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"What a legend": Michael J Fox receives emotional standing ovation

<p>Michael J Fox, who has Parkinson's disease, made a surprise appearance at the BAFTA Awards in London. </p> <p><em>The Back to the Future</em> actor came onstage in a wheelchair, but he insisted on standing up at the podium to present the Best Film award. </p> <p>The star-studded audience all rose to their feet and gave the actor a standing ovation.  </p> <p>When presenting the award, Fox described cinema as "magic" which can "change your life".</p> <p>"Five films were nominated in this category tonight and all five have something in common. They are the best of what we do," he said. </p> <p>He added that films can bring people together "no matter who you are or where you're from".</p> <p>"There's a reason why they say movies are magic because movies can change your day.</p> <p>"It can change your outlook. Sometimes it can change your life."</p> <p>Fox, who was diagnosed with Parkinson's in the 1990s, rarely makes public appearances. </p> <p>Many fans were pleasantly surprised at his appearance as he presented the night’s biggest award, Best Film, to <em>Oppenheimer</em>.</p> <p>"I was in tears the moment Michael J Fox came on the stage," one fan wrote on X, formerly known as Twitter.</p> <p>"THE MAN IS A LEGEND"</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">i was in tears the moment Michael J Fox came on the stage 😥😥😥</p> <p>THE MAN IS A LEGEND <a href="https://twitter.com/hashtag/BAFTAs?src=hash&amp;ref_src=twsrc%5Etfw">#BAFTAs</a> <a href="https://twitter.com/hashtag/BAFTA2024?src=hash&amp;ref_src=twsrc%5Etfw">#BAFTA2024</a> <a href="https://twitter.com/hashtag/EEBAFTAs?src=hash&amp;ref_src=twsrc%5Etfw">#EEBAFTAs</a> <a href="https://t.co/Uud368S9gb">pic.twitter.com/Uud368S9gb</a></p> <p>— RanaJi🏹 (@RanaTells) <a href="https://twitter.com/RanaTells/status/1759323180060299726?ref_src=twsrc%5Etfw">February 18, 2024</a></p></blockquote> <p>"Michael J Fox. Absolute hero. What a legend," wrote another. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Michael J Fox. Absolute hero. What a legend. <a href="https://twitter.com/hashtag/BAFTAs?src=hash&amp;ref_src=twsrc%5Etfw">#BAFTAs</a> <a href="https://t.co/62lxpCy3mn">pic.twitter.com/62lxpCy3mn</a></p> <p>— Jules 🌼 (@JulesItsjules) <a href="https://twitter.com/JulesItsjules/status/1759320058583568638?ref_src=twsrc%5Etfw">February 18, 2024</a></p></blockquote> <p>"All those stars in the room, and still the biggest and most affectionate reaction is for Michael J Fox, because the man is a legend," added a third. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">All those stars in the room, and still the biggest and most affectionate reaction is for Michael J Fox, because the man is a legend. <a href="https://twitter.com/hashtag/EEBAFTAs?src=hash&amp;ref_src=twsrc%5Etfw">#EEBAFTAs</a></p> <p>— Declan Cashin (@Tweet_Dec) <a href="https://twitter.com/Tweet_Dec/status/1759319831696855281?ref_src=twsrc%5Etfw">February 18, 2024</a></p></blockquote> <p>"He's a total legend and wonderful human," wrote a fourth. </p> <p>The actor has spoken <a href="https://www.oversixty.com.au/health/caring/i-m-not-gonna-be-80-michael-j-fox-s-tragic-admission" target="_blank" rel="noopener">candidly</a> about his experience with Parkinson's over the years, and has said that he has made peace with the degenerative nature of the disease. </p> <p>In a previous interview with AARP magazine profile, the actor admitted that he did not fear death. </p> <p>“I am genuinely a happy guy. I don’t have a morbid thought in my head — I don’t fear death. At all," he told the publication. </p> <p><em>Images: Getty</em></p>

TV

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"Devastating blow": Back to the Future star's tragic family news

<p><em>Back to the Future </em>star Lea Thompson, renowned for her role as Lorraine, the endearing mother of Michael J. Fox's iconic character, Marty McFly, has recently shared some deeply saddening family news.</p> <p>The 62-year-old actress opened up about her personal struggle, revealing that both of her older brothers have been diagnosed with Parkinson's disease within a few months of each other.</p> <p>This announcement resonated profoundly with her fans and followers, especially given Michael J. Fox's well-known battle with the condition since his diagnosis in 1991 at the tender age of 29.</p> <p>In an emotionally charged Instagram post, Thompson shared her family's ordeal, writing, "Both of my beloved exceptional big brothers have been diagnosed with Parkinson’s within a few months of each other. It was such a devastating blow."</p> <p>She went on to describe how the disease had stealthily crept into their lives, noting that her brothers had been displaying signs of slowing down, but the true nature of their condition hadn't been immediately apparent.</p> <p>Fortunately, their early diagnosis, made possible by the diligent efforts of researchers supported by the Michael J. Fox Foundation, has offered them access to medications and tools that have significantly improved their quality of life.</p> <p>Accompanying her heartfelt message, Thompson posted pictures of herself with her two brothers during a day of golf, capturing a precious family moment. Another poignant photo showed her brothers with their arms wrapped around each other.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/Cyz8bCxO9GF/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/Cyz8bCxO9GF/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Lea Thompson (@lea_thompson)</a></p> </div> </blockquote> <p>Thompson's dedication to raising awareness and support for Parkinson's research was evident when she expressed feeling "honoured" to be part of a "public service announcement" for the Michael J. Fox Foundation's gala, sharing a behind-the-scenes photo from the campaign. She also expressed gratitude for the support of scientists, philanthropists, and her "movie son", Michael J. Fox, who has been an unwavering advocate for Parkinson's research.</p> <p>The response from Thompson's fans and followers was heartwarming, as they flocked to the comments section to express their solidarity. Messages of love, hope and empathy poured in from all corners, with many sharing personal connections to Parkinson's disease and the advances in treatment and therapies they have witnessed.</p> <p>Parkinson's disease is a debilitating neurodegenerative condition, and it is the second most common neurological disorder in Australia, with over 100,000 Australians grappling with its impact. Common symptoms include tremors, slowness of movement, and rigidity.</p> <p>Michael J. Fox's diagnosis at the astonishingly young age of 29 stands as a stark reminder of the disease's unpredictable reach, as the average age of diagnosis hovers around 65.</p> <p>Parkinson's disease results from the brain's inability to produce sufficient dopamine, a neurotransmitter vital for controlling movement. Diagnosing Parkinson's is not straightforward; it often relies on clinical evaluation by specialists such as neurologists, who meticulously assess clinical signs and symptoms, as there are no definitive laboratory tests like blood work or brain scans available for diagnosis.</p> <p>Lea Thompson's open acknowledgment of her family's struggle with Parkinson's disease not only shines a light on the challenges faced by those living with the condition but also underscores the importance of continued research and support for those affected. </p> <p><em>Images: Instagram</em></p>

Caring

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Paul McCartney’s unusual relationship with Michael Parkinson

<p>Paul McCartney has paid tribute to Michael Parkinson, calling him a “great guy” and a “good friend” in a lengthy and heartfelt post on social media.</p> <p>The iconic interviewer passed away peacefully at home on August 16th after a battle with a brief illness according to a statement from his family.</p> <p>After his death, a flood of tributes poured in from celebrities around the world, including The Beatles frontman Paul McCartney.</p> <p>Parkinson was a personal friend of McCartney’s, as the pair even appeared on a famous album cover together.</p> <blockquote class="twitter-tweet"> <p>I first met Michael Parkinson in Liverpool when he and his team came to see us at the Cavern Club. He was a very likeable guy and we eventually did our first TV performances with Granada in Manchester, where Michael worked.</p> <p>Through the years I got to know him more and more, and… <a href="https://t.co/o0fMiXsWwN">pic.twitter.com/o0fMiXsWwN</a></p> <p>— Paul McCartney (@PaulMcCartney) <a href="https://twitter.com/PaulMcCartney/status/1692969489980063890?ref_src=twsrc%5Etfw">August 19, 2023</a></p></blockquote> <p>The two feature on the album cover of Wings‘ coveted "<em>Band On The Run</em>" record as escaped convicts, with Parkinson agreeing to appear on the cover if McCartney would return the favour by being a guest on his chat show.</p> <p>Taking to Twitter on Saturday, McCartney remembered his friend, writing, “I first met Michael Parkinson in Liverpool when he and his team came to see us at the Cavern Club. He was a very likeable guy and we eventually did our first TV performances with Granada in Manchester, where Michael worked.”</p> <p>“Through the years I got to know him more and more, and appeared on his chat show quite a few times. He was a pleasure to talk to and we always had fun. He appeared on the front cover of ‘<em>Band on the Run</em>’ as one of the escaping convicts in the title song. He was very knowledgeable about many subjects and a keen sports-lover.”</p> <p>He added, “I will miss him personally, as a good friend. I send all my love to his family and friends. Cheers Michael, you’re a great guy okay!”</p> <p><em>Image credits: Paul McCartney / Twitter (X)</em></p>

Music

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"One of the greats": Elton John's stirring tribute to Michael Parkinson

<p>The entertainment world has been cast into a somber veil of mourning as it bids farewell to the iconic Michael Parkinson, the legendary interviewer who has left us at the age of 88.</p> <p>Elton John, David Attenborough, Michael Caine, Eric Idle ...the long list of luminaries who have joined the chorus of heartfelt tributes to the "TV titan" and the undisputed "king of the chat show" seems limitless.</p> <p>The poignant words of Oscar-winning Michael Caine resonate with a sense of irreparable loss: “Michael Parkinson was irreplaceable," he wrote. "He was charming, always wanted to have a good laugh. He brought the best of everyone he met. Always looked forward to be interviewed by him.”</p> <p>David Attenborough's reflection on his interactions with the man affectionately known as "Parky" evokes a sense of melancholic nostalgia: “He was extremely generous, he wanted you to shine and would always laugh at your jokes and give you an opportunity to make them sound funnier than in fact they were. It was always friendly, it was always thorough, it was always intelligent, it was always a pleasure to do it and I think that came over no matter who his interviewee was.”</p> <p>Elton John said Parkinson was “a TV legend who was one of the greats. I loved his company and his incredible knowledge of cricket and Barnsley Football Club. A real icon who brought out the very best in his guests. Condolences and love to Mary and his family."</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CwC4JoBMmKq/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/CwC4JoBMmKq/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Elton John (@eltonjohn)</a></p> </div> </blockquote> <p>The reminiscences continue, with Stephen Fry's words dripping with a bittersweet tone, saying that being interviewed by Parkinson was an experience of impossibly intense thrill.</p> <p>“The genius of Parky was that (unlike most people (and most of his guests, me included) he was always 100 per cent himself. On camera and off. ‘Authentic’ is the word I suppose,” he wrote. “For one of the shows I was on with Robin Williams, a genius of unimaginable comic speed and brilliance. Now they’re both gone.</p> <p>“One should get used to the parade of people constantly falling off the edge, but frankly one doesn’t. So long #parky.”</p> <p>The poignant announcement of the loss came from Parkinson's family. “After a brief illness Sir Michael Parkinson passed away peacefully at home last night in the company of his family,” the statement read.</p> <p>“The family request that they are given privacy and time to grieve.”</p> <p>The memories flood in as the recollection of Parkinson's rise to prominence in the 1970s fills the air with a sense of wistfulness. His list of more than 2000 interviewees includes luminaries such as Sir Billy Connolly, Muhammad Ali, Prince Philip, Sir Elton John, Madonna, and Paul McCartney.</p> <p>Four-time guest Muhammad Ali's absence echoes through time as Parkinson's voice emerges: “When people ask me who I most enjoyed interviewing, I’m unable to give them an answer”, Parkinson once said in an interview. “If they ask me who was the most remarkable man I ever met, I answer without hesitation – Muhammad Ali. I interviewed him four times – I lost on every occasion.”</p> <p>These titanic verbal sparring matches stand as poignant testimonies of the show's indelible legacy, underscoring their magnetic effect on millions of viewers.</p> <p>Among the program's other poignant moments, the chaos induced by Rod Hull's puppet Emu assaulting Parkinson on his own talk show couch remains etched in memory. Parkinson jestingly admitted that his career would forever be epitomised by "that bloody bird".</p> <p><em>Images: Getty / BBC 1</em></p>

Caring

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Here’s how a new AI tool may predict early signs of Parkinson’s disease

<p>In 1991, the world was shocked to learn actor <a href="https://www.theguardian.com/film/2023/jan/31/still-a-michael-j-fox-movie-parkinsons-back-to-the-future">Michael J. Fox</a> had been diagnosed with Parkinson’s disease. </p> <p>He was just 29 years old and at the height of Hollywood fame, a year after the release of the blockbuster <em>Back to the Future III</em>. This week, documentary <em><a href="https://www.imdb.com/title/tt19853258/">Still: A Michael J. Fox Movie</a></em> will be released. It features interviews with Fox, his friends, family and experts. </p> <p>Parkinson’s is a debilitating neurological disease characterised by <a href="https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055">motor symptoms</a> including slow movement, body tremors, muscle stiffness, and reduced balance. Fox has already <a href="https://www.cbsnews.com/video/michael-j-fox-on-parkinsons-and-maintaining-optimism">broken</a> his arms, elbows, face and hand from multiple falls. </p> <p>It is not genetic, has no specific test and cannot be accurately diagnosed before motor symptoms appear. Its cause is still <a href="https://www.apdaparkinson.org/what-is-parkinsons/causes/">unknown</a>, although Fox is among those who thinks <a href="https://www.cbsnews.com/video/michael-j-fox-on-parkinsons-and-maintaining-optimism">chemical exposure may play a central role</a>, speculating that “genetics loads the gun and environment pulls the trigger”.</p> <p>In research published today in <a href="https://pubs.acs.org/doi/10.1021/acscentsci.2c01468">ACS Central Science</a>, we built an artificial intelligence (AI) tool that can predict Parkinson’s disease with up to 96% accuracy and up to 15 years before a clinical diagnosis based on the analysis of chemicals in blood. </p> <p>While this AI tool showed promise for accurate early diagnosis, it also revealed chemicals that were strongly linked to a correct prediction.</p> <h2>More common than ever</h2> <p>Parkinson’s is the world’s <a href="https://www.who.int/news-room/fact-sheets/detail/parkinson-disease">fastest growing neurological disease</a> with <a href="https://shakeitup.org.au/understanding-parkinsons/">38 Australians</a>diagnosed every day.</p> <p>For people over 50, the chance of developing Parkinson’s is <a href="https://www.parkinsonsact.org.au/statistics-about-parkinsons/">higher than many cancers</a> including breast, colorectal, ovarian and pancreatic cancer.</p> <p>Symptoms such as <a href="https://www.apdaparkinson.org/what-is-parkinsons/symptoms/#nonmotor">depression, loss of smell and sleep problems</a> can predate clinical movement or cognitive symptoms by decades. </p> <p>However, the prevalence of such symptoms in many other medical conditions means early signs of Parkinson’s disease can be overlooked and the condition may be mismanaged, contributing to increased hospitalisation rates and ineffective treatment strategies.</p> <h2>Our research</h2> <p>At UNSW we collaborated with experts from Boston University to build an AI tool that can analyse mass spectrometry datasets (a <a href="https://www.sciencedirect.com/topics/neuroscience/mass-spectrometry">technique</a> that detects chemicals) from blood samples.</p> <p>For this study, we looked at the Spanish <a href="https://epic.iarc.fr/">European Prospective Investigation into Cancer and Nutrition</a> (EPIC) study which involved over 41,000 participants. About 90 of them developed Parkinson’s within 15 years. </p> <p>To train the AI model we used a <a href="https://www.nature.com/articles/s41531-021-00216-4">subset of data</a> consisting of a random selection of 39 participants who later developed Parkinson’s. They were matched to 39 control participants who did not. The AI tool was given blood data from participants, all of whom were healthy at the time of blood donation. This meant the blood could provide early signs of the disease. </p> <p>Drawing on blood data from the EPIC study, the AI tool was then used to conduct 100 “experiments” and we assessed the accuracy of 100 different models for predicting Parkinson’s. </p> <p>Overall, AI could detect Parkinson’s disease with up to 96% accuracy. The AI tool was also used to help us identify which chemicals or metabolites were likely linked to those who later developed the disease.</p> <h2>Key metabolites</h2> <p>Metabolites are chemicals produced or used as the body digests and breaks down things like food, drugs, and other substances from environmental exposure. </p> <p>Our bodies can contain thousands of metabolites and their concentrations can differ significantly between healthy people and those affected by disease.</p> <p>Our research identified a chemical, likely a triterpenoid, as a key metabolite that could prevent Parkinson’s disease. It was found the abundance of triterpenoid was lower in the blood of those who developed Parkinson’s compared to those who did not.</p> <p>Triterpenoids are known <a href="https://www.sciencedirect.com/topics/neuroscience/neuroprotection">neuroprotectants</a> that can regulate <a href="https://onlinelibrary.wiley.com/doi/10.1002/ana.10483">oxidative stress</a> – a leading factor implicated in Parkinson’s disease – and prevent cell death in the brain. Many foods such as <a href="https://link.springer.com/article/10.1007/s11101-012-9241-9#Sec3">apples and tomatoes</a> are rich sources of triterpenoids.</p> <p>A synthetic chemical (a <a href="https://www.cdc.gov/biomonitoring/PFAS_FactSheet.html">polyfluorinated alkyl substance</a>) was also linked as something that might increase the risk of the disease. This chemical was found in higher abundances in those who later developed Parkinson’s. </p> <p>More research using different methods and looking at larger populations is needed to further validate these results.</p> <h2>A high financial and personal burden</h2> <p>Every year in Australia, the average person with Parkinson’s spends over <a href="https://www.hindawi.com/journals/pd/2017/5932675/">A$14,000</a>in out-of-pocket medical costs.</p> <p>The burden of living with the disease can be intolerable.</p> <p>Fox acknowledges the disease can be a “nightmare” and a “living hell”, but he has also found that “<a href="https://www.cbsnews.com/video/michael-j-fox-on-parkinsons-and-maintaining-optimism">with gratitude, optimism is sustainable</a>”. </p> <p>As researchers, we find hope in the potential use of AI technologies to improve patient quality of life and reduce health-care costs by accurately detecting diseases early.</p> <p>We are excited for the research community to try our AI tool, which is <a href="https://github.com/CRANK-MS/CRANK-MS">publicly available</a>.</p> <p><em>This research was performed with Mr Chonghua Xue and A/Prof Vijaya Kolachalama (Boston University).</em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/heres-how-a-new-ai-tool-may-predict-early-signs-of-parkinsons-disease-205221" target="_blank" rel="noopener">The Conversation</a>. </em></p>

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“I’m not gonna be 80": Michael J. Fox's tragic admission

<p>Beloved actor Michael J. Fox is acknowledging how difficult his more than 30-year battle with Parkinson’s disease has become.</p> <p>“I’m not gonna be 80,” the Back to the Future star said in a preview for an upcoming episode of the American current affairs program <em>CBS Sunday Mornin</em>g, according to <em>Page Six</em>.</p> <p>In the clip, Journalist Jane Pauley tells Fox that he has “not squandered” but that his condition will eventually “make the call” as to when it’s his time to go.</p> <p>“Yeah, it’s, it’s banging on the door,” the actor said.</p> <p>“I’m not gonna lie. It’s gettin’ hard, it’s gettin’ harder. It’s gettin’ tougher. Every day it’s tougher.”</p> <p>Fox revealed that he had surgery to remove a benign tumour on his spine, but the procedure “messed up” his walking and so he started to “break” other parts of his body, including his arm, elbow, face and hand.</p> <p>He added that the “big killer” of Parkinson’s disease is “falling” and can also be “aspirating food and getting pneumonia”, pointing out that it is “all these subtle ways that gets you.”</p> <p>You don’t die from Parkinson’s. You die with Parkinson’s,” he said. “So – so I’ve been – I’ve been thinking about the mortality of it.”</p> <p>The actor was diagnosed with the brain disorder at just 29. He has since become a leading advocate for research on the condition, with the launch of the Michael J. Fox Foundation in 2000 to help educate the public and fund studies.</p> <p>He has previously revealed that he does not fear death.</p> <p>“I’m really blunt with people about cures. When they ask me if I will be relieved of Parkinson’s in my lifetime, I say, ‘I’m 60 years old, and science is hard. So, no,’” he admitted in an AARP magazine profile in December 2021.</p> <p>“I am genuinely a happy guy. I don’t have a morbid thought in my head — I don’t fear death. At all.”</p> <p><em>Image credit: Instagram</em></p>

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“Game-changer”: Michael J Fox shares huge medical news

<p dir="ltr">Michael J Fox has shared news of a medical breakthrough into Parkinson’s disease.</p> <p dir="ltr">The 61-year-old – who was diagnosed with the disease in 1991 – was thrilled to share the news, despite suffering a “terrible year”.</p> <p dir="ltr">Fox told <a href="https://www.statnews.com/2023/04/12/michael-j-fox-parkinsons-biomarker/" target="_blank" rel="noopener"><em>Stat News</em></a> that he had broken multiple bones after a fall, including some in his hand and face, but has said that in some ways he is “feeling better”.</p> <p dir="ltr">Despite his own personal battle, the <em>Back to the Future</em> star was overjoyed to share the breakthrough in Parkinson’s research.</p> <p dir="ltr">The study – funded by Fox’s charity organisation that aims to find a cure for Parkinson’s – found that a key Parkinson's pathology can now be identified by examining spinal fluid from living patients, allowing earlier intervention.</p> <p dir="ltr">“It’s all changed. It can be known and treated early on. It’s huge,” he said</p> <p dir="ltr">“This is the thing. This is the big reward. This is the big trophy.”</p> <p dir="ltr">The findings, published in <em>The Lancet Neurology</em>, are the result of a 1,123-person study that Fox’s foundation has put hundreds of millions of dollars into since it began in 2010.</p> <p dir="ltr">An editorial in the medical journal has also called this research “a game-changer in Parkinson’s disease diagnostics, research, and treatment trials”.</p> <p dir="ltr">In late 2022 the actor opened up about his struggle with Parkinson’s in his emotional acceptance speech for the <a href="https://www.oversixty.co.nz/health/caring/michael-j-fox-reveals-more-details-about-his-struggle-with-parkinson-s" target="_blank" rel="noopener">Jean Hershel Humanitarian Award</a>.</p> <p dir="ltr">In the speech he said that the hardest part “was grappling with the certainty of the diagnosis and the uncertainty of the situation,” but has since felt relieved after an “outpouring of support” from the public and his peers.</p> <p><em>Image: Frazer Harrison for Getty Images</em></p>

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"The beat goes on": Neil Diamond opens up about life with Parkinson’s

<p>Neil Diamond has opened up about his experience living with Parkinson’s, and how it has taken a long and uphill battle to come to terms with his 2018 diagnosis. </p> <p>In a candid interview with Anthony Mason for <em>CBS Sunday Morning</em>, the 82-year-old singer - best known for his hit song ‘Sweet Caroline’ - detailed how he moved from denial to acceptance, and the impact it has had on his life and his career ever since.</p> <p>“When the doctor told me what it was, I was just not ready to accept it,” he said. “I said, ‘oh, okay, I’ll see you whenever you want to see me, but I have work to do, so I’ll see you later’.”</p> <p>For “the first year or two”, Diamond admits he refused to accept his condition,  but as acceptance finally came to him, so did a sort of calm and peace of mind</p> <p>“I think this has just been in the last few weeks,” he explained to Mason, “but somehow, a calm has moved in and the hurricane of my life, and things have gotten very quiet.</p> <p>“And I like it. I find that I like myself better. I’m easier on people. I’m easier on myself and the beat goes on and it will go on long after I’m gone.”</p> <p>He went on to note his understanding that “this is the hand that God’s given”, and how his only option was “to make the best of it”.</p> <p>“There’s no cure, there’s no getting away from it. You can’t just say ‘okay, enough already, let’s get back to life’. It doesn’t work like that,” he said. </p> <p>“But I’ve come to accept what limitations I have and still have great days.”</p> <p>And while Diamond retired from touring in 2018 in the wake of his diagnosis, he can still find those great days in music, with his life playing out in the musical A Beautiful Noise: The Neil Diamond Musical on Broadway.</p> <p>As for how it feels to see his story performed on the stage, he admits that initially it was difficult, and that he felt some embarrassment, before going on to add that he “was flattered, and I was scared. </p> <p>“Being found out is the scariest thing you can hope for because we all have a facade. And the truth be known to all of them. I’m not some big star - I’m just me.”</p> <p>“The show is part of my psychotherapy,” he explained, “and it hurt.”</p> <p>On opening night, Diamond even returned to the stage for a singalong performance of ‘Sweet Caroline’, and as he told Mason, “I can still sing. I’ve been doing it for 50 years and I enjoy it. It’s like all the systems of my mind and my body are working as one.</p> <p>“I’ve had a pretty amazing life, it’s true.”</p> <p><em>Images: Getty</em></p>

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Michael J Fox reveals more details about his struggle with Parkinson's

<p>Michael J. Fox has delivered an emotional and heartfelt speech, during which he recalled keeping his life-changing Parkinson’s diagnosis a secret, in fear it would impact his career.</p> <p>The famed actor was diagnosed with the disorder in 1991, at only 29 years old. It wasn’t until seven years after that he made public his health battle.</p> <p>As he accepted the Jean Hershel Humanitarian Award (an honorary Oscar recognising his philanthropic efforts), Fox said the “uncertainty” of his condition caused him to stay silent the entire time.</p> <p>"I was told I only had 10 years left to work. That was s---ty. That's what happened," he told the crowd, as per People magazine. "The hardest part of my diagnosis was grappling with the certainty of the diagnosis and the uncertainty of the situation. I only knew it would get worse. The diagnosis was definite, the progress was indefinite and uncertain."</p> <p>"Then I entered into seven years of denial, trying to make sense of it all," he recalled. "The kid who left Canada convinced that he would make anything happen, at least by working hard and by believing, now had a tall order in front of him.” He said he told "very few people" about his diagnosis and they all kept his "secret".</p> <p>"Then there were all kinds of doctors who helped me understand the physical processes that were at work, or not at work, in my brain, as the case may be," he shared. "Finally, I felt like I needed to tell everybody. I understood it would have a huge impact on my career."</p> <p>Fox eventually spoke about his diagnosis with American journalist Barbara Walters and the aftermath of the intimate interview surprised him.</p> <p>"What happened next was remarkable," he remembered. "The outpouring of support from the public at large, the beautiful reaction from all of my peers in the entertainment business, all of you, thank you, and the people that I worked with, was transformative."</p> <p><em>Images: Getty </em></p>

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COVID-19 has similar effect on brain as Parkinson’s disease

<p dir="ltr">A new study from the University of Queensland has found that being infected with COVID-19 can trigger a similar reaction in the brain to Parkinson’s disease - and they have identified a possible treatment to stop Covid’s impact on the brain in its tracks.</p> <p dir="ltr">A growing number of reports have found that Covid affects more than just our lungs, with several studies finding up to 85 percent of people with Covid, including severe, mild and asymptomatic infections, have neurological complications from being infected with the virus.</p> <p dir="ltr">This can show up in a variety of symptoms, such as headaches, dizziness, confusion, seizures, and change in mood, including depression and anxiety.</p> <p dir="ltr">The team of scientists has discovered that the virus can cause inflammation in the brain, which could make people more vulnerable to developing Parkinson's and other similar conditions.</p> <p dir="ltr">“We studied the effect of the virus on the brain’s immune cells, ‘microglia’ which are the key cells involved in the progression of brain diseases like Parkinson’s and Alzheimer’s,” Professor Woodruff said.</p> <p dir="ltr">“Our team grew human microglia in the laboratory and infected the cells with SARS-CoV-2, the virus that causes COVID-19.</p> <p dir="ltr">“We found the cells effectively became ‘angry’, activating the same pathway that Parkinson’s and Alzheimer’s proteins can activate in disease, the inflammasomes.”</p> <p dir="ltr">Inflammasomes are a kind of complex of proteins that activate inflammatory responses in the body.</p> <p dir="ltr">Dr Albornoz Balmaceda, another of the 33 authors of the study published in <em><a href="https://doi.org/10.1038/s41380-022-01831-0" target="_blank" rel="noopener">Molecular Psychiatry</a></em>, said that triggering this pathway can spark a “fire” in the brain that silently kills neurons over time in a similar way to Parkinson's and Alzheimer’s.</p> <p dir="ltr">“It’s kind of a silent killer, because you don’t see any outward symptoms for many years,” he said.</p> <p dir="ltr">“It may explain why some people who’ve had COVID-19 are more vulnerable to developing neurological symptoms similar to Parkinson’s disease.”</p> <p dir="ltr">They also found that the triggering of the inflammasome pathway was exacerbated in people who were already predisposed to developing Parkinson’s.</p> <p dir="ltr">“So if someone is already predisposed to Parkinson’s, having COVID-19 could be like pouring more fuel on that ‘fire’ in the brain,” Professor Woodruff said.</p> <p dir="ltr">“The same would apply for a predisposition for Alzheimer’s and other dementias that have been linked to inflammasomes.”</p> <p dir="ltr">While the findings are concerning, the team has also found a potential treatment that could stop the inflammation and put out the “fire” in the brain.</p> <p dir="ltr">Using inhibitory drugs developed at the University of Queensland currently being trialled with Parkinson’s patients, they found that inflammasome activation was reduced in comparison to no treatment at all.</p> <p dir="ltr">“We found it successfully blocked the inflammatory pathway activated by COVID-19, essentially putting out the fire,” Dr Balmaceda said.</p> <p dir="ltr">“The drug reduced inflammation in both COVID-19-infected mice and the microglia cells from humans, suggesting a possible treatment approach to prevent neurodegeneration in the future.”</p> <p dir="ltr">As a result, Professor Woodruff said that it means that potential treatments for Covid’s impact on the brain already exist.</p> <p dir="ltr">“Further research is needed, but this is potentially a new approach to treating a virus that could otherwise have untold long-term health ramifications,” he said.</p> <p dir="ltr"><em>Image: Getty Images</em></p>

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Michael J Fox shares sad family news

<p>Michael J Fox has revealed that his mother Phyllis died in late September at age 92. </p> <p>The actor shared the news during his appearance at the 2022 New York Comic Con on Saturday, where he also reunited with his <em>Back to The Future</em> co-star Christopher Lloyd. </p> <p>Michael remembered Phyllis by recalling a funny anecdote about how she thought he was being overworked when he was filming <em>Family Ties</em> in the daytime and <em>Back to the Future</em> at night in the 1980s.</p> <p>He said, "I was 23 years old, and I called her, she was in Canada, and I said, 'They want me to do this Steven Spielberg movie, but I have to do it at night and I have to do <em>Family Ties</em> in the daytime.' And she said, 'You'll be too tired,"' he shared. </p> <p>The 61-year-old star told his mom in response, "I live for this kind of tired. It'll be okay."</p> <p>He then added, "To this day — well, till two weeks ago — my mother thought it was a really bad idea for me to do <em>Back to the Future</em>. She loved the movie, [but she was right], I got tired."</p> <p>During his Comic Con appearance, Michael also updated his fans on how his Parkinson's disease is progressing, and how he remains optimistic despite his ongoing health battle. </p> <p>"Well, in the last year I've broken my cheek, my eye socket, my hand, my elbow … my shoulder. I had a rough year of getting beat up. But that was really cool because it made me realise … with gratitude, it's sustainable," he stated.</p> <p>"If you can find something to be grateful for, if you can find something and say, 'Well, that's good,' … It'll always get better… I'm very optimistic." </p> <p>"I'd say optimism is thinking that things are more likely to get better than they are to get worse. If you believe in that, and you are grateful for it, that'll sustain you the rest of your life," he added.</p> <p><em>Image credits: Getty Images</em></p>

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“I don’t let it dictate who I am”: Billy Connolly opens up on living with Parkinson’s

<p dir="ltr">Billy Connolly has opened up about living with Parkinson’s in a rare interview as he prepares to receive one of the highest accolades from the British Academy of Film and Television Arts (BAFTA) at the awards next week.</p> <p dir="ltr">Connolly will be receiving the BAFTA Fellowship - which is awarded to those who have made outstanding contributions in film, games and television - at the May 8 ceremony.</p> <p dir="ltr">Speaking to <a href="https://www.bafta.org/media-centre/press-releases/sir-billy-connolly-to-be-honoured-with-bafta-fellowship-2022" target="_blank" rel="noopener">Bafta.org</a>, Connolly discussed his neurodegenerative condition and how he doesn’t let it “dictate” his day-to-day life.</p> <p dir="ltr">“It’s really important to work, to draw, to write, to walk silly for your grandchildren,” he said. “Doing the same thing you’ve always done is good for you.</p> <p><span id="docs-internal-guid-64596dfa-7fff-1483-6149-0267844f75f0"></span></p> <p dir="ltr">“I don’t let Parkinson’s dictate who I am - I just get on with it. I’ve had a very successful career and I have no regrets at all.”</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CdGDwIKDgfy/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/CdGDwIKDgfy/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by BAFTA (@bafta)</a></p> </div> </blockquote> <p dir="ltr">Connolly was diagnosed with Parkinson’s in 2013 and retired from live performances in 2018.</p> <p dir="ltr">He still continues to record projects and make TV appearances.</p> <p dir="ltr">Although his extensive filmography has earned him a slew of awards, Connolly revealed that he was never in show-business for the accolades. </p> <p dir="ltr">“I have a collection of shiny things that I’m very proud of. But I never set out to get them or hunt them down,” he said.</p> <p dir="ltr">He added that he was humbled to be receiving the award, which has previously been awarded to David Attenborough, Dawn French, and Jennifer Saunders.</p> <p dir="ltr">“I don’t believe in aiming at it because if you don’t get it for whatever reason you’re all disappointed. Just do what you do well and you’ll find yourself a fellow before you know it.”</p> <p dir="ltr"><span id="docs-internal-guid-58064ccf-7fff-301b-71e4-bafe6798c4cb"></span></p> <p dir="ltr"><em>Image: @bafta (Instagram)</em></p>

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Parkinson’s early warning signs and at-home care options

<p dir="ltr">It’s estimated that out of every 1,000 Australians, <a href="https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/parkinsons-disease" target="_blank" rel="noopener">four</a> will be diagnosed with Parkinson’s disease (or <a href="https://www.nzbri.org/Labs/parkinsons/Epidemiology/#:~:text=The%20number%20of%20people%20with,to%20reach%2022%2C000%20by%202040." target="_blank" rel="noopener">one out of 500 Kiwis</a>), the disorder that targets the nervous system and can cause tremors, poor balance, and even changes to how we speak and write.</p> <p dir="ltr">In Australia, 37 people will hear the words, “You have Parkinson’s” each day, and <a href="https://www.parkinsonsnsw.org.au/world-parkinsons-day/" target="_blank" rel="noopener">World Parkinson’s Day</a>, on April 11, hopes to raise awareness of the incurable condition.</p> <p dir="ltr">Though anyone at any age can be diagnosed, people over the age of 65 are more commonly diagnosed than other age groups.</p> <p dir="ltr">Bob Linton knows this all too well after he was diagnosed at the age of 72.</p> <p dir="ltr">Initially, he and his wife Liz struggled to manage his condition until they connected with Home Instead, one of Australia’s leading in-home care providers, and his new carer, Janine.</p> <p dir="ltr">Now about to celebrate his 75th birthday, Bob has no intention of slowing down and has even picked up his golf clubs again.</p> <p dir="ltr">“Janine has been helping me get to the golfing range and the golf course twice a week. It’s great. I just forget about the Parkinson’s and keep on moving forward,” Bob said.</p> <p dir="ltr">“We do nine holes, and Janine is my caddy. I really enjoy it because I’ve always liked playing golf. I had a stroke three years ago and I find it difficult to walk on my own, but Janine helps me get out and about. Though I’ve lost quite a bit of sight, I just ask Janine, ‘Was it straight? Was it to the right or the left?’ and she gives me the guidance I need. I can’t ask for much more than that. </p> <p dir="ltr">“Janine and I also go for walks, to my medical appointments, and sometimes have lunch out. Life is very, very good. Home Instead has been excellent. We didn’t want to look at any other options because I want to stay living at home.”</p> <p dir="ltr">His wife has also appreciated the difference, and now gets some much-needed time to herself.</p> <p dir="ltr">“Having help from Home Instead is a great arrangement for us – it’s ideal as Bob doesn’t need to go into care and we just feel so comfortable with Janine in our home. Knowing he is being looked after by someone I can trust is so important to us as a family. It’s been wonderful,” Liz said.</p> <p dir="ltr">Though Parkinson’s is treatable with different medications, and sometimes surgery, it’s important to notice the signs early, before they worsen with time.</p> <p dir="ltr">According to the <a href="https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055" target="_blank" rel="noopener">Mayo Clinic</a>, experiencing tremors in your hands or fingers, slowed movement, a stooped posture, impaired balance, or changes to your writing or speech should prompt you to visit your doctor to determine whether it is Parkinson’s or something else entirely.</p> <p><span id="docs-internal-guid-512e78ed-7fff-805e-32f0-df99418a04f3"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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Life-changing infra-red treatment for Parkinson's sufferers

<p><em>Image: 7News</em></p> <p>A new treatment for Parkinson’s disease is set to be trialled in Sydney following reports of positive results using light therapy.</p> <p>Results from a previous light therapy trial in Adelaide published in the<span> </span><em>BMC Neurology</em><span> </span>journal, showed enhanced senses and improved cognition, mood and sleep, mobility, balance, and fine motor skills among patients.</p> <p>The SYMBYX trial conducted with Parkinson’s SA, used the light therapy known as photobiomodulation (PBM) on two small groups of patients, all diagnosed with Parkinson’s disease.</p> <p>The study reports no adverse side effects and that the therapy was “a safe and potentially effective treatment”. Parkinson’s disease is an incurable, progressive neurological illness which effects between 10-15 million people worldwide.</p> <p>It’s the world’s fastest growing neurological disease, with symptoms including tremors, muscle rigidity, difficulty walking and swallowing, loss of smell, depression and anxiety.</p> <p>Caused by a lack of dopamine, a chemical produced by both the brain and the gut to help promote and control body movement, the light therapy treatments work by stimulating dopamine production in the gut.</p> <p>For 75-year-old Parkinson’s sufferer Margaret Jarrett, who has been a participant in medical trials of the infra-red relief, the results have been a welcome relief. She used a laser light device clinically for 12 weeks, and for 40 weeks from home.</p> <p>“I don’t know how it’s happening, but it’s happening and that’s all I care about,” she said.</p> <p>“Some people regained their sense of smell, some people have improved sleep, and some people had improved microbiomes. So, improved gut health,” Parkinson’s SA executive Olivia Nassaris said of the treatment.</p> <p>Those already suffering with Parkinson’s don’t need to wait for the trial results, as there are light therapy products from SYMBYX already available on the market. “It is legal and regulated and it’s available for purchase”, Dr Wayne Markman, CEO of SYMBYX an Australian medical technology company told 7NEWS.</p> <p>Light technology is just the latest in research to support the treatment of Parkinson’s disease.</p>

Mind

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New “miracle” Parkinson’s treatment can be done “anywhere in the world”

<p><span style="font-weight: 400;">World-first technology has opened doors for new treatment of Parkinson’s disease, with the new wireless implants being dubbed a “miracle” by patients.</span></p> <p><span style="font-weight: 400;">Deep Brain Stimulation (DBS) implants reduce the symptoms of Parkinsons, and have required adjusting from a neurologist every time a patient’s condition changes - until now.</span></p> <p><span style="font-weight: 400;">The new technology from neuromodulation company Abbott allows specialists to adjust DBS devices remotely over the internet.</span></p> <p><span style="font-weight: 400;">For 70-year-old Clive Couperthwaite, the first patient to use the new tech as part of a clinical trial last year, the development has put an end to his two-hour commutes for 20-minute adjustments to his implant.</span></p> <p><span style="font-weight: 400;"> “I’m not the patient that lives the furthest away, but it’s a complication to get in [to visit a specialist] … if you live in Longreach or some place out of the city - it’s a major demand, Mr Couperthwaite <a rel="noopener" href="https://www.abc.net.au/news/2021-10-29/qld-remote-brain-function-parkinsons-treatment-breakthrough/100576716" target="_blank">said</a>.</span></p> <p><span style="font-weight: 400;">“When you live so far away from your specialist, it’s anxiety-provoking because what if something goes wrong.</span></p> <p><img style="width: 0px; height:0px;" src="https://oversixtydev.blob.core.windows.net/media/7845200/_0-17-screenshot.png" alt="" data-udi="umb://media/b2d4ab738fcf499ea41e2d814c23d5f2" /></p> <p><em><span style="font-weight: 400;">Clive Couperthwaite, the first person to use the new remote technology. Image: Abbott / YouTube</span></em></p> <p><span style="font-weight: 400;">“You feel like you can live again - you don’t have to keep looking over your shoulder.”</span></p> <p><span style="font-weight: 400;">The technology has been approved for use in Australia, Europe, and the United States.</span></p> <p><span style="font-weight: 400;">Professor Peter Silburn, a neurologist from the Queensland Brain Institute, said the development of the new technology has been “the most exciting development” in treatment of the neurological disease since the DBS device itself.</span></p> <p><span style="font-weight: 400;">The DBS device works as a pacemaker for the brain, sending electrical signals to areas responsible for movement to reduce symptoms.</span></p> <p><span style="font-weight: 400;">“We take away the cardinal symptoms of Parkinson’s and we’re able to take the drugs right down - if not stop them all together,” Dr Silburn said.</span></p> <p><img style="width: 0px; height:0px;" src="https://oversixtydev.blob.core.windows.net/media/7845199/_1-26-screenshot.png" alt="" data-udi="umb://media/80b1ad454cf64e9bbdeab17e3c6b2dce" /></p> <p><em><span style="font-weight: 400;">Two electrodes are implanted in the brain and receive electrical signals from the device, implanted in the chest. Image: Abbott / YouTube</span></em></p> <p><span style="font-weight: 400;">Without the new technology, Dr Silburn said the device may need to be adjusted as frequently as every two weeks.</span></p> <p><span style="font-weight: 400;">Now, the wireless technology allows specialists such as Dr Silburn to connect with patients via an app installed on paired devices - meaning that adjustments can be made from anywhere in the world.</span></p> <p><span style="font-weight: 400;">“This is going to have a major impact for particularly regional Australians,” Dr Silburn said.</span></p> <p><span style="font-weight: 400;">“It reduces the burden of care, whether you’re remote in the bush or an hour away in the car - someone has to give up their time to bring you in.</span></p> <p><span style="font-weight: 400;">“If you’re way out in the middle of Australia and something goes wrong, you need to have a Careflight, that could be completely eliminated.”</span></p> <p><span style="font-weight: 400;">Mr Couperthwaite said the DBS implant is the source of his autonomy, allowing him to complete tasks from painting to kayaking.</span></p> <p><span style="font-weight: 400;">“Before I was shaking through my hands, I couldn’t write my name legibly,” he said.</span></p> <p><span style="font-weight: 400;">Migual Diaz, the chief executive of Parkinson’s Australia, said the new development could lead more people to pursue DBS as a form of treatment, especially if they are geographically isolated.</span></p> <p><span style="font-weight: 400;">“People [who] may have been put off by the fact that you have to come to Brisbane to have [adjustments] and have opted not to have DBS surgery might now reconsider that,” he said.</span></p> <p><span style="font-weight: 400;">“Currently, there is no cure for Parkinson’s, so anything that will improve their wellbeing is an absolute benefit and we’ve got to pursue it.”</span></p> <p><em><span style="font-weight: 400;">Image: Abbott / YouTube</span></em></p>

Technology

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Traffic noise could increase your risk of dementia

<p><span style="font-weight: 400;">The amount of noise a person is exposed to from road and railway traffic could affect their risk of developing dementia, according to international research.</span></p> <p><span style="font-weight: 400;">A team from Denmark has investigated the connection between long-term residential exposure to road traffic and railway noise and dementia risk among two million adults over the age of 60 living in Denmark between 2004 and 2017.</span></p> <p><span style="font-weight: 400;">To do this, they estimated the level of road traffic and railway noise at the most and least exposed sides of every residential address in Denmark.</span></p> <p><span style="font-weight: 400;">Then, they analysed national health registers in search of all cases of all-cause dementia and different types, including Alzheimer’s disease, vascular dementia, and Parkinson’s disease related dementia.</span></p> <p><span style="font-weight: 400;">After taking other potentially influential factors into account, the team found that an average of 10 years exposure to noise was associated with a higher risk of dementia.</span></p> <p><span style="font-weight: 400;">They also found that both road and railway noise were associated with a higher risk of Alzheimer’s, with a 27 percent increase for exposure to road traffic noise of 55 decibels and a 24 percent increase for exposure to railway noise of 50 decibels.</span></p> <p><span style="font-weight: 400;">But, they found that the increased risk of vascular dementia was only associated with road traffic noise.</span></p> <p><span style="font-weight: 400;">The researchers note that the study is observational and doesn’t include information about how lifestyle habits could have played a part in participants’ risks of developing dementia.</span></p> <p><span style="font-weight: 400;">They conclude: “If these findings are confirmed in future studies, they might have a large effect on the estimation of the burden of disease and healthcare costs attributed to transportation noise.</span></p> <p><span style="font-weight: 400;">“Expanding our knowledge of the harmful effects of noise on health is essential for setting priorities and implementing effective policies and public health strategies focused on the prevention and control of diseases, including dementia.”</span></p> <p><span style="font-weight: 400;">The researchers estimate that as many as 14 percent of the 8,475 cases of dementia in Denmark in 2017 could be attributed to transportation noise exposure.</span></p> <p><span style="font-weight: 400;">Transportation noise has been previously linked to several other health conditions, including coronary heart disease, obesity, and diabetes.</span></p> <p><span style="font-weight: 400;">The study was published in the journal </span><em><a rel="noopener" href="https://www.bmj.com/content/374/bmj.n1954" target="_blank"><span style="font-weight: 400;">The BMJ</span></a></em><span style="font-weight: 400;">.</span></p> <p><em><span style="font-weight: 400;">Image: Getty Images</span></em></p>

Mind

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Study finds dancing to music can slow progression of Parkinson’s disease

<p><span style="font-weight: 400;">After being diagnosed with Parkinson’s disease at age 49, J.M. Tolani’s life was thrown upside down. </span></p> <p><span style="font-weight: 400;">He had to quit his job as a photojournalist and learn to cope with a new physical and emotional struggle. </span></p> <p><span style="font-weight: 400;">“I felt as though I had been hit by a truck. Everything felt like it came to a standstill. My life was altogether changed,” he said to WebMD.</span></p> <p><span style="font-weight: 400;">He was then introduced to a unique program called Dance for PD, which was recommended to him by a member of a support group he attended.</span></p> <p><span style="font-weight: 400;">Dance for PD is a specialised dance program for people with Parkinson’s disease, their families, friends, and care partners.</span></p> <p><span style="font-weight: 400;">The company was founded in 2001, with program director David Leventhal saying the program is designed to inspire.</span></p> <p><span style="font-weight: 400;">“[I] wanted to commit energy and time to working with people with Parkinson’s and sharing what we had learned with teaching artists around the world,” he says.</span></p> <p><span style="font-weight: 400;">After attending classes, Tolani felt his condition, and his emotional state, improve drastically.</span></p> <p><span style="font-weight: 400;">“I found I could move, and the dancing seemed to provide a replacement for the dopamine lost in the brain. Dancing motivates me and makes me happy, flexible, and mobile,” Tolani says.</span></p> <p><span style="font-weight: 400;">Tolani’s claims have been backed up by scientific research that shows individuals diagnosed with mild to moderate Parkinson’s had the progression of the disease slowed down by participating in regular dancing. </span></p> <p><span style="font-weight: 400;">Senior investigator Joseph DeSouza PhD said, “The classes were very beneficial for these individuals with PD, and we know that dance activates brain areas, even in people without PD.” </span></p> <p><span style="font-weight: 400;">Following an in-depth study, research showed that those with a mild condition who danced for an hour per week had a slower loss of their motor neuron function to those who didn’t. </span></p> <p><span style="font-weight: 400;">Tolani was able to return to his passion for photography, as he continues to move to the beat. </span></p> <p><span style="font-weight: 400;">“I take three to four classes a week, and they allow me to get out and meet people and interact with them. They put me in a good, positive state of mind,” he says. </span></p> <p><span style="font-weight: 400;">“I wake up and look forward to enjoying myself, and dancing with others in the Parkinson’s community, where I feel I’m allowed to completely be myself.”</span></p> <p><em>Image credit: Shutterstock</em></p>

Music

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Michael J. Fox opens up about secret health battle

<p>Michael J. Fox, who has battled Parkinson’s disease for decades, says the lowest moment in his life happened while he was recovering from an unrelated health issue. </p> <p>In 2018, the 59-year-old actor underwent a risky spinal cord surgery to remove a non-cancerous tumour.</p> <p>“I was heading for paralysis if I didn’t get it operated on,” he told People. A few months later, the Family Ties star, who had to learn to walk again, was alone in his family’s New York City apartment when he fell and shattered his arm.</p> <p>“That was definitely my darkest moment,” he said.</p> <p>“I just snapped. I was leaning against the wall in my kitchen, waiting for the ambulance to come, and I felt like, ‘This is as low as it gets for me.’</p> <p>“It was when I questioned everything. Like, ‘I can’t put a shiny face on this. There’s no bright side to this, no upside. This is just all regret and pain’.”</p> <p>While he’s known to be an optimistic person, his positive attitude began dwindling.</p> <p>“Parkinson’s, my back, my arm … it still didn’t add up to moving the needle on the misery index compared to what some people go through,” he said. “I thought, ‘How can I tell these people, chin up; look at the bright side; things are going to be great?’”</p> <p>Fox revealed that he convalesced by watching game shows from the ’70s and slowly regained his positive outlook.</p> <p>“Optimism is really rooted in gratitude,” he said. “Optimism is sustainable when you keep coming back to gratitude, and what follows from that is acceptance. Accepting that this thing has happened, and you accept it for what it is. It doesn’t mean that you can’t endeavour to change.</p> <p>“It doesn’t mean you have to accept it as a punishment or a penance, but just put it in its proper place. Then see how much the rest of your life you have to thrive in, and then you can move on.”</p> <p>These days, Fox lives a quiet life with his wife Tracy Pollan and their four children, son Sam, 31, twins Aquinnah and Schuyler, 25, and daughter Esme, 19.</p> <p>“I’m actually having a really good time,” he said.</p> <p>“People don’t believe me, but I love life. I love being with my family. I love being with Tracy. I love that I don’t do a lot of useless stuff that I used to do, because I don’t have the energy or the time. I’m grateful that I went through a crucible there in my late 50s. I figured some of this crap out finally.”</p> <p>Fox’s new memoir No Time Like The Future comes out on November 17.</p>

News

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Billy Connolly quits stand-up comedy amid Parkinson’s diagnosis

<p>Sir Billy Connolly has confirmed his career as a stand-up comedian has ended due to his Parkinson’s diagnosis.</p> <p>The 77-year-old made his diagnosis public in 2013 and retired five years later, but said last year he had hoped to continue performing in some way.</p> <p>“I’m finished with stand-up – it was lovely, and it was lovely being good at it,” he told <em><a href="https://news.sky.com/story/sir-billy-connolly-comedian-says-im-finished-with-stand-up-as-he-talks-about-his-new-career-as-an-artist-11950537">Sky News</a></em>.</p> <p>Connolly, who now works as an artist, said he does not want Parkinson’s to define him.</p> <p>“I’m always being asked to go to Parkinson’s things and spend time with Parkinson’s people, having lunch or something like that. And I don’t approve of it,” he said.</p> <p>“I don’t think you should let Parkinson’s define you and all your pals be Parkinson’s people. I don’t think it’s particularly good for you. So I don’t do it.”</p> <p>He said living with the condition was difficult at times.</p> <p>“Certain things go wrong, your brain goes adrift and affects your body, and so you walk differently, you walk like a drunk man sometimes. And you’re frightened you’ll be judged on it. And you shake sometimes.”</p> <p>However, he said he had “no regrets at all” and urged more people to “listen to comedians and poets”.</p> <p>“More people should listen to comedians, and fewer people should listen to politicians,” he said.</p> <p>“People should listen to comedians and poets, they’re telling the truth.”</p>

News

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8 early Parkinson’s disease symptoms that are too easy to miss

<p>This movement disorder is more treatable when caught early, but Parkinson’s disease symptoms can appear quite differently from one person to another. Talk to your doctor if you’re worried about any of these signs.</p> <p><strong>Changed handwriting</strong></p> <p>If your handwriting starts to go from big and loopy to small and cramped, this could be one of the earliest Parkinson’s disease symptoms. “Teachers with Parkinson’s will notice students complaining that they can’t read their handwriting when they write on the blackboard,” says Deborah Hall, MD, a neurologist. Look for letters getting smaller and words crowding together. Many patients have slower movement and trouble with repetitive tasks, like handwriting.</p> <p><strong>Reduced sense of smell</strong></p> <p>If you’re having trouble smelling pungent foods or no longer pick up your favourite scents, see a doctor. It’s not the most common symptom of Parkinson’s, but Dr. Hall says patients who suffer a loss of smell report it being the earliest sign they experience. The link between reduced sense of smell and Parkinson’s isn’t clear, but one theory is that the clumps of the protein alpha-synuclein, found in the brains of all Parkinson’s patients, may form in the part of the brain responsible for smell before migrating to other areas and affecting motor function.</p> <p><strong>Trouble sleeping</strong></p> <p>If you were once a peaceful sleeper, but now toss and turn, flail your limbs, or even fall out of bed, those sleep problems could be Parkinson’s disease symptoms. It’s normal to have an occasional restless night, but talk to your doctor if you or your partner notices extra movement when you’re in a deep sleep, or if you start sleep-talking. More research is needed to discover why disturbed sleep and Parkinson’s are related, but one theory is that the degeneration of specific regions of the brain stem that can cause disordered sleeping may play a role in other Parkinson’s disease symptoms.</p> <p><strong>Constipation</strong></p> <p>If you’re not moving your bowels every day, or are increasingly straining, this can be an early sign of Parkinson’s. The disease alters the body’s autonomic nervous system, which controls processes like digestion and bowel function. Constipation on its own isn’t unusual, but if you’re experiencing other symptoms like difficulty sleeping and trouble moving or walking, talk to your doctor.</p> <p><strong>Depression</strong></p> <p>Sometimes patients can develop depression after learning they have Parkinson’s, but it’s also common for people to be depressed years before they start to exhibit physical symptoms, says Michele Tagliati, MD, director of the Movement Disorders Program at Cedars-Sinai Medical Center in California.</p> <p>“Parkinson’s is characterised as a movement disorder because of a lack of dopamine in the brain, but there are also low levels of other neurotransmitters like serotonin, which are intimately related to depression,” he says.</p> <p>Parkinson’s patients who are depressed tend to feel apathetic and generally disinterested in things they used to enjoy, compared to feeling intensely sad or helpless, as is common in primary depression. “They lose pleasure in the simple things of life, like waking up in the morning and buying the paper,” says Dr. Tagliati. Treatment for depression includes counselling, antidepressant medication, and in the most extreme cases, electric shock therapy.</p> <p><strong>Tremors or shaking when relaxed</strong></p> <p>Shaking can be normal after lots of exercise or if you’re anxious, or as a side effect of some medications. But a slight shake in your finger, thumb, hand, chin, lip, or limbs when your body is at rest and your muscles are relaxed could signal Parkinson’s disease symptoms, according to the National Parkinson Foundation. About 70 percent of people with the disease experience a resting tremor, and it can become more noticeable during stress or excitement. These are the most common symptoms and often tip people off to the disease, but when Parkinson’s patients think back they realise they experienced loss of smell, disturbed sleep, or anxiety before the tremors began.</p> <p><strong>Stiffness and slowed movements</strong></p> <p>Watch for an abnormal stiffness in your joints along with muscle weakness that doesn’t go away and makes everyday tasks like walking, teeth brushing, buttoning shirts, or cutting food difficult. If you no longer swing your arms when walking, your feet feel “stuck to the floor” (causing you to hesitate before taking a step), or people comment that you look stiff when you haven’t been injured, the National Parkinson Foundation suggests seeing a doctor.</p> <p><strong>Softer voice, or masked face</strong></p> <p>Doctors say that a softer voice or masked, expressionless face is a common sign of the disease. Some patients with Parkinson’s disease symptoms may also talk softer without noticing or have excessively fast speech or rapid stammering. Parkinson’s causes disruption of movement, including facial muscles.</p> <p><em>Written by Alyssa Jung. This article first appeared in </em><a rel="noopener" href="https://www.readersdigest.com.au/healthsmart/conditions/8-early-parkinsons-disease-symptoms-that-are-too-easy-to-miss/" target="_blank"><em>Reader’s Digest</em></a><em>. For more of what you love from the world’s best-loved magazine, </em><a rel="noopener" href="http://readersdigest.innovations.co.nz/c/readersdigestemailsubscribe?utm_source=over60&amp;utm_medium=articles&amp;utm_campaign=RDSUB&amp;keycode=WRN93V" target="_blank"><em>here’s our best subscription offer.</em></a></p> <p><img style="width: 100px !important; height: 100px !important;" src="https://oversixtydev.blob.core.windows.net/media/7820640/1.png" alt="" data-udi="umb://media/f30947086c8e47b89cb076eb5bb9b3e2" /></p>

Body