Lebanese Prime Minister Hassan Diab has announced that his entire Government's resignation after the deadly explosion in Beirut that killed more than 150 people.

In a fiery speech, Mr Diab slammed Lebanon’s ruling elite for allowing “an apparatus of corruption bigger than the state”, and compared the explosion to an “earthquake that rocked the country”.

“We have fought valiantly and with dignity,” he said, referring to his cabinet.

“Between us and change is big powerful barrier.

“We have decided to stand with the people.”

The entire resignation of the government comes after three cabinet ministers and seven members of parliament quit.

The country's health ministry confirmed that at least 160 people were killed, with 6,000 wounded and around 20 people remaining missing.

Lebanese protestors are asking how a massive amount of ammonium nitrate was left unsecured at the port for years, with the country's top officials have promised a thorough investigation.

Protestors were also furious about security forces using tear gas against victims of the blast instead of helping them clean their homes and find a safe place to stay.

“We need an international investigation and trial to tell us who killed our friends and all the other victims, because they might try to conceal the truth,” said Michelle.

However, the country's top officials have stopped short of agreeing to an independent prove led by foreign experts, which is a demand of the protestors.