad-divorce-wife-memoir.html" target="_blank" rel="noopener">Mail on Sunday</a></em>, the 60-year-old said, "It is immensely sad."</p> <p>"I just want to devote myself to all my children, and to my grandchildren, and I wish Karen every happiness in the future."</p> <p>Spencer and Gordon, a Canadian philanthropist, first met on a blind date at a restaurant in Los Angeles in 2010, and got married just one year later in June 2011 on the Althorp estate, where Princess Diana is buried. </p> <p>The couple share a 12-year-old daughter named Charlotte Diana, while Spencer also has four children from his previous marriage to his first wife, Victoria Lockwood, and two children with his second wife, Caroline Freud.</p> <p>Karen was notably absent at events held at Althorp and Spencer House in London in mid-March to launch the Earl's tell-all book, <em>A Very Private School</em>.</p> <p>Charles Spencer told the <em>Mail on Sunday</em> that the five years of work on his memoir has deeply affected him and led to him undergoing residential treatment for trauma late last year.</p> <p>In a March interview with <em><a href="https://people.com/charles-spencer-reveals-he-was-sexually-abused-by-a-woman-as-a-child-at-boarding-school-8606246" target="_blank" rel="noopener">People</a></em>, Spencer opened up about how “supportive” Karen had been throughout his healing journey as he recalled the traumatic details of his childhood.</p> <p>“I think it was very challenging for her to have a husband going through what was essentially four and a half years of the most profound therapy with very difficult undertones to it. And she supported the idea of me doing it,” he said.</p> <p>“I think she always hoped I would come out happier and healthier and that seems to be the case very much. So, I’m grateful to have her standing by me while I went through this, what I now realise was an essential process.”</p> <p><em>Image credits: Splashnews.com/Shutterstock Editorial </em></p>

Relationships

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New link to Madeleine McCann suspect revealed for the first time

<p dir="ltr">Detectives have uncovered an email account belonging to convicted paedophile Christian Brueckner that ties him to the disappearance of Madeleine McCann, a court has heard. </p> <p dir="ltr">Detective Titus Stampa told a court that the German FBI had identified two email accounts linked to the man, but was unable to discuss one of them because it was “related to the killing” of the child. </p> <p dir="ltr">The second email account was used for trading child pornography images with people online. </p> <p dir="ltr">However, the account had all of the messages deleted from the first half of 2007: the time Maddie vanished.</p> <p dir="ltr">Detective Stampa refused to confirm if the “murder” account contained any “photos”, but he said investigators were also in possession of a hard drive related to the “murder” which he was not allowed to discuss.</p> <p dir="ltr">The detective told the court, “An external hard drive is also belonging to the killing case – and I am not allowed to talk about it.”</p> <p dir="ltr">Asked about the account used for swapping child sex abuse images, Detective Stampa said, “I can remember that things were ‘massively’ deleted in the inbox.</p> <p dir="ltr">“There was nothing in there from January 2007.”</p> <p dir="ltr">The revelation offered the first glimpse into the physical proof that has led German investigators to believe Brueckner kidnapped and killed Maddie.</p> <p dir="ltr">Brueckner has long been the main suspect in the case of Maddie’s disappearance, after a key witness came forward in 2017 to report the man, who claimed that while discussing the McCann case, Brueckner said, “She didn’t scream.”</p> <p dir="ltr">Madeleine was last seen when she was just three years old in 2007 in Praia da Luz on Portugal’s Algarve coast, when she was on holiday with her family. </p> <p dir="ltr"><em>Image credits: MGG/Shutterstock Editorial</em></p>

Legal

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Five tips to help you start new hobbies in retirement

<p><em><a href="https://theconversation.com/profiles/alison-bishop-1522973">Alison Bishop</a>, <a href="https://theconversation.com/institutions/university-of-east-london-924">University of East London</a></em></p> <p>Retirement can be an exciting but also scary prospect for many. How you fill your time is totally up to you, but with so many choices it can be a bit daunting. But it’s important to make sure you keep active, physically and mentally.</p> <p>Hobbies can <a href="https://www.careuk.com/help-advice/why-are-long-lost-hobbies-important-for-older-people">increase wellbeing</a> by boosting brain function, enhancing social skills and improving fine motor skills. <a href="https://www.researchgate.net/publication/366160647_Psychological_benefits_of_hobby_engagement_in_older_age_a_longitudinal_cross-country_analysis_of_93263_older_adults_in_16_countries">A study carried out in 2022</a> found that spending time on hobbies was associated with lower symptoms of depression and a perceived increase in a person’s sense of health, happiness and overall life satisfaction.</p> <p>However, many older people don’t take up hobbies for all sorts of reasons. This might include fears that they are not as good at something in their older age as they were when they were younger. This fear of trying new things can lead to increased feelings of <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338142/">loneliness and isolation</a>.</p> <p>Here are five tips using <a href="https://ppc.sas.upenn.edu/sites/default/files/ppintroarticle.pdf">positive psychology</a> that could help you or someone in your life if they are scared or nervous about picking up a hobby.</p> <h2>1. Broaden your strengths</h2> <p>Our idea of what we are good at is formed at a very young age and often reflects subjects that we were good at in our school days. Positive psychology’s “<a href="https://www.viacharacter.org/character-strengths-and-virtues">theory of strengths</a>” encourages us to think more broadly about what constitutes a strength. For instance, it considers curiosity, kindness and bravery as strengths. When applied to choosing a hobby, it means that if you believe one of your strengths is kindness, you could consider working in outreach or charity as a hobby or spending time speaking with people who are housebound.</p> <h2>2. Find activities you already enjoy</h2> <p>The “<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693418/pdf/15347528.pdf?inf_contact_key=9944754ba1372fa9ce5ee1421d8427bc">broaden and build theory”</a> suggests that when we feel positive emotions such joy or love, we are more likely to engage in new activities, thoughts and behaviours. It follows then, that if you look at times in your life when you experience these emotions this could help you start a new hobby. So, if you enjoy walking in the countryside, then the theory suggests that those feelings would enable you to join a rambling club.</p> <h2>3. Remember moments you’ve lost track of time</h2> <p>Another way to identify an activity that would be good to do is by using “<a href="https://www.medicalnewstoday.com/articles/flow-state#what-it-is">flow theory”</a>. This suggests that when we are doing something that we become completely absorbed in, that our brainwave patterns change and we can lose track of time. For this to happen, we need an activity that is meaningful to us to complete, with just the right amount of challenge so that it is not too easy or too hard.</p> <p>An exercise that reveals your personal flow template involves looking back on your life to find as many times as possible when you’ve been doing something and completely lost track of time. Write these down and see if these moments have anything in common. For example, are they all creative activities or all outdoors and physical? This will reveal something about yourself and the type of activity that is aligned with who you are, and could suggest new hobbies.</p> <h2>4. Be kind to yourself</h2> <p>“<a href="https://self-compassion.org/">Self-compassion theory</a>” teaches us the importance of being as kind to ourselves as we would be to a friend. When we are thinking about what we are good at, we can be unkind to ourselves by comparing ourselves unfavourably to others or to an imagined high standard.</p> <p>Self-compassion theory states that our imperfections make us human, and it is our shared knowledge of this that connects us to others. Where a goal in an activity is kindness with ourselves and those doing the activity with us rather than performance, we can access a new more meaningful reason to take part in something.</p> <h2>5. Imagine your perfect day</h2> <p>The last tip from positive psychology involves creating <a href="https://www.thepositivepsychologypeople.com/reflections-on-a-beautiful-day/">a story of the perfect average day</a> and then planning to actually live it. How do your hobbies fit into this? How does this day tap into your broadened idea of your strengths? How does it include kindness to yourself and others?</p> <p>It also helps to identify goals either for retirement more generally or for participating in a hobby. By picturing the perfect average day you can create more meaning and purpose in life by seeing how all the parts of your life fit together. It also reveals short term goals for example, if you plan to go to an art club but can’t get there, then a goal could be asking for a lift from another club member. When these pieces are in place, hope is ignited, and a vision created of how life can go forward so that you really can live your best retired life.</p> <p><em><a href="https://theconversation.com/profiles/alison-bishop-1522973">Alison Bishop</a>, Lecturer in Positive Psychology Coaching, <a href="https://theconversation.com/institutions/university-of-east-london-924">University of East London</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/five-tips-to-help-you-start-new-hobbies-in-retirement-226764">original article</a>.</em></p>

Retirement Life

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5 ways your sleep affects what you eat

<p>We know a good night’s sleep is good for us but logging in those hours of sleep can be a difficult task. Without quality shut-eye, our productivity decreases, immune system weakens and even our dietary health is negatively affected.</p> <p><strong>You eat more when you sleep less</strong></p> <p>A Mayo Clinic study comparing the eating habits of people who slept as much as they needed and those who only slept two-thirds of their required rest time for eight days, found the subject who were sleep-deprived ended up eating an average of 549 extra calories each day.</p> <p><strong>You snack more, especially at night</strong></p> <p>A lack of sleep can lead to decrease in physical activity and an increase in snacking behaviour. Such behaviours typically leads to weight gain.</p> <p><strong>You crave extra carbs and fatty foods</strong></p> <p>The foods we’re snacking on aren’t usually the healthy variety. A 2013 study found that when we’re tired we not only crave unhealthy, -carbohydrate, and high-fat foods but we’re less likely to consider the consequences of such food choices over time.</p> <p><strong>Disrupted sleep cycle equal changing eating patterns</strong></p> <p>Your internal clock guides both your sleep patterns and your eating patterns – aka when you feel hungry during the day. A 2011 study found that people who are “late sleepers” tend to delay their meals throughout the day and end up consuming more calories than the average meal. Those late-eating habits affect sleep and perpetuates the cycle.</p> <p><strong>You don’t eat the right foods</strong></p> <p>A 2013 study found that sleep-deprived subjects ate half the fruit and vegetable servings of a normal sleeper. This meant losing key nutrients from their diet, which can lead to dietary imbalances and effect the regular functioning of the body. </p> <p><em>Image credits: Shutterstock</em></p>

Body

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"Fly high, Bette!": World's longest-serving flight attendant dies aged 88

<p>Bette Nash, the world's longest-serving flight attendant has passed away aged 88, after a short battle with breast cancer. </p> <p>American Airlines, where Nash devoted almost seven decades of her life, announced her death on social media on Saturday. </p> <p>"We mourn the passing of Bette Nash, who spent nearly seven decades warmly caring for our customers in the air," they began their post. </p> <p>“Bette was a legend at American and throughout the industry, inspiring generations of flight attendants. </p> <p>“Fly high, Bette. We’ll miss you.”</p> <p>A spokesperson for the airlines confirmed that she was still an active employee at the time of her death. </p> <p>Nash, who was born on December 31, 1935,  began her flight-attendant career with Eastern Airlines in 1957, at just 21-years-old. </p> <p>In January 2022, she was officially recognised as the world’s longest-serving flight attendant by Guinness World Records, after surpassing the previous record a year earlier. She continued to hold the title until her passing. </p> <p>Tributes have poured in from people all over the world on social media, with many praising her for her unwavering dedication and kindness. </p> <p>"Fly high Bette! It was a pleasure being your passenger," wrote one person on X, alongside a selfie he took with her. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Fly high Bette! It was a pleasure being your passenger. <a href="https://t.co/9N63YPB5Ia">pic.twitter.com/9N63YPB5Ia</a></p> <p>— Jon Kruse (@JonKruseYacht) <a href="https://twitter.com/JonKruseYacht/status/1794459429997273423?ref_src=twsrc%5Etfw">May 25, 2024</a></p></blockquote> <p>"She was flying as a passenger when she sat next to me, pinned her jacket to the bulkhead, gave me a three minute story of her life then said 'So what's your story?'. She was a dynamo. Rest easy," another added.  </p> <p>"She was an absolute delight in my earliest airline life working the USAir shuttle at LGA. Godspeed and eternal silvered wings Bette!" a third wrote. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">She was an absolute delight in my earliest airline life working the USAir shuttle at LGA. Godspeed and eternal silvered wings Bette!</p> <p>— Ryan Spellman (@JustJettingThru) <a href="https://twitter.com/JustJettingThru/status/1794480142766531034?ref_src=twsrc%5Etfw">May 25, 2024</a></p></blockquote> <p>"Rest in Peace Bette Nash," wrote a fourth. </p> <p>"Bette was a class act. Truly a loss for the skies. She was truly an Angel," added another. </p> <p><em>Image: CBS/ X</em></p>

Caring

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Another man dies after fall from world's biggest cruise ship

<p>A passenger has died after he fell from the world's largest cruise ship on the first night of a week-long voyage. </p> <p>The unidentified man allegedly jumped from Royal Caribbean’s new 366 metre-long Icon of the Seas, just hours after it left a port in Miami, Florida on its way to Honduras, according to the US Coast Guard.</p> <p>“The cruise ship deployed one of their rescue boats, located the man and brought him back aboard,” the Coast Guard told the <em><a href="https://nypost.com/2024/05/28/us-news/passenger-dead-after-jumping-off-worlds-largest-cruise-ship/" target="_blank" rel="noopener">New York Post</a></em>.</p> <p>“He was pronounced deceased. Beyond assisting in the search, the US Coast Guard did not have much involvement in this incident,” the agency added.</p> <p>Royal Caribbean told the publication, “The ship’s crew immediately notified the US Coast Guard and launched a search and rescue operation”. </p> <p>“Our care team is actively providing support and assistance to the guest’s loved ones during this difficult time.”</p> <p>At the time of the incident, the cruise ship had only travelled 500km from Florida, and stopped for two hours to help the search and rescue Coast Guard team to locate the passenger. </p> <p>The man was brought back on-board in critical condition before he succumbed to his injuries and died on the ship. </p> <p>The Icon of the Seas, the world’s largest cruise ship, took its maiden voyage in January this year.</p> <p>The Royal Caribbean ship has 20 decks and is nearly the size of four city blocks, holding 7,600 passengers and 2,350 crew members.</p> <p><em>Image credits: Royal Caribbean</em></p>

Travel Trouble

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New study reveals people who do this daily make more money over their lifetimes

<p>You’ve heard that regular exercise can help you live richly. Frequent movement, even in short bursts throughout the day, has been linked to lower all-cause mortality rates and reduced risk of heart disease, type-2 diabetes and other age-related conditions, helping you age healthfully and stay independent.</p> <p>Now, new research suggests frequent exercise might help you live well in another meaningful way; in terms of income. In a recent study published in the journal Clinical Orthopaedics and Related Research, doctors from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), which is part of the National Institute of Health (NIH), investigated whether individuals who stayed active would earn more money as a result of their active lifestyle.</p> <p>The researchers’ findings revealed that staying active not only resulted in higher present earnings, but also predicted increased future income throughout one’s life. In essence, the science was clear: Getting more exercise could make you wealthier.</p> <h2>How exercise predicted future earnings</h2> <p>The researchers set out to explore three key correlations: How mobility affected income, how mobility influenced income over time, and whether exercise could help people maintain their mobility as they aged.</p> <p>The team analysed data from the US-federally-supported Health and Retirement Study (HRS), the largest study tracking changes over time in Americans aged 50 and above. This comprehensive study takes into account various life aspects, including work, socio-economic status, health, psychology and family matters, as individuals age.</p> <p>To assess the impact of current mobility on income, the researchers examined data from over 19,000 respondents to determine how well they could perform simple tasks, such as walking several blocks, climbing multiple flights of stairs, or moving around a room. Each person received a numerical score, with 5 indicating full mobility and 0 indicating difficulties with these tasks.</p> <h2>What earnings over time revealed</h2> <p>The researchers found that for each decrease in the mobility category, individuals lost out on an average of US$3000 in annual income compared to their peers. Those who were active were also significantly more likely to remain working for longer than the other group. It appeared that engaging in exercise enabled individuals to maintain mobility and engage in professional life for a longer period of time than those who were less active.</p> <p>Looking at earnings over time revealed even more substantial benefits for those who remained active throughout their lives. Active individuals showed an overall income level that was US$6500 higher, along with higher rates of employment.</p> <p>For the third part of the study, it’s not surprising that those who engaged in exercise continued to maintain their mobility after the age of 55 and had higher employment rates. Even exercising just one day a week showed improvements in mobility outcomes.</p> <h2>Moving more benefits more than just health</h2> <p>While this study doesn’t definitively prove that leading a healthy lifestyle directly leads to higher earnings, it strongly suggests that staying healthy and mobile brings benefits beyond just lower levels of disease (which is a type of wealth in and of itself). NIAMS Director Lindsey A. Criswell, M.D., M.P.H., underscores this point: “We have long understood that greater mobility is an important indicator of good health … The notion that mobility can have economic rewards further extends the evidence for the benefits of exercise and maintaining an active lifestyle.”</p> <p>If this science inspires you to make a healthy lifestyle change, speak with a licensed healthcare provider to determine the right exercise programme for you.</p> <p><em>Image credits: Shutterstock </em></p> <p><em>This article originally appeared on <a href="https://www.readersdigest.co.nz/food-home-garden/money/new-study-reveals-people-who-do-this-daily-make-more-money-over-their-lifetimes" target="_blank" rel="noopener">Reader's Digest</a>.</em> </p>

Body

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Want to reduce your dementia risk? Eat these 4 foods, says new study

<p>If you are what you eat, this might make you hungrier for foods that are bright in every sense. Research has shown that living, vibrant foods can slow down aging at a cellular level; while fruit and vegetables in particular have been associated with lower incidence of cognitive decline as individuals age.</p> <p>However, research has been relatively lacking on just how much of these brain-healthy foods you really need and which fruit and vegetables are best for the job.</p> <p>In collaboration with public health experts at Harvard University, medical researchers at China’s Zhejiang University School of Medicine conducted a meta-analysis that’s slated to be published in the June 2024 issue of <em>The Journal of Nutrition, Health, and Aging</em>. They combined data from two large-scale population-representative studies that analysed the diets and cognitive function of more than 10,000 participants ages 55 and older from China and the US.</p> <h2>What daily diets revealed</h2> <p>The data included diet questionnaires that honed in on the average of participants’ total daily intake of several different types of foods, including fruit and vegetables, and also broke them down into sub-types like green leafy vegetables and berries. Over a period of five years, the participants also took part in activities designed to assess their cognitive function and the average rate of cognitive decline.</p> <p>Overall, participants who included the most fruit and vegetables in their daily diets performed best on the brain tests and maintained those results over time. This suggested that both fruit and vegetables had protective elements that slowed cognitive decline.</p> <h2>Vegetables that help protect cognition</h2> <p>Interestingly, certain types of vegetables appeared to be more beneficial than others—say the researchers: “Our findings support the potential beneficial roles of VF, especially cruciferous vegetables, green leafy vegetables, and red and yellow vegetables, in maintaining cognitive function and slowing cognitive decline in middle-aged and older adults.”</p> <p>The researchers pointed to several reasons these particular vegetables might have shown a substantial impact, including anti-inflammatory and antioxidation nutrients like flavonoids and various vitamins or even gut improvements that have been shown to help improve or protect cognition.</p> <p>While beans didn’t figure prominently in both studies, they showed a protective element in the US study, so they are also worth keeping on your plate. (Beans are also thought to be one of the top foods for longevity.)</p> <h2>Fruit that pack a punch</h2> <p>As for fruit, while some didn’t show as much of a protective effect across the board, berries and apples are two examples of fruit that experts have previously said provide major polyphenol and antioxidant effect.</p> <p>Participants whose brains maintained performance were shown to have eaten three or more servings of vegetables and two or more servings of fruit per day. This is on par with the five servings of vegetables and two servings of fruit recommended we eat every day.</p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article originally appeared on <a href="https://www.readersdigest.co.nz/healthsmart/want-to-reduce-your-dementia-risk-eat-these-4-foods-says-new-study" target="_blank" rel="noopener">Reader's Digest</a>. </em></p>

Mind

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Yoko Ono selling John Lennon's New York home for first time in 50 years

<p>For the first time in 50 years, the house where John Lennon and Yoko Ono lived in New York City has hit the market.</p> <p>The brick, bluestone and terra cotta structure at 496 Broome St. was the first home the pair bought together in New York City before they moved to the Upper West Side of Manhattan. </p> <p>Yoko Ono has held onto the property since she first bought it with the late Beatles member, and has now listed it with her son with JLL Real Estate, for an asking price of $US5.5 million ($8.23m AUD).</p> <p>“The building on Broome St. was sort of like a base for their artistic ventures,” Philip Norman, author of “John Lennon: The Life,” told the <em><a href="https://nypost.com/2024/05/21/real-estate/yoko-ono-lists-former-nyc-home-for-5-5m/" target="_blank" rel="noopener">New York Post</a></em>. “Bank Street was their salon, where people could just walk in.”</p> <p>First built in 1885, the two-storey building has an open-plan format, with a gallery-like ground floor space with 14.4-foot-high ceilings, an open kitchen and a lofted bedroom.</p> <p>On the second floor, there’s a live-work space and a recording studio.</p> <p>“496 Broome St. is both a unique piece of New York history and popular culture and a prime investment opportunity for the right buyer,” said Paul Smadbeck, who holds the listing.</p> <p>“Versatile zoning and its location in one of the city’s most desirable and trendsetting neighbourhoods offers an exciting opportunity to create a one-of-a-kind property.”</p> <p><em>Image credits: Mediapunch / JLL Real Estate </em></p>

Real Estate

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After 180 years, new clues are revealing just how general anaesthesia works in the brain

<div class="theconversation-article-body"><em><a href="https://theconversation.com/profiles/adam-d-hines-767066">Adam D Hines</a>, <a href="https://theconversation.com/institutions/queensland-university-of-technology-847">Queensland University of Technology</a></em></p> <p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773932/pdf/BLT.15.159293.pdf/">Over 350 million surgeries</a> are performed globally each year. For most of us, it’s likely at some point in our lives we’ll have to undergo a procedure that needs general anaesthesia.</p> <p>Even though it is one of the safest medical practices, we still don’t have a complete, thorough understanding of precisely how anaesthetic drugs work in the brain.</p> <p>In fact, it has largely remained a mystery since general anaesthesia was introduced into medicine over <a href="https://www.tandfonline.com/doi/full/10.3109/08941939.2015.1061826">180 years ago</a>.</p> <p>Our study published <a href="https://doi.org/10.1523/JNEUROSCI.0588-23.2024">in The Journal of Neuroscience today</a> provides new clues on the intricacies of the process. General anaesthetic drugs seem to only affect specific parts of the brain responsible for keeping us alert and awake.</p> <h2>Brain cells striking a balance</h2> <p>In a study using fruit flies, we found a potential way that allows anaesthetic drugs to interact with specific types of neurons (brain cells), and it’s all to do with proteins. Your brain has around <a href="https://onlinelibrary.wiley.com/doi/10.1002/cne.21974">86 billion neurons</a> and not all of them are the same – it’s these differences that allow general anaesthesia to be effective.</p> <p>To be clear, we’re not completely in the dark on <a href="https://linkinghub.elsevier.com/retrieve/pii/S0165614719300951">how anaesthetic drugs affect us</a>. We know why general anaesthetics are able to make us lose consciousness so quickly, thanks to a <a href="https://www.nature.com/articles/367607a0">landmark discovery made in 1994</a>.</p> <p>But to better understand the fine details, we first have to look to the minute differences between the cells in our brains.</p> <p>Broadly speaking, there are <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591655/">two main categories of neurons in the brain</a>.</p> <p>The first are what we call “excitatory” neurons, generally responsible for keeping us alert and awake. The second are “inhibitory” neurons – their job is to regulate and control the excitatory ones.</p> <p>In our day-to-day lives, excitatory and inhibitory neurons are constantly working and balancing one another.</p> <p><a href="https://www.nature.com/articles/npp2017294">When we fall asleep</a>, there are inhibitory neurons in the brain that “silence” the excitatory ones keeping us awake. This happens <a href="https://askdruniverse.wsu.edu/2018/01/07/why-do-we-get-tired/">gradually over time</a>, which is why you may feel progressively more tired through the day.</p> <p>General anaesthetics speed up this process by directly silencing these excitatory neurons without any action from the inhibitory ones. This is why your anaesthetist will tell you that they’ll “put you to sleep” for the procedure: <a href="https://www.nature.com/articles/nrn2372">it’s essentially the same process</a>.</p> <h2>A special kind of sleep</h2> <p>While we know why anaesthetics put us to sleep, the question then becomes: “why do we <em>stay</em> asleep during surgery?”. If you went to bed tonight, fell asleep and somebody tried to do surgery on you, you’d wake up with quite a shock.</p> <p>To date, there is no strong consensus in the field as to why general anaesthesia causes people to remain unconscious during surgery.</p> <p>Over the last couple of decades, researchers have proposed several potential explanations, but they all seem to point to one root cause. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709148/#:%7E:text=At%20presynaptic%20part%2C%20voltage%2Dgated,anesthetics%20to%20inhibiting%20neurotransmitter%20release.">Neurons stop talking to each other</a> when exposed to general anaesthetics.</p> <p>While the idea of “cells talking to each other” may sound a little strange, it’s a <a href="https://qbi.uq.edu.au/brain-basics/brain/brain-physiology/action-potentials-and-synapses">fundamental concept in neuroscience</a>. Without this communication, our brains wouldn’t be able to function at all. And it allows the brain to know what’s happening throughout the body.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/593888/original/file-20240514-16-5fletd.png?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/593888/original/file-20240514-16-5fletd.png?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/593888/original/file-20240514-16-5fletd.png?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=600&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/593888/original/file-20240514-16-5fletd.png?ixlib=rb-4.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=600&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/593888/original/file-20240514-16-5fletd.png?ixlib=rb-4.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=600&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/593888/original/file-20240514-16-5fletd.png?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=754&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/593888/original/file-20240514-16-5fletd.png?ixlib=rb-4.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=754&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/593888/original/file-20240514-16-5fletd.png?ixlib=rb-4.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=754&amp;fit=crop&amp;dpr=3 2262w" alt="Two branching structures in orange, green, blue and yellow colours on a black background." /></a><figcaption><span class="caption">Colourised neurons in the brain of a fly.</span> <span class="attribution"><span class="source">Adam Hines</span></span></figcaption></figure> <h2>What did we discover?</h2> <p>Our new study shows that general anaesthetics appear to stop excitatory neurons from communicating, but not inhibitory ones. <a href="https://www.jneurosci.org/content/40/21/4103">This concept isn’t new</a>, but we found some compelling evidence as to <em>why</em> only excitatory neurons are affected.</p> <p>For neurons to communicate, proteins have to get involved. One of the jobs these proteins have is to get neurons to release molecules called <a href="https://my.clevelandclinic.org/health/articles/22513-neurotransmitters">neurotransmitters</a>. These chemical messengers are what gets signals across from one neuron to another: dopamine, adrenaline and serotonin are all neurotransmitters, for example.</p> <p>We found that general anaesthetics impair the ability of these proteins to release neurotransmitters, but only in excitatory neurons. To test this, we used <a href="https://www.eneuro.org/content/8/3/ENEURO.0057-21.2021"><em>Drosophila melanogaster</em> fruit flies</a> and <a href="https://imb.uq.edu.au/research/facilities/microscopy/training-manuals/microscopy-online-resources/image-capture/super-resolution-microscopy">super resolution microscopy</a> to directly see what effects a general anaesthetic was having on these proteins at a molecular scale.</p> <p>Part of what makes excitatory and inhibitory neurons different from each other is that they <a href="https://journals.physiology.org/doi/full/10.1152/physrev.00007.2012">express different types of the same protein</a>. This is kind of like having two cars of the same make and model, but one is green and has a sports package, while the other is just standard and red. They both do the same thing, but one’s just a little bit different.</p> <p>Neurotransmitter release is a complex process involving lots of different proteins. If one piece of the puzzle isn’t exactly right, then general anaesthetics won’t be able to do their job.</p> <p>As a next research step, we will need to figure out which piece of the puzzle is different, to understand why general anaesthetics only stop excitatory communication.</p> <p>Ultimately, our results hint that the drugs used in general anaesthetics cause massive global inhibition in the brain. By silencing excitability in two ways, these drugs put us to sleep and keep it that way.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/229713/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/adam-d-hines-767066">Adam D Hines</a>, Research fellow, <a href="https://theconversation.com/institutions/queensland-university-of-technology-847">Queensland University of Technology</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/after-180-years-new-clues-are-revealing-just-how-general-anaesthesia-works-in-the-brain-229713">original article</a>.</em></p> </div>

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World No.1 golfer breaks silence after bizarre arrest

<p>World No. 1 golfer Scottie Scheffler has broken his silence after he was arrested and charged by police on Friday, ahead of the second round of the PGA Championships. </p> <p>Scheffler was detained by Louisville Metro police, after he drove onto a curb to try and get around a fatal accident that occurred in front of the Valhalla Golf Club. </p> <p>Earlier that morning, a man who was working  for a vendor at the tournament, was hit and killed by a shuttle bus while attempting to cross the street near the golf club.</p> <p>The tragic incident caused the road to close in both directions, but Scheffler reportedly “refused to comply and accelerated forward” when Detective Bryan Gillis stopped the golfer to give instructions.</p> <p>The police report obtained by <em>ESPN </em>also said that the detective who stopped him “suffered pain, swelling and abrasions to his left wrist and knee." </p> <p>Scheffler was charged with felony assault on a police officer, criminal mischief, reckless driving and disregarding signals from an officer directing traffic and was released almost four hours later. </p> <p>He returned to the golf course and issued a statement on the incident before completing his second round. </p> <p>“This morning I was proceeding as directed by police officers,” Scheffler began.</p> <p>“It was a very chaotic situation, understandably considering the tragic accident that had occurred earlier and there was a big misunderstand of what I thought I was being asked to do.</p> <p>“I never intended to disregard any of the instructions.</p> <p>“I am hopeful to put this to the side and focus on golf today.</p> <p>“Of course, all of us involved in the tournament express our deepest sympathies to the family of the man passed away in the earlier accident this morning. It truly puts everything into perspective.”</p> <p>After completing the second round, he spoke further about the incident and said: “My head is still kind of spinning, I can’t really explain what happened this morning." </p> <p>He also recalled stretching and doing his warm-ups in the jail cell, in attempt to lower his heart rate. </p> <p>“I was never angry. I was just in shock, and I think my body was just -- I was shaking the whole time. I was shaking for like an hour. It was definitely a new feeling for me," he said.</p> <p>An officer even offered him a sandwich. </p> <p>“I was like, ‘Sure, I’ll take a sandwich’. I hadn’t eaten breakfast yet. I mean, they were really kind. I’m grateful that we have such strong police, and they’re our protectors out there, and like I said, we just got into a chaotic situation this morning. That’s really all it was," he recalled. </p> <p>Scheffler’s lawyer Steve Romines said that there was a bit of confusion as the officer directing traffic didn’t appear to be part of the tournament traffic detail “and that’s where the miscommunication arose”.</p> <p><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">He also said that they will be pleading not guilty and told </span><em style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">The Golf Channel </em><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">that charges against Scheffler “will either be dropped or we will go to trial because Scottie didn’t do anything wrong.</span></p> <p>“We’re not interested in any sort of settlement negotiations or anything like that. It was just a big miscommunication.”</p> <p><em>Images: Twitter</em></p> <p> </p>

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6 strange wedding traditions around the world

<p>Every country – indeed, every family – has their own wedding traditions and marriage superstitions. Most of us would be familiar with the rule of the newlyweds-to-be not seeing each other before the wedding and the “something old, something new, something borrowed, something blue” rhyme, but what goes on around the rest of the world? Let’s find out.</p> <p><strong>1. Greece</strong></p> <p>If you’ve ever attended a Greek wedding, you’ll know it’s a colourful, fun, family-oriented affair – you’ll also probably be familiar with koufeta. They’re sugar-coated almonds given to guests by the newlyweds as a way to secure happiness, health, wealth, children and a long life. How? The white of the almond is said to symbolise purity, the egg shape fertility, the hardness represents the endurance of marriage and the sugar shows the sweetness of married life.</p> <p><strong>2. Scotland</strong></p> <p>Many modern Scots have done away with this tradition, and we can’t blame them. Essentially, before the big day, the bride (and occasionally the groom) is covered head-to-toe in pungent foods like rotten eggs, curdled milk and fish sauce by her friends. Supposedly, it prepares the couple for the difficulties of marriage and wards away evil spirits. We’d rather give it a miss.</p> <p><strong>3. South America</strong></p> <p>Pearls might be the jewellery of choice for some woman, but you’re not likely to see a single stone on a South American bride. Many Latin cultures see pearls as “tears of the sea” and believe that wearing them on your wedding day could bring sadness into the new marriage.</p> <p><strong>4. India</strong></p> <p>It’s traditional for Indian brides to get henna tattoos on their hands and feet for their wedding day, and there’s often a sweet hidden message in them – the groom’s initials. If he is able to find his initials in the elaborate tattoo on the wedding night, it’s believed the couple will have good luck. Lucky for the bride, if he fails, he has to give his new wife a present. Score!</p> <p><strong>5. Poland</strong></p> <p>Polish brides have to be very careful when it comes to picking out their wedding shoes. According to tradition, open-toed shoes are bad luck since they allow the couple’s future wealth and fortune to escape through the opening. However, there’s also an opportunity for the newlyweds to make a bit of money, too! As they leave the church, their guests shower them with coins, which they then have to collect to secure a happy and prosperous future.</p> <p><strong>6. Germany</strong></p> <p>If you’re a young German woman, you might want to avoid splashing out on porcelain – come the night before your wedding, it’ll all be destroyed. Yep, “polterabend” is a tradition in which wedding guests arrive at the bride’s home the night before and smash anything made of porcelain they can get their hands on. This is thought to bring good luck, and since it’s up to the couple to clean up the mess, it’s also designed to teach them that married life isn’t always easy – but they can work through any challenges they may face.</p> <p><em>Image credits: Shutterstock</em></p>

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World's most disappointing tourist hotspots revealed

<p>While many travellers tend to flock to must-see tourists attractions while exploring somewhere new on their holiday, it turns out not everyone is impressed with the hype. </p> <p>A host of scathing online reviews have targeted landmarks such as Stonehenge, the Eiffel Tower, the Leaning Tower of Pisa and even Bondi Beach, calling the sites "unimpressive", "boring" and "pointless".</p> <p>According to travellers, there are 15 tourist hotspots that don't live up to the hype, with many leaving the destinations feeling disappointed. </p> <p><strong>Mona Lisa - Paris, France</strong></p> <p>One of the most "disappointing" attractions, according to travellers, is da Vinci's masterpiece the Mona Lisa, which hangs in the Louvre in the French capital city. </p> <p>According to online reviews, nearly four in ten (37.1 per cent) visitors posted negative comments about visiting the work, saying it did not live up to their expectations. </p> <p>One review left on TripAdvisor described the experience as "a bit boring", adding, "The Mona Lisa was very small and not as beautiful as I thought it would be."</p> <p>Several other reviews stated how irritating the experience of actually seeing the artwork was, with one person claiming the Louvre had a "zoo-like atmosphere".</p> <p><strong>The Eiffel Tower - Paris, France</strong></p> <p>Tourists visiting France were double disappointed, after also being let down by the iconic Eiffel Tower, which many described as "not a very special place... it's just an iron building."</p> <p>"It's boring, nothing special about it. You have to wait in a long queue just to go up and take pictures," another person wrote. </p> <p>Others claimed the landmark is nothing but a "tourist trap", claiming it is "seriously underwhelming".</p> <p><strong>Stonehenge - England</strong></p> <p>For many, Stonehenge continues to be a wonder of mystery, as one of the most architecturally sophisticated ancient stone sculptures in the world, but for others, it's just a "big disappointment". </p> <p>One reviewer went so far as to say it was the "biggest disappointment of my life", saying, "I was expecting so much more. Do not waste your time people. The only magical thing about this place is that somehow it has the power to draw people on to look at it."</p> <p>Another person put simply, "It's a pile of rocks. Pointless."</p> <p><strong>The Leaning Tower of Pisa - Italy </strong></p> <p>While many tourists visiting Italy opt to check out the famous leaning tower, others tend to lean away from it, calling it a "tourist trap". </p> <p>One person reviewed the famous landmark, saying, "It's literally just a leaning tower. I wouldn’t make a stop here just to see it. It is overly crowded and hot in the summertime."</p> <p>Others claim they were hassled by countless street sellers, writing, "The whole area is crawling with at times aggressive street hawkers who feel it is OK to keep hassling and trying to sell you tourist crap."</p> <p><strong>Checkpoint Charlie - Berlin, Germany</strong></p> <p>Set up as a reminder of the former border crossing and the partition between East and West Berlin during the Cold War, Checkpoint Charlie is often known as a must-see spot. </p> <p>However, others have been left feeling let down by the historic spot. </p> <p>One traveller rated the site just one star, writing, "The only place in Berlin where we encountered street traders who were deeply unpleasant. The museum is overpriced and very tired. The whole area was uninspiring and a complete waste of our time."</p> <p><strong>The Empire State Building - New York City, USA</strong></p> <p>Every year, thousands of people pay to head to the top of the iconic Empire State Building to catch a glimpse of the New York City skyline. </p> <p>However, given the over-crowding of the observation platform and the hefty cost to enter, many have left feeling "underwhelmed" and "ripped-off".</p> <p>One person reviewed the landmark, writing, "Wow! What a waste of $185 for a family of three to struggle to fight our way to finally see a view obscured by a metal crisscross railing. Long lines, rude staff, cheesy "museum", and overpriced. It's as bad as an amusement park."</p> <p><strong>Bondi Beach - Sydney, Australia</strong></p> <p>A trip to Bondi Beach is often at the top of a tourist's travel itinerary when heading Down Under for the first time.</p> <p>But as the beach gains popularity, travellers have been increasingly underwhelmed by the picturesque beach given the over-crowding. </p> <p>One review read, "The beach is all the hype and show but it's like having a bath with your entire family and a dozen strangers. It's packed on any normal day and should be regulated with a fence line and tickets so it's not like cramming sardines into a can."</p> <p><em>Image credits: Getty Images </em></p>

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How much time should you spend sitting versus standing? New research reveals the perfect mix for optimal health

<div class="theconversation-article-body"><em><a href="https://theconversation.com/profiles/christian-brakenridge-1295221">Christian Brakenridge</a>, <a href="https://theconversation.com/institutions/baker-heart-and-diabetes-institute-974">Baker Heart and Diabetes Institute</a></em></p> <p>People have a pretty intuitive sense of what is healthy – standing is better than sitting, exercise is great for overall health and getting <a href="https://theconversation.com/could-not-getting-enough-sleep-increase-your-risk-of-type-2-diabetes-225179">good sleep is imperative</a>.</p> <p>However, if exercise in the evening may disrupt our sleep, or make us feel the need to be more sedentary to recover, a key question emerges – what is the best way to balance our 24 hours to optimise our health?</p> <p><a href="https://link.springer.com/article/10.1007/s00125-024-06145-0">Our research</a> attempted to answer this for risk factors for heart disease, stroke and diabetes. We found the optimal amount of sleep was 8.3 hours, while for light activity and moderate to vigorous activity, it was best to get 2.2 hours each.</p> <p><iframe id="dw4bx" class="tc-infographic-datawrapper" style="border: none;" src="https://datawrapper.dwcdn.net/dw4bx/" width="100%" height="400px" frameborder="0"></iframe></p> <h2>Finding the right balance</h2> <p>Current health guidelines recommend you stick to a <a href="https://www.health.gov.au/topics/physical-activity-and-exercise/physical-activity-and-exercise-guidelines-for-all-australians/for-adults-18-to-64-years">sensible regime</a> of moderate-to vigorous-intensity physical activity 2.5–5 hours per week.</p> <p>However <a href="https://doi.org/10.1016/j.jacc.2019.02.031">mounting evidence</a> now <a href="https://doi.org/10.2337/dc14-2073">suggests</a> how you spend your day can have meaningful ramifications for your health. In addition to moderate-to vigorous-intensity physical activity, this means the time you spend sitting, standing, doing light physical activity (such as walking around your house or office) and sleeping.</p> <p>Our research looked at more than 2,000 adults who wore body sensors that could interpret their physical behaviours, for seven days. This gave us a sense of how they spent their average 24 hours.</p> <p>At the start of the study participants had their waist circumference, blood sugar and insulin sensitivity measured. The body sensor and assessment data was matched and analysed then tested against health risk markers — such as a heart disease and stroke risk score — to create a model.</p> <p>Using this model, we fed through thousands of permutations of 24 hours and found the ones with the estimated lowest associations with heart disease risk and blood-glucose levels. This created many optimal mixes of sitting, standing, light and moderate intensity activity.</p> <p>When we looked at waist circumference, blood sugar, insulin sensitivity and a heart disease and stroke risk score, we noted differing optimal time zones. Where those zones mutually overlapped was ascribed the optimal zone for heart disease and diabetes risk.</p> <h2>You’re doing more physical activity than you think</h2> <p>We found light-intensity physical activity (defined as walking less than 100 steps per minute) – such as walking to the water cooler, the bathroom, or strolling casually with friends – had strong associations with glucose control, and especially in people with type 2 diabetes. This light-intensity physical activity is likely accumulated intermittently throughout the day rather than being a purposeful bout of light exercise.</p> <p>Our experimental evidence shows that <a href="https://diabetesjournals.org/care/article/39/6/964/29532/Benefits-for-Type-2-Diabetes-of-Interrupting">interrupting our sitting</a> regularly with light-physical activity (such as taking a 3–5 minute walk every hour) can improve our metabolism, especially so after lunch.</p> <p>While the moderate-to-vigorous physical activity time might seem a quite high, at more than 2 hours a day, we defined it as more than 100 steps per minute. This equates to a brisk walk.</p> <p>It should be noted that these findings are preliminary. This is the first study of heart disease and diabetes risk and the “optimal” 24 hours, and the results will need further confirmation with longer prospective studies.</p> <p>The data is also cross-sectional. This means that the estimates of time use are correlated with the disease risk factors, meaning it’s unclear whether how participants spent their time influences their risk factors or whether those risk factors influence how someone spends their time.</p> <h2>Australia’s adult physical activity guidelines need updating</h2> <p>Australia’s <a href="https://www.health.gov.au/topics/physical-activity-and-exercise/physical-activity-and-exercise-guidelines-for-all-australians/for-adults-18-to-64-years">physical activity guidelines</a> currently only recommend exercise intensity and time. A <a href="https://www.uow.edu.au/media/2023/why-adults-need-to-move-more-stop-sitting-and-sleep-better-.php">new set of guidelines</a> are being developed to incorporate 24-hour movement. Soon Australians will be able to use these guidelines to examine their 24 hours and understand where they can make improvements.</p> <p>While our new research can inform the upcoming guidelines, we should keep in mind that the recommendations are like a north star: something to head towards to improve your health. In principle this means reducing sitting time where possible, increasing standing and light-intensity physical activity, increasing more vigorous intensity physical activity, and aiming for a healthy sleep of 7.5–9 hours per night.</p> <p>Beneficial changes could come in the form of reducing screen time in the evening or opting for an active commute over driving commute, or prioritising an earlier bed time over watching television in the evening.</p> <p>It’s also important to acknowledge these are recommendations for an able adult. We all have different considerations, and above all, movement should be fun.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/228894/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/christian-brakenridge-1295221"><em>Christian Brakenridge</em></a><em>, Postdoctoral research fellow at Swinburne University, Centre for Urban Transitions, <a href="https://theconversation.com/institutions/baker-heart-and-diabetes-institute-974">Baker Heart and Diabetes Institute</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/how-much-time-should-you-spend-sitting-versus-standing-new-research-reveals-the-perfect-mix-for-optimal-health-228894">original article</a>.</em></p> </div>

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New birthday portrait of Princess Charlotte revealed

<p>The Prince and Princess of Wales have shared a new photo of their daughter, Princess Charlotte, to celebrate her ninth birthday. </p> <p>“Happy 9th birthday, Princess Charlotte! Thank you for all of the kind messages today,” they captioned the portrait of the young royal, which was posted on Instagram. </p> <p>Charlotte smiled confidently for the camera as she leaned against a fence surrounded by flowers in the garden of their home in Windsor.</p> <p>The young royal donned a dark red cardigan, a blue top and a denim skirt with stockings in the picture taken by her mother, Kate Middleton. </p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/C6dejAktAsO/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/C6dejAktAsO/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by The Prince and Princess of Wales (@princeandprincessofwales)</a></p> </div> </blockquote> <p>Royal fans shared their birthday wishes and praised the Princess of Wales' photography skills. </p> <p>“Another gorgeous photo taken by Catherine,” wrote one fan. </p> <p>“Am enjoying seeing her grow up and flourish.”</p> <p>“She’s growing up so fast and isn’t she the image of her father,” another follower wrote.</p> <p>“Magical. Happy birthday young lady,” commented a third. </p> <p>One fan noted that Charlotte had her father’s eyes and her mother’s “beautiful smile”, while a few others commented on how quickly she was growing up. </p> <p>Just last week Charlotte’s younger brother Louis turned six, and as part of their tradition, a portrait <a href="https://www.oversixty.com.au/lifestyle/family-pets/kate-middleton-shares-new-birthday-photo-of-prince-louis" target="_blank" rel="noopener">photo</a> of him that was taken by his mother was also released. </p> <p><em>Image: Instagram/ Getty</em></p> <p> </p>

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What is childhood dementia? And how could new research help?

<p><em><a href="https://theconversation.com/profiles/kim-hemsley-1529322">Kim Hemsley</a>, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a>; <a href="https://theconversation.com/profiles/nicholas-smith-1529324">Nicholas Smith</a>, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a>, and <a href="https://theconversation.com/profiles/siti-mubarokah-1529323">Siti Mubarokah</a>, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a></em></p> <p>“Childhood” and “dementia” are two words we wish we didn’t have to use together. But sadly, around <a href="https://doi.org/10.1093/brain/awad242">1,400 Australian children and young people</a> live with currently untreatable childhood dementia.</p> <p>Broadly speaking, childhood dementia is caused by any one of <a href="https://www.childhooddementia.org/what-is-childhood-dementia#what">more than 100</a> rare genetic disorders. Although the causes differ from dementia acquired later in life, the progressive nature of the illness is the same.</p> <p><a href="https://doi.org/10.1093/brain/awad242">Half</a> of infants and children diagnosed with childhood dementia will not reach their tenth birthday, and most will die <a href="https://www.childhooddementia.org/what-is-childhood-dementia#what">before turning 18</a>.</p> <p>Yet this devastating condition has lacked awareness, and importantly, the research attention needed to work towards treatments and a cure.</p> <h2>More about the causes</h2> <p>Most types of childhood dementia are <a href="https://academic.oup.com/brain/article/146/11/4446/7226999">caused</a> by <a href="https://www.genome.gov/genetics-glossary/Mutation">mutations</a> (or mistakes) in our <a href="https://www.genome.gov/genetics-glossary/Deoxyribonucleic-Acid">DNA</a>. These mistakes lead to a range of rare genetic disorders, which in turn cause childhood dementia.</p> <p><a href="https://doi.org/10.1093/brain/awad242">Two-thirds</a> of childhood dementia disorders are caused by “<a href="https://www.ncbi.nlm.nih.gov/books/NBK459183/">inborn errors of metabolism</a>”. This means the metabolic pathways involved in the breakdown of carbohydrates, lipids, fatty acids and proteins in the body fail.</p> <p>As a result, nerve pathways fail to function, neurons (nerve cells that send messages around the body) die, and progressive cognitive decline occurs.</p> <h2>What happens to children with childhood dementia?</h2> <p>Most children initially appear unaffected. But after a period of apparently normal development, children with childhood dementia <a href="https://doi.org/10.1016/j.pediatrneurol.2023.09.006">progressively lose</a> all previously acquired skills and abilities, such as talking, walking, learning, remembering and reasoning.</p> <p>Childhood dementia also leads to significant changes in behaviour, such as aggression and hyperactivity. Severe sleep disturbance is common and vision and hearing can also be affected. Many children have seizures.</p> <p>The age when symptoms start can vary, depending partly on the particular genetic disorder causing the dementia, but the average is around <a href="https://doi.org/10.1093%2Fbrain%2Fawad242">two years old</a>. The symptoms are caused by significant, progressive brain damage.</p> <h2>Are there any treatments available?</h2> <p>Childhood dementia treatments currently <a href="https://www.childhooddementia.org/news/report-reveals-global-research-inequity">under evaluation</a> or approved are for a very limited number of disorders, and are only available in some parts of the world. These include gene replacement, <a href="https://doi.org/10.1002/jmd2.12378">gene-modified cell therapy</a> and protein or <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1712649">enzyme replacement therapy</a>. Enzyme replacement therapy is available in Australia for <a href="https://australianprescriber.tg.org.au/articles/cerliponase-alfa-for-neuronal-ceroid-lipofuscinosis-type-2-disease.html">one form of childhood dementia</a>. These therapies attempt to “fix” the problems causing the disease, and have shown promising results.</p> <p>Other experimental therapies include ones that <a href="https://doi.org/10.3390/life12050608">target</a> faulty protein production or <a href="https://doi.org/10.1056/nejmoa2310151">reduce inflammation</a> in the brain.</p> <h2>Research attention is lacking</h2> <p>Death rates for Australian children with cancer <a href="http://www.childhooddementia.org/getasset/2WX39O">nearly halved</a> between <a href="https://www.aihw.gov.au/reports/children-youth/australias-children/contents/health/cancer-incidence-survival">1997 and 2017</a> thanks to research that has enabled the development of multiple treatments. But over recent decades, <a href="http://www.childhooddementia.org/getasset/2WX39O">nothing has changed</a> for children with dementia.</p> <p>In 2017–2023, research for childhood cancer received over four times more funding per patient compared to funding for <a href="https://www.childhooddementia.org/getasset/2WX39O">childhood dementia</a>. This is despite childhood dementia causing a <a href="https://doi.org/10.1093/brain/awad242">similar number of deaths</a> each year as childhood cancer.</p> <p>The success <a href="https://www.aihw.gov.au/reports/children-youth/australias-children/contents/health/cancer-incidence-survival">for childhood cancer sufferers</a> in recent decades demonstrates how adequately funding medical research can lead to improvements in patient outcomes.</p> <p>Another bottleneck for childhood dementia patients in Australia is the lack of access to clinical trials. An <a href="https://www.childhooddementia.org/news/report-reveals-global-research-inequity">analysis</a> published in March this year showed that in December 2023, only two clinical trials were recruiting patients with childhood dementia in Australia.</p> <p>Worldwide however, 54 trials were recruiting, meaning Australian patients and their families are left watching patients in other parts of the world receive potentially lifesaving treatments, with no recourse themselves.</p> <p>That said, we’ve seen a slowing in the establishment of <a href="https://www.childhooddementia.org/news/report-reveals-global-research-inequity">clinical trials</a> for childhood dementia across the world in recent years.</p> <p>In addition, we know from <a href="https://www.childhooddementia.org/join-us/professionals/impacts">consultation with families</a> that current care and support systems <a href="https://www.childhooddementia.org/getasset/44MLP8">are not meeting the needs</a> of children with dementia and their families.</p> <h2>New research</h2> <p>Recently, we were awarded <a href="https://www.premier.sa.gov.au/media-releases/news-items/major-funding-boost-for-research-into-childhood-dementia">new funding</a> for <a href="https://www.flinders.edu.au/giving/our-donors/impact-of-giving/improving-the-lives-of-children-with-dementia">our research</a> on childhood dementia. This will help us continue and expand studies that seek to develop lifesaving treatments.</p> <p>More broadly, we need to see increased funding in Australia and around the world for research to develop and translate treatments for the broad spectrum of childhood dementia conditions.</p> <p><em>Dr Kristina Elvidge, head of research at the <a href="https://www.childhooddementia.org/our-people">Childhood Dementia Initiative</a>, and Megan Maack, director and CEO, contributed to this article.</em><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/228508/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/kim-hemsley-1529322">Kim Hemsley</a>, Head, Childhood Dementia Research Group, Flinders Health and Medical Research Institute, College of Medicine and Public Health, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a>; <a href="https://theconversation.com/profiles/nicholas-smith-1529324">Nicholas Smith</a>, Head, Paediatric Neurodegenerative Diseases Research Group, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a>, and <a href="https://theconversation.com/profiles/siti-mubarokah-1529323">Siti Mubarokah</a>, Research Associate, Childhood Dementia Research Group, Flinders Health and Medical Research Institute, College of Medicine and Public Health, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-is-childhood-dementia-and-how-could-new-research-help-228508">original article</a>.</em></p>

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Kate Middleton shares new birthday photo of Prince Louis

<p>Prince Louis has turned six! </p> <p>Prince William and Princess Kate have released a new photo of the young royal to mark his special day. </p> <p>"Happy 6th Birthday, Prince Louis! Thank you for all the kind wishes today,” the couple wrote on social media. </p> <p>In the picture, taken by the Princess of Wales, the young royal donned a plaid shirt with blue pants and was smiling at the camera. </p> <p>Eagle-eyed royal watchers noticed one sweet detail in the photo: Prince Louis appears to have had a visit from the tooth fairy, as one of his bottom front-teeth was missing. </p> <p>“Thank you so much for sharing this delightful picture. I see the tooth fairy has been visiting - goodness time flies so fast,” one fan wrote on X. </p> <p>"Happy birthday Prince Louis!! Can’t believe how grown up he is looking, hope he has the best day!" wrote another on Instagram. </p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/C6GhkvDNg0H/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/C6GhkvDNg0H/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by The Prince and Princess of Wales (@princeandprincessofwales)</a></p> </div> </blockquote> <p>"So glad to hear from Princess Catherine via this delightful photo. HBD, little Louis !" added a third. </p> <p>"Wishing this sweet little prince the happiest of the birthdays," commented a fourth. </p> <p>Kate is known for taking photos of her kids for their birthdays, and this milestone comes after a difficult period for the royal family, with both Kate and King Charles' cancer diagnosis. </p> <p>The family of five have taken time out of the spotlight in recent weeks and celebrated a more low-key and private Easter break in Norfolk. </p> <p><em>Image: Getty</em></p> <p> </p>

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Does hosting the Olympics, the World Cup or other major sports events really pay off?

<p><em><a href="https://theconversation.com/profiles/ivan-savin-678930">Ivan Savin</a>, <a href="https://theconversation.com/institutions/escp-business-school-813">ESCP Business School</a></em></p> <p>After a long battle, <a href="https://www.france24.com/en/europe/20240213-paris-booksellers-stay-olympics-macron-bouquiniste-france">Paris’s beloved <em>bouquinistes</em> will be staying put</a> this summer. The decision, announced on 13 February by the French government, came after considerable public backlash to the police prefecture’s original plan to move part of the iconic Seine booksellers elsewhere for the inauguration of the Olympics Games on 26 July.</p> <p>Meanwhile, less than six months away from the event, Parisians continue to grumble over a <a href="https://www.ouest-france.fr/jeux-olympiques/cest-aberrant-ce-maire-vient-dapprendre-que-sa-ville-accueillera-les-jeux-de-paris-ab1fa968-cfd1-11ee-89c0-6cefac77e04a">lack of consultations</a> with locals, warnings of <a href="https://www.rfi.fr/en/france/20231130-paris-vehicle-traffic-to-be-heavily-restricted-during-2024-olympic-games">gridlocked traffic</a>, closed metro stations, extensive video surveillance and other grievances. So for host countries, what was the point of the Olympics, again?</p> <p>In academia, the debate about the potential positive and negative effects of large-scale sporting events is ongoing. Although these events are often associated with substantial economic losses, the long-term benefits are the main argument in favour of hosting them. These include the development of material and soft infrastructure such as hotels, restaurants or parks. Big games can also help put the host region on the map as an attractive place for sports and cultural events, and inspire a better entrepreneurial climate.</p> <h2>The pros and the cons of big sporting events?</h2> <p>The cost of these benefits, as the Parisians have realised, is steep. Host countries appear to suffer from increased tax burdens, low returns on public investments, high construction costs, and onerous running cost of facilities after the event. Communities can also be blighted by noise, pollution, and damage to the environment, while increased criminal activity and potential conflicts between locals and visitors can take a toll on their quality of life. As a result, in the recent past several major cities, including Rome and Hamburg, <a href="https://www.dw.com/en/6-cities-that-rejected-the-olympics/a-46289852">withdrew their bids to host the games</a>.</p> <p>A common feature of the economics of large-scale sporting events is that our expectations of them are more optimistic than what we make of them once they have taken place. Typically, expenditure tends to tip over the original budget, while the revenue-side indicators (such as the number of visitors) are rarely achieved.</p> <p>When analysing the effect of hosting large-scale sporting events on tourist visits, it is important to take into consideration both the positive and negative components of the overall effect. While positive effects may be associated with visitors, negative effects may arise when “regular” tourists refuse to visit the location due to the event. This might be because of overloaded infrastructure, sharp increases in accommodation costs, and inconveniences associated with overcrowding or raucous or/and violent visitors. On top of that, reports of poverty or crime in the global media can actually undermine the location’s attractiveness.</p> <h2>When big sporting events crowd out regular tourists</h2> <p>In an <a href="https://doi.org/10.1177/1527002523120639">article published in the <em>Journal of Sports Economics</em></a> with Igor Drapkin and Ilya Zverev, I assess the effects of hosting large-scale sporting events, such as Winter and Summer Olympics plus FIFA World Cups, on international tourist visits. We utilise a comprehensive dataset on flow of tourists covering the world’s largest destination and origin countries between 1995 and 2019. As a first step, we built an econometric model that effectively predicts the flow of tourists between any pair of countries in our data. Subsequently we compared the predicted tourist inflow in a hypothetical scenario where no large-scale sporting event would have taken place with the actual figures. If the actual figures exceed the predicted ones, we consider the event to have a net positive impact. Otherwise, we consider that it had a “crowding out” effect on “regular” tourists. While conducting this analysis, we distinguished between short-term (i.e., focusing just on the year of the event) and mid-term (year of the event plus three subsequent years).</p> <p>Our results show that the effects of large-scale sporting events vary a lot across host countries: The World Cup in Japan and South Korea 2002 and South Africa 2010 were associated with a distinct increase in tourist arrivals, whereas all other World Cups were either neutral or negative. Among the Summer Olympics, China in 2008 is the only case with a significant positive effect on tourist inflows. The effects of the other four events (Australia 2000, Greece 2004, Great Britain 2012, and Brazil 2016) were found to be negative in the short- and medium-term. As for the Winter Olympics, the only positive case is Russia in 2014. The remaining five events had a negative impact except the one-year neutral effect for Japan 1998.</p> <p>Following large-scale sporting events, host countries are therefore typically less visited by tourists. Out of the 18 hosting countries studied, 11 saw tourist numbers decline over four years, and three did not experience a significant change.</p> <h2>The case for cautious optimism</h2> <p>Our research indicates that the positive effect of hosting large-scale sporting events on tourist inflows is, at best, moderate. While many tourists are attracted by FIFA World Cups and Olympic games, the crowding-out effect of “regular” tourists is strong and often underestimated. This implies that tourists visiting for an event like the Olympics typically dissuade those who would have come for other reasons. Thus, efforts to attract new visitors should be accompanied by efforts to retain the already existing ones.</p> <p>Large-scale sporting events should be considered as part of a long-term policy for promoting a territory to tourists rather than a standalone solution. Revealingly, our results indicate that it is easier to get a net increase in tourist inflows in countries that are less frequent destinations for tourists – for example, those in Asia or Africa. By contrast, the United States and Europe, both of which are traditionally popular with tourists, have no single case of a net positive effect. Put differently, the large-scale sporting events in Asia and Africa helped promote their host countries as tourist destinations, making the case for the initial investment. In the US and Europe, however, those in the last few decades brought little return, at least in terms of tourist inflow.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/222118/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/ivan-savin-678930">Ivan Savin</a>, Associate professor of quantitative analytics, research fellow at ICTA-UAB, <a href="https://theconversation.com/institutions/escp-business-school-813">ESCP Business School</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/does-hosting-the-olympics-the-world-cup-or-other-major-sports-events-really-pay-off-222118">original article</a>.</em></p>

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Teen with Down Syndrome sets new world record

<p>A 19-year-old teen with Down Syndrome has conquered the London Marathon and became a Guinness World Record after just five months of training. </p> <p>Lloyd Martin from Cardiff completed the 42.1 km course across the capital with his mother cheering him on. </p> <p>Guinness World Record has awarded him the certificate for becoming the youngest person in his learning disability category to finish a marathon. </p> <p>"I'm so excited to run London. I love being fit and healthy and I want to make my family and friends proud," the teenager said. </p> <p>Mum Ceri Hooper also told the<em> BBC</em> how proud she was of her son's accomplishment. </p> <p>"In Lloyd's words, it's achieving his dream," she said. </p> <p>"Really anything is possible if you put your mind to it. With a bit of work, you can achieve it."</p> <p>Recalling the experience, the proud mum said: "He ran continuously for 14 miles which is the longest he's ever run before." </p> <p>Although Lloyd walked for a bit after his 14-mile-long streak, the crowd cheered him on every step of the way, and despite the challenge the mother-and-son duo had "a ball". </p> <p>The pair were at a loss for words when he finally crossed the finish line and they both "burst into tears." </p> <p>Lloyd is also now the third Welsh Special Olympics athlete to compete in the London Marathon. </p> <p>Prior to completing the world-famous marathon, Lloyed had completed an astonishing 30 Parkruns. </p> <p>Until last Christmas the teenager had never run further than three miles, but his mother was determined to get him marathon-ready. </p> <p>Ceri, who has taken on the London Marathon four times, created a specialised training regime for her son which included weekly runs. </p> <p>Lloyd managed to secure a spot in the marathon thanks to the help of the Special Olympics GB, where he is also a footballer and a gymnast. </p> <p><em>Images: Facebook/ Twitter</em></p>

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World's most expensive house up for sale

<p>A French chateau, once owned by a member of the Rothschild family and, later on, the King of Morocco, has gone up for sale with a £363 million (AU$699) price tag. </p> <p>Chateau d’Armainvilliers located at Seine-et-Marne, 48km east of the Eiffel Tower, is the world's most expensive home. </p> <p>Built upon the foundations of a 12th century castle, the sprawling mansion boasts 1,000 hectares of land, 100 rooms across 2,500 square metres of living space, a private lake, and plenty of sequoia trees - the largest trees in the world. </p> <p>Ignace Meuwissen, a self-acclaimed "real estate advisor to the global elite" described the property as a display of "opulence and grandeur".</p> <p>"It is the most expensive castle in France and perhaps in the world. The price of €425million is justified by the property itself but also by the 1,000 hectare land which offers numerous possibilities," he told Paris Match magazine. </p> <p>"An investor could build thousands of apartments there if he wanted."</p> <p>The chateau was first bought by the Rothschild banking empird in the late 19th century, before King Hassan II of Morocco bought it in the 1980s. </p> <p>He then made the chateau more fit for a king, adding a hammam spa, a beauty and hairdressing salon, and a fully-equipped medical and dental facility.</p> <p>The Moroccan King  also added a basement level, which has a network of tunnels, kitchens, cold rooms, storage spaces and staff quarters.</p> <p>The lucky owner will also find Moroccan mosaics and wall tiles decorating the home, and for any avid equestrians, the home also has a stable big enough for 50 horses. </p> <p>However, some luxury property agents have expressed their doubts on whether the property would sell with its nine-figure sum, with one saying it was an "unrealistic" price tag. </p> <p>"It doesn’t make sense, it’s absurd Properties of this type could sell for 20-25 million, or even 30 million if we really fall in love with them. I’m not even sure that Vaux-le-Vicomte (a Baroque French château), which has no marketing plans, would sell at this price," one agent told French real estate publication <em>Le Figaro Immobilier</em>.</p> <p>Others were unsure whether the changes made by the King in the 1980s would suit modern tastes. </p> <p><em>Images: Whisper Auctions</em></p>

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