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1. Nicole Kidman

In 2001, Kidman lost out in starring in David Fincher’s Panic Room just a few weeks before filming because a recent knee injury became too painful to move. Kidman sustained the injury while starring in Moulin Rouge! and said it happened while doing a scene in heels until 3am.

While the life of a famous Hollywood actor can seem very glamorous, like all people in the world, their career is filled with their fair share of disappointments as well.

From unfortunate injuries to horrid miscommunication, these actors lost out on very famous roles for the silliest reasons.

Scroll through the gallery above to see which actors lost out.