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Susan Sarandon's daughter claps back at wedding dress critics

<p>Susan Sarandon's daughter has spoken out against body-shaming trolls who were criticising her wedding dress. </p> <p>Eva Amurri, who like her mum is also an actress, became the subject of online criticism after she shared photos from her wedding day online. </p> <p>Writing on her blog <em>Happily Eva After </em>the 39-year-old admitted that the comments left her in tears, "in a way that brought me right back to Middle School".</p> <p>"Here were people I didn't even know and who didn't know me, spending time and energy typing something that they hoped would bring me one thing and one thing only: Shame," she recalled the moment she came across the "hundreds of cruel comments". </p> <p>"It wasn't what they were saying per se, I've had much more horrible things directed at me on the internet, but it was the yucky feeling of knowing that there are people out there (and lots of them!) whose immediate reaction upon witnessing my little family's joy was to try to hurt us."</p> <p>She continued to explain that she was shocked that her wedding photos had gone viral due to something beyond her control. </p> <p>"I was so taken aback by the fact that it was already viral... and for two reasons completely out of my control: My Breasts," she wrote.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/C82pK8juxqM/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/C82pK8juxqM/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by People Magazine (@people)</a></p> </div> </blockquote> <p>"I've always been naturally very large-chested, and my breast size fluctuates with my weight (as real breasts often do)," she wrote, adding that she is a mother of three and she had breastfed all of her children. </p> <p>"Are my breasts the same perkiness they were at 20 years old before they sustained human life three times over? Definitely not. Do I care? Some days more than others. But my body isn't something I'm ashamed of."</p> <p>She then said that she chose the dress because she wanted to feel "sexy and elegant" on her special day. </p> <p>"I had purposefully gone into my wedding dress shopping wanting to show my figure and really celebrate myself as a woman - body parts included," she shared.</p> <p>"It had never occurred to me that people I don't even know would find my body so offensive, and especially that they would care so much about what I would choose to wear on my own wedding day."</p> <p>She then criticised the online trolls for their "embarrassing" behaviour and how unfortunate it was that women still experience this kind of criticism. </p> <p>"You don't need anybody's permission to make the choices you make for yourself," she wrote.</p> <p>"And when people feel something about those choices? Well, that's none of your business."</p> <p><em>Images: Instagram</em></p> <p> </p>

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Shocking moment Queen Mary is struck by electric scooter

<p>Concerns over the safety of the Danish royal family have been raised after a video surfaced showing Queen Mary being struck by a scooter during a visit to Greenland last month.</p> <p>The footage, released by Danish tabloid Ekstra Bladet, depicts the incident in which Queen Mary, wife of King Frederik X, is seen greeting fans before being struck. Onlookers quickly surrounded the scene in shock.</p> <p>The 52-year-old monarch, who has four children, was visibly distressed as she fell but managed to maintain her composure after getting back on her feet. Her security team promptly intervened, halting the scooter's movement. The driver, an elderly man, appeared more shaken than the Queen and stated that he "did not know what happened", explaining that he had intended to extend his arm towards the Queen but accidentally accelerated instead.</p> <p>This incident has prompted widespread debate over the adequacy of security measures for the Danish monarchy. Royal expert Kenth G. Madsen, in an interview with FEMAIL, called for enhanced security protocols during public appearances by royalty and political figures. Madsen cited a recent incident involving Prime Minister Mette Frederiksen, who was assaulted by a drunk man in Copenhagen.</p> <p>"Threat assessments must be updated regularly to reflect the current security situation," Madsen said. He called for increased surveillance, a larger security presence, the establishment of safe zones around public events, and improved crisis response plans. He also stressed the importance of clear communication between security units.</p> <p>Ekstra Bladet's royal commentator, Kim Bach, criticised Denmark's national security and intelligence service, PET, for allowing a vehicle to get so close to the Queen. "It's strange that they are not more vigilant, just because they are in Greenland," Bach remarked, highlighting the perceived laxity in security measures.</p> <p>Queen Mary was reportedly shaken by the incident, which occurred near her youngest children, Prince Vincent and Princess Josephine. King Frederik was also in the vicinity, greeting fans when the accident happened. The palace confirmed that Queen Mary was not injured and continued with her scheduled events.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/C9LUBJWIGqD/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/C9LUBJWIGqD/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by š‡šžš« šŒššš£šžš¬š­š² šš®šžšžš§ šŒššš«š² (@denmarksqueenmary)</a></p> </div> </blockquote> <p>Eyewitnesses described the shock of the crowd following the incident. One spectator told <em>The Australian</em>, "I could see how much it hurt her; her eyes watered immediately. It must hurt to be hit at that speed."</p> <p>While both police and palace security concluded that the incident was an innocent mistake, fans and observers have expressed concerns about the Queen's safety. Comments on social media questioned why a motorised scooter ā€“ even a mobility one such as this ā€“ was allowed so close to the monarch.</p> <p>The incident has sparked a debate about the balance between the royals' accessibility to the public and the need for more robust security measures. Fans and commentators alike have called for a reassessment of the security protocols surrounding the Danish royal family, particularly during public engagements.</p> <p><em>Images: Instagram</em></p>

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The tragic reason Miriam Margolyes is still working at 83

<p>Miriam Margolyes has shared the tragic reason that she is still working in showbiz at the age of 83. </p> <p>The acting legend has long suffered with spinal stenosis ā€“ a condition that occurs when the spinal canal or neural foramen narrows, putting pressure on the spinal cord and nerve roots.</p> <p>Despite suffering from the debilitating illness, the 83-year-old British star has appeared on numerous TV shows over the years. </p> <p>Now, speaking candidly to the <em>Radio Times</em>, Margolyes admitted that she is still working to fund her medical bills. </p> <p>She said, ā€œIā€™m worried that I wonā€™t have enough money for carers when I finally get paralysed or whatever it is thatā€™s going to happen to me.ā€ </p> <p>Despite dealing with the physical constraints that come from both her spinal stenosis and her age, which she finds ā€œlimiting and depressingā€, she said she refuses to slow her pace.</p> <p>ā€œWhen you know that you havenā€™t got long to live and Iā€™m probably going to die within the next five or six years, if not before, Iā€™m loath to leave behind performing. Itā€™s such a joy.ā€</p> <p>ā€œI yearn to play roles that donā€™t confine me to wheelchairs, but Iā€™m just not strong enough.ā€</p> <p>Margolyes recently underwent major heart surgery, speaking candidly about the operation with the <em>Table Manners</em> podcast.</p> <p>ā€œIā€™ve got a cowā€™s heart now,ā€ she said.</p> <p>ā€œWell, not the whole heart. Iā€™ve had an aortic valve replaced by a cowā€™s aortic valve.</p> <p>ā€œI donā€™t know how common it is. Iā€™d never heard of that operation. But it saves you from having open-heart surgery, which would be infinitely more invasive.ā€</p> <p>In the same interview, Margolyes revealed she expected to be a wheelchair soon.</p> <p>ā€œWhen you get old you become obviously aware of your vulnerability. I have a bad back, Iā€™m probably going to be in a wheelchair soon and you have to come to terms with what life throws at you.ā€</p> <p><em>Image credits: Ken McKay/ITV/Shutterstock Editorial</em></p>

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Cranberry juice really can help with UTIs ā€“ and reduce reliance on antibiotics

<p><em><a href="https://theconversation.com/profiles/christian-moro-121754">Christian Moro</a>, <a href="https://theconversation.com/institutions/bond-university-863">Bond University</a> and <a href="https://theconversation.com/profiles/charlotte-phelps-1187658">Charlotte Phelps</a>, <a href="https://theconversation.com/institutions/bond-university-863">Bond University</a></em></p> <p>Cranberry juice has been <a href="https://www.ncbi.nlm.nih.gov/books/NBK92762/">used medicinally for centuries</a>. Our new research indicates it should be a normal aspect of urinary tract infection (UTI) management today.</p> <p>While some benefits of cranberry compounds for the prevention of UTIs have been suspected for <a href="https://theconversation.com/cranberry-juice-can-prevent-recurrent-utis-but-only-for-some-people-203926">some time</a>, it hasnā€™t been clear whether the benefits from cranberry juice were simply from drinking <a href="https://bjgp.org/content/70/692/e200">more fluid</a>, or something in the fruit itself.</p> <p>For our <a href="https://www.sciencedirect.com/science/article/pii/S2405456924001226">study</a>, published this week, we combined and collectively assessed 3,091 participants across more than 20 clinical trials.</p> <p>Our analysis indicates that increasing liquids reduces the rate of UTIs compared with no treatment, but cranberry in liquid form is even better at reducing UTIs and antibiotic use.</p> <h2>Are UTIs really that bad?</h2> <p>Urinary tract infections affect more than <a href="https://journals.sagepub.com/doi/pdf/10.1177/1756287219832172">50% of women</a> and <a href="https://bjgpopen.org/content/bjgpoa/5/2/bjgpopen20X101140.full.pdf">20% of men</a> in their lifetime.</p> <p>Most commonly, UTIs are caused from the bug called <em>Escherichia coli</em> (E.coli). This bug lives harmlessly in our <a href="https://www.ncbi.nlm.nih.gov/books/NBK562895/">intestines</a>, but can cause infection in the <a href="http://doi.org/10.33235/anzcj.30.1.4-10">urinary tract</a>. This is why, particularly for women, it is recommended people wipe from front to back after using the toilet.</p> <p>An untreated UTI can move up to the kidneys and cause even more serious illness.</p> <p>Even when not managing infection, many people are anxious about contracting a UTI. Sexually active women, pregnant women and older women may all be at <a href="https://www.ncbi.nlm.nih.gov/books/NBK436013/">increased risk</a>.</p> <h2>Why cranberries?</h2> <p>To cause a UTI, the bacteria need to attach to the wall of the <a href="https://www.nature.com/articles/s41598-023-44916-8">urinary bladder</a>. Increasing fluids helps to flush out bacteria before it attaches (or makes its way up into the bladder).</p> <p>Some beneficial compounds in cranberry, such as <a href="https://www.cochrane.org/CD001321/RENAL_cranberries-preventing-urinary-tract-infections">proanthocyanidins</a> (also called condensed tannins), prevent the bacteria from attaching to the wall itself.</p> <p>While there are treatments, over 90% of the bugs that cause UTIs exhibit some form of <a href="https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance">microbial resistance</a>. This suggests that they are rapidly changing and some cases of UTI might be left <a href="https://www.scientificamerican.com/article/antibiotic-resistant-utis-are-common-and-other-infections-may-soon-be-resistant-too/">untreatable</a>.</p> <h2>What we found</h2> <p>Our analysis <a href="https://www.sciencedirect.com/science/article/pii/S2405456924001226">showed</a> a 54% lower rate of UTIs from cranberry juice consumption compared to no treatment. This means that significantly fewer participants who regularly consumed cranberry juice (most commonly around 200 millilitres each day) reported having a UTI during the periods assessed in the studies we analysed.</p> <p>Cranberry juice was also linked to a 49% lower rate of antibiotic use than placebo liquid and a 59% lower rate than no treatment, based on analysis of indirect and direct effects across six studies. The use of cranberry compounds, whether in drinks or tablet form, also reduced the prevalence of symptoms associated with UTIs.</p> <p>While some studies we included presented conflicts of interest (such as receiving funding from cranberry companies), we took this ā€œhigh risk of biasā€ into account when analysing the data.</p> <h2>So, when can cranberry juice help?</h2> <p>We found three main benefits of cranberry juice for UTIs.</p> <p><strong>1. Reduced rates of infections</strong></p> <p>Increasing fluids (for example, drinking more water) reduced the prevalence of UTIs, and taking cranberry compounds (such as tablets) was also beneficial. But the most benefits were identified from increasing fluids and taking cranberry compounds at the same time, such as with cranberry juice.</p> <p><strong>2. Reduced use of antibiotics</strong></p> <p>The data shows cranberry juice lowers the need to use antibiotics by 59%. This was identified as fewer participants in randomised cranberry juice groups required antibiotics.</p> <p>Increasing fluid intake also helped reduce antibiotic use (by 25%). But this was not as useful as increasing fluids at the same time as using cranberry compounds.</p> <p>Cranberry compounds alone (such as tablets without associated increases in fluid intake) did not affect antibiotic use.</p> <p><strong>3. Reducing symptoms</strong></p> <p>Taking cranberry compounds (in any form, liquid or tablet) reduced the symptoms of UTIs, as measured in the overall data, by more than five times.</p> <h2>Take home advice</h2> <p>While cranberry juice cannot treat a UTI, it can certainly be part of UTI management.</p> <p>If you suspect that you have a UTI, see your GP as soon as possible.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/235314/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><a href="https://theconversation.com/profiles/christian-moro-121754"><em>Christian Moro</em></a><em>, Associate Professor of Science &amp; Medicine, <a href="https://theconversation.com/institutions/bond-university-863">Bond University</a> and <a href="https://theconversation.com/profiles/charlotte-phelps-1187658">Charlotte Phelps</a>, Senior Teaching Fellow, Medical Program, <a href="https://theconversation.com/institutions/bond-university-863">Bond University</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/cranberry-juice-really-can-help-with-utis-and-reduce-reliance-on-antibiotics-235314">original article</a>.</em></p>

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Poor sleep is really bad for your health. But we found exercise can offset some of these harms

<div class="theconversation-article-body"><em><a href="https://theconversation.com/profiles/bo-huei-huang-1243280">Bo-Huei Huang</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/emmanuel-stamatakis-161783">Emmanuel Stamatakis</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p>Despite the well-known links between poor sleep and poorer health, getting enough good quality sleep has become a luxury in modern society.</p> <p>Many of us struggle to improve our sleep, while amid the COVID pandemic and recurring lock-downs, <a href="https://theconversation.com/were-sleeping-more-in-lockdown-but-the-quality-is-worse-155797">our sleep has deteriorated</a>.</p> <p>But <a href="https://doi.org/10.1136/bjsports-2021-104046">our new study</a>, published today in the British Journal of Sports Medicine, bears some encouraging news.</p> <p>We found doing enough physical activity (including exercise such as running or going to the gym) may counter some of the adverse health effects of unhealthy sleep patterns.</p> <p>Let us explain.</p> <h2>Does poor sleep really harm our health?</h2> <p>Unhealthy sleep patterns include:</p> <ul> <li> <p>not sleeping for long enough (less than seven hours per night for adults)</p> </li> <li> <p>sleeping for too long (more than nine hours per night for adults)</p> </li> <li> <p>snoring</p> </li> <li> <p>insomnia</p> </li> <li> <p>being a night owl, also known as ā€œlate chronotypeā€. This is people who naturally feel most awake and motivated in the evening, and are sluggish in the morning.</p> </li> </ul> <p>They are <a href="https://doi.org/10/ggjqrt">all associated</a> with poorer health.</p> <p>Recent research shows poor sleep may:</p> <ul> <li> <p>cause <a href="https://doi.org/10.1038/s41577-019-0190-z">inflammation</a></p> </li> <li> <p>impair the metabolism of glucose (also known as blood sugar) and reduce the number of calories burned, thereby increasing the risk of <a href="https://theconversation.com/why-sleep-is-so-important-for-losing-weight-145058">obesity</a></p> </li> <li> <p>increase the risk of <a href="https://doi.org/10/gg6x87">heart disease</a> and <a href="https://doi.org/10/ggnw5h">premature death</a>.</p> </li> </ul> <p>However, very few studies have examined how sleep and physical activity interact and impact our health.</p> <p>We set out to answer the question: if I have poor sleep but I do quite a lot of physical activity, can that offset some of the harms of my poor sleep in the long-term? Or would this not make any difference?</p> <h2>What did we do?</h2> <p>We analysed the information provided by 380,055 middle-aged adults in the UK Biobank study, recruited between 2006 and 2010. Participants reported their level of physical activity and five aspects of their sleep.</p> <p>We grouped people based on their sleep behaviour into healthy, intermediate or poor.</p> <p>We categorised peopleā€™s level of physical activity based on <a href="https://bjsm.bmj.com/content/54/24/1451">the World Health Organization (WHO) guidelines</a>. People who met the upper bounds of the guidelines did 300 minutes of moderate intensity physical activity a week, or 150 minutes of vigorous exercise, or a combination of both. Those who met the lower bound did 150 minutes of moderate intensity exercise a week, or 75 minutes of vigorous exercise, or a combination.</p> <p>Moderate intensity physical activity usually makes you slightly out of breath if sustained for a few minutes and includes brisk walking or cycling at a leisurely pace.</p> <p>Vigorous exercise usually makes you breath hard and can include running, swimming, and playing sports like tennis, netball, soccer or footy.</p> <figure class="align-center "><img src="https://images.theconversation.com/files/408096/original/file-20210624-15-1qfe1ay.png?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/408096/original/file-20210624-15-1qfe1ay.png?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=409&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/408096/original/file-20210624-15-1qfe1ay.png?ixlib=rb-4.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=409&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/408096/original/file-20210624-15-1qfe1ay.png?ixlib=rb-4.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=409&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/408096/original/file-20210624-15-1qfe1ay.png?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=515&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/408096/original/file-20210624-15-1qfe1ay.png?ixlib=rb-4.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=515&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/408096/original/file-20210624-15-1qfe1ay.png?ixlib=rb-4.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=515&amp;fit=crop&amp;dpr=3 2262w" alt="" /><figcaption><span class="caption">Doing at least 150 minutes of moderate intensity physical activity a week, or 75 minutes of vigorous exercise, can offset some of the health harms of poor sleep.</span> <span class="attribution"><a class="source" href="https://apps.who.int/iris/bitstream/handle/10665/336656/9789240015128-eng.pdf?sequence=1&amp;isAllowed=y">World Health Organization, CC BY-NC-SA 3.0 IGO</a></span></figcaption></figure> <h2>What did we find?</h2> <p>We followed up with the participants after 11 years. By May 2020, 15,503 participants had died, of which 4,095 died from heart disease and 9,064 died from cancer.</p> <p><a href="https://doi.org/10.1136/bjsports-2021-104046">We found</a> that, compared to healthy sleepers, people with poor sleep had a 23% higher risk of premature death, a 39% higher risk of dying from heart disease, and a 13% higher risk of dying from cancer.</p> <p>We then compared the data of people who slept well with those who slept poorly, and how much they exercised. We found people who had the highest risk of dying from heart disease and cancer were those who had poor sleep and didnā€™t meet the WHO physical activity guidelines. On the other hand, those who had poor sleep but did enough physical activity to meet the WHO guidelines didnā€™t have as high a risk of dying from heart disease or cancer, compared to those who slept poorly and didnā€™t meet the physical activity guidelines.</p> <p>For example, letā€™s look at the risk of dying from cancer. Those who had poor sleep and did no physical activity had a 45% higher risk of dying from cancer compared to those who had healthy sleep and exercised a lot. But among those who met the physical activity guidelines, despite poor sleep, they didnā€™t really have a higher risk of dying from cancer any more.</p> <p>We found physical activity levels which met at least the bottom threshold of the WHO guidelines could reduce or eliminate some of the health harms of poor sleep. So people who did at least 150 minutes of moderate intensity or 75 minutes of vigorous intensity exercise per week were to some extent protected against the detrimental health effects of poor sleep.</p> <p>Those who had both poor sleep and did no moderate-to-vigorous intensity physical activity had the highest risks of premature death.</p> <p>Our study wasnā€™t designed to find out how and why physical activity may counteract some of the bad physiological impacts of poor sleep. But other research provides theories. For example, adequate physical activity may <a href="https://doi.org/10.1249/MSS.0000000000001179">reduce inflammation, help maintain a healthy glucose metabolism</a>, and <a href="https://doi.org/10.1016/j.pcad.2018.07.014">increase the number of calories burned</a>.</p> <p>Itā€™s important to note our study was whatā€™s called an ā€œobservational studyā€. It shows an association between adequate physical activity and reduced harms from poor sleep, but we must be careful in interpreting causation. It canā€™t conclusively say adequate physical activity <em>causes</em> the reduction of harms from poor sleep, though thereā€™s strong evidence for an association in the right direction.</p> <p>Our study offers a hopeful message, that even if you havenā€™t been able to improve your sleep, you can still offset some of the health harms by doing enough exercise. <a href="https://www.sciencedirect.com/science/article/abs/pii/S009174352030339X">Our previous research</a> has also shown physical activity may help improve poor sleep patterns, which are a serious health problem across the world.</p> <p>In addition to combating some of the negative outcomes of poor sleep, physical activity can also provide many other health benefits and extend our lives. For example, a 2019 study found people who met WHOā€™s physical activity target above <a href="https://doi.org/10.1186/s12916-019-1339-0">lived three years longer on average</a> than those who didnā€™t.</p> <p>During lockdowns, access to parks, gyms, and swimming pools might be limited in many places. But there are still many ways to <a href="https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/publications-and-technical-guidance/noncommunicable-diseases/stay-physically-active-during-self-quarantine">to stay fit and active at home during the coronavirus</a>.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/163270/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/bo-huei-huang-1243280">Bo-Huei Huang</a>, PhD candidate, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a> and <a href="https://theconversation.com/profiles/emmanuel-stamatakis-161783">Emmanuel Stamatakis</a>, Professor of Physical Activity, Lifestyle, and Population Health, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p><em>Image credits: Shutterstock </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/poor-sleep-is-really-bad-for-your-health-but-we-found-exercise-can-offset-some-of-these-harms-163270">original article</a>.</em></p> </div>

Body

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Cheeky diet soft drink getting you through the work day? Hereā€™s what that may mean for your health

<p><em><a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/emily-burch-438717">Emily Burch</a>, <a href="https://theconversation.com/institutions/southern-cross-university-1160">Southern Cross University</a></em></p> <p>Many people are <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230225/">drinking less</a> sugary soft drink than in the past. This is a great win for public health, given the <a href="https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2749350">recognised risks</a> of diets high in sugar-sweetened drinks.</p> <p>But over time, intake of diet soft drinks has <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230225/">grown</a>. In fact, itā€™s so high that these products are now regularly <a href="https://www.sciencedirect.com/science/article/pii/S0160412020319188">detected in wastewater</a>.</p> <p>So what does the research say about how your health is affected in the long term if you drink them often?</p> <h2>What makes diet soft drinks sweet?</h2> <p>The World Health Organization (WHO) <a href="https://www.who.int/news/item/04-03-2015-who-calls-on-countries-to-reduce-sugars-intake-among-adults-and-children">advises</a> people ā€œreduce their daily intake of free sugars to less than 10% of their total energy intake. A further reduction to below 5% or roughly 25 grams (six teaspoons) per day would provide additional health benefits.ā€</p> <p>But most regular soft drinks contain <a href="https://www.actiononsugar.org/surveys/2014/sugar-sweetened-beverages/">a lot of sugar</a>. A regular 335 millilitre can of original Coca-Cola contains at least <a href="https://www.coca-cola.com/ng/en/about-us/faq/how-much-sugar-is-in-cocacola-original-taste">seven</a> teaspoons of added sugar.</p> <p>Diet soft drinks are designed to taste similar to regular soft drinks but without the sugar. Instead of sugar, diet soft drinks contain artificial or natural sweeteners. The artificial sweeteners include aspartame, saccharin and sucralose. The natural sweeteners include stevia and monk fruit extract, which come from plant sources.</p> <p>Many artificial sweeteners are much sweeter than sugar so less is needed to provide the same burst of sweetness.</p> <p>Diet soft drinks are marketed as healthier alternatives to regular soft drinks, particularly for people who want to reduce their sugar intake or manage their weight.</p> <p>But while surveys of Australian <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551593/">adults</a> and <a href="https://www.cambridge.org/core/journals/public-health-nutrition/article/adolescents-knowledge-and-beliefs-regarding-health-risks-of-soda-and-diet-soda-consumption/32F3E0FD6727F18F04C63F0390595131">adolescents</a> show most people understand the benefits of reducing their sugar intake, they often arenā€™t as aware about how diet drinks may affect health more broadly.</p> <h2>What does the research say about aspartame?</h2> <p>The artificial sweeteners in soft drinks are considered safe for consumption by food authorities, including in the <a href="https://www.fda.gov/food/food-additives-petitions/aspartame-and-other-sweeteners-food">US</a> and <a href="https://www.foodstandards.gov.au/consumer/additives/aspartame">Australia</a>. However, some <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899993/">researchers</a> have raised concern about the long-term risks of consumption.</p> <p>People who drink diet soft drinks regularly and often are <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446768/">more likely</a> to develop certain metabolic conditions (such as diabetes and heart disease) than those who donā€™t drink diet soft drinks.</p> <p>The link was found even after accounting for other dietary and lifestyle factors (such as physical activity).</p> <p>In 2023, the WHO announced reports had found aspartame ā€“ the main sweetener used in diet soft drinks ā€“ was ā€œ<a href="https://www.who.int/news/item/14-07-2023-aspartame-hazard-and-risk-assessment-results-released">possibly carcinogenic to humans</a>ā€ (carcinogenic means cancer-causing).</p> <p>Importantly though, the report noted there is not enough current scientific evidence to be truly confident aspartame may increase the risk of cancer and emphasised itā€™s safe to consume occasionally.</p> <h2>Will diet soft drinks help manage weight?</h2> <p>Despite the word ā€œdietā€ in the name, diet soft drinks are not strongly linked with weight management.</p> <p>In 2022, the WHO conducted a <a href="https://www.who.int/news/item/15-05-2023-who-advises-not-to-use-non-sugar-sweeteners-for-weight-control-in-newly-released-guideline">systematic review</a> (where researchers look at all available evidence on a topic) on whether the use of artificial sweeteners is beneficial for weight management.</p> <p>Overall, the randomised controlled trials they looked at suggested slightly more weight loss in people who used artificial sweeteners.</p> <p>But the observational studies (where no intervention occurs and participants are monitored over time) found people who consume high amounts of artificial sweeteners tended to have an increased risk of higher body mass index and a 76% increased likelihood of having obesity.</p> <p>In other words, artificial sweeteners may not directly help manage weight over the long term. This resulted in the WHO <a href="https://www.who.int/news/item/15-05-2023-who-advises-not-to-use-non-sugar-sweeteners-for-weight-control-in-newly-released-guideline">advising</a> artificial sweeteners should not be used to manage weight.</p> <p><a href="http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30296-0">Studies</a> in animals have suggested consuming high levels of artificial sweeteners can signal to the brain it is being starved of fuel, which can lead to more eating. However, the evidence for this happening in humans is still unproven.</p> <h2>What about inflammation and dental issues?</h2> <p>There is <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10817473/">some early evidence</a> artificial sweeteners may irritate the lining of the digestive system, causing inflammation and increasing the likelihood of diarrhoea, constipation, bloating and other symptoms often associated with irritable bowel syndrome. However, this study noted more research is needed.</p> <p>High amounts of diet soft drinks have <a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-17223-0">also been</a> linked with liver disease, which is based on inflammation.</p> <p>The consumption of diet soft drinks is also <a href="https://link.springer.com/article/10.1007/s40368-019-00458-0#:%7E:text=Diet%20soft%20drinks%20often%20have,2006">associated</a> with dental erosion.</p> <p>Many soft drinks contain phosphoric and citric acid, which can damage your tooth enamel and contribute to dental erosion.</p> <h2>Moderation is key</h2> <p>As with many aspects of nutrition, moderation is key with diet soft drinks.</p> <p>Drinking diet soft drinks occasionally is unlikely to harm your health, but frequent or excessive intake may increase health risks in the longer term.</p> <p>Plain water, infused water, sparkling water, herbal teas or milks remain the best options for hydration.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/233438/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, Professor of Community Health and Wellbeing, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/emily-burch-438717">Emily Burch</a>, Accredited Practising Dietitian and Lecturer, <a href="https://theconversation.com/institutions/southern-cross-university-1160">Southern Cross University</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/cheeky-diet-soft-drink-getting-you-through-the-work-day-heres-what-that-may-mean-for-your-health-233438">original article</a>.</em></p>

Food & Wine

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Want the health benefits of strength training but not keen on the gym? Try ā€˜exercise snackingā€™

<p><em><a href="https://theconversation.com/profiles/justin-keogh-129041">Justin Keogh</a>, <a href="https://theconversation.com/institutions/bond-university-863">Bond University</a> and <a href="https://theconversation.com/profiles/jackson-fyfe-134774">Jackson Fyfe</a>, <a href="https://theconversation.com/institutions/deakin-university-757">Deakin University</a></em></p> <p>The science is clear: <a href="https://cdnsciencepub.com/doi/full/10.1139/apnm-2020-0245">resistance training</a> is crucial to ageing well. Lifting weights (or doing bodyweight exercises like lunges, squats or push-ups) can help you live independently for longer, make your bones stronger, reduce your risk of diseases such as diabetes, and may even improve your <a href="https://pubmed.ncbi.nlm.nih.gov/28919335/">sleep and mental health</a>.</p> <p>But not everyone loves the gym. Perhaps you feel youā€™re not a ā€œgym personā€ and never will be, or youā€™re too old to start. Being a gym-goer can be expensive and time-consuming, and some people report feeling <a href="https://www.reddit.com/r/StartingStrength/comments/j3hq32/unwelcome_feeling_at_the_gym/">unwelcome</a> or <a href="https://www.quora.com/I-feel-awkward-and-I-want-to-start-a-gym-but-could-not-What-should-I-do">awkward</a> at the gym.</p> <p>The good news is you donā€™t need the gym, or lots of free time, to get the health benefits resistance training can offer.</p> <p>You can try ā€œexercise snackingā€ instead.</p> <h2>What is exercise snacking?</h2> <p>Exercise snacking involves doing multiple shorter bouts (as little as 20 seconds) of exercise throughout the day ā€“ often with minimal or no equipment. Itā€™s OK to have <a href="https://doi.org/10.1007/s40279-021-01605-8">several hours of rest</a> between.</p> <p>You could do simple bodyweight exercises such as:</p> <ul> <li> <p>chair sit-to-stand (squats)</p> </li> <li> <p>lunges</p> </li> <li> <p>box step-ups</p> </li> <li> <p>calf raises</p> </li> <li> <p>push-ups.</p> </li> </ul> <p>Exercise snacking like this can help improve muscle mass, strength and physical function.</p> <p>Itā€™s OK to hold onto a nearby object for balance, if you need. And doing these exercises regularly will also improve your balance. That, in turn, reduces your risk of falls and fractures.</p> <h2>OK I have done all those, now what?</h2> <p>Great! You can also try using resistance bands or dumbbells to do the previously mentioned five exercises as well as some of the following exercises:</p> <ul> <li> <p><a href="https://youtu.be/IP4wM2JpDdQ?si=1B1GyV_FY5rcArW8&amp;t=6">seated rows</a></p> </li> <li> <p><a href="https://youtu.be/G6GIffCaJCQ?si=RxXZtzMqQ0DGxF3k&amp;t=48">chest</a> and <a href="https://www.youtube.com/watch?v=TUnnz5i4Mnw&amp;t=5s">shoulder presses</a></p> </li> <li> <p><a href="https://youtu.be/z0omicIkYu4?si=8WffT3ij12SNTqEs">bicep curls</a></p> </li> <li> <p><a href="https://www.youtube.com/watch?v=5wXVnxBgLHo">knee extensions</a></p> </li> <li> <p><a href="https://www.youtube.com/watch?v=LtTcXXgeRYo">leg curls</a>.</p> </li> </ul> <p>When using resistance bands, make sure you hold them tightly and that theyā€™re securely attached to an immovable object.</p> <p>Exercise snacking works well when you pair it with an activity you do often throughout the day. Perhaps you could:</p> <ul> <li> <p>do a few extra squats every time you get up from a bed or chair</p> </li> <li> <p>do some lunges during a TV ad break</p> </li> <li> <p>chuck in a few half squats while youā€™re waiting for your kettle to boil</p> </li> <li> <p>do a couple of elevated push-ups (where you support your body with your hands on a chair or a bench while doing the push-up) before tucking into lunch</p> </li> <li> <p>sneak in a couple of calf raises while youā€™re brushing your teeth.</p> </li> </ul> <h2>What does the evidence say about exercise snacking?</h2> <p>One <a href="https://pubmed.ncbi.nlm.nih.gov/31687210/">study</a> had older adults without a history of resistance training do exercise snacks at home twice per day for four weeks.</p> <p>Each session involved five simple bodyweight exercises (chair sit-to-stand, seated knee extension, standing knee bends, marching on the spot, and standing calf raises). The participants did each exercise continuously for one minute, with a one-minute break between exercises.</p> <p>These short and simple exercise sessions, which lasted just nine minutes, were enough to improve a personā€™s ability to stand up from a chair by 31% after four weeks (compared to a control group who didnā€™t exercise). Leg power and thigh muscle size improved, too.</p> <p>Research involving one of us (Jackson Fyfe) has also <a href="https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-03207-z">shown</a> older adults found ā€œexercise snackingā€ feasible and enjoyable when done at home either once, twice, or three times per day for four weeks.</p> <p>Exercise snacking may be a more sustainable approach to improve muscle health in those who donā€™t want to ā€“ or canā€™t ā€“ lift heavier weights in a gym.</p> <h2>A little can yield a lot</h2> <p>We know from other research that the more you exercise, the more likely it is you will <a href="https://www.sciencedirect.com/science/article/pii/S0167268119302586">keep exercising in future</a>.</p> <p>Very brief resistance training, albeit with heavier weights, may be more <a href="https://pubmed.ncbi.nlm.nih.gov/29975122/">enjoyable</a> than traditional approaches where people aim to do many, many sets.</p> <p>We also know brief-and-frequent exercise sessions can break up <a href="https://pubmed.ncbi.nlm.nih.gov/26378942/">periods</a> of sedentary behaviour (which usually means sitting too much). Too much sitting increases your risk of chronic diseases such as diabetes, whereas exercise snacking can help keep your <a href="https://pubmed.ncbi.nlm.nih.gov/36921112/">blood sugar levels steady</a>.</p> <p>Of course, longer-term studies are needed. But the evidence we do have suggests exercise snacking really helps.</p> <h2>Why does any of this matter?</h2> <p>As you age, you lose strength and mass in the muscles you use to walk, or stand up. Everyday tasks can become a struggle.</p> <p>All this <a href="https://pubmed.ncbi.nlm.nih.gov/36907247/">contributes</a> to disability, hospitalisation, chronic disease, and reliance on community and residential aged care support.</p> <p>By preserving your muscle mass and strength, you can:</p> <ul> <li> <p>reduce joint pain</p> </li> <li> <p>get on with activities you enjoy</p> </li> <li> <p>live independently in your own home</p> </li> <li> <p>delay or even eliminate the need for expensive health care or residential aged care.</p> </li> </ul> <h2>What if I walk a lot ā€“ is that enough?</h2> <p>Walking may maintain some level of lower body muscle mass, but it wonā€™t preserve your <a href="https://pubmed.ncbi.nlm.nih.gov/38190393/">upper body muscles</a>.</p> <p>If you find it difficult to get out of a chair, or can only walk short distances without getting out of breath, resistance training is the best way to regain some of the independence and function youā€™ve lost.</p> <p>Itā€™s even more important for women, as muscle mass and strength are typically lower in older women than men. And if youā€™ve been diagnosed with osteoporosis, which is more common in older women than men, resistance exercise snacking at home can improve your balance, strength, and bone mineral density. All of this reduces the risk of falls and fractures.</p> <p>You donā€™t need <a href="https://pubmed.ncbi.nlm.nih.gov/37171517/">heavy weights</a> or fancy equipment to benefit from resistance training.</p> <p>So, will you start exercise snacking today?<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/232374/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/justin-keogh-129041">Justin Keogh</a>, Associate Dean of Research, Faculty of Health Sciences and Medicine, <a href="https://theconversation.com/institutions/bond-university-863">Bond University</a> and <a href="https://theconversation.com/profiles/jackson-fyfe-134774">Jackson Fyfe</a>, Senior Lecturer, Strength and Conditioning Sciences, <a href="https://theconversation.com/institutions/deakin-university-757">Deakin University</a></em></p> <p><em>Image credits: Shutterstock </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/want-the-health-benefits-of-strength-training-but-not-keen-on-the-gym-try-exercise-snacking-232374">original article</a>.</em></p>

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Taking too many medications can pose health risks. Hereā€™s how to avoid them

<p><em><a href="https://theconversation.com/profiles/caroline-sirois-1524891">Caroline Sirois</a>, <a href="https://theconversation.com/institutions/universite-laval-1407">UniversitĆ© Laval</a></em></p> <p>When we see an older family member handling a bulky box of medications sorted by day of the week, we might stop and wonder, is it too much? How do all those pills interact?</p> <p>The fact is, as we get older we are more likely to develop different chronic illnesses that require us to take several different medications. This is known as polypharmacy. The concept applies to people taking five or more medications, but there are all sorts of <a href="https://doi.org/10.3390/pharmacy7030126">definitions with different thresholds</a> (for example, four, 10 or 15 medicines).</p> <p>Iā€™m a pharmacist and pharmacoepidemiologist interested in polypharmacy and its impact on the population. The research I carry out with my team at the Faculty of Pharmacy at UniversitĆ© Laval focuses on the appropriate use of medication by older family members. We have published this <a href="https://doi.org/10.1093/ageing/afac244">study</a> on the perceptions of older adults, family carers and clinicians on the use of medication among persons over 65.</p> <h2>Polypharmacy among older adults</h2> <p>Polypharmacy is very common among older adults. In 2021, a quarter of persons over 65 in Canada were prescribed <a href="https://www.cihi.ca/en/drug-use-among-seniors-in-canada">more than ten different classes of medication</a>. In QuĆ©bec, persons over 65 used an average of <a href="https://www.inspq.qc.ca/sites/default/files/publications/2679_portrait_polypharmacie_aines_quebecois.pdf">8.7 different drugs in 2016</a>, the latest year available for statistics.</p> <p>Is it a good idea to take so many drugs?</p> <p>According to <a href="https://journals.sagepub.com/doi/10.1177/07334648211069553">our study</a>, the vast majority of seniors and family caregivers would be willing to stop taking one or more medications if the doctor said it was possible, even though most are satisfied with their treatments, <a href="https://doi.org/10.1093/ageing/afac244">have confidence in their doctors</a> and feel that their doctors are taking care of them to the best of their ability.</p> <p>In the majority of cases, medicine prescribers are helping the person they are treating. Medications have a positive impact on health and are essential in many cases. But while the treatment of individual illnesses is often adequate, the whole package can sometimes become problematic.</p> <h2>The risks of polypharmacy: 5 points to consider</h2> <p>When we evaluate cases of polypharmacy, we find that the quality of treatment is often compromised when many medications are being taken.</p> <ol> <li> <p>Drug interactions: polypharmacy increases the risk of drugs interacting, which can lead to undesirable effects or reduce the effectiveness of treatments.</p> </li> <li> <p>A drug that has a positive effect on one illness may have a negative effect on another: what should you do if someone has both illnesses?</p> </li> <li> <p>The greater the number of drugs taken, the greater the risk of undesirable effects: for adults over 65, for example, there is an increased risk of confusion or falls, which have significant consequences.</p> </li> <li> <p>The more medications a person takes, the more likely they are to take a <a href="https://www.doi.org/10.1093/fampra/cmz060">potentially inappropriate medication</a>. For seniors, these drugs generally carry more risks than benefits. For example, benzodiazepines, medicine for anxiety or sleep, are the <a href="https://www.inspq.qc.ca/sites/default/files/publications/2575_utilisation_medicaments_potentiellement_inappropries_aines.pdf">most frequently used class</a> of medications. We want to reduce their use as much as possible <a href="https://www.canada.ca/en/health-canada/services/substance-use/controlled-illegal-drugs/benzodiazepines.html">to avoid negative impacts</a> such as confusion and increased risk of falls and car accidents, not to mention the risk of dependence and death.</p> </li> <li> <p>Finally, polypharmacy is associated with various adverse health effects, such as an <a href="https://www.doi.org/10.1007/s41999-021-00479-3">increase in frailty, hospital admissions and emergency room visits</a>. However, studies conducted to date have not always succeeded in isolating the effects specific to polypharmacy. As polypharmacy is more common among people with multiple illnesses, these illnesses may also contribute to the observed risks.</p> </li> </ol> <p>Polypharmacy is also a combination of medicines. There are almost as many as there are people. The risks of these different combinations can vary. For example, the risks associated with a combination of five potentially inappropriate drugs would certainly be different from those associated with blood pressure medication and vitamin supplements.</p> <p>Polypharmacy is therefore complex. <a href="https://doi.org/10.1186/s12911-021-01583-x">Our studies attempt to use artificial intelligence</a> to manage this complexity and identify combinations associated with negative impacts. There is still a lot to learn about polypharmacy and its impact on health.</p> <h2>3 tips to avoid the risks associated with polypharmacy</h2> <p>What can we do as a patient, or as a caregiver?</p> <ol> <li> <p>Ask questions: when you or someone close to you is prescribed a new treatment, be curious. What are the benefits of the medication? What are the possible side effects? Does this fit in with my treatment goals and values? How long should this treatment last? Are there any circumstances in which discontinuing it should be considered ?</p> </li> <li> <p>Keep your medicines up to date: make sure they are all still useful. Are there still any benefits to taking them? Are there any side effects? Are there any drug interactions? Would another treatment be better? Should the dose be reduced?</p> </li> <li> <p>Think about de-prescribing: this is an increasingly common clinical practice that involves stopping or reducing the dose of an inappropriate drug after consulting a health-care professional. It is a shared decision-making process that involves the patient, their family and health-care professionals. The <a href="https://www.deprescribingnetwork.ca">Canadian Medication Appropriateness and Deprescribing Network</a> is a world leader in this practice. It has compiled a number of tools for patients and clinicians. You can find them on their website and subscribe to the newsletter.</p> </li> </ol> <h2>Benefits should outweigh the risks</h2> <p>Medications are very useful for staying healthy. Itā€™s not uncommon for us to have to take more medications as we age, but this shouldnā€™t be seen as a foregone conclusion.</p> <p>Every medication we take must have direct or future benefits that outweigh the risks associated with them. As with many other issues, when it comes to polypharmacy, the saying, ā€œeverything in moderation,ā€ frequently applies.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/230612/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/caroline-sirois-1524891">Caroline Sirois</a>, Professor in Pharmacy, <a href="https://theconversation.com/institutions/universite-laval-1407">UniversitĆ© Laval</a></em></p> <p><em>Image credits: Shutterstock </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/taking-too-many-medications-can-pose-health-risks-heres-how-to-avoid-them-230612">original article</a>.</em></p>

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Revolutionary diabetes detection via smartphone: A game-changer in healthcare

<p>In a groundbreaking advancement, scientists from <a href="https://www.klick.com/" target="_blank" rel="noopener">Klick Labs</a> have discovered a method that could revolutionise diabetes detection ā€“ using just a 10-second smartphone voice recording.</p> <p>No more travelling to clinics or waiting anxiously for blood test results. This new approach promises immediate, on-the-spot results, potentially transforming how we diagnose type 2 diabetes.</p> <p>The study, published in <a href="https://www.mcpdigitalhealth.org/article/S2949-7612(23)00073-1/fulltext" target="_blank" rel="noopener">Mayo Clinic Proceedings: Digital Health</a>, involved 267 participants, including 192 non-diabetic and 75 type 2 diabetic individuals. Each participant recorded a specific phrase on their smartphone multiple times a day over two weeks, resulting in 18,465 recordings.</p> <p>These recordings, lasting between six and 10 seconds each, were meticulously analysed for 14 acoustic features, such as pitch and intensity. Remarkably, these features exhibited consistent differences between diabetic and non-diabetic individuals, differences too subtle for the human ear but detectable by sophisticated signal processing software.</p> <p>Building on this discovery, the scientists developed an AI-based program to analyse the voice recordings alongside patient data like age, sex, height and weight. The results were impressive: the program accurately identified type 2 diabetes in women 89% of the time and in men 86% of the time.</p> <p>These figures are competitive with traditional methods, where fasting blood glucose tests show 85% accuracy and other methods, like glycated haemoglobin and oral glucose tolerance tests, range between 91% and 92%.</p> <p>"This technology has the potential to remove barriers entirely," said Jaycee Kaufman, a research scientist at Klick Labs and the study's lead author. Traditional diabetes detection methods can be time-consuming, costly and inconvenient, but voice technology could change all that, providing a faster, more accessible solution.</p> <p><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">Looking ahead, the team plans to conduct further tests on a larger, more diverse population to refine and validate this innovative approach. If successful, this could mark a significant leap forward in diabetes management and overall healthcare, making early detection simpler and more accessible than ever before.</span></p> <p>Stay tuned as this exciting development unfolds, potentially bringing us closer to a future where managing and detecting diabetes is as simple as speaking into your smartphone.</p> <p><em>Image: Shutterstock</em></p>

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How often should you really weigh yourself?

<p><em><a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p>Few topics are more debated in health than the value of the humble bathroom scale. Some experts advocate daily self-weigh-ins to promote accountability for weight management, particularly when weā€™re following a diet and exercise program to lose weight.</p> <p>Others suggest ditching self-weigh-ins altogether, arguing they can trigger negative <a href="https://link.springer.com/article/10.1007/s13679-015-0142-2">psychological responses and unhealthy behaviours</a> when we donā€™t like, or understand, the number we see on the scale.</p> <p>Many, like me, recommend using scales to weigh yourself weekly, even when weā€™re not trying to lose weight. Hereā€™s why.</p> <h2>1. Weighing weekly helps you manage your weight</h2> <p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588640/?tool=pmcentrez&amp;report=abstract">Research</a> confirms regular self-weighing is an effective weight loss and management strategy, primarily because it helps increase awareness of our current weight and any changes.</p> <p>A <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588640/?tool=pmcentrez&amp;report=abstract">systematic review of 12 studies</a> found participants who weighed themselves weekly or daily over several months lost 1ā€“3 BMI (body mass index) units more and regained less weight than participants who didnā€™t weight themselves frequently. The weight-loss benefit was evident with weekly weighing; there was no added benefit with daily weighing.</p> <p>Self-weigh-ins are an essential tool for weight management as we age. Adults <a href="https://pubmed.ncbi.nlm.nih.gov/23638485/">tend to gain weight</a> progressively <a href="https://pubmed.ncbi.nlm.nih.gov/8363190/">through middle age</a>. While the average weight gain is typically between <a href="https://www.sciencedirect.com/science/article/abs/pii/S0031938414001528">0.5ā€“1kg per year</a>, this modest accumulation of weight can lead to obesity over time. Weekly weighing and keeping track of the results helps avoid unnecessary weight gain.</p> <p>Tracking our weight can also help identify medical issues early. Dramatic changes in weight can be an early sign of some conditions, including problems with our thyroid, digestion and diabetes.</p> <h2>2. Weekly weighing accounts for normal fluctuations</h2> <p>Our body weight can fluctuate within a single day and across the days of the week. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192384/">Studies</a> show body weight fluctuates by 0.35% within the week and itā€™s typically higher after the weekend.</p> <p>Daily and day-to-day body weight fluctuations have several causes, many linked to our bodyā€™s water content. The more common causes include:</p> <p><strong>The type of food weā€™ve consumed</strong></p> <p>When weā€™ve eaten a dinner higher in carbohydrates, weā€™ll weigh more the next day. This change is a result of our bodies temporarily carrying more water. We <a href="https://pubmed.ncbi.nlm.nih.gov/25911631/">retain 3ā€“4 grams of water</a> per gram of carbohydrate consumed to store the energy we take from carbs.</p> <p>Our water content also increases when we consume <a href="https://www.ncbi.nlm.nih.gov/books/NBK50952/">foods higher in salt</a>. Our bodies try to maintain a balance of sodium and water. When the concentration of salt in our bloodstream increases, a mechanism is triggered to restore balance by retaining water to dilute the excess salt.</p> <p><strong>Our food intake</strong></p> <p>Whether itā€™s 30 grams of nuts or 65 grams of lean meat, everything we eat and drink has weight, which increases our body weight temporarily while we digest and metabolise what weā€™ve consumed.</p> <p>Our weight also tends to be lower first thing in the morning after our food intake has been restricted overnight and higher in the evening after our daily intake of food and drinks.</p> <p><strong>Exercise</strong></p> <p>If we weigh ourselves at the gym after a workout, thereā€™s a good chance weā€™ll weigh less due to sweat-induced fluid loss. The amount of water lost varies depending on things like our workout intensity and duration, the temperature and humidity, along with our sweat rate and hydration level. On average, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993146/">we lose 1 litre of sweat</a> during an hour of <a href="https://link.springer.com/article/10.1007/BF00421168">moderate-intensity exercise</a>.</p> <p><strong>Hormonal changes</strong></p> <p><a href="https://theconversation.com/from-energy-levels-to-metabolism-understanding-your-menstrual-cycle-can-be-key-to-achieving-exercise-goals-131561">Fluctuations in hormones</a> within your menstrual cycle can also affect fluid balance. Women may experience <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154522/">fluid retention</a> and temporarily gain 0.5ā€“2kg of weight at this time. Specifically, the luteal phase, which represents the second half of a womanā€™s cycle, results in a shift of fluid from your blood plasma to your cells, and <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154522/">bloating</a>.</p> <p><strong>Bowel movements</strong></p> <p>Going to the bathroom can lead to small but immediate weight loss as waste is eliminated from the body. While the amount lost will vary, we generally eliminate <a href="https://pubmed.ncbi.nlm.nih.gov/1333426/">around 100 grams of weight</a> through our daily bowel movements.</p> <p>All of these fluctuations are normal, and theyā€™re not indicative of significant changes in our body fat or muscle mass. However, seeing these fluctuations can lead to unnecessary stress and a fixation with our weight.</p> <h2>3. Weekly weighing avoids scale obsession and weight-loss sabotage</h2> <p>Weighing too frequently can create an obsession with the number on the scales and do more harm than good.</p> <p>Often, our reaction when we see this number not moving in the direction we want or expect is to further restrict our food intake or embark on fad dieting. Along with not being enjoyable or sustainable, fad diets also ultimately increase our weight gain rather than reversing it.</p> <p>This was confirmed in a <a href="https://pubmed.ncbi.nlm.nih.gov/21829159/">long-term study</a> comparing intentional weight loss among more than 4,000 twins. The researchers found the likelihood of becoming overweight by the age of 25 was significantly greater for a twin who dieted to lose 5kg or more. This suggests frequent dieting makes us more susceptible to weight gain and prone to future weight gain.</p> <h2>So what should you do?</h2> <p>Weighing ourselves weekly gives a more accurate measure of our weight trends over time.</p> <p>Aim to weigh yourself on the same day, at the same time and in the same environment each week ā€“ for example, first thing every Friday morning when youā€™re getting ready to take a shower, after youā€™ve gone to the bathroom, but before youā€™ve drunk or eaten anything.</p> <p>Use the best quality scales you can afford. Change the batteries regularly and check their accuracy by using a ā€œknownā€ weight ā€“ for example, a 10kg weight plate. Place the ā€œknownā€ weight on the scale and check the measurement aligns with the ā€œknownā€ weight.</p> <p>Remember, the number on the scale is just one part of health and weight management. Focusing solely on it can overshadow other indicators, such as <a href="https://theconversation.com/can-you-be-overweight-and-healthy-182219">how your clothes fit</a>. Itā€™s also essential to pay equal attention to how weā€™re feeling, physically and emotionally.</p> <p>Stop weighing yourself ā€“ at any time interval ā€“ if itā€™s triggering anxiety or stress, and get in touch with a health-care professional to discuss this.</p> <hr /> <p><em>At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can <a href="https://redcap.sydney.edu.au/surveys/?s=RKTXPPPHKY">register here</a> to express your interest.</em><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/223864/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/nick-fuller-219993">Nick Fuller</a>, Charles Perkins Centre Research Program Leader, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p><em>Image credits: Shutterstock </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/how-often-should-you-really-weigh-yourself-223864">original article</a>.</em></p>

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We finally know why some people got COVID while others didnā€™t

<p><em><a href="https://theconversation.com/profiles/marko-nikolic-1543289">Marko Nikolic</a>, <a href="https://theconversation.com/institutions/ucl-1885">UCL</a> and <a href="https://theconversation.com/profiles/kaylee-worlock-1543639">Kaylee Worlock</a>, <a href="https://theconversation.com/institutions/ucl-1885">UCL</a></em></p> <p>Throughout the pandemic, one of the key questions on everyoneā€™s mind was why some people avoided getting COVID, while others caught the virus multiple times.</p> <p>Through a collaboration between University College London, the Wellcome Sanger Institute and Imperial College London in the UK, we set out to answer this question using the worldā€™s first controlled <a href="https://www.nature.com/articles/s41591-022-01780-9">ā€œchallenge trialā€ for COVID</a> ā€“ where volunteers were deliberately exposed to SARS-CoV-2, the virus that causes COVID, so that it could be studied in great detail.</p> <p>Unvaccinated healthy volunteers with no prior history of COVID were exposed ā€“ via a nasal spray ā€“ to an extremely low dose of the original strain of SARS-CoV-2. The volunteers were then closely monitored in a quarantine unit, with regular tests and samples taken to study their response to the virus in a highly controlled and safe environment.</p> <p>For our <a href="https://www.nature.com/articles/s41586-024-07575-x">recent study</a>, published in Nature, we collected samples from tissue located midway between the nose and the throat as well as blood samples from 16 volunteers. These samples were taken before the participants were exposed to the virus, to give us a baseline measurement, and afterwards at regular intervals.</p> <p>The samples were then processed and analysed using single-cell sequencing technology, which allowed us to extract and sequence the genetic material of individual cells. Using this cutting-edge technology, we could track the evolution of the disease in unprecedented detail, from pre-infection to recovery.</p> <p>To our surprise, we found that, despite all the volunteers being carefully exposed to the exact same dose of the virus in the same manner, not everyone ended up testing positive for COVID.</p> <p>In fact, we were able to divide the volunteers into three distinct infection groups (see illustration). Six out of the 16 volunteers developed typical mild COVID, testing positive for several days with cold-like symptoms. We referred to this group as the ā€œsustained infection groupā€.</p> <p>Out of the ten volunteers who did not develop a sustained infection, suggesting that they were able to fight off the virus early on, three went on to develop an ā€œintermediateā€ infection with intermittent single positive viral tests and limited symptoms. We called them the ā€œtransient infection groupā€.</p> <p>The final seven volunteers remained negative on testing and did not develop any symptoms. This was the ā€œabortive infection groupā€. This is the first confirmation of abortive infections, which were previously <a href="https://www.nature.com/articles/s41586-021-04186-8">unproven</a>. Despite differences in infection outcomes, participants in all groups shared some specific novel immune responses, including in those whose immune systems prevented the infection.</p> <p>When we compared the timings of the cellular response between the three infection groups, we saw distinct patterns. For example, in the transiently infected volunteers where the virus was only briefly detected, we saw a strong and immediate accumulation of immune cells in the nose one day after infection.</p> <p>This contrasted with the sustained infection group, where a more delayed response was seen, starting five days after infection and potentially enabling the virus to take hold in these volunteers.</p> <p>In these people, we were able to identify cells stimulated by a key antiviral defence response in both the nose and the blood. This response, called the ā€œinterferonā€ response, is one of the ways our bodies signal to our immune system to help fight off viruses and other infections. We were surprised to find that this response was detected in the blood before it was detected in the nose, suggesting that the immune response spreads from the nose very quickly.</p> <h2>Protective gene</h2> <p>Lastly, we identified a specific gene called HLA-DQA2, which was expressed (activated to produce a protein) at a much higher level in the volunteers who did not go on to develop a sustained infection and could hence be used as a marker of protection. Therefore, we might be able to use this information and identify those who are probably going to be protected from severe COVID.</p> <p>These findings help us fill in some gaps in our knowledge, painting a much more detailed picture regarding how our bodies react to a new virus, particularly in the first couple of days of an infection, which is crucial.</p> <p>We can use this information to compare our data to other data we are currently generating, specifically where we are ā€œchallengingā€ volunteers to other viruses and more recent strains of COVID. In contrast to our current study, these will mostly include volunteers who have been vaccinated or naturally infected ā€“ that is, people who already have immunity.</p> <p>Our study has significant implications for future treatments and vaccine development. By comparing our data to volunteers who have never been exposed to the virus with those who already have immunity, we may be able to identify new ways of inducing protection, while also helping the development of more effective vaccines for future pandemics. In essence, our research is a step towards better preparedness for the next pandemic.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/233063/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/marko-nikolic-1543289">Marko Nikolic</a>, Principal Research Fellow/Honorary consultant Respiratory Medicine, <a href="https://theconversation.com/institutions/ucl-1885">UCL</a> and <a href="https://theconversation.com/profiles/kaylee-worlock-1543639">Kaylee Worlock</a>, Postdoc Research Fellow, Molecular and Cellular Biology, <a href="https://theconversation.com/institutions/ucl-1885">UCL</a></em></p> <p><em>Image credits: Shutterstock </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/we-finally-know-why-some-people-got-covid-while-others-didnt-233063">original article</a>.</em></p>

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"Worst nightmare": Teen dies one day after flu diagnosis

<p>William Jones was complaining of a sore throat and cough last month and when his mum called the doctor, they were told that it was most likely the flu. </p> <p>However, the following morning when Rebecca Rollason went to check on her 16-year-old son, he was found unresponsive in his bed in their Wellington home. </p> <p>"We ask ourselves how what started as a sore throat, snotty nose and a cough on Tuesday to no longer with us three days later,"  the grieving mum told the <em>NZ Herald</em>. </p> <p>"No one understands, we don't know what happened... it feels like the worst nightmare that we cannot wake from."</p> <p>Rollason explained that her family have to "wait for results" in hopes of understanding what happened and how the teenager, who was barely sick, passed away so suddenly. </p> <p>"We just donā€™t understand how this can happen to a boy who was barely ever sick and was very healthy," she said.</p> <p> "It is an incredibly hard and devastating time for us."</p> <p>A family friend has helped set up a <a href="https://givealittle.co.nz/cause/rebecca-lost-her-son-william-last-friday" target="_blank" rel="noopener">fundraising page</a> to help relieve the financial pressure on her and William's two brothers while they grieve. </p> <p>"It is every parents worst nightmare and a shocking tragedy to lose a healthy child from a sudden and brief illness," a statement from the fundraising page read. </p> <p>"The money will help the family with funeral costs and ease Financial burden while they grieve and come to terms with Williams passing." </p> <p>On July 1 they shared an update on the fundraising page, saying: "Rebecca and family would like all to know that are incredibly grateful for all the support and kindness." </p> <p><em>Image: Givealittle </em></p>

Caring

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Hollywood star's heartbreaking health update

<p>Gena Rowlands's son has shared his mother's heartbreaking health battle, that is reminiscent of one of her most iconic movie character's similar health issue.</p> <p>The 94-year-old Golden Globe winner who portrayed an older version of Rachel McAdamā€™s character, Allie, in the 2004 film<em> The Notebook</em>, has been battling Alzheimerā€™s disease for the past five years.</p> <p>While discussing the film's 20 year anniversary, Nick Cassavetes, the director of the movie and Rowlandsā€™ son, revealed his motherā€™s diagnosis. </p> <p>ā€œI got my mum to play older Allie, and we spent a lot of time talking about Alzheimerā€™s and wanting to be authentic with it, and now, for the last five years, sheā€™s had Alzheimerā€™s,ā€ Cassavetes told <em><a href="https://ew.com/the-notebook-star-gena-rowlands-has-alzheimers-8668642">Entertainment Weekly</a></em> of Rowlandsā€™ character, who also had dementia. </p> <p>ā€œSheā€™s in full dementia. And itā€™s so crazy ā€” we lived it, she acted it, and now itā€™s on us.ā€</p> <p>Back in 2004, Rowlands ā€” whose mother, actress Lady Rowlands, also suffered from the disease ā€” explained why playing Allie was ā€œparticularly hard.ā€</p> <p>ā€œThis last one ā€” The Notebook, based on the novel by Nicholas Sparks ā€” was particularly hard because I play a character who has Alzheimerā€™s,ā€ she told <em><a href="https://www.oprah.com/spirit/gena-rowlands-aha-moment">O magazine</a></em>. </p> <p>ā€œI went through that with my mother, and if Nick hadnā€™t directed the film, I donā€™t think I would have gone for it ā€” itā€™s just too hard. It was a tough but wonderful movie.ā€</p> <p><em>Image credits: New Line Cinema/Demmie Todd/Warner Bros/Spring Creek/Kobal/Shutterstock Editorial </em></p>

Caring

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Is social media making you unhappy? The answer is not so simple

<p><em><a href="https://theconversation.com/profiles/melissa-humphries-584274">Melissa Humphries</a>, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a> and <a href="https://theconversation.com/profiles/lewis-mitchell-266859">Lewis Mitchell</a>, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a></em></p> <p>You may have seen headlines that link social media to sadness and depression. Social media use goes up, happiness goes down. But recent studies suggest those findings might not be so straightforward.</p> <p>Although it is true that peopleā€™s feelings of envy and depression are linked to high social media use, there is evidence to suggest social media use may not be <em>causing</em> that relationship. Instead, your mindset may be the biggest thing affecting how social media connects to your wellbeing.</p> <p>People who feel they are able to use social media, rather than social media ā€œusing themā€, tend to gain more benefits from their online interactions.</p> <h2>Why do people use social media?</h2> <p>Social media covers a broad range of platforms: social networking, discussion forums, bookmarking and sharing content, disseminating news, exchanging media like photos and videos, and microblogging. These appeal to a wide range of users, from individuals of all ages through to massive businesses.</p> <p>For some, social media is a way to connect with people we may not otherwise see. In the United States, 39% of people say they <a href="https://www.americansurveycenter.org/research/the-state-of-american-friendship-change-challenges-and-loss">are friends with people they only interact with online</a>.</p> <p>For older people, this is especially important for increasing feelings of connectedness and wellbeing. Interestingly though, for older people, <a href="https://www.sciencedirect.com/science/article/pii/S0747563223004545">social media contact with family does not increase happiness</a>. Meanwhile, younger adults report <em>increased</em> happiness when they have more social media contact with family members.</p> <p>Teens, in particular, find social media most useful for <a href="https://www.pewresearch.org/internet/2022/11/16/connection-creativity-and-drama-teen-life-on-social-media-in-2022/">deepening connections and building their social networks</a>.</p> <p>With social media clearly playing such an important role in society, many researchers have tried to figure out: does it make us happier or not?</p> <h2>Does social media make us happier?</h2> <p>Studies have taken a variety of approaches, including asking people directly through surveys or looking at the content people post and seeing how positive or negative it is.</p> <p>One survey study from 2023 showed that as individualsā€™ social media use increased, <a href="https://www.researchgate.net/publication/372582895_The_Relationship_Between_Social_Media_Addiction_Happiness_and_Life_Satisfaction_in_Adults_Analysis_with_Machine_Learning_Approach">life satisfaction and happiness decreased</a>. Another found that <a href="https://www.tandfonline.com/doi/full/10.1080/0144929X.2023.2286529">less time on social media</a> was related to increases in work satisfaction, work engagement and positive mental health ā€“ so improved mental health and motivation at work.</p> <p>Comparing yourself to others on social media is connected to feelings of envy and depression. However, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955439/">there is evidence</a> to suggest depression is the predictor, rather than the outcome, of both social comparison and envy.</p> <p>All this shows <a href="https://academic.oup.com/jcmc/article/29/1/zmad048/7612379?login=false">the way you <em>feel</em> about social media matters</a>. People who see themselves using social media rather than ā€œbeing usedā€ by it, tend to gain benefits from social media and not experience the harms.</p> <p>Interviews with young people (15ā€“24 years) using social media suggest that positive mental health among that age group was influenced by <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933808/">three features</a>:</p> <ul> <li>connection with friends and their global community</li> <li>engagement with social media content</li> <li>the value of social media as an outlet for expression.</li> </ul> <p>There are also studies that look at the emotions expressed by more frequent social media users.</p> <p>The so-called ā€œ<a href="https://epjdatascience.springeropen.com/articles/10.1140/epjds/s13688-017-0100-1">happiness paradox</a>ā€ shows that most people think their friends on social media appear happier than themselves. This is a <a href="https://dl.acm.org/doi/10.1145/3110025.3110027">seeming impossibility</a> that arises because of <a href="https://www.nature.com/articles/srep04603">the mathematical properties</a> of how friendship networks work on social media.</p> <p>In one of our studies, Twitter content with recorded locations showed residents of cities in the United States that <a href="https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0064417.g007">tweeted more tended to express less happiness</a>.</p> <p>On the other hand, in Instagram direct messages, happiness has been found to be <a href="https://journals.sagepub.com/doi/full/10.1177/20563051241229655">four times more prevalent than sadness</a>.</p> <h2>How does internet use in general affect our wellbeing?</h2> <p>Some of the factors associated with decreased mental health are not aligned with social media use alone.</p> <p><a href="https://journals.sagepub.com/doi/full/10.1177/0963721419838244">One recent study</a> shows that the path to decreased wellbeing is, at least partially, connected to digital media use overall (rather than social media use specifically). This can be due to sleep disruption, reduced face-to-face social interaction or physical activity, social comparison, and cyberbullying. None of these exist for social media alone.</p> <p>However, social media platforms are known to be driven by recommendation algorithms that may send us down ā€œrabbit holesā€ of the same type of (increasingly extreme) content. This can lead to a distorted view of the world and our place in it. The important point here is to maintain a diverse and balanced information diet online.</p> <p>Interestingly, interacting on social media is not the only thing affecting our mental state. <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090315">Rainfall influnces</a> the emotional content of social media posts of both the user experiencing rain, and parts of their extended network (even if they donā€™t experience rain!).</p> <p>This suggests that how we feel is influenced by the emotions in the posts we see. The good news is that happy posts are the most influential, with each happy post encouraging close to two additional happy updates from a userā€™s friends.</p> <p>The secret to online happiness therefore may not be to ā€œdelete your accountā€ entirely (which, <a href="https://www.nature.com/articles/s41562-018-0510-5">as we have found</a>, may not even be effective), but to be mindful about what you consume online. And if you feel like social media is starting to use you, it might be time to change it up a bit.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/232490/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/melissa-humphries-584274">Melissa Humphries</a>, Senior Lecturer, School of Computer and Mathematical Sciences, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a> and <a href="https://theconversation.com/profiles/lewis-mitchell-266859">Lewis Mitchell</a>, Professor of Data Science, <a href="https://theconversation.com/institutions/university-of-adelaide-1119">University of Adelaide</a></em></p> <p><em>Image credits: Shutterstock </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/is-social-media-making-you-unhappy-the-answer-is-not-so-simple-232490">original article</a>.</em></p>

Mind

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Why do I poo in the morning? A gut expert explains

<div class="theconversation-article-body"> <p><em><a href="https://theconversation.com/profiles/vincent-ho-141549">Vincent Ho</a>, <a href="https://theconversation.com/institutions/western-sydney-university-1092">Western Sydney University</a></em></p> <p>No, youā€™re not imagining it. People really are more likely to poo in the morning, shortly after breakfast. Researchers have actually studied this.</p> <p>But why mornings? What if you tend to poo later in the day? And is it worth training yourself to be a morning pooper?</p> <p>To understand what makes us poo when we do, we need to consider a range of factors including our body clock, gut muscles and what we have for breakfast.</p> <p>Hereā€™s what the science says.</p> <h2>So morning poos are real?</h2> <p>In a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379343/">UK study</a> from the early 1990s, researchers asked nearly 2,000 men and women in Bristol about their bowel habits.</p> <p>The most common time to poo was in the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379343/pdf/gut00573-0122.pdf">early morning</a>. The peak time was 7-8am for men and about an hour later for women. The researchers speculated that the earlier time for men was because they woke up earlier for work.</p> <p>About a decade later, <a href="https://pubmed.ncbi.nlm.nih.gov/16200717/">a Chinese study</a> found a similar pattern. Some 77% of the almost 2,500 participants said they did a poo in the morning.</p> <h2>But why the morning?</h2> <p>There are a few reasons. The first involves our <a href="https://theconversation.com/circadian-rhythm-nobel-what-they-discovered-and-why-it-matters-85072">circadian rhythm</a> ā€“ our 24-hour internal clock that helps regulate bodily processes, such as digestion.</p> <p>For healthy people, our internal clock means the muscular contractions in our colon follow <a href="https://pubmed.ncbi.nlm.nih.gov/19926812/">a distinct rhythm</a>.</p> <p>Thereā€™s minimal activity in the night. The deeper and more restful our sleep, the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677652">fewer</a> of these muscle contractions we have. Itā€™s one reason why we donā€™t tend to poo in our sleep.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/597362/original/file-20240530-21-v2gvrq.jpg?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/597362/original/file-20240530-21-v2gvrq.jpg?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/597362/original/file-20240530-21-v2gvrq.jpg?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=450&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/597362/original/file-20240530-21-v2gvrq.jpg?ixlib=rb-4.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=450&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/597362/original/file-20240530-21-v2gvrq.jpg?ixlib=rb-4.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=450&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/597362/original/file-20240530-21-v2gvrq.jpg?ixlib=rb-4.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=565&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/597362/original/file-20240530-21-v2gvrq.jpg?ixlib=rb-4.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=565&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/597362/original/file-20240530-21-v2gvrq.jpg?ixlib=rb-4.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=565&amp;fit=crop&amp;dpr=3 2262w" alt="Diagram of digestive system including colon and rectum" /></a><figcaption><span class="caption">Your lower gut is a muscular tube that contracts more strongly at certain times of day.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-vector/illustration-healthcare-medical-education-drawing-chart-1984316789">Vectomart/Shutterstock</a></span></figcaption></figure> <p>But thereā€™s increasing activity during the day. Contractions in our colon are most active in the morning after waking up and after any meal.</p> <p>One particular type of colon contraction partly controlled by our internal clock are known as ā€œ<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1411356/">mass movements</a>ā€. These are powerful contractions that push poo down to the rectum to prepare for the poo to be expelled from the body, but donā€™t always result in a bowel movement. In healthy people, these contractions occur a few times a day. They are more frequent in the morning than in the evening, and after meals.</p> <p>Breakfast is also a trigger for us to poo. When we eat and drink our stomach stretches, which triggers the ā€œ<a href="https://www.ncbi.nlm.nih.gov/books/NBK549888/">gastrocolic reflex</a>ā€. This reflex stimulates the colon to forcefully contract and can lead you to push existing poo in the colon out of the body. We know the gastrocolic reflex is strongest in the morning. So that explains why breakfast can be such a powerful trigger for a bowel motion.</p> <p>Then thereā€™s our morning coffee. This is a very <a href="https://pubmed.ncbi.nlm.nih.gov/2338272/">powerful stimulant</a> of contractions in the sigmoid colon (the last part of the colon before the rectum) and of the rectum itself. This leads to a bowel motion.</p> <h2>How important are morning poos?</h2> <p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1846921/pdf/brmedj02601-0041.pdf">Large international</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20205503/">surveys</a> show the vast majority of people will poo between three times a day and three times a week.</p> <p>This still leaves a lot of people who donā€™t have regular bowel habits, are regular but poo at different frequencies, or who donā€™t always poo in the morning.</p> <p>So if youā€™re healthy, itā€™s much more important that your bowel habits are comfortable and regular for you. Bowel motions <em>do not</em> have to occur once a day in the morning.</p> <p>Morning poos are also not a good thing for everyone. <a href="https://gut.bmj.com/content/61/Suppl_2/A318.1">Some people</a> with <a href="https://theconversation.com/explainer-what-is-irritable-bowel-syndrome-and-what-can-i-do-about-it-102579">irritable bowel syndrome</a> feel the urgent need to poo in the morning ā€“ often several times after getting up, during and after breakfast. This can be quite distressing. It appears this early-morning rush to poo is due to overstimulation of colon contractions in the morning.</p> <h2>Can you train yourself to be regular?</h2> <p>Yes, for example, to help treat constipation using the gastrocolic reflex. Children and elderly people with constipation can use the toilet immediately after eating breakfast <a href="https://www.ncbi.nlm.nih.gov/books/NBK549888/">to relieve symptoms</a>. And for adults with constipation, drinking coffee regularly can help stimulate the gut, particularly in the morning.</p> <p>A disturbed circadian rhythm can also lead to irregular bowel motions and people more likely to poo in the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147411/">evenings</a>. So better sleep habits can not only help people get a better nightā€™s sleep, it can help them get into a more regular bowel routine.</p> <p>Regular physical activity and avoiding <a href="https://pubmed.ncbi.nlm.nih.gov/2787735/">sitting down a lot</a> are also important in <a href="https://pubmed.ncbi.nlm.nih.gov/16028436/">stimulating bowel movements</a>, particularly in people with constipation.</p> <p>We know <a href="https://theconversation.com/nervous-tummy-why-you-might-get-the-runs-before-a-first-date-106925">stress</a> can contribute to irregular bowel habits. So minimising stress and focusing on relaxation <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193306/">can help</a> bowel habits become more regular.</p> <p>Fibre from fruits and vegetables also <a href="https://pubmed.ncbi.nlm.nih.gov/665565/">helps</a> make bowel motions more regular.</p> <p>Finally, ensuring <a href="https://theconversation.com/health-check-what-causes-constipation-114290">adequate hydration</a> helps minimise the chance of developing constipation, and helps make bowel motions more regular.</p> <h2>Monitoring your bowel habits</h2> <p>Most of us consider pooing in the morning to be regular. But thereā€™s a wide variation in normal so donā€™t be concerned if your poos donā€™t follow this pattern. Itā€™s more important your poos are comfortable and regular for you.</p> <p>If thereā€™s a major change in the regularity of your bowel habits thatā€™s concerning you, see your GP. The reason might be as simple as a change in diet or starting a new medication.</p> <p>But sometimes this can signify an important change in the health of your gut. So your GP may need to arrange further investigations, which could include blood tests or imaging.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/229624/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/vincent-ho-141549">Vincent Ho</a>, Associate Professor and clinical academic gastroenterologist, <a href="https://theconversation.com/institutions/western-sydney-university-1092">Western Sydney University</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-do-i-poo-in-the-morning-a-gut-expert-explains-229624">original article</a>.</em></p> </div>

Body

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"Lucky to be here": Gordon Ramsay reveals brutal injury after bike crash

<p>Gordon Ramsay has been left shaken after a bicycle crash left him in need of trauma surgery. </p> <p>The celebrity chef took to social media on Sunday to tell fans that he had been in an accident while biking in Connecticut US early last week.</p> <p>"This week I had a really bad accident while riding my bike in Connecticut. I'm doing ok and did not break any bones or suffer any major injuries but I am a bit bruised up looking like a purple potato," he wrote in the caption of the one minute-clip. </p> <p>In the video, he said that the accident "shook" him and added" Honestly, I'm lucky to be here.'</p> <p>Ramsay showed the horrific bruise covering his torso and stressed on the importance of wearing a helmet. </p> <p>"Those incredible trauma surgeons, doctors, nurses, who looked after me this week, they were amazing but honestly you've got to wear a helmet," he said.</p> <p>"I don't care how short the journey is, I don't care [about] the fact that these helmets cost money, but they're crucial. Even with the kids, or a short journey."</p> <p>He also shared a before and after photo of his cycling gear, with parts of his helmet broken and his clothing ripped. </p> <p>"Now, I'm lucky to be standing here. I'm in pain, it's been a brutal week, and I'm sort of getting through it," he said. </p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/C8PYfVNxxFC/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/C8PYfVNxxFC/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Gordon Ramsay (@gordongram)</a></p> </div> </blockquote> <p>The comment section was flooded with messages of support and well-wishes from concerned fans. </p> <p>"I thought it might have been a small crash but my god that bruise says otherwise! Glad youā€™re doing okay," wrote one fan. </p> <p>"The way my heart sank when you lifted your shirt," added another.</p> <p>"The world needs you chef!! Beyond happy to hear you are going to be okay, and thank God for that helmet! Happy Father's Day and speedy recovery goat!!"</p> <p>"Glad you're ok and hope you heal up quick!" added another. </p> <p><em>Images: Instagram</em></p>

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"Do not cry for me": Teacher announces own death

<p>A teacher and mum-of-two who chronicled her breast cancer journey online has announced her own death, through a social media post written before her passing. </p> <p>"If you're reading this, it means I have died," Kate Rackham, 45, shared on her <em>Teacher With Cancer </em>X account. </p> <p>"But do not cry for me. I have lived my life on my own terms, the way I have wanted to."</p> <p>The mum told her followers that she joined X, formerly Twitter, as she "needed an outlet", but "what I got was so much more". </p> <p>"You made me feel validated in my feelings and much less alone. Thank you."</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">If youā€™re reading this, it means I have died. But do not cry for me. I have lived my life on my own terms, the way I have wanted to. I joined X because I needed an outlet, what I got was so much more. You made me feel validated in my feelings and much less alone. Thank you ā¤ļø</p> <p>ā€” Teacher with Cancer (@kate_rackham) <a href="https://twitter.com/kate_rackham/status/1801137648146243756?ref_src=twsrc%5Etfw">June 13, 2024</a></p></blockquote> <p>The British mum was only 39 when she was diagnosed with  incurable oestrogen-receptive breast cancer and spent the past six years fighting the disease. </p> <p>She began documenting her journey online, and explained that she had no obvious risk factors leading to the disease. </p> <p>Just before her passing, she was admitted into hospital and was told by doctors that "there is nothing more we can do" and that she "needed a bit of time" to process the news. </p> <p>"I'm now home, where I want to be. With Mark and the girls. Surrounded by love, family and friends," she shared at the time. </p> <p>"Everyone is rallying around and I have so much support. Despite everything I feel blessed."</p> <p>Many have shared their condolences, including friends and those who are also battling breast cancer. </p> <p>"When my time comes, I can but hope I display the dignity and strength of character you did. Much love and condolences to your family and friends," one wrote.</p> <p>"I hope you are free from the pain. You still live in your children your husband. Your legacy," another said.</p> <p>"Thank you for sharing your journey with grace and dignity," a third added. </p> <p>"I hope wherever you are you are no longer in pain. Sending love and thoughts to your family."</p> <p>Rackham is survived by her husband Mark and their two daughters Ruby and Nancy. </p> <p><em>Images: X/ Nine</em></p> <p> </p>

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Michael Mosley used science communication to advance health and wellbeing. We can learn a lot from his approach

<p><em><a href="https://theconversation.com/profiles/lauren-ball-14718">Lauren Ball</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/kirsten-adlard-684475">Kirsten Adlard</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p>Overnight, we learned of the <a href="https://www.abc.net.au/news/2024-06-09/michael-mosley-body-found-greek-island-clare-bailey-mosley/103957382">tragic passing</a> of Michael Mosley, who went missing last week while on holiday on the Greek island of Symi.</p> <p>The British celebrity doctor was a household name in many countries, including Australia. Mosley was well known for his television shows, documentaries, books and columns on healthy eating, weight management, physical activity and sleep.</p> <p>During the days he was missing and once his death was confirmed, media outlets have acknowledged Mosleyā€™s <a href="https://www.independent.co.uk/arts-entertainment/tv/features/michael-mosley-tv-doctor-death-b2558717.html">career achievements</a>. He is being celebrated for his connection to diverse public audiences and his unrelenting focus on science as the best guide to our daily habits.</p> <h2>From medicine to the media</h2> <p>Mosley was born in India <a href="https://www.bbc.com/news/articles/c8770jyz6vvo">in 1957</a> and was sent to England at age seven to attend boarding school. He later studied philosophy, politics and economics at the <a href="https://michaelmosley.co.uk/biog/">University of Oxford</a>. After a short stint in investment banking, Mosley opted to train in medicine at the Royal Free Hospital in London.</p> <p>Rather than forging a career in clinical practice, <a href="https://michaelmosley.co.uk/biog/">Mosley</a> started working at the BBC in 1985 as a trainee assistant producer. In the decades that followed, Mosley continued to work with the BBC as a producer and presenter.</p> <p>Mosley became a popular public figure by applying his medical training to journalism to examine a breadth of health and wellbeing topics. In 1995, following his documentary on <em><a href="https://genome.ch.bbc.co.uk/baf970949e3a46a992ae52420395a7c2">Helicobacter pylori</a></em>, a bacterium that causes ulcers in the stomach, the British Medical Association named him <a href="https://www.bbc.co.uk/programmes/profiles/2kczjZKp8sGSDxSxKYzxsyr/michael-mosley">medical journalist of the year</a>.</p> <p>His other television work on diet, weight management, exercise and sleep earned him <a href="https://www.emmys.com/bios/michael-mosley">Emmy</a>, <a href="https://www.imdb.com/name/nm0608839/awards/">BAFTA</a> (the British Academy of Film and Television Arts), and <a href="https://rts.org.uk/tags/michael-mosley">Royal Television Society</a> <a href="https://www.bbc.co.uk/programmes/profiles/2kczjZKp8sGSDxSxKYzxsyr/michael-mosley">award nominations</a>.</p> <p>Over the past decade, Mosley published <a href="https://www.amazon.com.au/Fast-Diet-Original-Revised-Research/dp/1780722370/ref=sr_1_6?dib=eyJ2IjoiMSJ9.75_akcxo8tanyLrD4CVMwd1lCTliHyckSLPU2W7K4HmdPqRlVqvMbKWKkJ6CPCsrFsAw4Vfw5SWOYkl_Y8ah4yNCSjQksdT3ByCSHhiycNB9AB5h6vVUqB99okxDDWPaXUCwD-CZMzHZDvAjuAotTN">several books</a> on <a href="https://www.fishpond.com.au/Books/Fastexercise-Michael-Mosley-Peta-Bee-With/9781476759982?utm_source=googleps&amp;utm_medium=ps&amp;utm_campaign=AU&amp;gad_source=1&amp;gclid=CjwKCAjw34qzBhBmEiwAOUQcF3wd7d1bj8KMFeEtKS6ZU7py5rRzjiycZhcsMbSEQ9lXhjEBcY4GRxoCwgIQAvD_BwE">exercise</a>, <a href="https://www.amazon.com.au/8-Week-Blood-Sugar-Diet-Recipe/dp/1925456595/ref=sr_1_7?dib=eyJ2IjoiMSJ9.75_akcxo8tanyLrD4CVMwd1lCTliHyckSLPU2W7K4HmdPqRlVqvMbKWKkJ6CPCsrFsAw4Vfw5SWOYkl_Y8ah4yNCSjQksdT3ByCSHhiycNB9AB5h6vVUqB99okxDDWPaXUCwD-CZMzHZDvAjuAotTNxxkW3">healthy eating</a>, <a href="https://www.amazon.com.au/Fast-800-Australian-New-Zealand/dp/B07MPRQWJP/ref=sr_1_8?dib=eyJ2IjoiMSJ9.75_akcxo8tanyLrD4CVMwd1lCTliHyckSLPU2W7K4HmdPqRlVqvMbKWKkJ6CPCsrFsAw4Vfw5SWOYkl_Y8ah4yNCSjQksdT3ByCSHhiycNB9AB5h6vVUqB99okxDDWPaXUCwD-CZMzHZDvAjuAotTNxxkW">intermittent fasting</a>, <a href="https://www.amazon.com.au/Weeks-Better-Sleep-life-changing-improved/dp/1761425927/ref=sr_1_1?dib=eyJ2IjoiMSJ9.75_akcxo8tanyLrD4CVMwd1lCTliHyckSLPU2W7K4HmdPqRlVqvMbKWKkJ6CPCsrFsAw4Vfw5SWOYkl_Y8ah4yNCSjQksdT3ByCSHhiycNB9AB5h6vVUqB99okxDDWPaXUCwD-CZMzHZDvAj">sleep</a> and <a href="https://www.amazon.com.au/Just-One-Thing-Changes-Transform/dp/B0BJVRP94X/ref=sr_1_9?dib=eyJ2IjoiMSJ9.75_akcxo8tanyLrD4CVMwd1lCTliHyckSLPU2W7K4HmdPqRlVqvMbKWKkJ6CPCsrFsAw4Vfw5SWOYkl_Y8ah4yNCSjQksdT3ByCSHhiycNB9AB5h6vVUqB99okxDDWPaXUCwD-CZMzHZDvAjuAotTNxxk">behaviour change</a>. He sold millions of copies of his books around the world, including at least <a href="https://www.simonandschuster.com.au/p/mosley-1mil-sales">one million</a> in Australia and New Zealand.</p> <p>Alongside his wife, Dr Clare Bailey Mosley, he recently embarked on a <a href="https://michaelmosley.co.uk/live/">live theatre show tour</a>, yet another vehicle to bring his key messages to audiences.</p> <h2>A trusted voice</h2> <p>Mosley became a trusted voice for health and wellbeing throughout his journalistic career. His television program <a href="https://www.bbc.co.uk/programmes/b04j9gny">Trust Me, Iā€™m a Doctor</a> drew on his medical qualifications to discuss health and wellbeing credibly on a public platform. His medical training also inferred credibility in examining the scientific literature that underpins the topics he was communicating.</p> <p>At the same time, Mosley used simple terminology that captured the attention of diverse audiences.</p> <p>For many of Mosleyā€™s outputs, he used himself as an example. For instance, in his <a href="https://www.bbc.co.uk/programmes/p09by3yy/episodes/downloads">podcast series</a> Just One Thing and <a href="https://www.amazon.com.au/Just-One-Thing-Changes-Transform/dp/B0BJVRP94X/ref=sr_1_9?dib=eyJ2IjoiMSJ9.75_akcxo8tanyLrD4CVMwd1lCTliHyckSLPU2W7K4HmdPqRlVqvMbKWKkJ6CPCsrFsAw4Vfw5SWOYkl_Y8ah4yNCSjQksdT3ByCSHhiycNB9AB5h6vVUqB99okxDDWPaXUCwD-CZMzHZDvAjuAotTNxxk">companion book</a>, Mosley self-tested a range of evidence-based behavioural habits (while also interviewing subject-matter experts), covering topics such as eating slowly, yoga, listening to music, cooking, gardening and drinking green tea.</p> <p>His focus on intermittent fasting and high-intensity training was fuelled by his <a href="https://www.abc.net.au/news/2024-06-08/how-dr-michael-mosley-popularised-intermittent-fasting/103952408">diagnosis of type 2 diabetes</a>, and his work on sleep health was based on his experience <a href="https://www.sbs.com.au/food/article/sleep-revolution-michael-mosley/okmv5o7qe">with chronic insomnia</a>.</p> <p>At the most extreme end of the spectrum, Mosley <a href="https://www.bbc.com/news/science-environment-25968755">infested himself with tapeworms</a> in the pursuit of exploring their effects on the human body.</p> <p>By using himself as a <a href="https://www.theguardian.com/media/article/2024/jun/09/michael-mosley-favourite-health-tip-slow-deep-breathing">human guinea pig</a>, he fostered a connection with his audience, showing the <a href="https://www.chronicle.com/article/the-personal-touch-using-anecdotes-to-hook-a-reader">power</a> of personal anecdotes.</p> <h2>Some controversies along the way</h2> <p>Despite his notable career achievements, Mosley received ongoing criticisms about his work due to differing opinions within the medical and scientific communities.</p> <p>One key concern was around his promotion of potentially risky diets such as intermittent fasting and other restrictive diets, including the 5:2 diet and low-carb diets. While <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946909/">some evidence</a> supports intermittent fasting as a way to improve metabolic health and enable weight management, Mosley was criticised for not fully acknowledging the potential risks of these diets, such as a potential to lead to <a href="https://clindiabetesendo.biomedcentral.com/articles/10.1186/s40842-023-00152-7">disordered eating</a> habits.</p> <p>His promotion of low-carb diets also raised concerns that his work added to a diet-focused <a href="https://www.independent.co.uk/life-style/health-and-families/lose-a-stone-in-21-days-channel-4-criticism-eating-disorder-food-relationship-beat-a9656531.html">culture war</a>, ultimately to the detriment of many peopleā€™s relationship with food and their bodies.</p> <p>More broadly, in his efforts to make scientific concepts simple and accessible to the general public, Mosley was sometimes criticised for overgeneralising science. The concern was that he didnā€™t properly discuss the nuance and tension inherent in scientific evidence, thereby providing an incomplete synthesis of the evidence.</p> <p>For example, Mosley conceptualised the <a href="https://thebloodsugardiet.com">blood sugar diet</a> (a low-carbohydrate Mediterranean-style diet), which was <a href="https://www.bbc.com/news/health-68452019">criticised</a> for lacking a strong grounding in scientific evidence. Similarly, <a href="https://www.thetimes.com/life-style/health-fitness/article/smoke-and-mirrors-the-truth-about-vaping-nmpf3przr">associating his name with e-cigarettes</a> may have drawn unhelpful attention to the topic, irrespective of the underlying details.</p> <h2>What can we learn from Mosley?</h2> <p>Overall, Mosley has been objectively successful in communicating scientific concepts to large, engaged audiences. Mosley showed us that people want to consume scientific information, whether through the news media, social media, podcasts or books.</p> <p>His passion and persistence in using science to promote health and wellbeing have likely supported public health efforts across the globe.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/231934/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><a href="https://theconversation.com/profiles/lauren-ball-14718"><em>Lauren Ball</em></a><em>, Professor of Community Health and Wellbeing, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a> and <a href="https://theconversation.com/profiles/kirsten-adlard-684475">Kirsten Adlard</a>, Supervisor of Engagement, Communication, and Outreach, Centre for Community Health and Wellbeing, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p><em>Image credits: Ken McKay/ITV/Shutterstock Editorial </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/michael-mosley-used-science-communication-to-advance-health-and-wellbeing-we-can-learn-a-lot-from-his-approach-231934">original article</a>.</em></p>

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Michael Mosley's cause of death revealed in autopsy

<p>The sudden and tragic death of renowned TV doctor Michael Mosley has left his fans and family in deep sorrow. New details from an initial autopsy report reveal the beloved health expert likely died of natural causes during a challenging trek on the Greek island of Symi.</p> <p>Mosley disappeared on a Wednesday afternoon after bidding farewell to his wife on Saint Nikolas Beach. He inadvertently took a wrong turn, embarking on a gruelling two-hour hike in intense heat. According to The Sun, he tragically collapsed near a beach bar at Agia Marina, just a few metres away from safety. His body was discovered five days later by a television crew from Greece's ERT public channel.</p> <p>The initial autopsy indicated that Mosley most likely succumbed to natural causes at around 4pm on the day he went missing. The scorching temperatures, exceeding 40Ā°C in the rocky terrain, contributed to the arduous conditions he faced. The post-mortem examination revealed no external injuries that could have caused his death. The position of his body suggested that he had sat down to rest against a wall before losing consciousness and passing away.</p> <p>CCTV footage captured Mosley walking slowly through the mountainous area, indicating exhaustion. His last recorded sighting was at 2pm in Pedi, implying he had been navigating the rough terrain for nearly two hours. The grainy footage showed him collapsing near a wall and barbed wire fence, just 100m from the beach resort and shoreline.</p> <p>Despite extensive search efforts, including drones, helicopters and specially trained dogs, Mosleyā€™s body was not found until five days later. The condition of his body made it challenging to pinpoint the exact cause of death, but it was clear he was extremely close to reaching safety before he collapsed.</p> <p>The search for Dr Mosley mobilised the small island community of Symi, with 2600 residents and numerous volunteers talking part. His wife, Dr Claire Bailey, expressed her profound grief in a heartfelt statement.</p> <p>ā€œI donā€™t know quite where to begin with this,ā€ she said. ā€œItā€™s devastating to have lost Michael, my wonderful, funny, kind and brilliant husband. </p> <p>ā€œWe had an incredibly lucky life together. We loved each other very much and were so happy together. I am incredibly proud of our children, their resilience and support over the past days. </p> <p>ā€œMy family and I have been hugely comforted by the outpouring of love from people from around the world. Itā€™s clear that Michael meant a huge amount to so many of you. </p> <p>ā€œWeā€™re taking comfort in the fact that he so very nearly made it. </p> <p>ā€œHe did an incredible climb, took the wrong route and collapsed where he couldnā€™t be easily seen by the extensive search team. </p> <p>ā€œMichael was an adventurous man, itā€™s part of what made him so special. </p> <p>ā€œWe are so grateful to the extraordinary people on Symi who have worked tirelessly to help find him. </p> <p>ā€œSome of these people on the island, who hadnā€™t even heard of Michael, worked from dawn till dusk unasked. Weā€™re also very grateful to the press who have dealt with us with great respect. </p> <p>ā€œI feel so lucky to have our children and my amazing friends. Most of all, I feel so lucky to have had this life with Michael.ā€</p> <p>Dr Mosley was a respected and beloved figure in the medical and television community. Known for his insightful health advice and engaging personality, he had a significant impact on many lives. His adventurous spirit and dedication to promoting health and well-being will be remembered fondly by all who knew him.</p> <p><em>Image credits: Ken McKay/ITV/Shutterstock Editorial / Facebook</em></p>

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Why itā€™s still a scientific mystery how some can live past 100 ā€“ and how to crack it

<p><em><a href="https://theconversation.com/profiles/richard-faragher-224976">Richard Faragher</a>, <a href="https://theconversation.com/institutions/university-of-brighton-942">University of Brighton</a> and <a href="https://theconversation.com/profiles/nir-barzilai-1293752">Nir Barzilai</a>, <a href="https://theconversation.com/institutions/albert-einstein-college-of-medicine-3638">Albert Einstein College of Medicine</a></em></p> <p>A 35-year-old man <a href="https://pubmed.ncbi.nlm.nih.gov/18544745/">only has a 1.5% chance of dying in the next ten years</a>. But the same man at 75 has a 45% chance of dying before he reaches 85. Clearly, ageing is bad for our health. On the bright side, we have made unprecedented progress in understanding the fundamental mechanisms that control ageing and late-life disease.</p> <p>A few tightly linked biological processes, sometimes called the <a href="https://pubmed.ncbi.nlm.nih.gov/23746838/">ā€œhallmarks of ageingā€</a>, including our supply of stem cells and communication between cells, act to keep us healthy in the early part of our lives ā€“ with <a href="https://theconversation.com/the-secret-to-staying-young-scientists-boost-lifespan-of-mice-by-deleting-defective-cells-54068">problems arising as these start to fail</a>. <a href="https://pubmed.ncbi.nlm.nih.gov/34699859/">Clinical trials are ongoing</a> to see if targeting some of these hallmarks can improve <a href="https://pubmed.ncbi.nlm.nih.gov/31542391/">diabetic kidney disease</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/29997249/">aspects of</a> <a href="https://pubmed.ncbi.nlm.nih.gov/33977284/">immune function</a> and age-related <a href="https://pubmed.ncbi.nlm.nih.gov/30616998/">scarring of the lungs</a> among others. So far, so good.</p> <p>Unfortunately, big, unanswered questions remain in the biology of ageing. To evaluate what these are and how to address them, the <a href="https://www.afar.org/">American Federation For Aging Research</a>, a charity, recently convened a series of <a href="https://www.afar.org/imported/AFAR_GeroFuturesThinkTankReport_November2021.pdf">meetings for leading scientists and doctors</a>. The experts agreed that understanding what is special about the biology of humans who survive more than a century is now a key challenge.</p> <p>These centenarians <a href="https://www.statista.com/chart/18826/number-of-hundred-year-olds-centenarians-worldwide/">comprise less than 0.02% of the UK population</a> but have exceeded the life expectancy of their peers by almost 50 years (babies born in the 1920s typically had a life expectancy of less than 55). How are they doing it?</p> <p>We know that centenarians live so long because they are unusually healthy. They remain in good health for about 30 years longer than most normal people and when they finally fall ill, they are only sick for a very short time. This <a href="https://pubmed.ncbi.nlm.nih.gov/27377170/">ā€œcompression of morbidityā€</a> is clearly good for them, but also benefits society as a whole. In the US, the medical care costs for a centenarian in their last two years of life <a href="https://www.cdc.gov/nchs/data/series/sr_10/sr10_198.pdf">are about a third of those of someone who dies in their seventies</a> (a time when most centenarians donā€™t even need to see a doctor).</p> <p>The children of centenarians are also much healthier than average, indicating they are inheriting something beneficial from their parents. But is this genetic or environmental?</p> <h2>Centenarians arenā€™t always health conscious</h2> <p>Are centenarians the poster children for a healthy lifestyle? For the general population, watching your weight, not smoking, drinking moderately and eating at least five servings of fruit and vegetables a day can <a href="https://pubmed.ncbi.nlm.nih.gov/27296932/">increase life expectancy by up to 14 years</a> compared with someone who does none of these things. This difference <a href="https://publications.parliament.uk/pa/ld5801/ldselect/ldsctech/183/18305.htm#_idTextAnchor012">exceeds that seen</a> between the least and most deprived areas in the UK, so intuitively it would be expected to play a role in surviving for a century.</p> <p>But astonishingly, this neednā€™t be the case. <a href="https://pubmed.ncbi.nlm.nih.gov/21812767/">One study</a> found that up to 60% of Ashkenazi Jewish centenarians have smoked heavily most of their lives, half have been obese for the same period of time, less than half do even moderate exercise and under 3% are vegetarians. The children of centenarians appear no more health conscious than the general population either.</p> <p>Compared to peers with the same food consumption, wealth and body weight, however, <a href="https://pubmed.ncbi.nlm.nih.gov/29050682/">they have half the prevalence of cardiovascular disease</a>. There is something innately exceptional about these people.</p> <h2>The big secret</h2> <p>Could it be down to rare genetics? If so, then there are two ways in which this could work. Centenarians might carry unusual genetic variants that extend lifespan, or instead they might lack common ones that cause late-life disease and impairment. Several studies, including our own work, <a href="https://pubmed.ncbi.nlm.nih.gov/32860726/">have shown</a> that centenarians have just as many bad genetic variants as the general population.</p> <p>Some even carry two copies of the largest known common risk gene for Alzheimerā€™s disease (APOE4), but still donā€™t get the illness. So a plausible working hypothesis is that centenarians carry rare, beneficial genetic variations rather than a lack of disadvantageous ones. And the best available data is consistent with this.</p> <p>Over 60% of centenarians have genetic changes that alter the genes which regulate growth in early life. This implies that these remarkable people are human examples of a type of lifespan extension observed in other species. Most people know that <a href="https://pubmed.ncbi.nlm.nih.gov/28803893/">small dogs tend to live longer than big ones</a> but fewer are aware that this is a general phenomenon across the animal kingdom. <a href="https://pubmed.ncbi.nlm.nih.gov/26857482/">Ponies can live longer than horses</a> and many strains of laboratory mice with dwarfing mutations <a href="https://pubmed.ncbi.nlm.nih.gov/29653683/">live longer than their full-sized counterparts</a>. One potential cause of this is reduced levels of a growth hormone called IGF-1 ā€“ although human centenarians <a href="https://pubmed.ncbi.nlm.nih.gov/28630896/">are not necessarily shorter than the rest of us</a>.</p> <p>Obviously, growth hormone is necessary early on in life, but there is increasing evidence that high levels of IGF-1 in mid to late life <a href="https://pubmed.ncbi.nlm.nih.gov/18316725/">are associated with increased late-life illness</a>. The detailed mechanisms underlying this remain an open question, but even among centenarians, women with the lowest levels of growth hormone <a href="https://pubmed.ncbi.nlm.nih.gov/24618355/">live longer than those with the highest</a>. They also have better cognitive and muscle function.</p> <p>That doesnā€™t solve the problem, though. Centenarians are also different from the rest of us in other ways. For example, they tend to have good cholesterol levels ā€“ hinting there may several reasons for their longevity.</p> <p>Ultimately, centenarians are ā€œnatural experimentsā€ who show us that it is possible to live in excellent health even if you have been dealt a risky genetic hand and chose to pay no attention to health messages ā€“ but only if you carry rare, poorly understood mutations.</p> <p>Understanding exactly how these work should allow scientists to develop new drugs or other interventions that target biological processes in the right tissues at the right time. If these become a reality perhaps more of us than we think will see the next century in. But, until then, donā€™t take healthy lifestyle tips from centenarians.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/172020/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/richard-faragher-224976">Richard Faragher</a>, Professor of Biogerontology, <a href="https://theconversation.com/institutions/university-of-brighton-942">University of Brighton</a> and <a href="https://theconversation.com/profiles/nir-barzilai-1293752">Nir Barzilai</a>, Professor of Medicine and Genetics, <a href="https://theconversation.com/institutions/albert-einstein-college-of-medicine-3638">Albert Einstein College of Medicine</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-its-still-a-scientific-mystery-how-some-can-live-past-100-and-how-to-crack-it-172020">original article</a>.</em></p>

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