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Celine Dion shares powerful message of hope

<p>Celine Dion has shared a powerful statement about her health battle since being diagnosed with stiff person syndrome. </p> <p>The French-Canadian musician has chronicled her health journey in a new documentary titled <em>I Am: Celine Dion</em>, and took to Instagram to promote the new film. </p> <p>While sharing with her legion of fans how her health has progressed, she said she remains hopeful that she will one day return to the stage.</p> <p>In a lengthy post, she wrote, “This last couple of years has been such a challenge for me, the journey from discovering my condition to learning how to live with and manage it, but not to let it define me." </p> <p>"As the road to resuming my performing career continues, I have realised how much I have missed it, of being able to see my fans." </p> <p>"During this absence, I decided I wanted to document this part of my life, to try to raise awareness of this little-known condition, to help others who share this diagnosis.” </p> <p>In December 2022, Celine announced that she would be taking some time away from performing  to focus on her health after revealing her stiff person syndrome diagnosis.</p> <p>At the time, she said the condition did not allow her “to sing the way I’m used to”.</p> <p>According to the <a href="https://www.ninds.nih.gov/health-information/clinical-trials/cause-development-and-progression-stiff-person-syndrome#:~:text=Stiff%2Dperson%20syndrome%20(SPS),recurrent%20falls%20and%20impaired%20ambulation." target="_blank" rel="noopener">National Institute of Neurological Disorders and Stroke</a>, stiff person syndrome is “a rare, progressive syndrome that affects the nervous system, specifically the brain and spinal cord.”</p> <p>According to an official synopsis, <em>I Am: Celine Dion</em> will give viewers an intimate look inside her life “as she reveals her battle with stiff person syndrome (SPS) and the lengths she has gone to continue performing for her beloved and loyal fans”.</p> <p>Capturing over a year’s worth of Dion’s life, including “never-before-seen” private moments, the film will showcase the legendary singer navigating “her journey toward living an open and authentic life amidst illness”.</p> <p><em>Image credits: Getty Images </em></p>

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Why did Hamas attack, and why now? What does it hope to gain?

<p><em><a href="https://theconversation.com/profiles/ian-parmeter-932739">Ian Parmeter</a>, <a href="https://theconversation.com/institutions/australian-national-university-877">Australian National University</a></em></p> <p>In hindsight, the drivers of Hamas’s startlingly well-planned, land-sea-air attack on Israel on Saturday were in plain sight.</p> <p>The operation reflects a pattern of four wars and regular outbreaks of violence between Israel and Hamas militants in Gaza since 2005, when Israel withdrew its military posts and <a href="https://www.cfr.org/backgrounder/middle-east-gaza-withdrawal">forcibly removed</a> 9,000 Israeli settlers from the territory.</p> <p>Each time Hamas has launched rockets at Israel or engaged in similar provocations, it has drawn heavy retaliation from Israel in the form of major bombings on the Gaza Strip. Hamas, however, seems to regard this as a cost of doing business.</p> <p>An important factor motivating Hamas towards violence is that it has to watch its flanks. Other smaller, but increasingly extremist groups, are contesting its authority in Gaza, notably Palestinian Islamic Jihad.</p> <p>These groups have, at times, independently launched rocket attacks on Israel, which bring retribution on the whole territory.</p> <p>On top of this, the Israeli government formed by Prime Minister Benjamin Netanyahu last December is the most right wing in Israeli history. This government has made no secret of its desire to <a href="https://www.theguardian.com/world/2022/dec/28/benjamin-netanyahu-government-makes-west-bank-settlement-expansion-its-priority">annex</a> the West Bank and has permitted significant expansion of Jewish settlements in the territory, which are illegal under <a href="https://press.un.org/en/2016/sc12657.doc.htm">international law</a>.</p> <p>That has led to conflict between settlers and young West Bank Palestinians, who in the past year have formed a loose grouping known as the “<a href="https://www.economist.com/1843/2023/07/07/inside-the-lions-den-the-west-banks-gen-z-fighters">Lions’ Den</a>”.</p> <p>This grouping, comprising independent militants with apparently no central control, has scant regard for the Palestinian Authority, which governs the West Bank and is led by the octogenarian Mahmoud Abbas. The Palestinian Authority has little real administrative, security or moral authority in the territory.</p> <p>The “Lions’ Den” also vies with Gaza militant groups for influence among Palestinian youth – both in Gaza and the West Bank.</p> <p>Added to this, a minister in Netanyahu’s coalition, <a href="https://edition.cnn.com/2023/07/27/europe/ben-gvir-visit-israel-jerusalem-intl/index.html">Itamar Ben-Gvir</a>, has visited the Temple Mount, the site of the Al-Aqsa Mosque, one of the holiest shrines in Islam. This was considered a provocation by all Palestinians – both in the West Bank and Gaza. Further angering Palestinians, Israeli tourists also <a href="https://apnews.com/article/christians-jerusalem-old-city-spitting-524b3b8e92beb4c947b3b8b49e80cc45">travelled</a> to the site over the recent Sukkot holiday.</p> <p>A <a href="https://www.thenation.com/article/archive/september-28-2000-ariel-sharon-visits-the-temple-mount-sparking-the-second-intifada/">visit</a> to the Temple Mount by Ariel Sharon in 2000, then the leader of the opposition in Israel’s government, is generally regarded as the spark that ignited the Second Intifada from 2000-2005.</p> <p>Under an agreement predating Israel’s foundation, Jordan has <a href="https://www.middleeastmonitor.com/20231004-jordan-sends-memo-of-protest-to-israel-over-al-aqsa-settler-incursions/">custodianship</a> of the Al-Aqsa religious complex. Israel aimed to respect Jordan’s role when it signed the Israeli-Jordanian peace treaty in 1994. But Palestinians see the visits by Israeli ministers and non-Muslim tourists as disrespectful of the sanctity of the site and counter to this undertaking.</p> <p>Hamas has also claimed these visits have led to the desecration of the Al-Aqsa site, an argument obviously aimed at winning support from Muslims throughout the Arab and wider Islamic world.</p> <h2>Why attack now?</h2> <p>Significantly, Hamas has named its action “<a href="https://www.aljazeera.com/opinions/2023/10/8/there-is-nothing-surprising-about-hamass-operation">Operation Al-Aqsa Flood</a>”. This provides some clues to the primary reason for striking at this time, which emphasises what Hamas sees as Israeli acts of desecration of a holy Islamic site.</p> <p>However, an additional motivating factor was likely the increasing tendency of Arab states to make peace agreements with Israel, as evidenced by the <a href="https://www.state.gov/the-abraham-accords/">2020 Abraham Accords</a>, involving the United Arab Emirates, Bahrain, Sudan and Morocco.</p> <p>There has recently been strong speculation that Saudi Arabia is about to make its own agreement with Israel.</p> <p>This is of great concern to all Palestinians, not just those in the West Bank, as it further reduces pressure on Israel to reach a settlement with them. Netanyahu has made clear in his public statements that he prioritises peace with Arab states over eventual peace with the Palestinians.</p> <p>Hamas does not recognise Israel, but has said it would <a href="https://www.nbcnews.com/id/wbna24235665">observe a truce</a> if Israel withdrew to its 1967 borders. Israel would be unlikely to take Hamas’s word on this and withdraw as demanded. But there would be even less chance of that condition ever being realised if Saudi Arabia were to conclude its own deal with Israel.</p> <p>Another aspect of the timing is that it coincides almost precisely with the 50th anniversary of the start of the Yom Kippur or Ramadan War in October 1973, when Egypt and Syria attacked Israel together. The significance of a Palestinian entity being able to surprise Israel in the same way would not be lost on Hamas.</p> <p>So there were several objectives for Hamas to launch an attack at this time – and possibly a combination of them.</p> <p>Hamas is likely to gain much sympathy from the wider Arab world, but little in the way of material assistance. Hamas’s military operation will likely cause Saudi Arabia to hold back from normalising relations with Israel for now. That said, it’s unlikely any of the Arab states that have signed the Abraham Accords will withdraw from them now in protest over Israeli retaliation against Gaza.</p> <h2>Where the conflict is headed?</h2> <p>Where the conflict is headed is unclear. The Hezbollah militant group in Lebanon has already fired on positions in Israel’s north. But the extent to which it will become seriously involved will depend on its sponsor, Iran.</p> <p>Tehran has generally been seen to want to keep Hezbollah’s considerable rocket and missile strength in reserve in case of an Israeli strike on Iranian nuclear facilities.</p> <p>There is also the question of whether “Lions’ Den” militants in the West Bank will launch their own attacks, effectively creating a third front against Israel. And a possible fourth front could come from attacks on Jewish Israelis by Arab Israelis living in Israel.</p> <p>US President Joe Biden has <a href="https://www.bbc.com/news/world-us-canada-67049196">already promised</a> support for Israel, so there can be little doubt Israel will eventually get on top of these challenges. Netanyahu has warned of a long war, but it may prove reasonably short if Israel goes all out in its retaliation.</p> <p>The main constraint on Israeli action against Gaza will be the fact that an unknown number of Israeli citizens have been kidnapped by Hamas militants and taken to the strip. Indiscriminate Israeli bombing would certainly put those lives at risk.</p> <p>Israel will also be reluctant to put its defence forces in Gaza because of the risk of heavy casualties. However, it may send special forces if it gains intelligence on the whereabouts of its kidnapped citizens.</p> <p>A further risk for Israel in its retaliation is that too brutal an assault on Gaza could turn Western opinion against it. So far, however, Western governments are strongly supportive of Israel and unsympathetic towards Hamas.</p> <p>The overall lesson for Israel is that it has to develop a policy for managing the Palestinians living in the areas it controls.</p> <p>The current situation, in which hardline militants are contained in Gaza, while Israeli forces curtail the actions of Palestinians living in Israel and the West Bank, has suited the Israeli government for many years. It has been able to ignore Arab and international pressure to negotiate a two-state solution or to acquiesce in a <a href="https://theconversation.com/israels-new-government-doesnt-give-palestinians-much-hope-it-could-be-time-for-a-radical-approach-162077">one-state solution</a>.</p> <p>The real significance of Hamas’s operation is that such a non-policy can no longer continue.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/215248/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/ian-parmeter-932739">Ian Parmeter</a>, Research Scholar, Centre for Arab and Islamic Studies, <a href="https://theconversation.com/institutions/australian-national-university-877">Australian National University</a></em></p> <p><em>Image credits: CNN / X (Twitter)</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-did-hamas-attack-and-why-now-what-does-it-hope-to-gain-215248">original article</a>.</em></p>

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Sapling planted at Sycamore Gap to "restore hope" removed by National Trust

<p>UK resident Kieran Chapman, 27, is "absolutely gutted" after the sapling he planted in memory of the<a href="https://www.oversixty.co.nz/finance/legal/you-can-t-forgive-that-teen-arrested-after-felling-of-iconic-200-year-old-tree" target="_blank" rel="noopener"> felled Sycamore Gap tree</a> was heartbreakingly removed by National Trust. </p> <p>The 27-year-old spent hours on Friday planting the sapling just metres away from the stump of the iconic Sycamore Gap tree, but his efforts were in vain, as the sapling had been dug up by the National Trust on Sunday morning. </p> <p>The conservation charity said that they had to remove the sapling because it is a protected UNESCO World Heritage Site.</p> <p>A National Trust spokesperson told the <em>Newcastle Chronicle </em>that while they understand  “the strength of feeling following the events at Sycamore Gap” the site “is a scheduled ancient monument and a globally important archaeological setting, with UNESCO world heritage designation”.</p> <p>“Altering or adding to it can damage the archaeology, and is unlawful without prior consent from government.”</p> <p>But Chapman couldn't hide his disappointment: “It’s just devastating, isn’t it? It genuinely brought people a lot of joy and that’s been taken away," he told the publication. </p> <p>“I honestly thought if it got a good response they might end up keeping it.”</p> <p>Chapman planted the sapling because he wanted to “restore people’s faith in humanity, bring a smile back to people’s faces and just give them a bit of hope”.</p> <p>“I planned to go and take the dog for a walk next weekend there," he added. </p> <p>In a follow up post on Facebook, Chapman added that he was told by the National Trust that his tree will be replanted on another piece of land at the Housesteads Visitor Centre on Hadrian’s Wall. </p> <p>“Too many politics around all this for my liking, the top and bottom of it, it’s a tree, planted in soil. I understand the land is protected, but to protect a tree from being planted in the earth, where they’re designed to be, no matter where it’s location, is crazy,” he wrote.</p> <p>Two people were arrested over the incident,  a 16-year-old boy and 69-year-old former lumberjack. </p> <p>Both have been released on bail, with the lumberjack insisting that he had no involvement in the felling. </p> <p>“You’ve got the wrong feller,” he told<em> The Sun</em>.</p> <p>“I’m a former lumberjack and I’ve just been kicked off my property so I can see why people have pointed the finger.</p> <p>“My brother came down to make sure I hadn’t been arrested as he had heard a rumour that I had cut it down. I didn’t do it," he added. </p> <p><em>Images: Getty/ Facebook</em></p>

Travel Trouble

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"Without hope": Close friend shares sad Schumacher update

<p>It has been a decade since the tragic skiing accident that left Formula 1 racing legend Michael Schumacher with life-threatening injuries, and the most recent update on his condition paints a decidedly sombre picture.</p> <p>Renowned motorsport journalist Roger Benoit, a close friend of Schumacher, recently conveyed a disheartening assessment, describing Schumacher's situation as "a case without hope" in an interview with the Swiss newspaper <em>Blick</em>.</p> <p>Schumacher's catastrophic incident occurred in December 2013 when he struck his head on a rock while skiing in the French Alps, resulting in severe brain damage. Despite wearing a helmet and skiing with his son Mick, Schumacher's life took a tragic turn. He spent 250 days in a medically-induced coma before finally returning home.</p> <p>Since then, updates on Schumacher's condition have been exceptionally scarce, primarily due to the steadfast commitment of those close to him to protect his privacy.</p> <p>In his recent interview, when pressed for a specific update on Schumacher's condition, Benoit offered these bleak words: "This sentence says everything about how (Michael) has been doing for over 3500 days. A case without hope."</p> <p>In 2021, Schumacher's wife, Corinna, broke her silence and spoke about the accident for the first time in eight years during a <a href="https://www.oversixty.co.nz/lifestyle/family-pets/he-s-a-very-proud-dad-unearthed-snap-of-michael-schumacher-stuns-fans" target="_blank" rel="noopener">Netflix documentary</a>. She shared: "Michael is here. Different, but he's here, and that gives us strength, I find. We're together. We live together at home. We do therapy. We do everything we can to make Michael better and to make sure he's comfortable. And to simply make him feel our family, our bond. And no matter what, I will do everything I can. We all will."</p> <p>Now 54 years old, Michael Schumacher has not been seen in public for a decade. His absence has left a void in the world of Formula 1, where he was a legendary figure, having clinched the Drivers' World Championships seven times, a record tied with Lewis Hamilton for the most titles in history. Schumacher's impressive 91 career Grand Prix wins rank second only to Hamilton's 103 victories.</p> <p><em>Image: Netflix</em></p>

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Air travel is in a rut – is there any hope of recapturing the romance of flying?

<p><em><a href="https://theconversation.com/profiles/christopher-schaberg-1451119">Christopher Schaberg</a>, <a href="https://theconversation.com/institutions/arts-and-sciences-at-washington-university-in-st-louis-5659">Arts &amp; Sciences at Washington University in St. Louis</a></em></p> <p>Amelia Earhart broke a transcontinental speed record 90 years ago, in July 1933, by flying <a href="https://airandspace.si.edu/multimedia-gallery/web11183-2009640jpg">her signature red Lockheed Vega</a> from Los Angeles to New Jersey in just 17 hours, seven and a half minutes. Earlier that year, Earhart had flown as an observer on a Northwest Airways winter flight across the U.S., testing the possibilities of a “Northern Transcontinental” route.</p> <p>Because those early airplanes couldn’t reach high altitudes, they weaved through dangerous peaks and the erratic weather patterns that mountain ranges helped create. One co-pilot <a href="https://www.deltamuseum.org/about-us/blog/from-the-hangars/2019/07/24/delta-stories-amelia-earhart">remembers the journey</a> as “seat-of-the-pants flying across the Dakota and Montana plains and through, over and around the Western mountain ranges.”</p> <p>How does air travel today compare?</p> <p>I’ve studied <a href="https://www.theatlantic.com/technology/archive/2018/02/engine-failure/552959/">airplane technology</a>, <a href="https://www.theatlantic.com/technology/archive/2013/09/a-forgettable-passage-to-flight/279346/">airport design</a> and <a href="https://www.upress.umn.edu/book-division/books/grounded">cultural attitudes</a> toward air travel, and I’ve noticed how aspects of flying seem to have calcified over time.</p> <p>Long-distance flight <a href="https://theconversation.com/longing-for-the-golden-age-of-air-travel-be-careful-what-you-wish-for-34177">advanced rapidly between the 1930s and the early 1960s</a>, shaving off the number of hours in the sky by half. But over the past 60 years, the duration of such flights has remained roughly the same. Meanwhile, the ecosystem of air travel has grown more elaborate, often leaving passengers squirming in their seats on the tarmac before or after flight.</p> <p>Coast-to-coast air travel is in a rut – but there are still efforts to improve this mode of transit.</p> <h2>Just another ordinary miracle</h2> <p>Transcontinental air journeys are clearly different 90 years after Earhart’s record-breaking exploratory flights: Travelers now take such trips for granted, and often find them to be pure drudgery.</p> <p>In 2018, <a href="https://thepointsguy.com/reviews/united-757-200-first-class-ewr-sea/">travel blogger Ravi Ghelani reviewed in minute detail</a> a United Airlines flight from Newark, New Jersey, to Seattle – roughly the same northern route that Earhart explored in 1933.</p> <p>But for Ghelani, seated in first class, it wasn’t the terrain or frigid temperatures that were the most cumbersome part of his adventure. It was a cheap complimentary blanket, which “barely qualified as one – it was very thin, very scratchy.”</p> <p>The dreaded blanket reappears in Ghelani’s summary of his trip: “My main qualm with this flight was the lack of a decent blanket – the tiny, scratchy blanket that was provided wasn’t cutting it for the six-hour flight.”</p> <p>I can imagine Earhart rolling in <a href="https://airandspace.si.edu/stories/editorial/legend-amelia-earharts-disappearance">her watery grave</a>: “You zip across the continent in six hours and you complain about a scratchy blanket?”</p> <p>Yet Ghelani’s account of a mundane cross-country flight reveals a truth: Commercial air travel just isn’t the adventure it was back in Earhart’s time.</p> <p>As one captain of a major U.S. airline who regularly flies long routes told me, “Today jetliners fly across the country from Los Angeles to New York, or Boston to Seattle, full of passengers oblivious to the commonplace practice it has become.”</p> <p>This pilot compared coast-to-coast flights to “iPhones, microwaves or automobiles” – just one more ordinary miracle of modern life.</p> <h2>Little indignities multiply</h2> <p>The high-risk adventure of air travel has been subdued, yet long flights today can paradoxically feel torturous.</p> <p>As philosopher Michael Marder puts it in his 2022 book “<a href="https://mitpress.mit.edu/9780262543712/philosophy-for-passengers/">Philosophy for Passengers</a>”: “When crew members wish passengers a ‘pleasant journey,’ I hear a dash of cruel irony in their words. How pleasant can the passenger experience be when you are crammed in your seat, with little fresh air, too hot or miserably cold, and sleep deprived?”</p> <p>I asked my colleague and <a href="http://airplanereading.org/story/55/frequent-flight">frequent flier</a> Ian Bogost about his experience of coast-to-coast trips, and his reply was illuminating: “The same trip seems to get longer every year, and less comfortable. There are reasons – consolidation, reduced routes, pilot and air-traffic labor shortages, decaying technical infrastructure – but it still feels like moving backwards.” In spite of widespread attempts to update aircraft and modernize terminals, the vast system of air travel can seem cumbersome and outdated.</p> <p>Recently at The Atlantic, reporter <a href="https://www.theatlantic.com/technology/archive/2023/07/clear-airport-security-lines-tsa-infrastructure/674809/">Amanda Mull wrote about</a> the biometric screening company Clear, describing this firm’s high-tech service to skip the ubiquitous toil of identity checks before flight, at the cost of surrendering some privacy and personal information. Mull concludes the reason more travelers will likely enroll in this service is that “traversing American airport security is simply that grim.”</p> <p>For Mull, the adventure of contemporary air travel isn’t the destination, or even the journey itself – it’s what you must do to get through the airport.</p> <p>Still, it’s worth noting that the majority of the human population has never boarded an airplane; flying cross-country remains <a href="https://www.smithsonianmag.com/air-space-magazine/how-much-worlds-population-has-flown-airplane-180957719/">a relatively exclusive experience</a>. For most people, the closest they’ll get to a coast-to-coast flight is seeing a small white scratch across the sky, as another airliner makes its arc at 35,000 feet.</p> <h2>2 futures of cross-country flight</h2> <p>Coast-to-coast travel is no longer about breakneck speed or defying elemental odds, and Earhart’s quests to push the limits of aviation couldn’t be further from the bland routines of contemporary air travel. Nor does it involve people dressing to the hilt to step aboard a jetliner for the first time, with passengers stowing their fancy hats in spacious overhead bins.</p> <p>Where are the new frontiers for transcontinental flight today?</p> <p>One area of innovation is in a greener form of flight. Solar Impulse, a completely solar-powered plane, took two months to fly coast-to-coast in 2013. It averages a plodding 45 mph at cruising altitude. As <a href="https://apnews.com/ded34ccc19f24aeea67ba3da130a2be0">The Associated Press reported</a>: “Solar Impulse’s creators view themselves as green pioneers – promoting lighter materials, solar-powered batteries, and conservation as sexy and adventurous. Theirs is the high-flying equivalent of the Tesla electric sports car.” Solar Impulse was more recently <a href="https://aviationweek.com/aerospace/aircraft-propulsion/solar-powered-skydweller-completes-first-autonomous-flights?check_logged_in=1">reconfigured as a remotely piloted aircraft</a>, with new experiments in long-distance solar flight underway.</p> <p>The comparison of Solar Impulse to a Tesla is handy because a different extreme can be found in Elon Musk’s company SpaceX. As part of the relentless development of its biggest vehicle, “Starship,” SpaceX has advertised the possibility of “<a href="https://www.spacex.com/human-spaceflight/earth/">point-to-point</a>” travel on Earth: for example, flying on a commercial rocket from Los Angeles to New York in 25 minutes. Never mind the physical tolls of a normal <a href="https://theconversation.com/why-would-anyone-want-to-sit-on-a-plane-for-over-18-hours-an-economist-takes-the-worlds-longest-flight-122433">19-hour flight</a>; it’s hard to imagine what such a brief yet fast trip would feel like, not to mention what sort of class divisions and bleak industrial launch sites such jaunts would rely on.</p> <p>Get there as fast as possible, using as much fuel as necessary; or glide lazily along, powered by the sun, saving the planet. These are two starkly different visions of coast-to-coast flight, one a dystopian nightmare and the other a utopian dream.</p> <p>In the middle, there’s what most flying mortals do: wait in lines, board unceremoniously and be relieved if you get to your destination without too much discomfort or delay.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/210778/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/christopher-schaberg-1451119">Christopher Schaberg</a>, Director of Public Scholarship, <a href="https://theconversation.com/institutions/arts-and-sciences-at-washington-university-in-st-louis-5659">Arts &amp; Sciences at Washington University in St. Louis</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/air-travel-is-in-a-rut-is-there-any-hope-of-recapturing-the-romance-of-flying-210778">original article</a>.</em></p>

Travel Trouble

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Promising Alzheimer’s drug offers hope for a bright future in treatment

<p>A remarkable and significant breakthrough in the fight against Alzheimer’s disease is ushering in a new era of hope and possibilities for patients grappling with early onset dementia.</p> <p>Scientists and researchers are celebrating this groundbreaking development, viewing it as a tremendous opportunity to transform the landscape of Alzheimer's treatment.</p> <p>The drug in question, donanemab, developed by Eli Lilly, has shown remarkable success in clinical trials and is anticipated to receive approval from the Food and Drug Administration later this year, according to a report in the <a href="https://nypost.com/2023/07/17/alzheimers-drug-donanemab-lowers-risk-of-dementia/" target="_blank" rel="noopener"><em>New York Post</em></a>.</p> <p>Individuals who participated in the donanemab trials experienced a remarkable 40% reduction in the risk of transitioning from mild cognitive impairment to mild or moderate dementia. This is an extraordinary advancement that brings renewed optimism to those affected by this devastating condition.</p> <p>Donanemab would be the third Alzheimer’s drug to emerge in recent months, following the introduction of Leqembi and Aduhelm. This is just the beginning of an exciting new chapter in the realm of molecular therapies for Alzheimer's, as expressed by Dr. Gil Rabinovici, director of the University of California San Francisco’s Memory and Ageing Centre, in an editorial for <em>JAMA</em>.</p> <p>Dr. Daniel Skovronsky, the chief scientific and medical officer at Lilly, has emphasised the significance of this breakthrough. He states, "This will be a very important and meaningful drug," as quoted in <em>Fierce Biotech</em>. Skovronsky further adds, "[T]here’s a huge opportunity here for patients." Such resolute optimism is inspiring, reflecting the tremendous potential this drug holds for transforming lives.</p> <p>Similar to Leqembi and Aduhelm, donanemab is a monoclonal antibody designed to target plaque in the brain, specifically the amyloid protein. These amyloid plaques are responsible for the propagation of another protein called tau, which contributes to the development of Alzheimer's disease.</p> <p>Notably, the donanemab trial also revealed that the drug slowed cognitive decline by an impressive 35% compared to a placebo in individuals with low to intermediate levels of tau protein in the brain. In fact, donanemab demonstrated superior efficacy in clearing amyloid plaques when compared to Aduhelm and Leqembi.</p> <p>Moreover, unlike Leqembi, which necessitates long-term usage, patients taking donanemab may follow a fixed-duration dosing schedule, potentially allowing some individuals to discontinue the treatment after a certain period. "I expect that many patients will be able to stop dosing even as soon as 12 months," Skovronsky affirmed. This stands as a significant departure from being prescribed a lifelong medication, providing an exciting and meaningful prospect for patients.</p> <p>While it is important to note that these new Alzheimer’s drugs do carry limitations and risks, medical experts remain cautiously optimistic. Donanemab, along with the other emerging drugs, has been associated with brain swelling and bleeding. Tragically, three individuals in the donanemab clinical trial lost their lives due to these side effects.</p> <p>The risk of brain swelling and bleeding is heightened among those carrying the APOE4 gene, which is associated with an increased susceptibility to Alzheimer’s. Furthermore, individuals with more advanced stages of the disease showed minimal to no benefit compared to those who received a placebo.</p> <p>As a result, it is possible that donanemab will be recommended primarily for individuals with low to intermediate levels of tau proteins, indicating milder forms of the disease.</p> <p>Nevertheless, Skovronsky and other medical experts maintain their optimism regarding the FDA's approval, expressing the urgent need for it to come to fruition. Skovronsky highlights, "Every day that goes by, there are some patients who pass through this early stage of Alzheimer’s disease and become more advanced, and they won’t benefit from treatment. That’s a very pressing sense of urgency."</p> <p>While challenges and risks remain, the emergence of donanemab and its potential approval by the FDA represents a beacon of hope for the millions of individuals and families affected by Alzheimer's disease. It symbolises the start of a new chapter in the fight against this debilitating condition, offering renewed prospects for a brighter future filled with effective treatments and improved quality of life.</p> <p><em>Image: Shutterstock</em></p>

Mind

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Real estate agent divides internet with “sweet gesture” to hopeful homeowner

<p dir="ltr">A real estate agent has divided the internet after sending a hopeful homeowner a scratchie ticket along with a rejection letter. </p> <p dir="ltr">The anonymous wannabe buyer shared a photo of the letter they received from their agent with the scratchie card alongside it on Reddit, explaining how they had missed out on their dream home. </p> <p dir="ltr">The letter begins in capital letters, reading “Really sorry you missed out”.</p> <p dir="ltr">“I wanted to personally thank you for your interest in my recent listing and say how sorry we are that you missed out.”</p> <p dir="ltr">“I know how keen you were to make it yours, and as much as we love our work, there are parts that are difficult.”</p> <p dir="ltr">“Telling someone the bad news that they have missed out on a property they are very keen on, is certainly the worst part of our role.”</p> <p dir="ltr">“I wish we had more properties like this one for those who have missed out on this home.”</p> <p dir="ltr">“I enclose a scratchie to try and soften the disappointment.”</p> <p dir="ltr">“The agent said they hoped the wannabe homeowner would win some cash so ‘next time you can extend your offer just that little bit more’.”</p> <p dir="ltr">The $1 scratch card gave the unsuccessful applicant the chance to win $100,000 in a game of Tic Tac Toad. </p> <p dir="ltr">The gesture prompted a mixed response from commenters, with most readers calling out the agent for being “condescending”. </p> <p dir="ltr">One comment read, “Might just be poorly worded, but this comes across very condescending and patronising. ‘Lol sorry you’re too poor. Maybe if you win some money we’ll be able to take it from you.’”</p> <p dir="ltr">Another pointed out the agent’s potential grovelling to the buyer, saying “Absolutely no real estate agent is sending anything like this to mere tenants.”</p> <p dir="ltr">Another frustrated renter wrote, “Great! Now if I could get a scratchie with every unsuccessful rental application, I wouldn’t need to rent.”</p> <p dir="ltr">A few commenters praised the real estate agent’s actions, believing they had good intentions by including the scratchie. </p> <p dir="ltr">One person wrote, “They didn’t have to give anything but still did. The wording could’ve been better but still, something for nothing.”</p> <p dir="ltr">One other person was shocked by the support for the agent in the comments of the post, putting it blatantly, “They said ‘so next time you can extend your offer just that little bit more’.”</p> <p dir="ltr">“Their intention is clear. They’re saying to offer more money. I genuinely am surprised by the comments on this post thinking this is a nice gesture and not blatant manipulation.”</p> <p dir="ltr"><em>Image credits: Reddit</em></p>

Real Estate

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Banksy in Ukraine: how his defiant new works offer hope

<p>Art, in all its forms, has always been a powerful means of representing, resisting and remembering war. And the <a href="https://theconversation.com/ukraine-recap-poland-missile-scare-a-timely-reminder-of-how-dangerous-this-war-is-for-everyone-194873">Russo-Ukrainian War</a> is no different, with artists responding powerfully to Russian aggression through <a href="https://www.fastcompany.com/90754784/how-ukrainian-artists-are-resisting-russias-war">an explosion of artwork</a>drawing attention to, and reinforcing, the resilience of Ukrainian people and culture.</p> <p>A stream of artwork has been <a href="https://www.instagram.com/artists.support.ukraine/?utm_source=ig_embed&amp;ig_rid=79e6c95a-0a13-4ea9-a4d8-b24ed292d6b2">posted on Instagram</a> and Twitter. Some of the artworks represent grief and trauma, whereas others reflect <a href="https://war.ukraine.ua/articles/how-art-became-a-mirror-of-ukrainian-resistance/">“the fire of hope and defiance that comes with such tragedy.”</a></p> <p>International artists have also joined in the effort. On November 11, <a href="https://theconversation.com/uk/topics/banksy-7818">graffiti artist</a>Banksy <a href="https://www.instagram.com/p/Ck1bqL6MsMu/?igshid=YmMyMTA2M2Y=">posted a picture</a> to his Instagram of a gymnast doing a handstand, painted on the side of a building devastated by shelling in Borodyanka, Ukraine.</p> <p>A few days later, Banksy <a href="https://www.theartnewspaper.com/2022/11/14/banksy-in-ukraine-seven-new-works-appear-in-war-torn-sites">confirmed</a> that he was responsible for six other artworks in Kyiv and other cities across Ukraine, one of which appeared to take aim at Russian president Vladimir Putin, depicting him being thrown by a child in a judo match. It is not much of a stretch to interpret the child as a symbol of Ukrainian resistance.</p> <p>Banksy’s other works are shown in a video posted to Instagram (above) accompanied by a soundtrack of women singing Ukrainian folk music. They show children playing on a seesaw made from part of a tank, a bombed out transport truck, a man taking a bath and a woman in a dressing gown donning a gas mask and holding a fire extinguisher.</p> <p>Ukrainian messages of thanks and solidarity were posted to Banksy’s Instagram in response.</p> <h2>Russia’s war on culture</h2> <p>The destruction of culture and cultural heritage has been among the <a href="https://t.me/mkipu/3093">many alleged crimes</a> committed by Russia in Ukraine. In July 2022, <a href="https://www.unesco.org/en/articles/unesco-mission-ukraine-assesses-impact-war-culture-sector">Unesco reported</a>damage to over 164 cultural sites including religious sites, museums, historic buildings, buildings dedicated to cultural activities, monuments and libraries.</p> <p>As with so many aspects of the war, this reverberates with the Yugoslav War, where the searing image of <a href="https://www.bbc.co.uk/news/world-europe-27353635">the destruction of the national library</a> in Sarajevo and its two million books and artefacts in August 1992 was one of the most iconic of the war.</p> <p>An early cultural casualty in Ukraine was the <a href="https://www.bbc.co.uk/news/world-europe-60588885">Babyn Yar memorial park</a> in Kyiv, believed to have been directly targeted by Russian forces as part of an erasure of Ukrainian history and culture.</p> <p>In response, <a href="https://www.unesco.org/en/articles/unesco-funds-7-projects-support-artists-ukraine">Unesco committed</a> to the protection of cultural property as a priority. That commitment was based on the conviction that: “Culture is an essential public good for society, and access to cultural life is a basic universal human right.”</p> <p>While art alone cannot change the dynamics or the course of the war in Ukraine, it <a href="https://beyond.ubc.ca/kent-monkman-exhibition/">can play an important role</a> in reinforcing and demonstrating the <a href="https://www.instagram.com/p/CjDHkWKt9Ea/">resilience of cultural life</a>. Whether or not it can also play a role in building peace and fostering reconciliation depends on its protection.</p> <h2>Unesco responds to threats to Ukrainian culture</h2> <p>In September, <a href="https://www.unesco.org/en/articles/unesco-funds-7-projects-support-artists-ukraine?hub=365">Unesco announced</a> a joint initiative with the Ukrainian NGO Museum of Contemporary Art “to encourage the continuation of artistic creation and access to cultural life in Ukraine”.</p> <p><a href="https://www.unesco.org/sites/default/files/medias/fichiers/2022/09/Ukraine%20and%20MOCA_7%20finalists_Brief%20information.pdf">The fund will</a> initially disburse a total of US$100,000 (£84,000) from the Unesco Heritage Emergency Fund to support seven projects, with ten more to follow. The projects were selected from an open call and include residencies and support for displaced Ukrainian artists in Dnipro and Kharkiv.</p> <p>Unesco described their support of Ukrainian artists as “vital for preserving artistic expression as a basis for social cohesion, community resilience, and our common goal – fighting for freedom and democratic values”.</p> <h2>What role does art play in war?</h2> <p>All of this points to important questions about the <a href="https://www.newyorker.com/magazine/2022/03/21/art-in-a-time-of-war">role of art and the responsibility of artists</a> in times of war, <a href="https://www.tandfonline.com/doi/abs/10.1080/21624887.2021.1875711">artistic representation</a> of war and its horrors, <a href="https://www.taylorfrancis.com/books/mono/10.4324/9781315723211/political-street-art-holly-eva-ryan">art and the politics of resistance</a> and the <a href="https://www.cambridge.org/core/journals/american-journal-of-international-law/article/art-aesthetics-justice-and-reconciliation-what-can-art-do/8965A016EB04B26925F6CF16E1BF65B0">potential role of art</a> in building peace and fostering reconciliation.</p> <p>As historian <a href="https://books.google.com/books?id=3ChLAQAACAAJ&amp;dq=War+and+Art,+Reaktion+Books,&amp;hl=en&amp;newbks=1&amp;newbks_redir=1&amp;sa=X&amp;ved=2ahUKEwinntjpoLX7AhWFYcAKHRFgC0wQ6AF6BAgCEAI">Joanna Bourke observed</a> in her book War and Art, art is intrinsically political, whether deliberately so or not. Artists make choices about how they represent war, often invoking “both the bitterness and the vulnerability of modern war”.</p> <p>Banksy’s artwork in Ukraine draws our eye to the devastation wrought by the Russian invasion. By being painted on bombed out buildings, the images reflect how the experience of war disrupt the everyday, juxtaposing the mundane with the extraordinary – a woman in curlers and a dressing gown also wears a gas mask, children play on a tank trap seesaw.</p> <p>Banksy’s intervention was <a href="https://www.cbsnews.com/news/banksy-ukraine-mural-in-town-bombed-by-russia/">warmly welcomed</a> by Ukrainians, “hailed as a symbol of their country’s invincibility” as part of a wider Ukrainian effort to leverage art as a powerful <a href="https://www.theguardian.com/world/2022/apr/23/the-artists-of-ukraine-find-their-voice-in-a-cry-of-resistance">site of resistance</a> and demonstration of resilience.</p> <p>The extent to which <a href="https://www.britishcouncil.org/sites/default/files/the_art_of_peace_0419.pdf">art might be able to contribute to peace</a> and reconciliation is a question for later on. It seems quite far removed from the grief, anger and defiance evident in much of the artwork created to date.</p> <p>For now, as the response to Banksy’s artworks demonstrates, art in Ukraine serves as a site of expression, of solidarity and a symbol of resistance. As the Ukrainian government expressed, such works are not only <a href="https://war.ukraine.ua/articles/how-art-became-a-mirror-of-ukrainian-resistance/">“about blood, death, and destruction … but also – about love, support, and hope”.</a></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/banksy-in-ukraine-how-his-defiant-new-works-offer-hope-194952" target="_blank" rel="noopener">The Conversation</a>.</em></p>

Art

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Michael Klim shares hopes for his incurable disease

<p dir="ltr">Australian swimming legend Michael Klim has shared an update on how his neurological disorder has changed his day-to-day life and his hopes for raising awareness and finding a cure.</p> <p dir="ltr">In a recent interview with <em>Sunrise</em>, the Olympic gold medallist said it has “definitely been a very up and down three years” since <a href="https://www.oversixty.com.au/health/caring/it-s-not-easy-michael-klim-shares-health-update">he was diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)</a>, which has caused him to lose “pretty much all muscle and sensation” in his legs.</p> <p dir="ltr">“There was a grieving process for the first couple of years, trying to come to terms with a completely different lifestyle and a different mindset, really,” he told the program.</p> <p dir="ltr">“I’ve stabilised but my mobility is still very much compromised, most of the time I use a walking stick around the pool deck.”</p> <p dir="ltr">“I plan simple things, when I’m going to the shops I have to plan how far I have to walk ... to get my groceries.”</p> <p dir="ltr">Having established himself in Bali with his partner Michelle, where they run one of the swim schools in his franchise Klim Swim, the 44-year-old still returns to Sydney for specialist treatment - though he doesn’t visit Australia as much as he used to.</p> <p dir="ltr">“I don’t get back to Australia as much as I used to, mainly just for treatment, but I’ve had an enormous amount of support from the Australian public and my swimming community just to get through this, so I’ll keep fighting and hopefully we can find a cure one day,” he said.</p> <p dir="ltr">Klim revealed that doctors still don’t know the cause of his CIDP, but said it’s easy to question whether the physical demands of his athletic career may have contributed.</p> <p dir="ltr">“They (doctors) don’t know the cause of CIDP. It can be genetic but in my case it’s not,” he said.</p> <p dir="ltr">“We used to pride ourselves on our physicality (as Olympians), our ability to take on anything that was thrown at us, especially during our training.</p> <p dir="ltr">“I used to love overtraining, that was my way of being ready and making sure mentally I was ready.</p> <p dir="ltr">“It used to give me toughness and mental strength, and now I think sometimes, ‘did I overdo it? Are the last three or four decades (of training) catching up with me?’”</p> <p dir="ltr">According to <a href="https://www.hopkinsmedicine.org/health/conditions-and-diseases/chronic-inflammatory-demyelinating-polyradiculoneuropathy#:~:text=Chronic%20inflammatory%20demyelinating%20polyradiculoneuropathy%20(CIDP)%20is%20a%20slowly%20developing%20autoimmune,in%20the%20arms%20or%20legs." target="_blank" rel="noopener">John Hopkins Medicine</a>, CIDP is thought to be the chronic or long-term version of the disease Guillain-Barre syndrome, and occurs when the immune system attacks myelin, the fatty sheath around the nerve that acts as insulation and allows electrical impulses to travel along the nerve to stimulate muscles and transmit information to skin and joints.</p> <p dir="ltr">While the triggers of CIDP are still unknown, it doesn’t seem to have a link to genetics or occur after an infection, unlike Guillain-Barre syndrome.</p> <p dir="ltr">The <a href="https://www.gbs-cidp.org/cidp/" target="_blank" rel="noopener">GBS/CIDP Foundation International website</a> says that current theories are that CIDP is thought to start when the immune system perceives myelin as foreign and attacks it, causing damage to the myelin or removing it entirely.</p> <p dir="ltr">This damage or absence of myelin results in the electrical impulses being slowed down or lost, meaning that messages sent from the brain to move muscles don’t make it to their final destination.</p> <p dir="ltr">Despite the unknowns about his condition, Klim said he is optimistic that talking about his diagnosis will help to raise awareness and find a cure.</p> <p dir="ltr">“Hopefully we can put all our heads together, maybe there are certain treatments outside the realm we’re thinking of,” he said.</p> <p dir="ltr">“Maybe there’s future treatments that we can implement and…. we can knock it off.”</p> <p><span id="docs-internal-guid-6a353b7b-7fff-7940-3e08-f66483b071bb"></span></p> <p dir="ltr"><em>Image: @michaelklim1 (Instagram)</em></p>

Caring

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“I hope you didn't travel all the way here to ask that question”: Princess Mary shuts down journalist

<p dir="ltr">Princess Mary refused to stoop to her sister-in-law’s level when a journalist questioned her about Queen Margrethe of Denmark's decision to strip four grandchildren of their royal titles.</p> <p dir="ltr">The Australian-born Princess was on a royal tour of Vietnam when a journalist asked about the Queen’s decision.</p> <p dir="ltr">But Princess Mary was not having any of it and quickly shut down the question and put the journalist in their place.</p> <p dir="ltr">"I have nothing more to add to what I already said,” Princess Mary interjected.</p> <p dir="ltr">“I hope you didn't travel all the way here to ask that question. Do you have any other questions?"</p> <p dir="ltr">This however did not stop the journalist from going on saying: "Princess Marie told me that your relationship is complicated.”</p> <p dir="ltr">"I have nothing further to add,” the Princess replied, ending the conversation. </p> <p dir="ltr">The footage was shared to Twitter showing a composed Princess Mary shutting down the journalist and their incessant questions about the Queen’s decision. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">“I have nothing more to add to what I already said. I hope you didn't travel all the way here to ask that question. Do you have any other questions?”</p> <p>"Princess Marie told me that your relationship is complicated."</p> <p>"I have nothing further to add."</p> <p>🎥BT <a href="https://twitter.com/hashtag/CrownPrincessMary?src=hash&amp;ref_src=twsrc%5Etfw">#CrownPrincessMary</a> <a href="https://t.co/2SLo3ZG7Cw">pic.twitter.com/2SLo3ZG7Cw</a></p> <p>— ChristinZ (@ChristinsQueens) <a href="https://twitter.com/ChristinsQueens/status/1587695273274376193?ref_src=twsrc%5Etfw">November 2, 2022</a></p></blockquote> <p dir="ltr">Queen Margrethe II of Denmark <a href="https://oversixty.com.au/news/news/denmark-s-queen-strips-grandkids-of-royal-titles" target="_blank" rel="noopener">stripped four of her grandchildren of their royal titles</a> in hopes they will be “able to shape their own lives to a much greater extent”.</p> <p dir="ltr">The Queen has two sons, Crown Prince Frederik and Prince Joachim, and eight grandchildren. </p> <p dir="ltr">Her sons, their wives, and children all have the titles of count and countess of Monpezat, referring to Margrethe's husband, who was born Henri de Laborde de Monpezat.</p> <p dir="ltr">Prince Joachim’s children -  Prince Nikolai, 23, Prince Felix, 20, Prince Henrik, 13 and Princess Athena, 10 - will not be able to use their “prince” and “princess” titles from January 1, 2023. </p> <p dir="ltr">Prince Frederik and Crown Princess Mary’s children are not affected by the decision.</p> <p dir="ltr">Princess Mary was dragged into the family drama when Joachim and his second wife Marie said the relationship between Mary and Frederik is “complicated”.</p> <p dir="ltr">Princess Mary defended Queen Margrethe’s decision, saying that change is never easy.</p> <p dir="ltr">“Change can be extremely difficult and can really hurt,” Princess Mary said.</p> <p dir="ltr">“I think most people have tried it. But this does not mean that the decision is not the right one.</p> <p dir="ltr">“… And I can understand that it is a very difficult decision to have to make, and also a very difficult decision to receive.”</p> <p dir="ltr"><em>Images: Twitter</em></p>

Travel Trouble

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"Prima donna in pigtails": how Julie Andrews the child star embodied the hopes of post-war Britain

<p>In June, the American Film Institute presented its 48th Life Achievement Award, the highest honour in American cinema, to the beloved stage-and-screen star <a href="https://www.afi.com/laa/julie-andrews/">Julie Andrews</a>. </p> <p>On conferring the award, the AFI praised Andrews as “a legendary actress” who “has enchanted and delighted audiences around the world with her uplifting and inspiring body of work”.</p> <p>As anyone who has seen <em>Mary Poppins</em> (1964) or <em>The Sound of Music</em> (1965) can attest, “uplift” is central to the <a href="https://www.sensesofcinema.com/2002/female-glamour-and-star-power/andrews/">Julie Andrews screen persona</a>. </p> <p>It is a sweetness-and-light image that is easy to lampoon. <a href="https://www.instagram.com/p/BZtTQSbl-nw/?hl=en">Andrews herself</a> is alleged to have quipped “sometimes I’m so sweet even I can’t stand it”. But it’s an element of feel-good edification that fuels much of the star’s iconic appeal.</p> <p>The idea of Julie Andrews as a figure of uplift has a long history. </p> <p>Decades before she attained global film stardom in Hollywood, Andrews enjoyed an early career as <a href="https://www.tandfonline.com/doi/abs/10.1080/19392397.2022.2109303">a child performer</a>. </p> <p>Billed as “Britain’s youngest singing star”, she performed widely on the postwar concert and variety circuit with forays into radio, gramophone recording and even early television. </p> <p>Possessing a precociously mature soprano voice, Andrews was widely promoted in the era as a <a href="https://paralleljulieverse.tumblr.com/post/63601790519/julies-status-as-a-juvenile-prodigy-possessed">child prodigy</a>. A 1945 BBC talent report filed when the young singer was just nine years old enthused over “this wonderful child discovery” whose “breath control, diction, and range is quite extraordinary for so young a child”.</p> <h2>‘Infant prodigy of trills’</h2> <p>Andrews made her professional West End debut in 1947 where she dazzled audiences with a coloratura performance of the <em>Polonaise from Mignon</em>. Newspapers were ablaze with stories about the “12-year-old singing prodigy with the phenomenal voice”.</p> <p>Reports claimed the pint-sized singer had a vocal range of over four octaves, a fully formed adult larynx and an upper <a href="https://en.wikipedia.org/wiki/Whistle_register">whistle register</a> so high dogs would be beckoned whenever she sang. </p> <p>On the back of such stories, Andrews was given a slew of lionising monikers: “prima donna in pigtails”, “infant prodigy of trills”, “the miracle voice” and “Britain’s juvenile coloratura”.</p> <p>While much of it was PR hype, the representation of Andrews as an extraordinary musical prodigy resonated deeply with postwar British audiences. The devastation of the war cast <a href="https://www.ncbi.nlm.nih.gov/books/NBK436946/">a long shadow</a>, and there was a keen sense a collective social rejuvenation was needed to reestablish national wellbeing. </p> <p>The figure of the child was pivotal to the rhetoric of postwar British reconstruction. From political calls for <a href="https://journals.sagepub.com/doi/full/10.1177/0363199020945746">expanded child welfare</a> to the era’s booming <a href="https://www.jstor.org/stable/30036327">family-oriented consumerism</a>, images of children saturated the cultural landscape, serving as a lightning rod for both <a href="https://www.iwm.org.uk/history/growing-up-in-the-second-world-war">social anxieties and hopes</a>.</p> <p>In her status as “Britain’s youngest singing star”, Andrews chimed with these postwar discourses of child-oriented renewal. </p> <p>A popular myth even traced her prodigious talent to the very heart of the Blitz. Like a scene from a morale-boosting melodrama, the story claimed the young Andrews was huddled one night with family and friends in a Beckenham air raid shelter. In the middle of a communal singalong, a powerful voice suddenly materialised out of her tiny frame, astonishing all into silent delight.</p> <h2>‘Our Julie’</h2> <p>One of the most pointed alignments of Andrews’ juvenile stardom with a discourse of postwar British nationalism came with her appearance at the <a href="https://www.royalvarietycharity.org/royal-variety-performance/archive/detail/1948-london-palladium-">1948 Royal Command Variety Performance</a>. </p> <p>Appearing just two weeks after her 13th birthday, Andrews was the youngest artist ever to participate in the annual event. It generated considerable media coverage and yet another grand nickname: “command singer in pigtails”. </p> <p>Andrews performed a solo set at the event, and was also charged with leading the national anthem at the close.</p> <p>Ideals of restorative nationalism shaped Andrews’ child stardom in other ways. </p> <p>Much of her early repertoire was markedly British, drawn from the English classical canon and rounded out by traditional folk songs. </p> <p>Press reports emphasised, for all her remarkable talent, “our Julie” was still a typical English girl thoroughly unspoiled by fame. In accompanying images she would appear in idyllic scenarios of classic English childhood: playing with dolls, riding her bicycle, doing her homework.</p> <p>Elsewhere, commentary was rife with speculations about Andrews’ prospects as “the next <a href="https://en.wikipedia.org/wiki/Adelina_Patti">Adelina Patti</a>” or “future <a href="https://en.wikipedia.org/wiki/Lily_Pons">Lily Pons</a>”. The mix of nostalgia and hope helped make the young Andrews a reassuring figure in the anxious landscape of postwar Britain. </p> <h2>All grown up</h2> <p>Little prodigies can’t remain little forever. There lies the troubled rub for many child stars, doomed by biology to lose their principal claim to fame. </p> <p>In Andrews’ case, she was able to make the successful transition to adult stardom – and even greater fame – by moving country and professional register into the American stage and screen musical. </p> <p>Still, the themes of therapeutic uplift that defined her early child stardom would follow Julie Andrews as she graduated to become the world’s favourite singing nanny.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/prima-donna-in-pigtails-how-julie-andrews-the-child-star-embodied-the-hopes-of-post-war-britain-188363" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Music

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"Dramatic result": New drug shows hope for slowing down Alzheimer's disease

<p>A trial drug has shown "significant" results in slowing down Alzheimer's disease, with Australian healthcare experts hopeful in where this breakthrough can take their research. </p> <p>The drug, known as Lecanemab, has been proven to reduce cognitive decline by 27 per cent compared to placebo, according to an overseas study. </p> <p>More than 1,700 patients with mild cognitive impairment were enrolled in the study and the results were collected over 18 months.</p> <p>"Functionally and cognitively, it seems they did better and so that is a dramatic result," Dr Lawrence Honig, one of the study investigators from Columbia University Medical Centre, said.</p> <p>The drug works by removing the build-up of amyloid plaques in the brain which is one of the hallmarks of the disease, which featured in the scans of each study participant. </p> <p>Australian experts are excited about the findings, and how this can further their research. </p> <p>"This is the first time we've seen a drug like this have these kinds of effects," Professor Sharon Naismith, Clinical Neuropsychologist &amp; NHMRC Dementia Leadership Fellow at the University of Sydney, said.</p> <p>"The results of this trial have massive implications for our resourcing."</p> <p>Naismith warns there's a need to spend more money on better diagnosing patients with mild cognitive impairment.</p> <p>"In the past there has been a lot of reluctance from healthcare physicians to diagnose or ask about cognitive impairment, even in primary care," she said.</p> <p>She said being able to access a drug that can slow cognitive decline will change the paradigm and conversation around Alzheimer's disease. </p> <p>"I do think we're going to get a real avalanche of people coming to GPs and coming to memory clinics for that reason," she said.</p> <p>Professor Kathryn Goozee, Director of KaRa Minds at Macquarie Park said the study showed using an antibody to target amyloid in the brain can help with cognition.</p> <p>"To date there has been no disease-modifying medication so we want to be offering studies that can potentially change that trajectory," Goozee said.</p> <p>The full details of the results will be presented at an international conference of experts in the US in late November.</p> <p><em>Image credits: 9News</em></p>

Mind

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New study to “give hope” to childhood trauma survivors with depression

<p dir="ltr">A new study has challenged our understanding of how to treat adults with a history of childhood trauma, revealing that using psychotherapy, medication or a combination of the two are effective treatments for those with depression.</p> <p dir="ltr">Childhood trauma, defined as abuse or neglect of a person before they are 18 years old, is a known risk factor for major depressive disorders in adulthood. It often results in symptoms that start earlier, last longer and are more frequent, and increases the risk of developing co-occurring diseases and conditions.</p> <p dir="ltr">The study, published in <em><a href="https://doi.org/10.1016/S2215-0366(22)00227-9" target="_blank" rel="noopener">The Lancet Psychiatry</a></em>, found that adult survivors of childhood trauma who receive these common treatments experience improved symptoms at the same rate as those without childhood trauma.</p> <p dir="ltr">While previous studies have indicated that common treatments for major depressive disorders are less effective for people with childhood trauma, the team argues that these findings are inconsistent.</p> <p dir="ltr">The team then examined data from 29 clinical trials of psychotherapy and pharmacotherapy (the use of prescribed medications) among adults with major depressive disorders to determine whether those with trauma were more severely depressed before treatment, had more unfavourable outcomes after treatment, and whether they were less likely to benefit from treatment in comparison to those without trauma.</p> <p dir="ltr">Among the 46 percent of participants with childhood trauma, the team found that they showed more severe symptoms at the start of treatment and after treatment in comparison to the control group (those without trauma).</p> <p dir="ltr">But, they found that both groups experienced an improvement in symptoms at a similar rate.</p> <p dir="ltr">Erika Kuzminskaite, a PhD candidate and the first author of the study, said that this finding could be a source of hope.</p> <p dir="ltr">“Finding that patients with depression and childhood trauma experience similar treatment outcome when compared to patients without trauma can give hope to people who have experienced childhood trauma,” Kuzminskaite said.</p> <p dir="ltr">“Nevertheless, residual symptoms following treatment in patients with childhood trauma warrant more clinical attention as additional interventions may still be needed.”</p> <p dir="ltr">Antoine Yrondi, a professor at the University of Toulouse who wasn’t involved in the research, wrote that the study provides a message of hope for patients.</p> <p dir="ltr">“This meta-analysis could deliver a hopeful message to patients with childhood trauma that evidence-based psychotherapy and pharmacotherapy could improve depressive symptoms,” Dr Yrondi said.</p> <p dir="ltr">“However, physicians should keep in mind that childhood trauma could be associated with clinical features which may make it more difficult to reach complete symptomatic remission and, therefore, have an impact on daily functioning.”</p> <p dir="ltr">According to <a href="https://blueknot.org.au/resources/blue-knot-fact-sheets/trauma-classification/what-is-childhood-trauma/" target="_blank" rel="noopener">Blue Knot</a>, childhood trauma can have a wider and more extreme impact than trauma we experience as adults because a child’s brain is still developing. If the trauma is unresolved, coping strategies developed during childhood can become risk factors for poorer psychological and physical health in adulthood.</p> <p dir="ltr">But, it is possible to recover from childhood trauma, with this latest study going to show that common treatments can be effective.</p> <p dir="ltr"><em>If you’re in need of support, you can contact Lifeline on 13 11 14 or Blue Knot on 1300 657 380.</em></p> <p><em><span id="docs-internal-guid-62551377-7fff-7a7f-9e23-d352d2c29923"></span></em></p> <p dir="ltr"><em>Image: Getty Images</em></p>

Mind

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Low-cost gel film pulls clean drinking water from desert air, raising hopes of quenching the world’s driest communities

<p class="spai-bg-prepared">One in three people lives in <a class="spai-bg-prepared" href="https://www.un.org/en/events/desertification_decade/whynow.shtml" target="_blank" rel="noreferrer noopener">drylands</a>, areas covering more than 40% of the Earth’s surface that experience significant water shortages.</p> <p class="spai-bg-prepared">Scientists and engineers have now developed a new material that could help people living in these areas access <a class="spai-bg-prepared" href="https://cosmosmagazine.com/earth/water/an-answer-to-the-clean-water-crisis/" target="_blank" rel="noreferrer noopener">clean drinking water</a> by capturing it right out of the atmosphere, according to a new study in <em class="spai-bg-prepared">Nature Communications</em>.</p> <p class="spai-bg-prepared">They’ve developed a gel film that costs just $2 per kilogram to produce and can pull water from the air in even the driest climates; 1kg of it can produce more than 6 litres per day in less than 15% relative humidity (RH), and 13 litres in areas with up to 30% RH.</p> <p class="spai-bg-prepared">Relative humidity is the ratio of the current absolute humidity to the highest possible absolute humidity.  So a 100% RH means that the air is completely saturated with water vapour and cannot hold any more. People tend to feel most comfortable between 30% and 50%, and arid climates have less than 30% RH.</p> <p class="spai-bg-prepared">These results are promising, as previous attempts to pull water from the desert air have typically been energy-intensive and not very efficient.</p> <p class="spai-bg-prepared">“This new work is about practical solutions that people can use to get water in the hottest, driest places on Earth,” says senior author Guihua Yu, professor of Materials Science and Mechanical Engineering at the University of Texas in Austin, US. “This could allow millions of people without consistent access to drinking water to have simple, water-generating devices at home that they can easily operate.”</p> <div class="newsletter-box spai-bg-prepared"> <div id="wpcf7-f6-p192317-o1" class="wpcf7 spai-bg-prepared" dir="ltr" lang="en-US" role="form"> <form class="wpcf7-form mailchimp-ext-0.5.61 spai-bg-prepared resetting" action="/technology/gel-film-desert-drinking-water/#wpcf7-f6-p192317-o1" method="post" novalidate="novalidate" data-status="resetting"> <p class="spai-bg-prepared" style="display: none !important;"><span class="wpcf7-form-control-wrap referer-page spai-bg-prepared"><input class="wpcf7-form-control wpcf7-text referer-page spai-bg-prepared" name="referer-page" type="hidden" value="https://cosmosmagazine.com/technology/" data-value="https://cosmosmagazine.com/technology/" aria-invalid="false" /></span></p> <p><!-- Chimpmail extension by Renzo Johnson --></form> </div> </div> <p class="spai-bg-prepared">The gel is made with <a class="spai-bg-prepared" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hydroxypropyl-cellulose" target="_blank" rel="noreferrer noopener">hydroxypropyl cellulose</a> (HPC) which is produced from cellulose, and a common kitchen ingredient called <a class="spai-bg-prepared" href="https://www.sciencedirect.com/science/article/abs/pii/S0141813016310339" target="_blank" rel="noreferrer noopener">konjac glucomannan</a>, as well as lithium chloride salt (LiCl). It forms a hydrophilic (water attracting) porous film with a large surface area that collects the water vapour from air.</p> <p class="spai-bg-prepared">“The gel takes two minutes to set simply. Then, it just needs to be freeze dried, and it can be peeled off the mould and used immediately after that,” explains Weixin Guan, a doctoral student on Yu’s team and a lead researcher of the work.</p> <p class="spai-bg-prepared">And, because the cellulose is thermo-responsive, it becomes hydrophobic (water repelling) when heated which allows the collected water to be released within 10 minutes through mild heating at 60 °C.</p> <p class="spai-bg-prepared">This means that the overall energy needed to produce the water is minimised. The film is also flexible, can be moulded into a variety of shapes and sizes, and producing it requires only the gel precursor – which includes all the relevant ingredients poured into a mould.</p> <p class="spai-bg-prepared">“This is not something you need an advanced degree to use,” says lead author Youhong “Nancy” Guo, a former doctoral student in Yu’s lab and now a postdoctoral researcher at the Massachusetts Institute of Technology. “It’s straightforward enough that anyone can make it at home if they have the materials.”</p> <p class="spai-bg-prepared">And because it’s so simple, the authors say the challenges of scaling the technology up and achieving mass usage are reduced.</p> <p><!-- Start of tracking content syndication. Please do not remove this section as it allows us to keep track of republished articles --></p> <p><img id="cosmos-post-tracker" class="spai-bg-prepared" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=192317&amp;title=Low-cost+gel+film+pulls+clean+drinking+water+from+desert+air%2C+raising+hopes+of+quenching+the+world%E2%80%99s+driest+communities" width="1" height="1" /></p> <p><!-- End of tracking content syndication --></p> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/technology/gel-film-desert-drinking-water/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/imma-perfetto">Imma Perfetto</a>. Imma Perfetto is a science writer at Cosmos. She has a Bachelor of Science with Honours in Science Communication from the University of Adelaide.</em></p> <p><em>Image: The University of Texas at Austin/Cockrell School of Engineering</em></p> </div>

Technology

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New hope after new leads in Théo Hayez case

<p dir="ltr">Months after a $500,000 reward was announced, the private investigator searching for answers in the case of missing backpacker Théo Hayez says it has brought on new leads - but Théo’s family still have one question they’d like answered.</p> <p dir="ltr">“A key question we are seeking to address is whether he was with someone on the night of May 31, 2019 - which we strongly believe to be the case considering the circumstances,” Théo’s family said in a statement.</p> <p dir="ltr">The Belgian backpacker was last seen at about 11pm on May 31, when he was ejected from the Cheeky Monkeys bar in Byron Bay. Police were alerted six days later, after Théo didn’t return to his hostel, but he couldn’t be found or contacted.</p> <p dir="ltr">In February, nearly three years after the 18-year-old vanished, <a href="https://www.oversixty.co.nz/news/news/big-development-in-missing-theo-hayez-case" target="_blank" rel="noopener">NSW Police posted a $500,00 reward</a> for significant information relating to Théo’s disappearance, which the family hope “will yield the answers we so desperately need”.</p> <p dir="ltr">On Monday, private investigator Ken Gamble said the recent reward had “brought forward new leads” and that he was continuing to investigate “credible leads” on behalf of the family, as reported by <em><a href="https://7news.com.au/news/missing-person/new-credible-leads-emerge-after-police-post-500000-reward-in-theo-hayez-case-c-6987407" target="_blank" rel="noopener">7News</a></em>.</p> <p dir="ltr">“I am very thankful to everyone who has provided information. Some investigations are still ongoing,” Mr Gamble said in a statement.</p> <p dir="ltr">“The recent $500,000 reward offered by the NSW government has brought forward new leads that are also being thoroughly investigated. I am still very hopeful that the case will be solved.” </p> <p dir="ltr">Théo’s family thanked Mr Gamble for his efforts, as he continues “to work with us and investigates all new leads”, and that they welcomed the news that the Missing Persons Registry would “carry out further investigations into Théo’s disappearance”.</p> <p dir="ltr">“Since the reward was announced, we have continued to see people come forward offering information to support the search,” they said.</p> <p dir="ltr">As for someone being with Théo on the night he vanished, the family say it’s the only way his behaviour - which has been pieced together using location data - would make sense.</p> <p dir="ltr">“Walking into the bushland and climbing the grassy side of the Cape Byron cliff alone at night is something we believe Théo would never have done unless he was with someone at the time,” they said.</p> <p dir="ltr">The location data gleaned from Théo’s mobile phone connections and Google’s location services was part of the evidence presented to <a href="https://www.oversixty.co.nz/travel/travel-trouble/potential-breakthrough-in-theo-hayez-case" target="_blank" rel="noopener">an inquest into his disappearance</a>.</p> <p dir="ltr">After being ejected from the bar, Théo was tracked to a local sporting field, before he charted a route to the beach below the headland. The data from his phone then shows Théo climbing the steep ascent towards the lighthouse before it stops transmitting.</p> <p dir="ltr"><a href="https://www.oversixty.co.nz/finance/legal/theo-hayez-s-last-moments-before-disappearing-uncovered" target="_blank" rel="noopener">Police have theorised</a> that Théo climbed up the cliffs, dropped his phone, fell and was swept out to sea, but his family says this goes against his sensible, risk-averse nature.</p> <p dir="ltr">The inquest, which will resume sitting on June 7, will see the counsel assisting the coroner make their final submissions, with lawyers representing the Hayez family and NSW Police also making submissions.</p> <p dir="ltr">State Coroner Teresa O’Sullivan will then hand down her findings on October 21.</p> <p dir="ltr">In their statement, the family said they will continue to search for answers.</p> <p dir="ltr">“Every day Théo is missing is as difficult as the last as we navigate our endless and ambiguous grief and continue to seek answers to what happened to our boy,” the family said.</p> <p dir="ltr">“As with all families of missing people, we are unable to properly grieve and heal, as we don’t have a conclusion.”</p> <p dir="ltr">Anyone with any information about Théo’s disappearance is urged to contact the <a href="https://www.looking4theo.com/" target="_blank" rel="noopener">Looking4Theo</a> website or Crimestoppers directly.</p> <p><span id="docs-internal-guid-ad7e7ccc-7fff-16f4-0fe0-17ef85750e17"></span></p> <p dir="ltr"><em>Image: Looking4Theo</em></p>

Legal

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Why you should never give up hope of finding love later in life

<p dir="ltr">A lot of people think they may be either too young or too old for love.</p> <p dir="ltr">Love is love and it happens at the right time, right?</p> <p dir="ltr">Helen Fisher, senior research fellow at the Kinsey Institute in Indiana, as well as a biological anthropologist and self-help author, says that love later on in life should be celebrated. </p> <p dir="ltr">She explains that the brain pathways connected to intense romantic love are exactly the same “whether you are two-and-a-half or 92-and-a-half”, but that one of the great advantages of finding love later in life is that more mature people have a better sense of what they want and need – and how best to ask for it.</p> <p dir="ltr">Using herself as an example, Fisher – who is in her 70s and is organising her first wedding – says there is “beauty” in how she and her partner came to an agreement.</p> <p dir="ltr">The lovers had an agreed living situation in separate homes in New York City and would agree on spending time together. </p> <p dir="ltr">She explained that this agreement had brought them closer together and she would not change it even after saying “I do”.</p> <p dir="ltr">"The beauty of older people is that they can build the kind of partnerships that they want,” she told <a href="https://www.aarp.org/home-family/friends-family/info-2020/later-life-relationships.html" target="_blank" rel="noopener">AARP</a>.</p> <p dir="ltr">“It's not this cookie-cutter thing.”</p> <p dir="ltr">On the other hand, it is expected to be challenging and even difficult bringing someone new into your life. </p> <p dir="ltr">Psychoanalyst Polly Young-Eisendrath explains that the difficulty arises because each person already has their own life.</p> <p dir="ltr">“Be aware that you need to cultivate this relationship freshly,” she says. </p> <p dir="ltr">“Show up with each other's tribe; get to know each other's history and children."</p> <p dir="ltr"><em>Image: Shutterstock</em></p>

Relationships

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Hope Gap shows what can happen when a marriage ends

<p>A couple's visit with their son in the quaint seaside town of Seaford in England, takes a dramatic turn when the father tells him he plans on leaving his mother.</p> <p><span>As well-trodden as this subject might be, there’s still something terribly compelling about watching the end of a marriage play out on screen. Annette Bening plays the woman whose life crumbles as her husband leaves her and Bill Nighy plays the husband. </span>Josh O'Connor plays the couple's son.</p> <p>This drama is tastefully restrained to a fault in a particularly British manner. Veteran screenwriter William Nicholson, a two-time Oscar nominee, based the film on his Tony-nominated play <em>The Retreat from Moscow</em> – shows his talents here.</p> <p><iframe width="560" height="315" src="https://www.youtube.com/embed/oAP1fA-bp5k" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen=""></iframe></p> <p>The title of the film was inspired by Napoleon’s invasion of—and messy withdrawal from—the Russian city, a subject which fascinates Nighy’s character and serves as an obvious metaphor for the destruction of his own marriage.</p> <p><span>It’s obvious we have all the makings of a genuine story here in </span><em>Hope Gap</em><span> but some reviewers have said the film doesn't have the emotional depth for the areas being covered. </span></p> <p><span>As well, Annette Bening has come in for some criticism about her ill</span>-fitting British accent. But there are glimmers of insight along the way, particularly in how Grace (Bening’s character) compares a divorce to a murder and how spurned women are devalued in comparison with widows.</p> <p>Throughout the story, we're served up some stunning coastal vistas from Seaford which is close to Brighton in southern England. <em>Hope Gap</em> is worth it if just for these vistas and the great performances from Nighy and Bening.</p> <p><em><strong>Hope Gap</strong></em><strong> is streaming now on Amazon Prime.</strong></p> <p><em>Photo: Amazon Prime</em></p>

Movies

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Glimmer of hope: World reacts to Federer's sad news

<p>Swiss tennis legend Roger Federer has posted a new video to his Instagram account giving his legions of fans an update as to his health status.</p> <p>“I will be on crutches for many weeks and out of the game for many months,” the 20-time Grand Slam title winner said.</p> <p>But in even sadder news, many sports commentators are now asking whether we’ll ever see Federer playing competitively again – given that the Swiss star is now 40 and the knee surgery will take him out of the sport for “many months.”</p> <p>Federer's decision immediately rules him out of the US Open, where he has been champion five times and which starts in two weeks.</p> <blockquote style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" class="instagram-media" data-instgrm-permalink="https://www.instagram.com/tv/CSmtPCfIl66/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="13"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"></div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"></div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"></div> </div> </div> <div style="padding: 19% 0;"></div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"></div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" rel="noopener" href="https://www.instagram.com/tv/CSmtPCfIl66/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank">A post shared by Roger Federer (@rogerfederer)</a></p> </div> </blockquote> <p>“I’ve been doing a lot of checks with the doctors on my knee ... I hurt myself further during the grass-court season and it’s just not the way to go forward,” Federer added.</p> <p>“They told me ... to feel better I’ll need surgery. I decided to do it.</p> <p>“I want to give myself a glimmer of hope to return to the tour in some shape or form.</p> <p>“I am realistic, don’t get me wrong. I know how difficult it is at my age to go through another surgery. I will try it. I want to be healthy, I want to be running around.”</p> <p>Federer, who has played just 13 matches in 2021, underwent two knee surgeries in 2020. He had already pulled out of the Tokyo Olympics to rest his knee.</p> <p><em>Photo: Getty Images</em></p>

Caring

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New study offers hope to those with motor neurone disease

<p><span style="font-weight: 400;">Motor neurone disease, also called amyotrophic lateral sclerosis (ALS), is a rare condition that slowly kills off nerve cells in the brain and spine, leading to paralysis and eventually death.</span></p> <p><span style="font-weight: 400;">Though currently incurable, </span><a rel="noopener" href="https://academic.oup.com/braincomms/article/3/3/fcab166/6340444" target="_blank"><span style="font-weight: 400;">a new study</span></a><span style="font-weight: 400;"> may have brought us closer to finding one.</span></p> <p><span style="font-weight: 400;">Scientists have taken lab samples of one form of ALS and been able to reverse one of the hallmark biological abnormalities the disease introduces in cells.</span></p> <p><span style="font-weight: 400;">Although this is yet to be applied in other forms of the disease or in human beings, the finding represents a large step forward in understanding how ALS could be combatted, providing some hope that the disease could one day be beaten.</span></p> <p><strong>What the study found</strong></p> <p><span style="font-weight: 400;">The researchers found that three RNA binding proteins, which help regulate RNA, get stuck in the wrong place for most people with ALS.</span></p> <p><span style="font-weight: 400;">Instead of staying in the motor neuron nucleus, they end up in the surrounding cytoplasm.</span></p> <p><span style="font-weight: 400;">The team then found that blocking a particular enzyme, called VCP, was able to reverse this in their human cell samples and return the distribution of RNA binding proteins in the nucleus and cytoplasm back to normal.</span></p> <p><span style="font-weight: 400;">According to the scientists, this suggests that this enzyme becomes mutated and overactive in some cases of ALS.</span></p> <p><span style="font-weight: 400;">“Demonstrating proof-of-concept for how a chemical can reverse one of the key hallmarks of ALS is incredibly exciting,” said Jasmine Harley, a neuroscientist from the Francis Crick Institute in the UK.</span></p> <p><span style="font-weight: 400;">“We showed this worked on three key RNA binding proteins, which is important as it suggests it could work on other disease phenotypes too.”</span></p> <p><span style="font-weight: 400;">The drug they used to inhibit the enzyme is also being tested in cancer trials, which could speed up its development and availability if it is found to help cancer patients and ALS patients.</span></p> <p><span style="font-weight: 400;">In a second study, published in the journal </span><em><a rel="noopener" href="https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab078/6164957" target="_blank"><span style="font-weight: 400;">Brain</span></a></em><span style="font-weight: 400;">, the same researchers found over 100 types of RNA fragments, called intron-retaining transcripts, which can also move from the nucleus of cells into the cytoplasm in ALS cases.</span></p> <p><span style="font-weight: 400;">The researchers found that these fragments have sequences that bind to the RNA binding proteins, and they suspect these sequences are drawing the proteins out of the nucleus and into the cytoplasm.</span></p> <p><img style="width: 0px; height: 0px;" src="/nothing.jpg" alt="" data-udi="umb://media/1f84fdb6755a48e884e50245585f3db4" /><img style="width: 500px; height: 433.3333333333333px;" src="https://oversixtydev.blob.core.windows.net/media/7843072/gettyimages-1129371731.jpg" alt="" data-udi="umb://media/1f84fdb6755a48e884e50245585f3db4" /></p> <p><em><span style="font-weight: 400;">Image: Getty Images</span></em></p> <p><span style="font-weight: 400;">“To imagine what’s going on here we can consider watching a movie at the cinema,” neuroscientist Jacob Neeves explained.</span></p> <p><span style="font-weight: 400;">“Typically, we don’t expect to see adverts throughout the film, but, if something goes wrong these ads might start cropping up at odd and unexpected points. These retained introns are a little bit like these abnormal ad breaks.”</span></p> <p><strong>Why this matters</strong></p> <p><span style="font-weight: 400;">Though only 1-2 percent of ALS cases have the mutated enzyme the scientists found in the first study, both pieces of research add to our understanding of motor neurone disease.</span></p> <p><span style="font-weight: 400;">This additional information offers new hope that scientists could eventually figure out how to undo some of the damage that the disease causes to the brain and nervous system.</span></p> <p><span style="font-weight: 400;">“More research is needed to investigate this further,” Harley said. “We need to see if this might reverse other pathological hallmarks of ALS and also, in other ALS disease models.”</span></p>

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